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Current concepts on osteonecrosis of the femoral head

World Journal of Orthopedics 2015年第8期6卷 590-601页

作者： joaquin moya-angeler Arianna L Gianakos Jordan C Villa Amelia Ni Joseph M Lane Hospital for Special Surgery

It is estimated that 20000 to 30000 new patients are diagnosed with osteonecrosis annually accounting for approximately 10% of the 250000 total hip arthroplasties done annually in the United States. Thelack of level 1 evidence in the literature makes it difficult to identify optimal treatment protocols to manage patients with pre-collapse avascular necrosis of the femoral head, and early intervention prior to collapse is critical to successful outcomes in joint preserving procedures. There have been a variety of traumatic and atraumatic factors that have been identified as risk factors for osteonecrosis, but the etiology and pathogenesis still remains unclear. Current osteonecrosis diagnosis is dependent upon plain anteroposterior and frog-leg lateral radiographs of the hip, followed by magnetic resonance imaging(MRI). Generally, the first radiographic changes seen by radiograph will be cystic and sclerotic changes in the femoral head. Although the diagnosis may be made by radiograph, plain radiographs are generally insufficient for early diagnosis, therefore MRI is considered the most accurate benchmark. Treatment options include pharmacologic agents such as bisphosphonates and statins, biophysical treatments, as well as joint-preserving and joint-replacing surgeries. the surgical treatment of osteonecrosis of the femoral head can be divided into two major branches: femoral head sparing procedures(FHSP) and femoral head replacement procedures(FHRP). In general, FHSP are indicated at pre-collapse stages with minimal symptoms whereas FHRP are preferred at post-collapse symptomatic stages. It is difficult to know whether any treatment modality changes the natural history of core decompression since the true natural history of core decompression has not been delineated.

关键词： Osteonecrosis Femoral head Conservative treatment Core decompression Stem cells Total hip arthroplasty

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Transmission-reflection optoacoustic ultrasound(TROPUS)computed tomography of small animals

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Light(Science & Applications) 2019年第1期8卷 1051-1062页

作者： Elena Mercep joaquin LHerraiz Xose Luis Dean-Ben Daniel Razansky Faculty of Medicine Technical University of MunichMunichGermany iThera Medical GmbH MunichGermany Nuclear Physics Group and UPARCOS Complutense University of MadridCEI MoncloaMadridSpain Health Research Institute of Hospital Clinico San Carlos(IdISSC) MadridSpain Institute for Biological and Medical Imaging(IBMI) Helmholtz Center MunichNeuherbergGermany Faculty of Medicine and Institute of Pharmacology and Toxicology University of ZurichZurichSwitzerland Institute for Biomedical Engineering and Department of Information Technology and Electrical Engineering ETH ZurichZurichSwitzerland

Rapid progress in the development of multispectral optoacoustic tomography techniques has enabled unprecedented insights into biological dynamics and molecular processes in vivo and noninvasively at penetration and spatiotemporal scales not covered by modern optical microscopy *** imaging provides highly complementary information on elastic and functional tissue properties and further aids in enhancing optoacoustic image *** devised the first hybrid transmission–reflection optoacoustic ultrasound(TROPUS)small animal imaging platform that combines optoacoustic tomography with both reflection-and transmission-mode ultrasound computed *** system features full-view cross-sectional tomographic imaging geometry for concomitant noninvasive mapping of the absorbed optical energy,acoustic reflectivity,speed of sound,and acoustic attenuation in whole live mice with submillimeter resolution and unrivaled image ***-processing unit(GPU)-based algorithms employing spatial compounding and bent-ray-tracing iterative reconstruction were further developed to attain real-time rendering of ultrasound tomography images in the full-ring acquisition *** vivo mouse imaging experiments revealed fine details on the organ parenchyma,vascularization,tissue reflectivity,density,and *** further used the speed of sound maps retrieved by the transmission ultrasound tomography to improve optoacoustic reconstructions via two-compartment *** newly developed synergistic multimodal combination offers unmatched capabilities for imaging multiple tissue properties and biomarkers with high resolution,penetration,and contrast.

关键词： reflectivity rendering details

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Oxidative effects of the harmful algal blooms on primary organisms of the food web

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BIOCELL 2019年第2期43卷 41-50页

作者： joaquin CABRERA PAULA MARIELA GONZALEZ SUSANA PUNTARULO Universidad de Buenos Aires Facultad de Farmacia y BioquimicaFisicoquimica.Buenos AiresArgentina CONIONI CETET-Universidad de Buenos Aires.Instituto de Bioquimica y Medicina Molecular(IBI IBI MOLOL).Buenos Aires Argentina

Degraded water quality from nutrient pollution,physical,biological,and other chemical factors contributes to the development and persistence of many harmful algal blooms(HAB s).The complex dynamics of the HAB s is a challenge to marine ecosystems for the toxic effects *** consequences include fish,bird,and mammal mortality,respiratory or digestive tract problems,memory loss,seizures,lesions and skin irritation in many *** review is intended to briefly summarize the recent reported information on harmful marine toxin deleterious effects over the primary organisms of the food web,namely algae,zooplankton and *** focus is made on oxidative stress status of cells and *** though in situ field research is less controlled than laboratory studies,in which the organisms are directly exposed to the toxins under consideration,both types of approaches are required to fully understand such a complex *** top of that,the contribution of the increasing water temperatures in the sea,as a consequence of the global climate change,will be addressed as a topic for further studies,to evaluate the effect on regulating algal growth,species composition,trophic structure,metabolic stress and function of aquatic ecosystems.

关键词： Harmful algal toxins oxidative stress algae zooplankton invertebrates

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Determination of REE,U,Тh,Ba,and Zr in simulated hydrogeological leachates by ICP-AES after matrix solvent extraction

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Journal of Rare Earths 2009年第1期27卷 123-127页

作者： Marin Ayranov joaquin Cobos Karin Popa Vincenzo V.Rondinella European Commission Joint Research Centre Institute for Transuranium Elements Postfach 2340 76125 Karlsruhe Germany Paul Scherrer Institut CH-5232 Villigen PSI Switzerland "Al.I.Cuza"University Department of Chemistry 11-Carol I Blvd. 700506-Ia■i Romania

A fast, reliable and precise method for the determination of Ba, Zr, Th, U, La, Ce, Eu, Hf and Gd in leaching solutions containing up to 1 mol/L FeCl3 by inductively coupled plasma-atomic emission spectrometry（ICP-AES） was ***-liquid extraction with diethyl ether was applied for selective and quantitative extraction of the iron with a decontamination factor of *** study has enabled the determination of rare earth elements, U, Th Ba, and Zr, from the solution with high iron content with detection limits in the range of 1-24 ng/ml and a precision of 0.9%-4.6 % relative standard *** developed method was simple and was adopted for implementation in a glove box for handling radioactive materials.

关键词： rare earths elements ICP-AES iron

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Endoscopic mucosal ablation-an alternative treatment for colonic polyps:Three case reports

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World Journal of Gastroenterology 2020年第45期26卷 7258-7262页

作者： Antonio Mendoza Ladd joaquin Espinoza Cesar Garcia Department of Internal Medicine Division of GastroenterologyTexas Tech University Health Sciences CenterPaul L Foster School of MedicineEl PasoTX 79905United States Escuela de Medicina Luis Razetti Universidad Central de VenezuelaCaracas 999188Venezuela Department of Endoscopy University Medical Center of El PasoEl PasoTX 79905United States

BACKGROUND Endoscopic resection of non-invasive lesions is now the standard of care for lesions in the GI ***,resection techniques require extensive training,are not available in all endoscopy centers and are prone to *** mucosal ablation(EMA)is a combination of resection and ablation techniques and it may offer an alternative in the management of such *** SUMMARY In this case series we report the successful treatment of three flat colonic polyps using the EMA *** lesions were treatment naïve and 1 was a recurrence after an endoscopic mucosal *** sizes ranged from 2 to 4 *** three polyps were ablated successfully with no immediate or delayed *** recurrence rate at 1 year of follow up was 0%.CONCLUSION Based on this initial experience,we conclude that EMA is a safe and effective technique for the treatment of non-invasive colonic polyps when endoscopic resection techniques are not available.

关键词： Endoscopy Mucosal ablation Colon polyp Argon plasma coagulation Alternative Safe Case report

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Importance of sperm morphology during sperm transport and fertilization in mammals

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Asian Journal of Andrology 2016年第6期18卷 844-850页

作者： Francisco A Garcia-Vazquez joaquin Gadea Carmen Matas William V Holt Department of Physiology Faculty of Veterinary Science International Excellence Campus for Higher Education and Research 'Campus Mare Nostrum' University of Murcia Murcia 30100 Spain Institute for Biomedical Research of Murcia (IMIB-Arrixaca) Murcia Spain Department of Human Metabolism Academic Unit of Reproductive and Developmental Medicine Sheffield S10 2SF UK

After natural or artificial insemination, the spermatozoon starts a journey from the site of deposition to the place of fertilization. However, only a small subset of the spermatozoa deposited achieves their goal： to reach and fertilize the egg. Factors involved in controlling sperm transport and fertilization include the female reproductive tract environment, cell-cell interactions, gene expression, and phenotypic sperm traits. Some of the significant determinants of fertilization are known （i.e., motility or DNA status）, but many sperm traits are still indecipherable. One example is the influence of sperm dimensions and shape upon transport within the female genital tract towards the oocyte. Biophysical associations between sperm size and motility may influence the progression of spermatozoa through the female reproductive tract, but uncertainties remain concerning how sperm morphology influences the fertilization process, and whether only the sperm dimensions per se are involved. Moreover, such explanations do not allow the possibility that the female tract is capable of distinguishing fertile spermatozoa on the basis of their morphology, as seems to be the case with biochemical, molecular, and genetic properties. This review focuses on the influence of sperm size and shape in evolution and their putative role in sperm transport and selection within the uterus and the ability to fertilize the oocyte.

关键词： CASA-Morph female reproductive tract flagellum morphometry sperm competition sperm head sperm selectionsperm size

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Fe-dependent cellular alterations of oxidative balance in aquatic *** be ferroptosis involved?

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BIOCELL 2023年第5期47卷 1177-1189页

作者： PAULA MARIELA GONZÁLEZ joaquin CABRERA SUSANA PUNTARULO Fisicoquímica Facultad de Farmacia y BioquímicaUniversidad de Buenos AiresBuenos AiresC1113 AADArgentina Instituto de Bioquímica y Medicina Molecular(IBIMOL) CONICET-Universidad de Buenos AiresBuenos AiresC1113 AADArgentina

The purpose of this review is to briefly summarize the central role of iron(Fe)in terms of cellular alterations of the oxidative/protective balance with special emphasis on its possible involvement in ferroptosis-dependent disruption in aquatic *** ferroptotic cells or tissues,the intracellular Fe level increases;meanwhile the treatment with Fe chelators limits *** algae can assimilate Fe from the environment through several mechanisms,and aquatic animals incorporate dissolved Fe and Fe bound to both inorganic particles and organic *** central role of lipid peroxidation mediating ferroptosis was demonstrated in some algae where both low and high Fe concentrations could induce oxidative stress and programmed cell *** animals have high levels of polyunsaturated fatty acids and numerous studies have analyzed Fe effects on the lipidic fraction which could be related to *** ferroptosis reaction can be regulated through the antioxidant defense system,in combination with the protein degradation structure,metabolism,and gene *** depletion of nonenzymatic antioxidants like reduced glutathione(GSH)in animals,and the reduction of both GSH and ascorbate in photosynthetic organisms,are characteristic features of ***,ferroptosis can be prevented if Fe chelators,certain antioxidants,and specifically regulating genes are ***,the global scenario for the Fe role as a toxic component in biological systems seems to be even more complicated than it was previously *** more research on this subject is needed to improve the life span and survival of aquatic organisms after exposure to natural and anthropogenic adverse conditions.

关键词： Glutathione Labile Fe pool Lipid peroxidation Oxidative stress

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Oviductal epithelial cells selected boar sperm according to their functional characteristics

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Asian Journal of Andrology 2017年第4期19卷 396-403页

作者： Rebeca Lepez-Ubeda Francisco A Garcia-Vazquez joaquin Gadea Carmen Matas Department of Physiology Veterinary Faculty University of Murcia International Excellence Campus for Higher Education and Research (Campus Mare Nostrum) Murcia 30100 Spain IMIB-Arrixaca (Institute for Biomedical Research of Murcia) Murcia Spain

The interaction of oviductal epithelial cells （OECs） with the spermatozoa has beneficial effects on the sperm functions. The aim of this study is to evaluate the in vitro fertilizing capacity of incubating spermatozoa previously selected by density gradient in OEC and determinate some sperm characteristics that could explain the results obtained. In this study, we assessed in vitro fertilization （IVF）, tyrosine phosphorylation, phosphatidylserine translocation, nuclear DNA fragmentation, and chromatin decondensation. Three experimental sperm groups, previously selected by Percoll gradient, were established according to the origin of the sperm used for IVF：（i） W30 group： spermatozoa were incubated with oocytes in the absence of OEC; （ii） NB group： after sperm incubation in OEC, the unbound spermatozoa were incubated with oocytes, in the absence of OEC; and （iii） B group： after sperm incubation with OEC, the bound spermatozoa were incubated with oocytes in the OEC plates. The results showed that sperm from the NB group led to a lower IVF yield, accompanied by low penetration rates （NB： 19.6%, B： 94.9%, and W30： 62.9%; P 〈 0.001） and problems of nuclear decondensation. Moreover, higher levels of tyrosine phosphorylation were observed in the NB group compared with the W30 and B groups （NB： 58.7%, B： 2.5%, and W30： 4.5%; P 〈 0.01）. A similar trend was observed in phosphatidylserine translocation （NB： 93.7%, B. 5.7%, and W30： 44.2%; P 〈 0.01）. These results demonstrate that the OEC exerts a rigorous degree of sperm selection, even within an already highly selected population of spermatozoa, and can capture the best functional spermatozoa for fertilization.

关键词： DNA status in vitro fertilization oviductal epithelial cells phosphatidylserine translocation sperm selection tyrosinephosphorylation

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MoS2-wrapped silicon nanowires for photoelectro- chemical water reduction

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Nano Research 2015年第1期8卷 281-287页

作者： Liming Zhang Chong Liu Andrew Barnabas Wong joaquin Resasco Peidong Yang Department of Chemistry University of California Berkeley CA 94720 USA Department of Chemical Engineering University of California Berkeley CA 94720 USA Department of Materials Science and Engineering University of California Berkeley CA 94720 USA Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Department of Materials Science and Engineering Stanford University Stanford CA 94305 USA

Integration of molybdenum disulfide （MoS2） onto high surface area photocathod is highly desired to minimize the overpotential for the solar-powered hydrogen evolution reaction （HER）. Semiconductor nanowires （NWs） are beneficial use in photoelectrochemistry because of their large electrochemically availab surface area and inherent ability to decouple light absorption and the transpo of minority carriers. Here, silicon （Si） NW arrays were employed as a mod photocathode system for MoS2 wrapping, and their solar-driven HER activil was evaluated. The photocathode is made up of a well-defined MoSJTiO2/Si coaxial NW heterostructure, which yielded photocurrent density up to 15 mA/cm2 （at 0 V vs. the reversible hydrogen electrode （RHE）） with goo stability under the operating conditions employed. This work reveals the earth-abundant electrocatalysts coupled with high surface area NW electrod~ can provide performance comparable to noble metal catalysts for photocathod hydrogen evolution.

关键词： MoS2 Si nanowire array coaxial heterostructure photoelectrochemistry hydrogen evolutionreaction (HER)

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Enhancing biocompatibility of the brain-machine interface:A review

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Bioactive Materials 2024年第12期42卷 531-549页

作者： Jordan Villa joaquin Cury Lexie Kessler Xiaodong Tan Claus-Peter Richter Northwestern University-Feinberg School of Medicine Department of OtolaryngologyUSA The Hugh Knowles Center Department of Communication Sciences and DisordersNorthwestern UniversityUSA Department of Communication Sciences and Disorders Northwestern UniversityUSA Department of Biomedical Engineering Northwestern UniversityUSA

In vivo implantation of microelectrodes opens the door to studying neural circuits and restoring damaged neural pathways through direct electrical stimulation and *** some neuroprostheses have achieved clinical success,electrode material properties,inflammatory response,and glial scar formation at the electrode-tissue interfaces affect performance and *** challenges can be addressed by improving some of the materials’mechanical,physical,chemical,and electrical *** paper reviews materials and designs of current microelectrodes and discusses perspectives to advance neuroprosthetics performance.

关键词： Brain-machine interface Neuroprostheses Implantable devices Electrode coatings Immune reaction

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