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Carbapenemases: A worldwide threat to antimicrobial therapy

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World Journal of Pharmacology 2015年第1期4卷 75-95页

作者： José Miguel Sahuquillo-Arce Alicia Hernández-cabezas Fernanda Yarad-Auad Elisa Ibá?ez-Martínez Patricia Falomir-Salcedo Alba Ruiz-Gaitán Grupo de investigación de infecciones respiratorias Instituto de Investigación Sanitaria-Fundación para la Investigación Hospital La Fe.Torre A46026 ValenciaSpain Servicio de Microbiología Hospital Universitari i Politécnic La Fe46009 ValenciaSpain

Carbapenems are potent β-lactams with activity against extended-spectrum cephalosporinases and β-lactamases. These antibiotics, derived from thienamycn, a carbapenem produced by the environmental bacterium Streptomyces cattleya, were initially used as last-resort treatments forsevere Gram-negative bacterial infections presenting resistance to most β-lactams but have become an empirical option in countries with high prevalence of Extended Spectrum β-lactamase-producing bacterial infections. Imipenem, the first commercially available carbapenem, was approved for clinical use in 1985. Since then, a wide variety of carbapenem-resistant bacteria has appeared, primarily Enterobacteriaceae such as Escherichia coli or Klebsiella pneumoniae(K. pneumoniae), Pseudomonas aeruginosa and Acinetobacter baumannii, presenting different resistance mechanisms. The most relevant mechanism is the production of carbapenem-hydrolyzing β-lactamases, also known as carbapenemases. These enzymes also inactivate all known β-lactams, and some of these enzymes can be acquired through horizontal gene transfer. Moreover, plasmids, transposons and integrons harboring these genes typically carry other resistance determinants, rendering the recipient bacteria resistant to almost all currently used antimicrobials, as is the case for K. pneumoniae carbapenemase- or new Delhi metallo-β-lactamases-type enzymes. The recent advent of these enzymes in the health landscape presents a serious challenge. First, the emergence of carbapenemases limits the currently available treatment options; second, these enzymes pose a risk to patients, as some studies have demonstrated high mortality associated with carbapenemase-producing bacterial infections; and third, these circumstances require an extra cost to sanitary systems, which are particularly cumbersome in developing countries. Therefore, emphasis should be placed on the early detection of these enzymes, the prevention of the spread of carbapenemase-producing b

关键词： Carbapenemases Origin Epidemiology Evolution Multi-Drug-resistant bacteria

Re-irradiation for high-grade gliomas:Has anything changed?

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World Journal of Clinical Oncology 2021年第9期12卷 767-786页

作者： Sonia García-cabezas Eleonor Rivin del Campo Juan Solivera-Vela Amalia Palacios-Eito Department of Radiation Oncology Reina Sofia University HospitalCordoba 14004Spain Department of Radiation Oncology Tenon University HospitalParis 75020France Department of neurosurgery Reina Sofia University HospitalCordoba 14004Spain

Optimal management after recurrence or progression of high-grade gliomas is still undefined and remains a challenge for neuro-oncology multidisciplinary *** radiation therapy techniques,new imaging methods,published experience,and a better radiobiological knowledge of brain tissue have positioned re-irradiation(re-RT)as an option for many of these *** must be individualized,taking into account the pattern of relapse,previous treatment,and functional status,as well as the patient’s preferences and expected quality of *** questions remain unanswered with respect to re-RT:Who is the most appropriate candidate,which dose and fractionation are most effective,how to define the target volume,which imaging technique is best for planning,and what is the optimal timing?This review will focus on describing the most relevant studies that include re-RT as salvage therapy,with the aim of simplifying decision-making and designing the best available therapeutic strategy.

关键词： Re-irradiation Recurrent glioma High-grade gliomas Glioblastoma Radiosurgery Stereotactic radiotherapy

模块表达序列标签技术的建立及相关水稻cDnA阵列的应用

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中国水稻科学 2004年第1期18卷 1-6页

作者：庄晓峰李德葆 cabezas DAnIEL 戴承恩娄沂春董海涛浙江大学农业与生物技术学院生物信息与基因网络研究组浙江杭州310029

提出了一种新的表达序列标签制作技术———模块表达序列标签 (M EST)技术 ,利用该技术短时间内分离完成1985条水稻cDnA片段 ,制备完成相应的水稻cDnA阵列。实验证实 :该技术体系能成功分离目的基因 ,正确检测基因表达丰度的改变 ,并具... 详细信息

提出了一种新的表达序列标签制作技术———模块表达序列标签 (M EST)技术 ,利用该技术短时间内分离完成1985条水稻cDnA片段 ,制备完成相应的水稻cDnA阵列。实验证实 :该技术体系能成功分离目的基因 ,正确检测基因表达丰度的改变 ,并具备通过对基因群体表达模式的监测以实现对生物学事件的精确描述。M EST概念是对EST技术的完善和重要补充 ,运用M EST技术能有效利用生物信息学知识 ,加快基因克隆速率 ,为基因功能的研究提供手段和工具。

关键词：蛋白模体蛋白模块表达序列标签 cDnA阵列水稻

Constrained sintering and wear properties of Cu-WC composite coatings

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Transactions of nonferrous Metals Society of China 2017年第10期27卷 2214-2224页

作者： J.L.cabezas-VILLA L.OLMOS H.J.VERGARA-HERnánDEZ O.JIMénEZ P.GARnICA D.BOUVARD M.FLORES División de Estudios de Posgrado e Investigación TecNM/Instituto Tecnológico de MoreliaAv. Tecnológico #1500 Colonia Lomas de Santiaguito Morelia Michoacán C. P. 58120 México InICIT Universidad Michoacana de San Nicolás de HidalgoFco. J. Mujica S/N Morelia Michoacán C. P. 58060 México Universidad de Guadalajara Departamento de Ingeniería de ProyectosJosé Guadalupe Zuno # 48 Los Belenes Zapopan Jalisco C. P. 45100 México Univ. Grenoble Alpes CNRS SIMaP 38000 Grenoble France

Coatings of metal matrix composites(Cu?WC)were fabricated by solid-state *** reinforcing particles indifferent quantities from5%up to30%(volume fraction)were mixed with Cu *** mixing,the powders were poured ontothe surface of copper *** was carried out at1000°C under a reducing atmosphere in a vertical *** was affected by both rigid substrates and WC particles which retarded the radial and axial densification of ***,the coatings were strongly attached to the substrate,and WC particles were randomly distributed within the *** addition ofthe reinforcing particles enhanced the microhardness and reduced the volume loss in wear tests to1/17compared to the *** predominant wear mechanism was identified as abrasion at a load of5n.20%WC(volume fraction)reinforcingparticles led to the maximum values of properties for the composite coating.

关键词： constrained sintering dilatometry dry sliding wear microhardness metal matrix composites coating

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萨尔瓦多比特币败局

商业周刊（中文版） 2022年第24期 62-67页

作者： Zeke Faux Jose cabezas(摄影) 许诺(译) 不详

在萨尔瓦多共和国太平洋沿岸一个河口附近坐落着孔查瓜火山。距离火山以西几英里远(1英里约合1.6公里)的地方是一个叫弗洛·德·芒格的居民点,住着大约70户人家。这里因红树林而得名,居民们现在靠在河海交汇水域人工采收牡蛎和螃蟹谋生... 详细信息

在萨尔瓦多共和国太平洋沿岸一个河口附近坐落着孔查瓜火山。距离火山以西几英里远(1英里约合1.6公里)的地方是一个叫弗洛·德·芒格的居民点,住着大约70户人家。这里因红树林而得名,居民们现在靠在河海交汇水域人工采收牡蛎和螃蟹谋生。第一批居民大约二十年前来到这里,其中一些人曾是士兵和游击队员,在残酷的内战中流落到此地。

关键词：太平洋沿岸河口附近比特币萨尔瓦多居民点红树林

Potentiality of Vermicompost Humic Acids in Banana in Vitro Micropropagation Clone： Enano Guantanamero

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Journal of Environmental Science and Engineering(A) 2013年第11期2卷 677-685页

作者： Marcia B. Moya Fernandez Luis Eduardo Cosio-Vargas Daniel cabezas Montero Andres Calderin Garcia Dany Marrero Lopez Sandra Perez Alvarez Deperment of Plant Protection Agrarian University of Havana (Fructuoso Rodriguez Perez) Mayabeque 32 700 Cuba InIFAP (nacional Research Center of Forest Agrarian and Livestock) Uruapan 60150 Mexico Havana Biofabric Mayabeque 32700 Cuba

The research was done at Havana Biofabric, Mayabeque Province. The vitro plants of banana （Musa sp） used came from the clone Enano Guantanamero （viand type）. They come from multiplication phase in a Murashige and MS （Skoog medium）. The objective of this work was to study the potentialities of HA （humic acids） for stimulation of rooting and cell division process, searching for completely synthetic hormone substitution due to its high cost. The multiplication medium contained thiamine （2 mg·L^-1）, myo-inositol （100 mg·L^-1）, sugar （30mg·L^-1）. By the use of HA, five treatments were used with total substitution of auxin and cytokinin （TI： HA （10 ***）; （T2： HA （20 mg·L^-1）; （T3： HA （30mg·L^-1）; （T4： HA （40 mg·L^-1）; （T5： HA （50 mg·L^-1） and the control with 6BAP （benzil amino purine）（4 mg·L^-1）＋ IBA （indol butyric acid）（0.65 mg·L^-1）, pH of the medium was adjust just before agar were add. The results showed that in the explants under HA treatments, elongation and cell multiplication were favored confirmed by explants great high, root number and length due to dry mass. The total protein content, reduced carbohydrate and peroxidases enzymatic activity were determine. The use of Vermicompost HA in the in vitro micropropagation of banana allow the elimination of rooting phase saving materials and be able to pass explants directly to Acclimatization phase.

关键词： Banana multiplication phase HA (Humic Acids) rooting.

Sintering kinetics of ni_2FeSb powder alloys produced by mechanical milling

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Transactions of nonferrous Metals Society of China 2016年第8期26卷 2126-2135页

作者： F.ALVARADO-HERnánDEZ O.JIMénEZ G.GOnZALEZ-CASTAnEDA V.BALTAZAR-HERnánDEZ J.cabezas-VILLA M.ALBITER H.VERGARA-HERnánDEZ L.OLMOS Unidad Académica de Ingeniería I Universidad Autónoma de ZacatecasJardín Juárez 147 Centro Histórico Zacatecas Zacatecas C. P. 98000 México Departamento de Ingeniería de Proyectos CUCEI Universidad de GuadalajaraBlvd. Marcelino García Barragán 1421 Olímpica Guadalajara Jalisco C. P. 44430 Mexico InICIT Universidad Michoacana de San Nicolás de HidalgoFco. J. Mujica S/N C.U. Morelia Michoacán C. P. 58060 México División de Estudios de Posgrado e Investigación TecNM/Instituto Tecnológico de MoreliaAv. Tecnológico # 1500 Colonia Lomas de Santiaguito Morelia Michoacán C. P. 58120 México

A ternary ni2FeSb shape memory alloy was fabricated by powder metallurgy route. Sintering kinetics was estimated from dilatometry tests; whereas the microstructure and morphology of the powder and consolidated bulk samples were evaluated by XRD and SEM, respectively. Microhardness tests were performed on the surface of sintered samples. The results indicated that milling time has an effect on the shape and particle size as well as the homogeneity of the crystalline structures of the powders. Samples with longer milling time presented higher relative densities, better distribution of the elements on the alloy as well as the L21 and martensite phases, which will give the shape memory effect. The estimated activation energy values ranged from 109 to 282 kJ/mol at temperatures between 750 and 1273 K, indicating that sintering is controlled mainly by volume diffusion. Microhardness was improved by increasing the milling time and the heating rate.

关键词： ni-based shape memory alloy mechanical milling solid state sintering microhardness

Synthesis and Radiation Dosimetry of [68Ga]-Ga-Lys1, Lys3-DOTA-Bombesin (1,14) Antagonist for PET-Imaging, as a Potential Theragnostic Tracer in Oncology

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Journal of Encapsulation and Adsorption Sciences 2020年第2期10卷 29-41页

作者： Juan C. Manrique-Arias Quetzali Pitalua-Cortes Roberto Pedrero-Piedras Géiser Rodríguez-Mena Tessy López Cristian cabezas-Ortiz Osvaldo García-Pérez Departamento de Medicina nuclear Ciclotrón y Radiofarmacia Instituto Nacional de Cancerología México City México Cancer Center Cyclotron Department Doctors Hospital Monterrey México Departamento de Atención a la Salud Universidad Autónoma Metropolitana-Xochimilco México City México

This Bombesin (BBn), a tetradecapeptide analog of human gastrin-releasing peptide (GRP) with a high binding affinity for GRP receptors (GRPR), is over- expressed in early stages of androgen-dependent prostate carcinomas, but not in advanced stages. Therefore, there is a need to develop effective tracers for the accurate and specific detection of this disease. The objective of this study was to evaluate Lys1, Lys3-DOTA-BBn (1,14) analog with the radiolabeled positron emitter [68Ga]-Ga-BBn for receptor imaging with PET, and to determine its biodistribution and radiation dosimetry using whole-body (WB) PET scans in healthy volunteers. The highest uptake was in the pancreas, followed by urinary bladder. The critical organ was pancreas with a mean absorbed dose of 206 ± 0.7, 210 ± 0.7, 120 ± 0.9, 390.23 ± 0.6 μGy/MBq and the effective doses were estimated as 73.2 ± 0.6, 49.8 ± 0.3 μGy/MBq (women and men, respectively).

关键词： Radiation Dosimetry Biodistribution PET Imaging Radiopharmaceutical Lys1 Lys3-DOTA-BBn (1 14) Bombesin Analogs

Biological Invasions in Marine Ecosystems:Amphipods(Crustacea:Amphipoda)as a Model Group

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Journal of Marine Science 2022年第2期4卷 18-21页

作者： M.Pilar cabezas Associate Editor Journal of Marine Science Faculdade de Ciências da Universidade do Porto Rua do Campo Alegre s/nPorto4169-007Portugal

The introduction of non-indigenous species(nIS),deliberately or unintentionally,by means of human action,is considered one of the major threats to biodiversity and ecosystem functioning worldwide[1].Some of these species successfully establish,spread rapidly into new locations,and become invasive,altering ecosystem services and causing both significant ecological and socio-economic impacts[1,2].

关键词： Crustacea biodiversity Marine