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Platelet biomarkers in Alzheimer's disease

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World Journal of Psychiatry 2012年第6期2卷 95-101页

作者： Leda L Talib Helena PG joaquim Orestes V Forlenza Laboratory of Neuroscience (LIM-27) Department and Institute of PsychiatryFaculty of MedicineUniversity of S?o Paulo05403-010 S?o PauloSPBrazil

The search for diagnostic and prognostic markers in Alzheimer's disease(AD) has been an area of active research in the last decades. Biochemical markers are correlates of intracerebral changes that can be identified in biological fluids, namely: peripheral blood(total blood, red and white blood cells, platelets, plasma and serum), saliva, urine and cerebrospinal fluid. An important feature of a biomarker is that it can be measured objectively and evaluated as(1) an indicator of disease mechanisms(markers of core pathogenic processes or the expression of downstream effects of these processes), or(2) biochemical responses to pharmacological or therapeutic intervention, which can be indicative of disease modification. Platelets have been used in neuropharmacological models since the mid-fifties, as they share several homeostatic functions with neurons, such as accumulation and release of neurotransmitters, responsiveness to variations in calcium concentration, and expression of membrane-bound compounds. Recent studies have shown that platelets also express several components related to the pathogenesis of AD,in particular to the amyloid cascade and the regulation of oxidative stress: thus they can be used in the search for biomarkers of the disease process. For instance, platelets are the most important source of circulating forms of the amyloid precursor protein and other important proteins such as Tau and glycogen synthase kinase-3B. Moreover, platelets express enzymes involved in membrane homeostasis(e.g., phospholipase A2), and markers of the inflammatory process and oxidative stress. In this review we summarize the available literature and discuss evidence concerning the potential use of platelet markers in AD.

关键词： Alzheimer’s disease Biomarkers Platelets Amyloid precursor protein Glycogen synthase kinase-3B Phospholipase A2

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安哥拉社区警务

现代世界警察 2022年第8期 78-80页

作者： [安哥拉]孟乔乔江苏警官学院

安哥拉社区警务的开展情况通常来说,目前警察制度有三种类型:自治警察制度、集权警察制度、非自治非集权警察制度。安哥拉采取的是第三种,即非自治非集权警察制度。安哥拉警察局隶属于中央政府,地方的警察机构接受地方政府的领导和监督... 详细信息

安哥拉社区警务的开展情况通常来说,目前警察制度有三种类型:自治警察制度、集权警察制度、非自治非集权警察制度。安哥拉采取的是第三种,即非自治非集权警察制度。安哥拉警察局隶属于中央政府,地方的警察机构接受地方政府的领导和监督。安哥拉的社区警务也正是在这种体制内开展的。受很早之前的殖民影响,安哥拉国家的警察队伍带有军事性质。但是,伴随着全球化和社会生活的变迁,安哥拉警察也在从传统向现代发展,并努力成为遵循合法性原则、责任原则和自由原则的现代民主警察。

关键词：社区警务警察制度警察机构责任原则合法性原则警察队伍安哥拉全球化

Tilapia processing waste silage (TPWS): An alternative ingredient for Litopenaeus vannamei (Boone, 1931) diets in biofloc and clear-water systems

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Aquaculture and Fisheries 2019年第5期4卷 214-218页

作者： joaquim da Rocha Soares Neto Felipe de Azevedo Silva Ribeiro Alex Augusto Gonçalves Maurício Gustavo Coelho Emerenciano Universidade Federal Rural do Semi-Árido(UFERSA) Departamento de Ciência AnimalSetor de AquiculturaMossoró59625-900Brazil UFERSA Departamento de Ciência AnimalLaboratório de Tecnologia e Controle de Qualidade do PescadoMossoró59625-900Brazil Universidade do Estado de Santa Catarina(UDESC) Laboratório de Aquicultura(LAQ)88790-000LagunaSCBrazil and Programa de Pós-Graduação em Zootecnia(PPGZOO/UDESC)Chapecó89815-630Brazil

The aim of this study was to evaluate the growth performance of Litopenaeus vannamei juveniles reared under biofloc and clear-water conditions fed with different inclusion levels of tilapia processing waste silage(TPWS)*** experiment was performed in two individual systems:biofloc(BS)and clear-water systems(CWS).The trial used forty 40 L rectangular plastic bins(twenty per system)in a density of 63 shrimp/m^(2).The juveniles were distributed in a factorial completely randomized experimental *** treatments were based on the percentage of silage inclusion(control or 0,1.5%,3.0%,4.5%and 6.0%of inclusion)in BS or CWS,totalizing ten treatments and four *** was above 80%in all treatments and was not affected by both systems and *** final weight and SGR were statistically influenced by system(P<0.05)but not by the diet;and presented high values in *** inclusion of TPWS in *** diets did not affect shrimp *** addition,shrimp raised in BS demonstrated better growth performance as compared to CWS.

关键词： Silage Nutrition Waste BFT Pacific white shrimp

Process for Obtaining Conceptual Designs to Solve General Problems

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Process for Obtaining Conceptual Designs to Solve General Pr...

E-Business·Creative Design·Manufacturing——2009 IEEE 10th International Conference on Computer-Aided Industrial Design & Conceptual Design（CAID&CD’2009）

作者： joaquim Lloveras Josep M.Nacenta Dpt of Projects Technical University of Catalonia(UPC) Barcelona.Spain. Dpt of Thermal Machines and Engines.ETSEIB.Technical University of Catalonia(UPC) Barcelona.Spain.

The paper describes the creative process used by students in a free elective course offered at the Technical University of Catalonia（UPC）to obtain conceptual designs that contribute at least to the partial solution of a global crisis or major problem such as water shortage,food and energy crises,climate change and global *** example of this process,which is based on exercises of imagination,Mind Maps and the Six Thinking Hats method,is *** exercise is generalisable to other cases where a general problem is the starting point of a top-to-bottom process to find interesting solutions.

关键词： Free Elective Course General Problems Top-to-bottom Process Creativity Conceptual Design.

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销钉式花岗岩石材幕墙面板平面外承载力试验

南京工业大学学报（自然科学版） 2021年第1期43卷 101-107页

作者：王国威 TCHAMO joaquim Mimusse 卢文胜同济大学土木工程防灾国家重点实验室上海200092

传统销钉式花岗岩石材幕墙在外荷载作用下的破坏时有发生。为分析销钉式花岗岩石材幕墙面板在平面外荷载作用下的力学性能,通过单调与低周往复加载对其进行平面外承载力试验,分别得到对应的荷载位移关系曲线,结合有限元数值模拟验证试... 详细信息

传统销钉式花岗岩石材幕墙在外荷载作用下的破坏时有发生。为分析销钉式花岗岩石材幕墙面板在平面外荷载作用下的力学性能,通过单调与低周往复加载对其进行平面外承载力试验,分别得到对应的荷载位移关系曲线,结合有限元数值模拟验证试验结果的准确性,并对比研究两种加载方式对面板的强度、变形能力和破坏模式的影响。结果表明:花岗岩石材幕墙面板的力学性能和破坏模式受加载方式的影响;面板与销钉之间的滑移对低周往复荷载作用下的承载力影响较大,对单调荷载作用下的承载力影响较小;面板与销钉连接处是薄弱部位,在平面外荷载作用下面板会出现应力集中现象,且呈现脆性破坏的特征。试验研究结果可为销钉式花岗岩石材幕墙的设计提供参考。

关键词：花岗岩石材幕墙面板销钉式连接承载性能平面外加载滑移现象

Self-reported Taste and Smell Disorders in Patients with COVID-19:Distinct Features in China

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Current Medical Science 2021年第1期41卷 14-23页

作者： Jia SONG Yi-ke DENG Hai WANG Zhi-chao WANG Bo LIAO Jin MA Chao HE Li PAN Yang LIU Isam Alobid De-yun WANG Ming ZENG joaquim Mullol Zheng LIU Department of Otolaryngology-Head and Neck Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Rhinology Unit and Smell Clinic ENT DepartmentHospital ClinicIDIBAPSUniversitat de BarcelonaCIBERESBarcelona 08036Spain Department of Otolaryngology Yong Loo Lin School of MedicineNational University of Singapore 699010Singapore

Last December 2019,a cluster of viral pneumonia cases identified as coronavirus disease 2019(COVID-19)was reported in Wuhan,*** aimed to explore the frequencies of nasal symptoms in patients with COVID-19,including loss of smell and taste,as well as their presentation as the first symptom of the disease and their association with the severity of *** this retrospective study,1206 laboratory-confirmed COVID-19 patients were included and followed up by telephone one month after discharged from Tongji Hospital,*** data,laboratory values,comorbidities,symptoms,and numerical rating scale scores(0–10)of nasal symptoms were extracted from the hospital medical records,and confirmed or reevaluated by the telephone *** patients(n=1172)completing follow-up,199(17%)subjects had severe COVID-19 and 342(29.2%)reported nasal symptoms.20.6%COVID-19 patients had loss of taste(median score=6),while 11.4%had loss of smell(median score=5).Loss of taste scores,but not loss of smell scores,were significantly increased in severe *** COVID-19 ***(IL)-6 and lactose dehydrogenase(LDH)serum levels were positively correlated with loss of taste *** 80%of COVID-19 patients recovered from smell and taste dysfunction in 2 *** this cohort,only 1 out of 10 hospital admitted patients had loss of smell while 1 out of 5 reported loss of taste which was associated to severity of *** patients recovered smell and taste dysfunctions in 2 weeks.

关键词： taste smell coronavirus disease 2019 severe acute respiratory syndrome coronavirus 2

Extrahepatic right hepatic duct diverticulum: a rare entity

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Hepatobiliary & Pancreatic Diseases International 2010年第2期9卷 213-215页

作者： Eduardo SM Fernandes Raquel L Bernardo Moacir M Fernandes Rogério MC Araújo Renato Sebbe Asterio Monte JoséF Coelho Antonio AP Souza joaquim Ribeiro Filho Department of General Surgery Section of Hepatobiliary Surgery and TransplantationRio de Janeiro Federal University Department of Digestive Surgery and Gastroenterology Pio XII General Hospital

BACKGROUND:Douglas described choledochal cysts in 1852 and Todani proposed an anatomy-based classification in 1977. The classification is the most extensively used,but does not include some rare *** present a case of hepatic duct diverticulum,one of the variations,and discuss its diagnosis and treatment. METHODS:A 57-year-old woman presented with upper abdominal pain and discomfort associated with nausea and *** was finally diagnosed with cholelithiasis and right hepatic duct diverticulum. RESULT:The patient underwent resection of the hepatic duct diverticulum and cholecystectomy,and was asymptomatic 26 months after surgery. CONCLUSIONS:Hepatic duct diverticulum is a rare form of choledochal cyst,not included in Todani’s classification. Todani’s classification including this and other uncommon variations of choledochal cysts must be *** best diagnostic imaging methods and treatment for choledochal cysts must be defined.

关键词： choledochal cysts hepatic duct diverticulum Todani's classification intrahepatic diverticulum

Sinonasal Adenocarcinoma—Experience of an Oncology Center

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International Journal of Otolaryngology and Head & Neck Surgery 2013年第1期2卷 13-16页

作者： Teresa Bernardo Edite Ferreira joaquim Castro Silva Eurico Monteiro Servico de Otorrinolaringologia Instituto Portugues de Oncologia do PortoFrancisco GentilPortugal

Introduction and Objectives: Sinonasal tumours represent only 3% of all head and neck cancers. Adenocarcinoma is the second most frequent histopathology type. Hardwood exposure has been considered a risk factor. Sinonasal adenocarcinoma grows silently which leads to a late diagnosis and low survival rates. The aim of this study was to present our experience in the management of the patients with sinonasal adenocarcinoma. Method: Retrospective medical records review of patients with sinonasal adenocarcinomas (1974 to 2009). Results: From 301 patients with sinonasal tumors, 67 had histology of adenocarcinoma. Patient average age was 60.1 ± 11.1 years (30 - 84 years). 83.6% were man. 65.7% had history of working with wood. 70.1% of the patients had advance disease. The most common treatment strategy was external surgery (lateral rhinotomy (47.8%), sublabial (17.9%) or cranio-facial resection (6%)) or endoscopic approaches with postoperative radiotherapy. The 3 and 5 years overall survival rate were 60% and 49%, respectively. Conclusions: Our group study showed similar epidemiologic characteristics than other series. We confirmed sinonasal adenocarcinomas tendency to late diagnosis and wood dust exposure relation. In our experience, the limited surgical treatment (without craniofacial resection) and postoperative radiotherapy has good survival rates results, similar to other departments who consider the craniofacial resection as the standard treatment.

关键词： Sinonasal Adenocarcinomas Wood Dust Surgical Treatment Radiotherapy

Mitochondrial GPX1 silencing triggers differential photosynthesis impairment in response to salinity in rice plants

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Journal of Integrative Plant Biology 2016年第8期58卷 737-748页

作者： Yugo Lima-Melo Fabricio E.L.Carvalho Márcio O.Martins Gisele Passaia Rachel H.V.Sousa Milton C.Lima Neto Márcia Margis-Pinheiro joaquim A.G.Silveira Department of Biochemistry and Molecular Biology Federal University of Ceará Department of Genetics Federal University of Rio Grande do Sul

The physiological role of plant mitochondrial glutathione peroxidases is scarcely known. This study attempted to elucidate the role of a rice mitochondrial isoform（GPX1） in photosynthesis under normal growth and salinity conditions. GPX1 knockdown rice lines（GPX1s） were tested in absence and presence of 100 mM NaCl for 6 *** reduction of GPX1 s line under non-stressful conditions, compared with non-transformed（NT） plants occurred in parallel to increased H_2O_2 and decreased GSH contents. These changes occurred concurrently with photosynthesis impairment, particularly in Calvin cycle＇s reactions, since photochemical efficiency did not ***, GPX1 silencing and downstream molecular/metabolic changes modulated photosynthesis differentially. In contrast, salinity induced reduction in both phases of photosynthesis, which were more impaired in silenced *** changes were associated with root morphology alterations but not shoot growth. Both studied lines displayed increased GPX activity but H_2O_2 content did not change in response to salinity. Transformed plants exhibited lower photorespiration, water use efficiency and root growth, indicating that GPX1 could be important to salt tolerance. Growth reduction of GPX1 s line might be related to photosynthesis impairment, which in turn could have involved a cross talk mechanism between mitochondria and chloroplast originated from redox changes due to GPX1 deficiency.

关键词： CO2 assimilation glutathione peroxidase Oryza sativa photochemistry redox homeostasis