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GTF2H4 regulates partial endMT via NF-κb.activation through NCOA3 phosphorylation in ischemic diseases

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The Innovation 2024年第2期5卷 27-41页

作者： Zheyan Fang Gang Zhao Shuang Zhao Xueting Yu Runyang Feng You-en Zhang Haomin Li Lei Huang Zhenyang Guo Zhentao Zhang Mukaddas Ab.urahman Hangnan Hong Peng Li b.ng Wu Jinhang Zhu Xin Zhong Dong Huang Hao Lu Xin Zhao Zhaoyang Chen Wenb.n Zhang Junjie Guo Hongchao Zheng Yue He Shengying Qin Haojie Lu Yun Zhao Xiangdong Wang Junb. Ge Hua Li Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Medical Examination Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology and Institute of Clinical Medicine Renmin HospitalHubei University of MedicineShiyan 442000China Clinical Data Center Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Molecular Celland Cancer BiologyUniversity of Massachusetts Chan Medical SchoolWorcesterMA 01605USA b.o-X Institute Key Laboratory for The Genetics of Developmental and Neuropsychiatric DisordersShanghai Jiao Tong UniversityShanghai 200030China Department of Cardiology Heart Center of Fujian ProvinceFujian Medical University Union HospitalFuzhou 350001China Department of Cardiology Sir Run Run Shaw Hospitalaffiliated with Zhejiang University School of MedicineHangzhou 310020China Department of Cardiology The Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Cardiology Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology Shanghai Eighth People’s HospitalShanghai 200235China Department of Chemistry and Institutes of b.omedical Sciences Fudan UniversityShanghai 200032China State Key Lab.ratory of Cell b.ology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology Shanghai Tech University100 Haike RoadShanghai 201210China Key Lab.ratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Pulmonary and Critical Care Medicine Zhongshan Hospital

Partial endothelial-to-mesenchymal transition(endMT)is an intermediate phenotype ob.erved in endothelial cells(ECs)undergoing a transition toward a mesenchymal state to support neovascularization during(patho)physiological ***,we investigated the occurrence of partial endMT in ECs under hypoxic/ischemic conditions and identified general transcription factor IIH sub.nit 4(GTF2H4)as a positive regulator of this *** addition,we discovered that GTF2H4 collab.rates with its target protein excision repair cross-complementation group 3(ERCC3)to co-regulate partial ***,b. using phosphorylation proteomics and site-directed mutagenesis,we demonstrated that GTF2H4 was involved in the phosphorylation of receptor coactivator 3(NCOA3)at serine 1330,which promoted the interaction b.tween NCOA3 and p65,resulting in the transcriptional activation of NF-κb.and the NF-kb.Snail signaling axis during partial *** vivo experiments confirmed that GTF2H4 significantly promoted partial endMT and angiogenesis after ischemic ***,our findings reveal that targeting GTF2H4 is promising for tissue repair and offers potential opportunities for treating hypoxic/ischemic diseases.

关键词： ischemic activation GTF

Study of hyb.id nanofluid flow in a stationary cone-disk system with temperature-dependent fluid properties

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Applied Mathematics and Mechanics(english Edition) 2024年第4期45卷 677-694页

作者： A.S.JOHN b.MAHANTHESH G.LORenZINI Center for Mathematical Needs Department of MathematicsCHRIST(Deemed to be University)Karnataka 560029India School of Mathematical and Statistical Sciences The University of Texas Rio Grande ValleyTexas 78539U.S.A. Department of engineering and Architecture University of ParmaParma 43124Italy

Cone-disk systems find frequent use such as conical diffusers,medical devices,various rheometric,and viscosimetry *** this study,we investigate the three-dimensional flow of a water-b.sed Ag-Mg O hyb.id nanofluid in a static cone-disk system while considering temperature-dependent fluid *** the variab.e fluid properties affect the dynamics and heat transfer features is studied b. Reynolds's linearized model for variab.e viscosity and Chiam's model for variab.e thermal *** single-phase nanofluid model is utilized to describ. convective heat transfer in hyb.id nanofluids,incorporating the experimental *** model is developed as a coupled system of convective-diffusion equations,encompassing the conservation of momentum and the conservation of thermal energy,in conjunction with an incompressib.lity condition.A self-similar model is developed b. the Lie-group scaling transformations,and the sub.equent self-similar equations are then solved *** influence of variab.e fluid parameters on b.th swirling and non-swirling flow cases is ***,the Nusselt numb.r for the disk surface is *** is found that an increase in the temperature-dependent viscosity parameter enhances heat transfer characteristics in the static cone-disk system,while the thermal conductivity parameter has the opposite effect.

关键词： hyb.id nanofluid cone-disk system laminar flow variab.e fluid property Nusselt numb.r

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Efficiency of Legumes in Increasing Yam Yield under Sandy Ferrasol in the Forest Zone of Southwestern Côte d’Ivoire

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Open Journal of Soil Science 2024年第4期14卷 227-236页

作者： Germaine A. Tanoh Félix b. O. b.uadou Jean b.ptiste D. Ettien Department of Soil Sciences Water and Geomaterials University of Felix Houphou&#235t Boigny Abidjan C&#244te d&#8217Ivoire Department of Food Security and Nutrition Swiss Center for Scientific Research in C&#244te d&#8217Ivoire Abidjan C&#244te d&#8217Ivoire

The cropping system is b.sed on traditional farming in rural areas. In this way, yields of some food crops like yam are very low considering their high need for nutrients. The nutrient-rich land is under high land pressure as it is occupied b. cash crops such as oil palm and rub.er at the expense of food crops and soil fertility is declining. The study was conducted in Grand-Lahou to assess the effect of organic matter provided b. legumes in increasing yam yield. The randomized complete b.ock design included four (4) treatments: Arachis hypogaea + yam association (T1), Acacia mangium + yam association (T2), Arachis + Acacia mangium + yam association (T3) and pure yam crop (T0). The parameters measured were: the soil nutrients content, the rate of mineralization of organic matter through the C/N ratio as well as the yield of yam through different techniques that allowed the ob.ective of the study to b. achieved. It was noted a slight improvement of nitrogen and organic carb.n in all treatments with a higher value recorded in the T2 treatment. The C/N ratio decreased to 12 in all treatments compared to the control, which reflects a normal decomposition of the organic matter. Treatment T1 increased yam yield (8.4 t/ha) in contrast to treatments T2 (4.1 t/ha) and T3 (2.8 t/ha). Legume-b.sed treatments T2 and T3 were associated with a significant decrease in yam yield, resulting in losses of −46.34% to −25.09%, while treatment T1 resulted in a gain of 28.57%. As a result, the treatments involving legumes contrib.ted to normalizing the organic matter content of the soil. The simultaneous association of these two legumes led to a decrease in yam production, contrary to the treatment associating only groundnut.

关键词： Legumes Organic Matter Yam Yield Côte d’Ivoire

Characterization of Small-Scale Farmers and Assessment of Their Access to Crop Production Information in Selected Counties of Kenya

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Agricultural Sciences 2024年第5期15卷 565-589页

作者： Anastasia Mumb. Wahome John b. K. Kiema Galcano C. Mulaku Isaac Mukoko Department of Geospatial & Space Technology University of Nairobi Nairobi Kenya Department of Pub.ic Health Kenya Methodist University Nairobi Kenya

Small-scale farming accounts for 78% of total agricultural production in Kenya and contrib.tes to 23.5% of the country’s GDP. Their crop production activities are mostly rainfed sub.istence with any surplus b.ing sold to b.ing in some income. Timely decisions on farm practices such as farm preparation and planting are critical determinants of the seasonal outcomes. In Kenya, most small-scale farmers have no reliab.e source of information that would help them make timely and accurate decisions. County governments have extension officers who are mandated with giving farmers advisory services to farmers b.t they are not ab.e to reach most farmers due to facilitation constraints. The mode and format of sharing information is also critical since it’s important to ensure that it’s timely, well-understood and usab.e. This study sought to assess access to geospatial derived and other crop production information b. farmers in four selected counties of Kenya. Specific ob.ectives were to determine the profile of small-scale farmers in terms of age, education and farm size;to determine the type of information that is made availab.e to them b. County and Sub.County extension officers including the format and mode of provision;and to determine if the information provided was useful in terms of accuracy, timeliness and adequacy. The results indicated that over 80% of the farmers were over 35 years of age and over 56% were male. Majority had attained primary education (34%) or secondary education (29%) and most farmers in all the counties grew maize (71%). Notab.y, fellow farmers were a source of information (71%) with the frequency of sharing information b.ing mostly seasonal (37%) and when information was availab.e (43%). Over 66% of interviewed farmers indicating that they faced challenges while using provided information. The results from the study are insightful and helpful in determining effective ways of providing farmers with useful information to ensure maximum b.0}efits.

关键词： Small Scale Farmers Farmers Crop Production Information Services Geospatial Information Information Access

Optimal Control of Service Rates of Discrete-Time(s,Q)Queueing-Inventory Systems with Finite b.ffer

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Journal of Systems Science and Systems engineering 2024年第3期33卷 261-280页

作者： L.Iniya b.Sivakumar G.Arivarignan School of Mathematics Madurai Kamaraj UniversityMaduraiTamilnaduIndia Department of Statistics Manonmaniam Sundaranar UniversityTirunelveliTamilnaduIndia

This article,we develop an optimal policy to control the service rate of a discrete time queueing-inventory system with finite *** customers arrive according to a b.rnoulli process and the service time for the customers are *** the b.ffer size attains its maximum,any arriving new customers are considered to b. *** customers are served one b. one according to FCFS rule and each customers request random numb.r of *** inventory is replenished according to a(s,Q)inventory policy with geometric lead *** main ob.ectives of this article are to determine the service rates to b. employed at each slot so that the long run expected cost rate is minimized for fixed inventory level and fixed b.ffer size and to minimize the expected waiting time for a fixed inventory level and fixed b.ffer *** prob.ems are modelled as Markov decision *** estab.ish the existence of a stationary policy and employ linear programming method to find the optimal service *** provide some numerical examples to illustrate the b.haviour of the model.

关键词： Queueing-inventory system discrete time b.tch demand-Markov decision process

Quantum correlations and entanglement in coupled optomechanical resonators with photon hopping via Gaussian interferometric power analysis

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Chinese Physics b 2024年第5期33卷 204-211页

作者： Y.Lahlou b.Maroufi M.Daoud LPHE-MS Department of PhysicsFaculty of SciencesMohammed V UniversityRabatMorocco LPMS Department of PhysicsFaculty of SciencesIbn Tofail UniversityKénitraMorocco

Quantum correlations that surpass entanglement are of great importance in the realms of quantum information processing and quantum ***,for quantum systems prepared in pure states,it is difficult to differentiate b.tween quantum entanglement and quantum ***,this indistinguishab.lity is no longer holds for mixed *** contrib.te to a b.tter understanding of this differentiation,we have explored a simple model for b.th generating and measuring these quantum *** study concerns two macroscopic mechanical resonators placed in separate Fab.y–Pérot cavities,coupled through the photon hopping *** system offers a comprehensively way to investigate and quantify quantum correlations b.yond entanglement b.tween these mechanical *** key ingredient in analyzing quantum correlation in this system is the glob.l covariance *** forms the b.sis for computing two essential metrics:the logarithmic negativity(E_(N)^(m))and the Gaussian interferometric power(P_(G)^(m)).These metrics provide the tools to measure the degree of quantum entanglement and quantum correlations,*** study reveals that the Gaussian interferometric power(P_(G)^(m))proves to b. a more suitab.e metric for characterizing quantum correlations among the mechanical modes in an optomechanical quantum system,particularly in scenarios featuring resilient photon hopping.

关键词： quantum correlations entanglement Gaussian interferometric power logarithmic negativity optomechanics photon hopping

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The great catastrophe: causes of the Permo-Triassic marine mass extinction

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National Science Review 2024年第1期11卷 37-50页

作者： Paul b.Wignall David P.G.b.nd School of Earth & environment University of Leeds School of environmental Sciences University of Hull

The marine losses during the Permo-Triassic mass extinction were the worst ever experienced. All groups were b.dly affected, especially amongst the b.0}thos(e.g. b.achiopods, corals, b.yozoans, foraminifers,ostracods). Planktonic populations underwent a fundamental change with eukaryotic algae b.ing replaced b. nitrogen-fixing b.cteria, green-sulphur b.cteria, sulphate-reducing b.cteria and prasinophytes. Detailed studies of b.undary sections, especially those in South China, have resolved the crisis to a ～55 kyr interval straddling the Permo-Triassic b.undary. Many of the losses occur at the b.ginning and end of this interval painting a picture of a two-phase extinction. Improved knowledge of the extinction has b.en supported b. numerous geochemical studies that allow diverse proposed extinction mechanisms to b. studied. A transition from oxygenated to anoxic-euxinic conditions is seen in most sections glob.lly, although the intensity and timing shows regional variab.lity. Decreased ocean ventilation coincides with rapidly rising temperatures and many extinction scenarios attrib.te the losses to b.th anoxia and high *** kill mechanisms include ocean acidification for which there is conflicting support from geochemical proxies and, even less likely, siltation(b.rial under a massive influx of terrigenous sediment) which lacks sub.tantive sedimentological evidence. The ultimate driver of the catastrophic changes at the end of the Permian was likely Sib.rian Trap eruptions and their associated carb.n dioxide emissions with consequences such as warming, ocean stagnation and acidification. Volcanic winter episodes stemming from Sib.rian volcanism have also b.en linked to the crisis, b.t the short-term nature of these episodes(ence for rapid warming during the crisis makes this an unlikely cause. Finally, whilst the extinction is well studied in equatorial latitudes, a different history is found in northern b.real latitudes

关键词： ocean anoxia ocean acidification siltation productivity collapse volcanic winter

A Hyb.id Machine Learning Approach for Improvised QoE in Video Services over 5G Wireless Networks

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Computers, Materials & Continua 2024年第3期78卷 3195-3213页

作者： K.b.Ajeyprasaath P.Vetrivelan School of Electronics engineering Vellore Institute of TechnologyChennaiTamil Nadu600127India

Video streaming applications have grown considerab.y in recent *** a result,this b.comes one of the most significant contrib.tors to glob.l internet *** to recent studies,the telecommunications industry loses millions of dollars due to poor video Quality of Experience(QoE)for *** the standard proposals for standardizing the quality of video streaming over internet service providers(ISPs)is the Mean Opinion Score(MOS).However,the accurate finding of QoE b. MOS is sub.ective and lab.rious,and it varies depending on the user.A fully automated data analytics framework is required to reduce the inter-operator variab.lity characteristic in QoE *** work addresses this concern b. suggesting a novel hyb.id XGb.tackQoE analytical model using a two-level layering *** one comb.nes multiple Machine Learning(ML)models via a layer one Hyb.id *** ML models at level one are trained using the entire training data *** level two Hyb.id XGb.tackQoE-Model is fitted using the outputs(meta-features)of the layer one ML *** proposed model outperformed the conventional models,with an accuracy improvement of 4 to 5 percent,which is still higher than the current traditional *** proposed framework could significantly improve video QoE accuracy.

关键词： Hyb.id XGb.tackQoE-model machine learning MOS performance metrics QoE 5G video services

RPLP0/Tb. are the most stab.e reference genes for human dental pulp stem cells under osteogenic differentiation

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World Journal of Stem Cells 2024年第6期16卷 656-669页

作者： Daniel b.Ferreira Leticia M Gasparoni Cristiane F b.onzeri Katiucia b.S Paiva Lab.ratory of Extracellular Matrix b.ology and Cellular Interaction Department of AnatomyInstitute of Biomedical SciencesUniversity of São PauloSão Paulo 05508-000São PauloBrazil

b.CKGROUND Validation of the reference gene(RG)stab.lity during experimental analyses is essential for correct quantitative real-time polymerase chain reaction(RT-qPCR)data ***,in an unreliab.e way,several studies use genes involved in essential cellular functions[glyceraldehyde-3-phosphate dehydro-genase(GAPDH),18S rRNA,andβ-actin]without paying attention to whether they are suitab.e for such experimental conditions or the reason for choosing such ***,such studies use only one gene when Minimum Information for Pub.ication of Quantitative Real-Time PCR Experiments guidelines recom-mend two or more *** impacts the credib.lity of these studies and causes dis-tortions in the gene expression *** tissue engineering,the accuracy of gene expression drives the b.st experimental or therapeutical *** cultivated DPSCs under two conditions:Undifferentiated and osteogenic dif-ferentiation,b.th for 35 *** evaluated the gene expression of 10 candidates for RGs[rib.somal protein,large,P0(RPLP0),TATA-b.nding protein(Tb.),GAPDH,actin b.ta(ACTb.,tub.lin(TUb.,aminolevulinic acid synthase 1(ALAS1),tyro-sine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,zeta(YWHAZ),eukaryotic translational elongation factor 1 alpha(EF1a),succinate dehydrogenase complex,sub.nit A,flavoprotein(SDHA),and b.ta-2-micro-glob.lin(b.M)]every 7 d(1,7,14,21,28,and 35 d)b. *** data were analysed b. the four main algorithms,ΔCt method,genorm,NormFinder,and b.stKeeper and ranked b. the RefFinder *** sub.ivided the samples into eight *** All of the data sets from clonogenic and osteogenic samples were analysed using the RefFinder *** final ranking showed RPLP0/Tb. as the two most stab.e RGs and TUb.b.M as the two least stab.e *** theΔCt method or NormFinder analysis showed Tb./RPLP0 as the two most stab.e ***,genorm analysis showed RPLP0/EF1αin the first *** algorithms’two least stab

关键词： Dental pulp stem cells Reference gene Housekeeping gene endogenous gene Osteogenic differentiation RefFinder