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Current concepts on osteonecrosis of the femoral head

世界骨科杂志：英文版 2015年第8期6卷 590-601页

作者： joaquin moya-angeler Arianna L Gianakos Jordan C Villa Amelia Ni Joseph M Lane Hospital for Special Surgery

It is estimated that 20000 to 30000 new patients are diagnosed with osteonecrosis annually accounting for approximately 10% of the 250000 total hip arthroplasties done annually in the United States. Thelack of level 1 evidence in the literature makes it difficult to identify optimal treatment protocols to manage patients with pre-collapse avascular necrosis of the femoral head, and early intervention prior to collapse is critical to successful outcomes in joint preserving procedures. There have been a variety of traumatic and atraumatic factors that have been identified as risk factors for osteonecrosis, but the etiology and pathogenesis still remains unclear. Current osteonecrosis diagnosis is dependent upon plain anteroposterior and frog-leg lateral radiographs of the hip, followed by magnetic resonance imaging(MRI). Generally, the first radiographic changes seen by radiograph will be cystic and sclerotic changes in the femoral head. Although the diagnosis may be made by radiograph, plain radiographs are generally insufficient for early diagnosis, therefore MRI is considered the most accurate benchmark. Treatment options include pharmacologic agents such as bisphosphonates and statins, biophysical treatments, as well as joint-preserving and joint-replacing surgeries. the surgical treatment of osteonecrosis of the femoral head can be divided into two major branches: femoral head sparing procedures(FHSP) and femoral head replacement procedures(FHRP). In general, FHSP are indicated at pre-collapse stages with minimal symptoms whereas FHRP are preferred at post-collapse symptomatic stages. It is difficult to know whether any treatment modality changes the natural history of core decompression since the true natural history of core decompression has not been delineated.

关键词： Osteonecrosis Femoral head Conservative treatment Core decompression Stem cells Total hip arthroplasty

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深海环境海洋生态系统监测与修复新技术

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Engineering 2024年第3期34卷 195-211页

作者： Jacopo Aguzzi Laurenz Thomsen Sascha Flögel Nathan J.Robinson Giacomo Picardi Damianos Chatzievangelou Nixon Bahamon Sergio Stefanni Jordi Grinyó Emanuela Fanelli Cinzia Corinaldesi joaquin Del Rio Fernandez Marcello Calisti Furu Mienis Elias Chatzidouros Corrado Costa Simona Violino Michael Tangherlini Roberto Danovaro Instituto de Ciencias del Mar(ICM-CSIC) Barcelona 08003Spain Stazione Zoologica Anton Dohrn Naples 80121Italy University of Gothenburg Göteborg 40530Sweden GEOMAR Helmholtz Centre for Ocean Research Kiel 24148Germany Fundación Oceanogràfic de la Comunitat Valenciana Valencia 46013Spain Royal Netherlands Institute for Sea Research(NIOZ) Den Burg Texel 1790 ABNetherlands Polytechnic University of Marche(UNIVPM) Ancona 60131Italy SARTI-MAR of the Universitat Politecnica de Catalunya(UPC) Vilanova i la Geltrú08800Spain Lincoln Institute for Agri-food Technology University of LincolnLincoln LN22LGUK Engitec Systems International Limited Limassol 3083Cyprus Consiglio per la Ricerca in Agricoltura e L’analisi Dell’economia Agraria(CREA) Centro di Ricerca Ingegneria e Trasformazioni AgroalimentariMonterotondo 00015Italy

The United Nations(UN)’s call for a decade of“ecosystem restoration”was prompted by the need to address the extensive impact of anthropogenic activities on natural *** ecosystem restoration is increasingly necessary due to increasing habitat degredation in deep waters(>200 m depth).At these depths,which are far beyond those accessible by divers,only established and emerging robotic platforms such as remotely operated vehicles(ROVs),autonomous underwater vehicles(AUVs),landers,and crawlers can operate through manipulators and multiparametric sensor arrays(e.g.,optoacoustic imaging,omics,and environmental probes).The use of advanced technologies for deep-sea ecosystem restoration can provide:①high-resolution three-dimensional(3D)imaging and acoustic mapping of substrates and key taxa,②physical manipulation of substrates and key taxa,③real-time supervision of remote operations and long-term ecological monitoring,and④the potential to work ***,we describe how robotic platforms with in situ manipulation capabilities and payloads of innovative sensors could autonomously conduct active restoration and monitoring across large spatial *** expect that these devices will be particularly useful in deep-sea habitats,such as①reef-building cold-water corals,②soft-bottom bamboo corals,and③soft-bottom fishery resources that have already been damaged by offshore industries(i.e.,fishing and oil/gas).

关键词： Ecosystem restoration Robotic manipulation Acoustic tracking Fishery resources Artificial reefs

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Fe-dependent cellular alterations of oxidative balance in aquatic *** be ferroptosis involved?

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BIOCELL 2023年第5期47卷 1177-1189页

作者： PAULA MARIELA GONZÁLEZ joaquin CABRERA SUSANA PUNTARULO Fisicoquímica Facultad de Farmacia y BioquímicaUniversidad de Buenos AiresBuenos AiresC1113 AADArgentina Instituto de Bioquímica y Medicina Molecular(IBIMOL) CONICET-Universidad de Buenos AiresBuenos AiresC1113 AADArgentina

The purpose of this review is to briefly summarize the central role of iron(Fe)in terms of cellular alterations of the oxidative/protective balance with special emphasis on its possible involvement in ferroptosis-dependent disruption in aquatic *** ferroptotic cells or tissues,the intracellular Fe level increases;meanwhile the treatment with Fe chelators limits *** algae can assimilate Fe from the environment through several mechanisms,and aquatic animals incorporate dissolved Fe and Fe bound to both inorganic particles and organic *** central role of lipid peroxidation mediating ferroptosis was demonstrated in some algae where both low and high Fe concentrations could induce oxidative stress and programmed cell *** animals have high levels of polyunsaturated fatty acids and numerous studies have analyzed Fe effects on the lipidic fraction which could be related to *** ferroptosis reaction can be regulated through the antioxidant defense system,in combination with the protein degradation structure,metabolism,and gene *** depletion of nonenzymatic antioxidants like reduced glutathione(GSH)in animals,and the reduction of both GSH and ascorbate in photosynthetic organisms,are characteristic features of ***,ferroptosis can be prevented if Fe chelators,certain antioxidants,and specifically regulating genes are ***,the global scenario for the Fe role as a toxic component in biological systems seems to be even more complicated than it was previously *** more research on this subject is needed to improve the life span and survival of aquatic organisms after exposure to natural and anthropogenic adverse conditions.

关键词： Glutathione Labile Fe pool Lipid peroxidation Oxidative stress

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Double Consciousness of Chinese Modernity:in the Cosmopolitan Ruins of Shanghai

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Fudan Journal of the Humanities and Social Sciences 2022年第3期15卷 411-435页

作者： joaquin Lopez-Mugica Thomas William Whyke University of Wenzhou-Kean WenzhouChina University of Nottingham NingboChina School of International Communications University of Nottingham Ningbo ChinaNingboZhejiangChina

This paper examines the inextricable relationship between the uncanny effects of knocking down Shanghai’s central district and their traumatic post-colonial *** value of the Chinese ruin,with its apocalyptic and contemporary imagery,begs to be discussed from a western perspective of ruin admiration as a metaphor for decadence and *** points to a new consciousness of globalization as means of conceptualizing well-established post-colonial orders at the heart of the urban deterioration of *** a potential concept to spark a dialogue of cosmopolitanism between China and the west,urban ruins can be analyzed as a transnational,creative ethos that reimagines the Chinese city as never *** the work of the Canadian photographer Greg Girard(born 1955),this article examines how his photograph book presents a cosmopolitan image of Shanghai’s derelict‘community lanes’(longtang or lilong)built in the city’s International Concessions(1842–1949),in which the past,present,and future are interwoven and *** authors argue that his ruin photography not only retriggers material knowledge of the city but also repurposes transcultural and creative expressions of mutually spectral moments of destruction and production between the east and the west,in which a myriad of potential features are discovered.

关键词： Post-colonial spaces Material ruins Hospitality Cosmopolitanism Hauntology

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Calling for a Hero:The Displacement of the Nezha Archetypal Image from Chinese Animated Film Nezha Naohai(1979)to New Gods:Nezha Reborn(2021)

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Fudan Journal of the Humanities and Social Sciences 2022年第3期15卷 389-409页

作者： Thomas William Whyke joaquin Lopez Mugica Zhejiang University International Business School Institute of China StudiesZhejiang University718 East Haizhou RdHaining 314400ZhejiangPeople’s Republic of China Department of Liberal Arts University of Wenzhou-Kean in ChinaWenzhouPeople’s Republic of China

From the classical Chinese literary masterpiece Investiture of the Gods to contemporary flm animation,Nezha’s image is *** the portrayals of Nezha,namely in those most celebrated animated flms,we argue that his role as the epitome of a‘god like fgure’is in constant displacement and *** the framework of archetype and displacement as advanced by Northrop Frye,with a more pluralistic myth analysis extension found in the myth critique of Gilbert Durand,this article examines the multi-layered mythical mini structures within Nezha’s displacement and return in Chinese animation,to explore the themes,images,and archetype represented by the character from the perspective of Chinese history and *** argue that Nezha’s displacement and return in Chinese animation expresses the need and call for a traditional heroic image in a particular *** such,Nezha’s intertextuality exposes the profound inner patterns that form and refashion the Chinese collective unconscious,performing as a recurring mirror that symbolically inform and transform human experiences in China.

关键词： Chinese animation Nezha Archetype Displacement Return

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Towards Fully Secure 5G Ultra-Low Latency Communications: A Cost-Security Functions Analysis

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Computers, Materials & Continua 2023年第1期74卷 855-880页

作者： Borja Bordel Ramón Alcarria joaquin Chung Rajkumar Kettimuthu Tomás Robles Iván Armuelles Universidad Politecnica de Madrid MadridEspana Argonne National Laboratory LemontILUSA Universidad de Panama PanamaPanama

Future components to enhance the basic,native security of 5G networks are either complex mechanisms whose impact in the requiring 5G communications are not considered,or lightweight solutions adapted to ultrareliable low-latency communications(URLLC)but whose security properties remain under *** different 5G network slices may have different requirements,in general,both visions seem to fall short at provisioning secure URLLC in the *** this work we address this challenge,by introducing cost-security functions as a method to evaluate the performance and adequacy of most developed and employed non-native enhanced security mechanisms in 5G *** categorize those new security components into different groups according to their purpose and deployment *** propose to analyze them in the context of existing 5G architectures using two different ***,using model checking techniques,we will evaluate the probability of an attacker to be successful against each security ***,using analytical models,we will analyze the impact of these security mechanisms in terms of delay,throughput consumption,and ***,we will combine both approaches using stochastic cost-security functions and the PRISM model checker to create a global *** results are first evidence of how a 5G network that covers and strengthened all security areas through enhanced,dedicated non-native mechanisms could only guarantee secure URLLC with a probability of∼55%.

关键词： 5G networks security analysis secure low latency communications URLLC eMBBC

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Shallow landslide susceptibility assessment under future climate and land cover changes: A case study from southwest China

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Geoscience Frontiers 2023年第4期14卷 21-41页

作者： Zizheng Guo joaquin Vicente Ferrer Marcel Hürlimann Vicente Medina Carol Puig-Polo Kunlong Yin Da Huang School of Civil and Transportation Engineering Hebei University of Technology300401 TianjinChina Division of Geotechnical Engineering and Geosciences Department of Civil and Environmental EngineeringUPC BarcelonaTECH08034 BarcelonaSpain Faculty of Engineering China University of Geosciences430074 WuhanChina Institute of Environmental Science and Geography University of Potsdam14476 PotsdamGermany Potsdam Institute for Climate Impact Research 14473 PotsdamGermany College of Geological Engineering and Geomatics Chang’an University710064 Xi’anChina

There is no doubt that land cover and climate changes have consequences on landslide activity,but it is still an open issue to assess and quantify their *** County in southwest China was selected as the test area to study rainfall-induced shallow landslide susceptibility under the future changes of land use and land cover(LULC)and *** used a high-resolution meteorological precipitation dataset and frequency distribution model to analyse the present extreme and antecedent rainfall conditions related to landslide *** future climate change factors were obtained from a 4-member multimodel ensemble that was derived from statistically downscaled regional climate *** future LULC maps were simulated by the land change modeller(LCM)integrated into IDRISI Selva software.A total of six scenarios were defined by considering the rainfall(antecedent conditions and extreme events)and LULC changes towards two time periods(mid and late XXI century).A physically-based model was used to assess landslide susceptibility under these different *** results showed that the magnitude of both antecedent effective recharge and event rainfall in the region will evidently increase in the *** the scenario with a return period of 100 years,the antecedent rainfall in summer will increase by up to 63%whereas the event rainfall will increase by up to 54%for the late 21st *** most considerable changes of LULC will be the increase of forest cover and the decrease of farming *** magnitude of this change can reach+22.1%(forest)and–9.2%(farmland)from 2010 until 2100,*** found that the negative impact of climate change on landslide susceptibility is greater than the stabilizing effect of LULC change,leading to an over decrease in stability over the study *** is one of the first studies across Asia to assess and quantify changes of regional landslide susceptibility under scenarios driven by LULC and climate ***

关键词： Rainfall-induced landslide Susceptibility Climate change Land cover change China

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Old-age inflammatory bowel disease onset:A different problem?

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World Journal of Gastroenterology 2011年第22期17卷 2734-2739页

作者： joaquin Hinojosa del Val Gastroeneterology Service Hospital de Manises Valencia 46940 Spain

Inflammatory bowel disease (IBD) in patients aged > 60 accounts for 10%-15% of cases of the disease. Diganostic methods are the same as for other age groups. Care has to be taken to distinguish an IBD colitis from other forms of colitis that can mimick clinically, endoscopically and even histologically the IBD entity. The clinical pattern in ulcerative colitis (UC) is proctitis and left-sided UC, while granulomatous colitis with an inflammatory pattern is more common in Crohn's disease (CD). The treatment options are those used in younger patients, but a series of considerations related to potential pharmacological interactions and side effects of the drugs must be taken into account. The safety profile of conventional immunomodulators and biological therapy is acceptable but more data are required on the safety of use of these drugs in the elderly population. Biological therapy has risen question on the possibility of increased side effects, however this needs to be confirmed. Adherence to performing all the test prior to biologic treatment administration is very important. The overall response to treatment is similar in the different patient age groups but elderly patients have fewer recurrences. The number of hospitalizations in patients > 65 years is greater than in younger group, accounting for 25% of all admissions for IBD. Mortality is similar in UC and slightly higher in CD, but significantly increased in hospitalized patients. Failure of medicaltreatment continues to be the most common indication for surgery in patients aged > 60 years. Age is not considered a contraindication for performing restorative proctocolectomy with an ileal pouch-anal anastomosis. However, incontinence evaluation should be taken into account an individualized options should be

关键词：溃疡性结肠炎炎症老年鸡传染性法氏囊病发病生物治疗治疗方案免疫调节剂

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Anti-cancer liposomal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel

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Nano Research 2022年第5期15卷 4302-4309页

作者： Boyang Sun Sanjana Ghosh Xuedan He Wei-Chiao Huang Breandan Quinn Meiling Tian Dushyant Jahagirdar Moustafa T.Mabrouk joaquin Ortega Yumiao Zhang Shuai Shao Jonathan F.Lovell Translational Medicine Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Department of Biomedical Engineering University at BuffaloState University of New YorkBuffaloNY 14260USA Department of Anatomy and Cell Biology McGill UniversityMontrealQuebec H3A0C7Canada School of Chemical Engineering and Technology Tianjin UniversityTianjin 300000China

Photodynamic therapy(PDT)is a non-invasive tumor ablation modality that can be enhanced in combination with concurrent ***,we demonstrated that liposomes containing a bilayer-anchored photosensitizer(porphyrin-phospholipid;PoP)can be loaded with drugs in their aqueous core to improve drug delivery and tumor ablation upon target tissue irradiation with *** the present work,we demonstrate that this concept can be extended to drugs loaded within the hydrophobic bilayer of ***(CTX)is a potent second generation taxane anti-cancer drug that was loaded in the bilayer of liposomes also containing 0.1 molar%PoP,generating CTX-loaded PoP liposomes(CTX-PoP-Lip).CTX-PoP-Lip showed unilamellar vesicle morphology,and exhibited integrity in storage and serum,while maintaining drug stability under laser *** vitro cell killing evaluation showed that red-light laser irradiation induced cytotoxicity in cells incubated with CTX-PoP-Lip,compared to control *** vivo pharmacokinetic analysis revealed that following intravenous administration to mice,CTX and PoP exhibited somewhat altered circulation profiles,suggesting that the CTX may have exchanged with serum factors in ***,when a single treatment of CTX-PoP-Lip with laser irradiation was administered to mice bearing human MIA Paca-2 tumors,tumors were effectively ablated whereas the equivalent chemotherapy and PDT monotherapies were *** results demonstrate the versatility of liposome delivery systems for achieving tumor ablation with chemophototherapy.

关键词： photodynamic therapy cabazitaxel liposome chemotherapy porphyrin-phospholipid

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Liver steatosis in patients with rheumatoid arthritis treated with methotrexate is associated with body mass index

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World Journal of Hepatology 2023年第5期15卷 699-706页

作者： Agustin Castiella Luis Lopez-Dominguez Maria J Sanchez-Iturri Iratxe Urreta Andrea De Diego joaquin Belzunegui Eva Zapata Department of Gastroenterology Service Donostia University HospitalDonostia 20014Spain Department of Rheumatology Donostia University HospitalDonostia 20014Spain Department of Gastroenterology Donostia University HospitalDonostia 20014Spain Department of Clinical Epidemiology Donostia University HospitalDonostia 20014Spain

BACKGROUND Methotrexate(MTX)is the usual first-line treatment for rheumatoid arthritis(RA).Long-term use of MTX has been associated with liver steatosis(LS)and liver fibrosis(LF).AIM To determine if LS in patients treated with MTX for RA is associated with MTX cumulative dose(MTX-CD),metabolic syndrome(Mt S),body mass index(BMI),the male sex,or *** A single-center,prospective study of patients receiving MTX for RA was performed from February 2019 to February *** inclusion criteria were patients aged 18 years or older diagnosed with RA by a rheumatologist and being treated with MTX(without limitation on the duration of treatment).The exclusion criteria were previous diagnosis of liver disease(hepatitis B or C virus infection,known nonalcoholic fatty liver disease),alcohol consumption greater than 60 g/d in males or 40 g/d in females,human immunodeficiency virus infection on antiretroviral therapy,diabetes mellitus,chronic renal failure,congestive heart failure,or BMI greater than 30 kg/m^(2).Patients receiving leflunomide in the 3 years prior to the study were also *** elastography(Fibro Scan,Echosens?,Paris,France)was used for fibrosis determination(LF>7 Kp A)and computer attenuation parameter(CAP)for LS(CAP>248 d B/m).Demographic variables,laboratory data,MTX-CD(>4000 mg),Mt S criteria,BMI(>25),transient elastography,and CAP scores were collected from all *** Fifty-nine patients were ***-three were female(72.88%),and the mean age was 61.52 years(standard deviation:11.73).When we compared MTX-CD≤4000 mg(26 patients;14 with LS and 12 without)with>4000 mg(33 patients;12 with LS and 21 without),no statistical differences were found(P=0.179).We compared CAP scores stratified by Mt S,BMI,sex,and *** were no significant differences in CAP scores based on the presence of Mt S[CAP/Mt S:50 no Mt S(84.75%);9 Mt S(15.25%);P=0.138],the male sex(CAP/sex:8 male/18 female LS;8 male/25 female no LS;P=0.576),or LF[CAP/fibrosis:

关键词： patients diagnosis index

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