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Pharmacokinetics Evaluation of Nimotuzumab in Combination with Doxorubicin and Cyclophosphamide in Patients with Advanced Breast Cancer

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Journal of Life Sciences 2013年第11期7卷 1123-1133页

作者： Leyanis Rodriguez-Vera Eduardo Fernandez-Sanchez Jorge L. Soriano Noide Batista Maite Lima joaquin gonzalez Robin Garcia Carmen Viada Concepcion Peraire Helena Colom Mayra Ramos-Suzarte Laboratory of Pharmacokinetic Department of Pharmacology & Toxicology Institute of Pharmacy & Foods 222 St. and 23 Avenue La Coronela La Lisa University of Havana Havana CP 13600 Cuba Center for Research and Biological Evaluation Institute of Pharmacy & Foods 222 St. and 23 Avenue La Coronela La LisaUniversity of Havana Havana CP 13600 Cuba Hermanos Ameijeiras Hospital San L6zaro Avenue and Street Belascoain Havana Center Havana Cuba Center of Molecular Immunology Street 216 and 15 Atabey Playa Havana Cuba Pharmacy and Pharmaceutical Technology Department School of Pharmacy University of Barcelona Barcelona Spain

EGFr （Epidermal growth factor receptor） overexpression has been detected in many tumors of epithelial origin, specifically in breast cancer and it is often associated with tumor growth advantages and poor prognosis. The nimotuzumab is a genetically engineered humanized MAb （monoclonal antibody） that recognizes an epitope located in the extracellular domain of human EGFr. The aim of this study was to assess the pharmacokinetics of nimotuzumab in patients with locally advanced breast cancer who are receiving neoadyuvant therapy combined with the AC chemotherapy regimen （i.e., 60 mg/m2 of Doxorubicin and 600 mg/m2 of Cyclophosphamide in 4 cycles every 21 days）. A single center, non-controlled, open Phase I clinical trial, with histopathological diagnosis of locally advanced stage III breast cancer, was conducted in 12 female patients. Three patients were enrolled at each of the following fixed dose levels： 50, 100, 200 and 400 mg/week. Multiple intermittent short-term intravenous infusions of nimotuzumab were administered weekly, except on weeks 1 and 10, when blood samples were drawn for pharmacokinetic assessments. Nimotuzumab showed dose-dependent kinetics. No anti-idiotypic response against nimotuzumab was detected in blood samples of participants. There was not interaction between the administration of nimotuzumab and chemotherapy at the dose levels studied. The optimal biological doses ranging were estimated to be 200 mg/weekly to 400 mg/weekly.

关键词： Breast cancer epidermal growth factor receptor monoclonal antibody nimotuzumab pharmacokinetics

Oxidative effects of the harmful algal blooms on primary organisms of the food web

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BIOCELL 2019年第2期43卷 41-50页

作者： joaquin CABRERA PAULA MARIELA gonzalez SUSANA PUNTARULO Universidad de Buenos Aires Facultad de Farmacia y BioquimicaFisicoquimica.Buenos AiresArgentina CONIONI CETET-Universidad de Buenos Aires.Instituto de Bioquimica y Medicina Molecular(IBI IBI MOLOL).Buenos Aires Argentina

Degraded water quality from nutrient pollution,physical,biological,and other chemical factors contributes to the development and persistence of many harmful algal blooms(HAB s).The complex dynamics of the HAB s is a challenge to marine ecosystems for the toxic effects *** consequences include fish,bird,and mammal mortality,respiratory or digestive tract problems,memory loss,seizures,lesions and skin irritation in many *** review is intended to briefly summarize the recent reported information on harmful marine toxin deleterious effects over the primary organisms of the food web,namely algae,zooplankton and *** focus is made on oxidative stress status of cells and *** though in situ field research is less controlled than laboratory studies,in which the organisms are directly exposed to the toxins under consideration,both types of approaches are required to fully understand such a complex *** top of that,the contribution of the increasing water temperatures in the sea,as a consequence of the global climate change,will be addressed as a topic for further studies,to evaluate the effect on regulating algal growth,species composition,trophic structure,metabolic stress and function of aquatic ecosystems.

关键词： Harmful algal toxins oxidative stress algae zooplankton invertebrates

Diabetic Renal-Retinal Syndrome and Inflammatory Markers of Acute Phase

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Journal of Diabetes Mellitus 2014年第3期4卷 194-201页

作者： Francisco Jesus Sepulveda-Canamar Raul Trevino Hernandez joaquin Dario Trevino Baez Jesus H.gonzalez Cortes Ophtalmology and Nephrology Services Unidad Medica de Atencion AmbulatoriaInstituto Mexicano del Seguro SocialSan Pedro Garza GarciaMexico Universidad Juarez del Estado de Durango DurangoMexico Ophtalomology Department of Universidad Autonoma de Nuevo Leon San Nicolas de los GarzaMexico

Objective: To determine the association between the acute inflammatory markers and Diabetic Renal-Retinal Syndrome in our patients. Methods: A total of 44 patients were included in this transverse (cross sectional), observational, analytical, and comparative study. Two groups of patients were created. Results: In patients with chronic renal failure, stages 3, 4, or 5 (scale 1 to 5) were identified and divided into two groups: Group I (Patients with concomitant diabetic retinopathy stabilized with photocoagulation) 22 patients. Group II (Patients with progression of retinopathy, after photocoagulation, in the form of intraocular bleeding) 22 patients. The number of patients with chronic renal failure in stage 3 was: Group I;16. In Group II;12 patients (OR: 1.0). Stage 4: Group I;4 patients. Group II: 3 patients (OR: 1.0, CI 95%;0.3843 - 2.021). Stage 5: Group I;2 patients. Group II;7 patients (OR: 1.8148, CI 95%;1.0448 - 3.1523;Chi-squared (x2) 2.7450, p = 0.097). t-Test found statistical significance in Erythrocyte Sedimentation Rate (ESR): p < 0.0001 (CI 95%;7.8959 - 23.2515);R = 0.56 p = 0.001;and OR = 1.959 (CI 95%;1.193 - 3.217). By non-parametric tests, C-reactive protein with binomial test showed p < 0.001. ESR showed p < 0.001 with U of Mann Whitney. Conclusions: With this study revealed a possible association of inflammatory markers with Diabetic Renal-Retinal Syndrome.

关键词： Diabetic Renal-Retinal Syndrome Erythrocyte Sedimentation Rate C-Reactive Protein

Detection of HR-HPV cervical infection in women with normal Pap smear results:implications for clinical practice

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Detection of HR-HPV cervical infection in women with normal ...

Congenitally Corrected Transposition of the Great Arteries: Conduction Anomalies: A Case Report

24th International Papillomavirus Conference and Clinical Workshop

作者： Gustavo Hernandez-Suarez Fabian Mendez Mauricio gonzalez joaquin Luna Natascha Ortiz Raul Murillo Monica Molano Nubia Munoz National Cancer Insitute of Colombia National Cancer Insitute of Colombia National Cancer Insitute of Colombia National Cancer Insitute of Colombia National Cancer Insitute of Colombia National Cancer Insitute of Colombia National Cancer Insitute of Colombia National Cancer Insitute of Colombia

＜正＞Background:Clinical management of women with normal Pap smear and HR-HPV infection remains controversial. Objective :To assess the absolute risk of High Grade Squamous Intraepithelial Lesions（HSIL）in women wit...

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World Journal of Cardiovascular Diseases 2021年第9期11卷 439-444页

作者： Jose Antonio Luna-Alvarez-Amezquita Javier Ivan Armenta-Moreno joaquin Berarducci Jorge Luis Bermudez-gonzalez Jose Luis Siller-Nava Edson Alberto Escandón-Villalobos Nilda Espinola-Zavaleta Roberto Cano-Zarate Juan Ignacio Straface Department of Nuclear Cardiology National Institute of Cardiology Ignacio Chavez Mexico City Mexico Department of Echocardiography ABC Medical Center I.A.P. Mexico City Mexico Department of Magnetic Resonance National Institute of Cardiology Ignacio Chavez Mexico City Mexico

Introduction: Congenitally corrected transposition of the great arteries (CCTGA) is a rare heart disease that encompasses an atrioventricular and ventriculoarterial discordance and accounts for less than 1 percent of congenital heart diseases. Objective: To present an atypical case of a man with complex congenital heart disease and conduction anomalies. Case Presentation: This is a case of a 34-year-old patient who came to the hospital with 1 week of dyspnea on exertion and episodes of lipothymia. The patient was referred to our hospital after an electrocardiogram from his primary care with evidence of blocked atrial fibrillation. During the initial evaluation blocked atrial fibrillation was confirmed with a rescue ventricular rate of 38 bpm. A magnetic resonance confirmed the presence of the atrioventricular and ventriculoarterial discordance, the aorta had a left anterior position, perimembranous ventricular septal defect with a right to left shunt, biventricular systolic dysfunction, moderate tricuspid, and mitral regurgitation, interventricular septal intramyocardial and biatrial fibrosis, left atrial dilation, and dilation of the pulmonary artery. After pacemaker placement, the patient has an improvement in his clinical symptoms and quality of life. Conclusions: Cardiac arrhythmias are CCTGA’s leading cause of death, mostly ventricular tachycardia, and atrial fibrillation. Right bundle branch block is a previously unreported and potentially very rare presentati

关键词： Congenital Heart Disease Congenitally Corrected Transposition of the Great Arteries Cardiac Magnetic Resonance Echocardiography Arrhythmia

Fecal immunochemical test accuracy in average-risk colorectal cancer screening

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World Journal of Gastroenterology 2014年第4期20卷 1038-1047页

作者： Vicent Hernandez joaquin Cubiella M Carmen gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators Department of Gastroenterology Complexo Hospitalario Universitario de Vigo Department of Gastroenterology Complexo Hospitalario Universitario de Ourense Department of Clinical Analysis Complexo Hospitalario Universitario de Vigo Department of Pathology Complexo Hospitalario Universitario de Vigo Department of Gastroenterology Donostia Hospital Biodonostia Institute University of the Basque Country UPV/EHU

AIM: To assess the fecal immunochemical test (FIT) accuracy for colorectal cancer (CRC) and advanced neoplasia (AN) detection in CRC screening.

关键词： Colorectal neoplasms Early detection of cancer Sensitivity and specificity Adenoma Occult blood Cost-benefit analysis

Interferon Regulatory Factor 5 and Renin-Angiotensin-Aldosterone System Polymorphisms in Coronary Artery Disease: An Overview of Experimental and Clinical Studies

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World Journal of Cardiovascular Diseases 2021年第7期11卷 332-341页

作者： Jorge Luis Bermudez-gonzalez Rodrigo Dagio-Cuellar Cristina Villarreal-Guerrero Ana Gilabert-Garcia Luis Angel Ferral-Barbabosa joaquin Berarducci Jose Luis Siller-Nava Jose Antonio Luna-Alvarez-Amezquita Javier Iván Armenta-Moreno Nilda Espínola-Zavaleta Erick Alexanderson-Rosas Juan Ignacio Straface National Institute of Cardiology Ignacio Chavez Mexico City Mexico Medicine Faculty of National Autonomous University of Mexico Mexico City Mexico

Heart diseases are the main cause of mortality in Mexico, being coronary heart disease the most frequent in the country. Its high prevalence makes important the study of the pathophysiology and the search for prognostic factors. Different genes and polymorphisms promote atherogenesis and coronary artery disease, they affect inflammatory and vascular pathological processes. Interferon regulatory factor 5 (IRF5) is associated with coronary heart disease, it promotes chronic inflammation and cytokines release;it could trigger immune reactions and its activating receptors express in the vascular endothelium. Besides, polymorphisms in the renin-angiotensin-aldosterone system (RAAS) are implied with coronary disease, they are found in angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), and angiotensin-converting enzyme (ACE) genes. These genetic polymorphisms are associated with a prothrombotic state, endothelial dysfunction, and immune activation. Multiple experimental studies showed that chronic activation of RAAS and chronic expression of IRF5 generates an environment prone to the development of atherosclerosis, and autoimmune and cardiovascular diseases. Studying these specific genes and their relationship with coronary heart disease will allow a better understanding of the pathological process and possibly the quest for new treatments.

关键词： Interferon Regulatory Factor 5 (IRF5) Angiotensin-Converting Enzyme (ACE) Angiotensinogen (AGT) Angiotensin II Type 1 Receptor (AT1R) Angiotensin II Type 2 Receptor (AT2R) Polymorphisms

Interferon Regulatory Factor 5 and Renin-Angiotensin-Aldosterone System Polymorphisms in Coronary Artery Disease: An Overview of Experimental and Clinical Studies

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