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Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-Parrilla David reyes-Corona Yazmin M.Flores-Martinez Rasajna nadella Michael J.Bannon lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar luis O.Soto-Rojas Claudia luna-Herrera Jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio nava Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico Department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico laboratorio de neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's *** human cerebral dopamine neurotrophic factor(h CDnF)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CDnF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDnF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDnF in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDnF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and *** with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDnF *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were ***-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic *** findings support the potential of nanoparticle-mediated h CDnF gene delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization no.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

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DnAzymes directed to HPV-16 E6/E7 mRnA

DNAzymes directed to HPV-16 E6/E7 mRNA

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24th International Papillomavirus Conference and Clinical Workshop

作者： Alvarez-Salas luis reyes-Gutierrez Pablo laboratorio de Terapia Genica Departamento de Genetica y Biologia Molecular.Cinvestav laboratorio de Terapia Genica Departamento de Genetica y Biologia Molecular.Cinvestav

＜正＞The World Health Organization（WHO）estimates that 400 million Human Papillomavirus（HPV）cases are reported worldwide per *** is a necessary cause of cervical cancer and is responsible for approximately 510,000 cases *** under- developed regions of the world,it is the most common cause of death from cancer in women,accounting for 80% of the cases reported *** Coherence Tomography（OCT）is an optical imaging technique that uses near infrared light to

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lung cancer screening, what has changed after the latest evidence?

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World Journal of Radiology 2020年第7期12卷 130-136页

作者： Juan Carlos Trujillo-reyes luis Seijo Elisabeth Martinez-Tellez Felipe Counago Department of Thoracic Surgery Hospital de la Santa Creu I Sant PauBarcelona 08029Spain Department of Surgery Universitat Autonoma de BarcelonaBarcelona 08029Spain Department of Pneumology Clinica Universitaria de NavarraMadrid 28029Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridMadrid 28223Spain Universidad Europea de Madrid Madrid 28223Spain

lung cancer(lC)is still one of the most frequent cancers with a high related *** prognosis is directly proportional to the stage at the time of *** percent are currently diagnosed in advanced or locally advanced stage(higher than stage III),making a cure unlikely for the majority of *** in lC treatment are significant however they do not seem to be enough to reverse the current situation,at least,in a short period of *** recent advances in treatment,primary prevention and early diagnosis appear to be the key to reduce the incidence and mortality of this *** countries have developed lC screening programs based on the results of clinical trials published in recent *** aim of this paper is to review the latest results of the nEderlands leuvens longkanker Screenings Onderzoek and compare them with the findings of the national lung Screening *** address the question whether it is necessary to continue discussing the evidence regarding lC *** both trials,there is a clear impact on lC mortality but,with a modest reduction in over all ***,the benefit of screening can be expected to grow as low-dose computed tomographys are performed over longer periods of time.

关键词： lung cancer Epidemiology lung cancer screening low dose chest computed tomography scan Primary prevention Molecular biomarkers

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The Topological Conditions: The Properties of the Pair of Conjugate Tress

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Journal of Software Engineering and Applications 2010年第6期3卷 517-524页

作者： luis Hernandez-Martinez Arturo Sarmiento-reyes Miguel A. Gutierrez de Anda Electronics Department National Institute for Astrophysics Optics and Electronics P.O. Puebla Pue. Mexico

This paper presents some important properties emanating from the pair of conjugate trees. The properties are obtained by resorting to the fundamental loops and cutsets in the circuit topology. The existence of such a ... 详细信息

关键词： Pair of Conjugate Trees Topological Conditions Fundamental Cutsets and loops Analogue Circuits

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Computational Analysis of Flow Field on the Propulsion nozzle of a Micro-Turbojet Engine

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Engineering（科研） 2012年第1期4卷 1-5页

作者： Jorge luis Garrido-Téllez Miguel Toledo-Velázquez Samuel Alcántara-Montes José ángel l. Ortega-Herrera Arturo reyes-león 不详

The purpose of this paper is to analyze the flow field on the propulsion nozzle of a micro-turbojet engine in function of the velocity. The 2D axisymmetric numerical simulation was made by using commercial software FlUEnT?. A micro-turbojet engine was also employed for this study and it has the following characteristics: 100 n thrust, 130,000 rpm, mass flow rate 0.2650 kg/s, weight 1.2 kg. This engine is operating in Mexico city under the following conditions: P0, 78,000 Pa T0, 300 K, πc, 2.1 and a turbine entry temperature of 1000 K;it is considered that the nozzle is not choked. For this study, the viscous standard k- model, a semi-empirical model based on transport model equations for the turbulent kinetic energy (k) and its dissipation rate, is used. The transport model equation for k is derived from the ex-act equation, while the transport model equation for is obtained by using physical reasoning and bears resemblance to its mathematically exact counterpart. The employed grids are structured and the boundary conditions are obtained from a thermodynamic analysis. The results that are obtained show an increment of the velocity of 6.25% to the exit propulsion nozzle.

关键词： Propulsion nozzle Model Transport Equation numerical Simulation Small Micro Turbine

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Conductive Behavior and Morphology of Axially Modified Gallium Phthalocyanine Thin Films onto Indium Tin Oxide Substrates

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Advances in Materials Physics and Chemistry 2016年第7期6卷 211-219页

作者： Margarita Rivera Brenda reyes María Elena Sánchez-Vergara luis Humberto Mendoza-Huizar Instituto de Física Departamento de Materia Condensada Universidad Nacional Autónoma de México D.F. México México Facultad de Ingeniería Universidad Anáhuac México Norte Huixquilucan Estado de México México Centro de Investigaciones Químicas Mineral de la Reforma Universidad Autónoma del Estado de Hidalgo Hidalgo México

Semiconductor molecular films based on a gallium phthalocyanine chloride (GaPcCl) and a bidentate amine were prepared by using vacuum thermal evaporation and electrochemical techniques in order to investigate the preferred conduction paths within the films. Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM) were employed to characterize the morphology of the films. The conductivity measurements were performed with two different methods in order to investigate preferential conduction directions. The film transverse conductivity was obtained by using scanning tunneling spectroscopy (STS) and the in-plane film conductivity was measured with a four-point probe system. From spectroscopy measurements, the tunneling conductance (dI/dV) was also obtained. From these results, it was found that the conductive nature of the films was strongly influenced by the deposition technique which in turn defined the morphological characteristics of the film. The evaporated method showed better conductivity response and provided semiconductor characteristics in the film transverse direction with an in-plane ohmic response. Finally, contact angle measurements were performed and showed hydrophobic characteristics in all cases.

关键词： Thin Films Phthalocyanines Electronic Properties Electrical Conductivity

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Perinuclear anti-neutrophil cytoplasmic antibodies (p-anca) in chronic ulcerative colitis: Experience in a Mexican institution

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World Journal of Gastroenterology 2006年第21期12卷 3406-3409页

作者： Jesus K Yamamoto-Furusho Takeshi Takahashi-Monroy Omar Vergara-Fernandez Edgardo reyes luis Uscanga Departments of Gastroenterology. Instituto nacional de Ciencias Medicas y nutricion Salvador Zubiran Mexico City Mexico Departments of Surgery. Instituto nacional de Ciencias Medicas y nutricion Salvador Zubiran Mexico City Mexico Departments of Pathology. Institute nacional de Ciencias Medicas y nutricion Salvador Zubiran Mexico City Mexico

瞄准：在墨西哥 ulcerative (UC ) 的一件样品估计流行和 p-AnCA 的临床的价值病人。方法：在一个未来的、同意 IRB 的协议， p-AnCA 与 UC 在 80 个病人被决定(吝啬的年龄， 32 +/- 12.9 年) 。疾病的严厉和延期被临床的方法决定，寻找... 详细信息

瞄准：在墨西哥 ulcerative (UC ) 的一件样品估计流行和 p-AnCA 的临床的价值病人。方法：在一个未来的、同意 IRB 的协议， p-AnCA 与 UC 在 80 个病人被决定(吝啬的年龄， 32 +/- 12.9 年) 。疾病的严厉和延期被临床的方法决定，寻找有 p-AnCA 地位的一个统计协会。结果：p-AnCA 在 41 被检测(51%) 病人。疾病的严厉是统计上与他们的存在联系的唯一的临床的变量(P < 0.0001；或 = 9；CI 95%= 3.2-24.7 ) 。结论：p-AnCA 的流行类似于在另外的国家报导了那。他们的存在被联系到 UC 严厉，但是比提供了没有更多的信息由临床的方法获得了。

关键词：细胞周期抗中性细胞抗体大肠溃疡墨西哥

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Pesticides Recovery and Detection from Agricultural Soil leachates Using Gas Chromatography Masses with Electron Capture Detector

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American Journal of Analytical Chemistry 2017年第10期8卷 605-616页

作者： lluvia Paola Medina-Armenta Gustavo Cruz-Jiménez Margarita Teutli-león luis A. García de la Rosa Rossy Feria-reyes Chemistry Department Guanajuato University Guanajuato Mexico Pharmacia Department Guanajuato University Guanajuato Mexico Engineering Department Distinguished Autonomous University of Puebla Puebla Mexico UPIG Chemistry Department National Polytechnic Institute Guanajuato Mexico

In this study, it is reported an analytical approach to recover organochlorine pesticides from a clay soil. Soil was physical and chemically characterized. Also pesticides extraction was carried out using packed columns and various aqueous media (H2O-milliQ, naOH, HCl, SDS, Triton X-114, Humic acids and Acetonitrile). The leachate samples were analyzed on an Agilent Technologies 6890n Gas Chromatograph with electron capture in a# AB002 Column 30.0 m × 250 μm × 0.25 μm calibrated, 25 psi pressure, flow 2.9 ml/min, temperature 25°C, ultra-high purity Helium as the entrainment gas and an elution time of 50 min. The results show that the highest extraction percentage of pollutants in the soil washing was obtained with acetonitrile recovering: p, p’-DDT (91.0%);p, p’-DDE (92.0%);p, p’-DDD (96.0%);aldrin (98.6%);dieldrin (98.0%). With Triton X-114, the extractions recovery was: p, p’-DDT (63.0%);p, p’-DDE (64.0%);p, p’-DDD (65.0%);aldrin (67.0%);dieldrin (72.0%). This study illustrates the potential Applicability of SPME for routine analysis of organochlorine pesticides in soils.

关键词： leaching of Organochlorine Compounds Surfactants Desorption of Pesticides Packed Columns Soil Gas Chromatography-ECD

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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los reyes Jiménez-leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González luis Fernando lópez-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel lomas Claudio Bueno Rosario Amaya JoséAntonio lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-león Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia lanseros-Tenllado Carmina lópez Isabel lópez Álvaro lópez-Barrios luis F.lópez-Cortés Rafael luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez luis Martín-Villén JoséMolina Aurora Morillo María Dolores navarro-Amuedo Dolores nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain neurology and Clinical neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFn-α).In COVID-19 there is a deficit in DC numbers and IFn-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell long-COVID

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laser-Induced Breakdown Spectroscopy (lIBS) Applied in the Differentiation of <i>Arabica</i>and <i>Robusta</i>Coffee

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Optics and Photonics Journal 2017年第10期7卷 181-195页

作者： Abigail María Díaz Guerrero luis Vidal Ponce Cabrera Teresa Flores reyes Rogelio Ortega Izaguirre Research Center forApplied Science and Advanced Technology Altamira Unit National Polytechnic Institute Altamira Mexico

Coffee is one of the most consumed and commercialized crops in the world, which is why there is a potential risk to find arabica coffee (an expensive variety) adulterated with robusta coffee (a cheaper variety). The currently used technique for certifying coffee, High Performance liquid Chromatography (HPlC), requires the sample to be subjected to a chemical treatment prior to analysis;in addition, the equipment is bulky and can not be moved easily. laser Induced Breakdown Spectroscopy (lIBS) is a technique which does not require that samples be subjected to a chemical pretreatment, and equipment is small and portable, this can save valuable time in coffee trading. The purpose of this research was to demonstrate that lIBS can be applied to solve various problems related with the coffee authentication. Green coffee pills with different concentrations of arabica and robusta varieties were analyzed by lIBS, the results were used in the construction of calibration curves for the detection of the degree of simulated adulteration in coffee. It was found that the relative intensities of Ca (392.4 nm), Sr (407.1 nm), n (500.5 nm) and na (588.7 nm), as well as the intensity ratios of Ca II (392.4 nm)/n I (500.5 nm), Sr I (407.1 nm)/n I (500.5 nm)and n I (500.5 nm)/na I (588.7 nm) can be used for this purpose. It is concluded that the differentiation of coffee and the detection of its adulteration is possible with the use of lIBS. Further, with the use of an Artificial neural network (Ann) of type Multilayer Perceptron, it was possible to correctly classify the spectra of arabica and robusta roasted coffee.

关键词： laser Induced Breakdown Spectroscopy (lIBS) Calibration Curves Artificial neural network (Ann) Multilayer Perceptron

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