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24th International Papillomavirus Conference and Clinical Workshop

作者： Gustavo Hernandez-Suarez Fabian Mendez Mauricio Gonzalez joaquin luna Natascha Ortiz Raul Murillo Monica Molano Nubia Munoz National Cancer Insitute of Colombia National Cancer Insitute of Colombia National Cancer Insitute of Colombia National Cancer Insitute of Colombia National Cancer Insitute of Colombia National Cancer Insitute of Colombia National Cancer Insitute of Colombia National Cancer Insitute of Colombia

＜正＞Background:Clinical management of women with normal Pap smear and HR-HPV infection remains controversial. Objective :To assess the absolute risk of High Grade Squamous Intraepithelial Lesions（HSIL）in women wit...

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The Contribution Of HPV 6 AND 11 To The Burden Of HPV-Related Disease In Latin America:Natural History Analyses Of The Placebo Groups In Studies Of The Quadrivalent Hpv （Types 6,11,16,18） L1 Virus-like Particle （VIp） Vaccine

The Contribution Of HPV 6 AND 11 To The Burden Of HPV-Relate...

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24th International Papillomavirus Conference and Clinical Workshop

作者： Gonzalo Perez Munoz Nubia Hernandez-Avila Mauricio Lazcano-Ponce Eduardo Garcia Patricia Villa Luisa Jessferson Luz Costa Ronaldo luna joaquin Vuocolo Scott Sattler Carlos Barr Eliav Universidad del Rosario BogotaColombia Instituto Nacional de Cancerologaa BogotcColombia National Institute of Public Health.Cuernavaca MorelosMexico National Institute of Public Health.Cuernavaca MorelosMexico Universidad Peruana Cayetano Heredia LimaPeru Ludwig Institute for Cancer Research Hospital Alemao Oswaldo CruzSao PauloBrazil Universidad Peruana Cayetano Heredia Hospital Arzobispo LoayzaLimaPeru Instituto Brasileiro de Controle do Cancer and Hospital do CancerSao PauloBrazil Instituto Nacional de Cancerologaa BogotcColombia Merck ＆ Co Merck ＆ Co Merck ＆ Co

＜正＞Objectives HPV 6 and 11 cause most genital warts cases,as well as a proportion of dysplastic lesions of the cervix,vulva. and *** measured the contribution of HPV 6/11 to the overall burden of HPV-related cervical and genital disease in Latin American（LA）women. Methods A total of 2,795 16-24-year-old HPV infected and na?ve subjects with 0-4 lifetime sex partners were enrolled into the placebo arms of 3 Phase Ⅱ/Ⅲ trials of quadrivalent HPV *** were followed for 3 years and underwent genital

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Single-fraction stereotactic ablative body radiation therapy for primary and metastasic lung tumor:A new paradigm?

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World Journal of Clinical Oncology 2022年第2期13卷 101-115页

作者： Castalia Fernandez Arturo Navarro-Martin Andrea Bobo joaquin Cabrera-Rodriguez Patricia Calvo Rodolfo Chicas-Sett Javier luna Nuria Rodriguez de Dios Felipe Counago Department of Radiation Oncology GenesisCare MadridMadrid 28043Spain Department of Radiation Oncology Institut Catalád’OncologiaL’Hospitalet de LlobregatBarcelona 08908Spain Department of Radiation Oncology Hospital Ruber InternacionalMadrid 28034Spain Department of Radiation Oncology Hospital Universitario de BadajozBadajoz 06080Spain Department of Radiation Oncology Hospitalario Clínico Universitario de Santiago de CompostelaSantiago de Compostela 15706Spain Department of Radiation Oncology ASCIRES Grupo BiomédicoValencia 46004Spain Department of Radiation Oncology Hospital Fundación Jiménez DíazMadrid 28040Spain Department of Radiation Oncology Hospital del MarBarcelona 08003Spain Department of Radiation Oncology Hospital Universitario Quironsalud MadridMadrid 28223Spain Department of Radiation Oncology Hospital La LuzMadrid 28223Spain Department of Medicine School of Biomedical SciencesUniversidad EuropeaMadrid 28223Spain

Stereotactic ablative body radiotherapy(SABR)is an effective technique comparable to surgery in terms of local control and efficacy in early stages of non-small cell lung cancer(NSCLC)and pulmonary *** fractionation schemes have proven to be safe and effective,including the single fraction(SF)*** is an option costeffectiveness,more convenience and comfortable for the patient and flexible in terms of its management combined with systemic *** outbreak of the severe acute respiratory syndrome coronavirus 2 pandemic has driven this not new but underutilized paradigm,recommending this option to minimize patients’visits to *** SABR already has a long experience,strong evidence and sufficient maturity to reliably evaluate outcomes in peripheral primary NSCLC and there are promising outcomes in pulmonary metastases,making it a valid treatment option;although its use in central locations,synchronous and recurrencies tumors requires more prospective safety and efficacy *** SABR radiobiology study,together with the combination with systemic therapies,(targeted therapies and immunotherapy)is a direction of research in both advanced disease and early stages whose future includes SF.

关键词： Stereotactic body radiotherapy Sterotactic ablative body radiotherapy Radiosurgery Non-small cell lung cancer Lung cancer Lung metastases

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Congenitally Corrected Transposition of the Great Arteries: Conduction Anomalies: A Case Report

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World Journal of Cardiovascular Diseases 2021年第9期11卷 439-444页

作者： Jose Antonio luna-Alvarez-Amezquita Javier Ivan Armenta-Moreno joaquin Berarducci Jorge Luis Bermudez-Gonzalez Jose Luis Siller-Nava Edson Alberto Escandón-Villalobos Nilda Espinola-Zavaleta Roberto Cano-Zarate Juan Ignacio Straface Department of Nuclear Cardiology National Institute of Cardiology Ignacio Chavez Mexico City Mexico Department of Echocardiography ABC Medical Center I.A.P. Mexico City Mexico Department of Magnetic Resonance National Institute of Cardiology Ignacio Chavez Mexico City Mexico

Introduction: Congenitally corrected transposition of the great arteries (CCTGA) is a rare heart disease that encompasses an atrioventricular and ventriculoarterial discordance and accounts for less than 1 percent of congenital heart diseases. Objective: To present an atypical case of a man with complex congenital heart disease and conduction anomalies. Case Presentation: This is a case of a 34-year-old patient who came to the hospital with 1 week of dyspnea on exertion and episodes of lipothymia. The patient was referred to our hospital after an electrocardiogram from his primary care with evidence of blocked atrial fibrillation. During the initial evaluation blocked atrial fibrillation was confirmed with a rescue ventricular rate of 38 bpm. A magnetic resonance confirmed the presence of the atrioventricular and ventriculoarterial discordance, the aorta had a left anterior position, perimembranous ventricular septal defect with a right to left shunt, biventricular systolic dysfunction, moderate tricuspid, and mitral regurgitation, interventricular septal intramyocardial and biatrial fibrosis, left atrial dilation, and dilation of the pulmonary artery. After pacemaker placement, the patient has an improvement in his clinical symptoms and quality of life. Conclusions: Cardiac arrhythmias are CCTGA’s leading cause of death, mostly ventricular tachycardia, and atrial fibrillation. Right bundle branch block is a previously unreported and potentially very rare presentati

关键词： Congenital Heart Disease Congenitally Corrected Transposition of the Great Arteries Cardiac Magnetic Resonance Echocardiography Arrhythmia

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Interferon Regulatory Factor 5 and Renin-Angiotensin-Aldosterone System Polymorphisms in Coronary Artery Disease: An Overview of Experimental and Clinical Studies

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World Journal of Cardiovascular Diseases 2021年第7期11卷 332-341页

作者： Jorge Luis Bermudez-Gonzalez Rodrigo Dagio-Cuellar Cristina Villarreal-Guerrero Ana Gilabert-Garcia Luis Angel Ferral-Barbabosa joaquin Berarducci Jose Luis Siller-Nava Jose Antonio luna-Alvarez-Amezquita Javier Iván Armenta-Moreno Nilda Espínola-Zavaleta Erick Alexanderson-Rosas Juan Ignacio Straface National Institute of Cardiology Ignacio Chavez Mexico City Mexico Medicine Faculty of National Autonomous University of Mexico Mexico City Mexico

Heart diseases are the main cause of mortality in Mexico, being coronary heart disease the most frequent in the country. Its high prevalence makes important the study of the pathophysiology and the search for prognostic factors. Different genes and polymorphisms promote atherogenesis and coronary artery disease, they affect inflammatory and vascular pathological processes. Interferon regulatory factor 5 (IRF5) is associated with coronary heart disease, it promotes chronic inflammation and cytokines release;it could trigger immune reactions and its activating receptors express in the vascular endothelium. Besides, polymorphisms in the renin-angiotensin-aldosterone system (RAAS) are implied with coronary disease, they are found in angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), and angiotensin-converting enzyme (ACE) genes. These genetic polymorphisms are associated with a prothrombotic state, endothelial dysfunction, and immune activation. Multiple experimental studies showed that chronic activation of RAAS and chronic expression of IRF5 generates an environment prone to the development of atherosclerosis, and autoimmune and cardiovascular diseases. Studying these specific genes and their relationship with coronary heart disease will allow a better understanding of the pathological process and possibly the quest for new treatments.

关键词： Interferon Regulatory Factor 5 (IRF5) Angiotensin-Converting Enzyme (ACE) Angiotensinogen (AGT) Angiotensin II Type 1 Receptor (AT1R) Angiotensin II Type 2 Receptor (AT2R) Polymorphisms

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Interferon Regulatory Factor 5 and Renin-Angiotensin-Aldosterone System Polymorphisms in Coronary Artery Disease: An Overview of Experimental and Clinical Studies

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World Journal of Cardiovascular Diseases（心血管病） 2021年第7期

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