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Stem cell homing, tracking and therapeutic efficiency evaluation for stroke treatment using nanoparticles: A systematic review

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World Journal of Stem Cells 2020年第5期12卷 381-405页

作者： Mariana Penteado Nucci Igor Salerno Filgueiras joao matias ferreira Fernando Anselmo de Oliveira Leopoldo Penteado Nucci Javier Bustamante Mamani Gabriel Nery Albuquerque Rego Lionel Fernel Gamarra LIM44 Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 05529-060Brazil Hospital Israelita Albert Einstein Sao Paulo 05529-060Brazil Centro Universitário do Planalto Central BrasíliaDFBrazil

BACKGROUND Stroke is the second leading cause of death *** is a real need to develop treatment strategies for reducing neurological deficits in stroke survivors,and stem cell(SC)therapeutics appear to be a promising alternative for stroke therapy that can be used in combination with approved thrombolytic or thrombectomy ***,the efficacy of SC therapy depends on the SC homing ability and engraftment into the injury site over a long period of ***,tracking SCs from their niche to the target tissues is a complex *** To evaluate SC migration homing,tracking and therapeutic efficacy in the treatment of stroke using nanoparticles METHODS A systematic literature search was performed to identify articles published prior to November 2019 that were indexed in PubMed and *** following inclusion criteria were used:(1)Studies that used in vivo models of stroke or ischemic brain lesions;(2)Studies of SCs labeled with some type of contrast agent for cell migration detection;and(3)Studies that involved in vivo cellular homing and tracking *** A total of 82 articles were identified by indexing in Scopus and Pub *** inclusion criteria were applied,35 studies were selected,and the articles were assessed for eligibility;ultimately,only 25 studies were *** of the selected studies used SCs from human and mouse bone marrow labeled with magnetic nanoparticles alone or combined with fluorophore *** cells were administered in the stroke model(to treat middle cerebral artery occlusion in 74%of studies and for photothrombotic induction in 26%of studies).Fiftythree percent of studies used xenogeneic grafts for cell therapy,and the migration homing and tracking evaluation was performed by magnetic resonance imaging as well as other techniques,such as near-infrared fluorescence imaging(12%)or bioluminescence assays(12%).CONCLUSION Our systematic review provided an up-to-date evaluation of SC migration hom

关键词： Stem cell Nanoparticles Homing Tracking Near-infrared fluorescence image Cellular therapy Magnetic resonance image Bioluminescence Stroke

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The use of Artificial Neural Networks to estimate seismic damage and derive vulnerability functions for traditional masonry

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Frontiers of Structural and Civil Engineering 2020年第3期14卷 609-622页

作者： Tiago Miguel ferreira joao ESTEVAO Rui MAIO Romeu VICENTE ISISE Institute of Science and Innovation for Bio-Sustainability(IB-S)Department of Civil EngineeringUniversity of MinhoGuimaraes 4800-058Portugal Department of Civil Engineering University of AlgarveFaro 8005-139Portugal RISCO Department of Civil EngineeringUniversity of AveiroAveiro 3810-193Portugal

ABSTRACT This paper discusses the adoption of Artificial Intelligence-based techniques to estimate seismic damage,not with the goal of replacing existing approaches,but as a mean to improve the precision of empirical *** such,damage data collected in the aftermath of the 1998 Azores earthquake(Portugal)is used to develop a comparative analysis between damage grades obtained resorting to a classic damage formulation and an innovative approach based on Artificial Neural Networks(ANNs).The analysis is carried out on the basis of a vulnerability index computed with a hybrid seismic vulnerability asssment methodology,which is subsequently used as input to both *** results obtained are then compared with real post-earthquake damage observation and critically discussed taking into account the level of adjustment achieved by each ***,a computer routine that uses the ANN as an approximation function is developed and applied to derive a new vulnerability curve *** general terms,the ANN developed in this study allowed to obtain much better approximations than those achieved with the original vulnerability approach,which has revealed to be quite ***,the proposed vulnerability curve expression was found to provide a more accurate damage prediction than the traditional analytical expressions.

关键词： Artificial Neural Networks seismic vulnerability masonry buildings damage estimation,vulnerability curves

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Tunable Super-Structured Fiber Bragg Gratings with Perfect Sequences Based on m-Sequence

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Journal of Electronic Science and Technology 2017年第4期15卷 358-363页

作者： joao S.Pereira Marco P.M.ferreira Marko Gasparovic Instituto de Telecomunicacoes Lisboa 1049-001 Portugal Institute Polytechnic of Leiria Leiria 2411-901 Portugal Centro de Investigaao em Informaica e Comunicacoes Institute Polytechnic of Leiria Leiria 2411-901Portugal

Recently, a tunable fiber Bragg grating(FBG) was developed by using stress-responsive colloidal crystals. In this paper, we have simulated the application of these nanoparticles into the super-structured fiber Bragg grating(SSFBG) written with perfect sequences derived from a short maximal-length sequence. A tunable SSFBG will be available to overcome the prohibitive temperature variation of the optical codecs. Nevertheless,we presented a method to implement coherent time spreading optical code-division multiple-access(OCDMA) where a unique code(or perfect sequence) can be reused and mixed with different wavelengths to obtain a tunable wavelength-division multiplexing(WDM)system. In order to maximize the binary throughput, we have selected a unique short maximal-length sequence composed of 7 chips that can be tuned with 7 different optical wavelengths. We found thousands of different tunable combinations that presented power contrast ratios(P/C) higher than 12 dB. When a WDM-OCDMA system used 2 different combinations simultaneously, the perfect binary detection with error correction codes was achieved successfully. The tunable SSFBG with colloidal crystals will be a simple and good alternative choice for fiber-to-the-home(FTTH) communications.

关键词： Optical code-division multiple-access(OCDMA) super-structured fiber Bragg grating(SSFBG) wavelength-division multiplexing OCDMA(WDM-OCDMA)

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Integrating an academic management system with blockchain:A case study

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Blockchain(Research and Applications) 2022年第4期3卷 81-90页

作者： Sergio Guerreiro joao F.ferreira Tiago Fonseca Miguel Correia INESC-ID Rua Alves Redol 91000-029LisbonPortugal Instituto Superior Tecnico University of Lisbon1649-004LisbonPortugal

This paper reports the design,implementation,and experimental phases of the EU H2020 QualiChain pilot“Staffing the Public Sector—The Case of Portugal”.The overall purpose of this pilot is to ensure the authenticity and integrity of the diplomas for all involved stakeholders and therefore to contribute to solving the diploma counterfeiting and/or falsification that is a great threat to the recruitment of qualified *** main innovative aspect of this solution is the integration that is offered between an Academic Management System(the *** platform)and a Blockchain(Ethereum)to automatically deploy *** solution helps the involved stakeholders trust the diplomas *** case study involves four different stakeholders and studies,specifically,the increase in their satisfaction in terms of diploma control,diploma veracity,and diploma *** developed system was tested with external participants who were asked to follow a set of guidelines and complete a survey to assess their *** system interactions were recorded,and the data were *** results indicated that the participants successfully executed the guidelines and that a perception increase toward diploma control,veracity,and credibility was identified.

关键词： Blockchain University management system Authenticity Document verification Education certificate Ethereum Integrity Smart contrac

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New-onset diabetes after kidney transplantation:Incidence and associated factors

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World Journal of Diabetes 2018年第7期9卷 132-137页

作者： Vania Gomes Florbela ferreira JoséGuerra Maria joao Bugalho Endocrinology Diabetes and Metabolism DepartmentSanta Maria HospitalLisbon 1649-035Portugal Nephrology and Kidney Transplantation Department Santa Maria HospitalLisbon 1649-035Portugal

AIM To determine the incidence and associated factors of new-onset diabetes after transplantation(NODAT) in a Portuguese central hospital. METHODS This single-center retrospective study involved consecutive adult nondiabetic transplant recipients, who had undergone kidney transplantation between January 2012 and March 2016. NODAT was diagnosed according to the criteria of the American Diabetes Association. Data were collected from an institutional database of the Nephrology and Kidney Transplantation Department(Santa Maria Hospital, Lisbon, Portugal) and augmented with data of laboratorial parameters collected from the corresponding patient electronic medical records. Exclusion criteria were preexisting diabetes mellitus, missing information and follow-up period of less than 12 mo. Data on demographic and clinical characteristics as well as anthropometric and laboratorial parameters were also collected. Patients were divided into two groups: With and without NODAT-for statistical *** A total of 156 patients received kidney transplantduring the study period, 125 of who were included in our analysis. NODAT was identified in 27.2% of the patients(n = 34; 53% female; mean age: 49.5 ± 10.8 years; median follow-up: 36.4 ± 2.5 mo). The incidence in the first year was 24.8%. The median time to diagnosis was 3.68 ± 5.7 mo after transplantation, and 76.5% of the patients developed NODAT in the first 3 mo. In the group that did not develop NODAT(n = 91), 47% were female, with mean age of 46.4 ± 13.5 years and median follow-up of 35.5 ± 1.6 mo. In the NODAT group, the pretransplant fasting plasma glucose(FPG) levels were significantly higher [101(96.1-105.7) mg/d L vs 92(91.4-95.8) mg/d L, P = 0.007] and pretransplant impaired fasting glucose(IFG) was significantly more frequent(51.5% vs 27.7%, P = 0.01). Higher pretransplant FPG levels and pretransplant IFG were found to be predictive risk factors for NODAT development [odds ratio(OR): 1.059, P = 0.003; OR: 2.77

关键词： New-onset diabetes after transplant Incidence Kidney transplantation Impaired fasting glucose Immunosuppression

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Mitigating adjacent channel interference in vehicular communication systems

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Digital Communications and Networks 2016年第2期2卷 57-64页

作者： joao Almeida Muhammad Alam Joacluim ferreira Arnaldo S.R. Oliveira lnstituto de Telecomunicar/Ses Campus Universitdirio de Santiago 3810-193 Aveiro Portugal DETI - Universidade de Aveiro Campus Universitdrio de Santiago 3810-193 Aveiro Portugal ESTGA - Universidade de Aveiro 3754-909 gueda Portugal

In the last few decades, dedicated wireless channels were specifically allocated to enable the development and implementation of vehicular communication systems. The two main protocol stacks, the WAVE stan- dards proposed by the IEEE in the United States and the ETSI ITS-G5 in Europe, reserved 10 MHz wide channels in the 5.9 GHz spectrum band. Despite the exclusive use of these frequencies for vehicular com- munication purposes, there are still cross channel interference problems that have been widely reported in the literature. In order to mitigate these issues, this paper presents the design of a two-stage FIR low-pass filter, targeting the integration with a digital baseband receiver chain of a custom vehicular communications platform. The filter was tested, evaluated and optimized, with the simulation results proving the effectiveness of the proposed method and the low delay introduced in the overall operation of the receiver chain. 2016 Chongqing University of Posts and Telecommunications. Production and Hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license

关键词： Intelligent transportation systemsVehicular communicationsAdjacent Channel InterferenceFilter designMulti-rate systemsDigital Hardware Design

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Conformal and continuous deposition of bifunctional cobalt phosphide layers on p-silicon nanowire arrays for improved solar hydrogen evolution

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Nano Research 2018年第9期11卷 4823-4835页

作者： Sitaramanjaneva Mouli Thalluri Jerome Borme Kang Yu Junyuan Xu Isilda Amorim joao Gaspar Liang Qiao Paulo ferreira Pedro Alpuim Lifeng Liu International Iberian Nanotechnology Laboratory (INL) Av. Mestre. Jose Veiga Braga 4715-330 Portugal Materials Science and Engineering Program University of Texas at Austin Austin TX78712 USA Deportment of Chemistry State Key Laboratory of Molecular Engineering of Polymers and Institute of Biomedical Sciences Fudon University Shanghai 200433 China Mechanical Engineering Department and IDMEC Instituto Superior Tdcnico University of Lisbon Av. Rovisco Pais Lisboa 1049-007 Portugal Center of Physics University of Minho Braga 4710-057 Portugal

Vertically aligned p-silicon nanowire （SiNW） arrays have been extensively investigated in recent years as promising photocathodes for solar-driven hydrogen evolution. However, the fabrication of SiNW photocathodes with both high photoelectrocatalytic activity and long-term operational stability using a simple and affordable approach is a challenging task. Herein, we report conformal and continuous deposition of a di-cobalt phosphide （C02P） layer on lithography- patterned highly ordered SiNW arrays via a cost-effective drop-casting method followed by a low-temperature phosphorization treatment. The as-deposited C02P layer consists of crystalline nanoparticles and has an intimate contact with SiNWs, forming a well-defined SiNW@Co2P core/shell nanostructure. The conformal and continuous Co2P layer functions as a highly efficient catalyst capable of substantially improving the photoelectrocatalytic activity for the hydrogen evolution reaction （HER） and effectively passivates the SiNWs to protect them from photo-oxidation, thus prolonging the lifetime of the electrode. As a consequence, the SiNW@Co2P photocathode with an optimized C02P layer thickness exhibits a high photocurrent density of -21.9 mA·cm^-2 at 0 V versus reversible hydrogen electrode and excellent operational stability up to 20 h for solar-driven hydrogen evolution, outperforming many nanostructured silicon photocathodes reported in the literature. The combination of passivation and catalytic functions in a single continuous layer represents a promising strategy for designing high-performance semiconductor photoelectrodes for use in solar-driven water splitting, which may simplify fabrication procedures and potentially reduce production costs.

关键词： solar-driven hydrogenevolution silicon nanowire cobalt phosphide photoelectrochemical water splitting drop-casting

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The contribution of resources and capabilities to the competitiveness： The case of Port of Sines

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Chinese Business Review 2009年第3期8卷 14-26页

作者： Susana Garrido Azevedo joao ferreira Department of Management and Economics University of Beira Interior Covilha 6200-209 Portugal

The main objective of this paper is to analyse the competitiveness of the main maritime Port sited in Portugal - Port of Sines. This paper is developed under the resource-based view approach. A literature review about the resource-based view is presented with a special highlight on the contribution of organisation owns＇ resources to the competitiveness. With this study we intend to emphasize the applicability of a management theory to a different type of organisation which only recently starts to be preoccupied with its competitiveness. A case study methodology is used in order to collect all information needed about its main resources and capabilities of Port and also its competitiveness. The resources analysed in this paper are： The infrastructures, the accessibilities, the Port operations and also the information systems used on it. Also, a set of performance data is analysed as the main indicators of competitiveness. After that, a conceptual model is presented in order to systematise the main resources and capabilities under which the competitiveness of the Port of Sines is built on.

关键词： competitiveness sea Port resource-based view case study

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The growth and production modeling of individual trees of Eucalyptus urophylla plantations

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Journal of Forestry Research 2020年第5期31卷 1663-1672页

作者： joao Victor Nobre Carrijo Ana Beatriz de Freitas ferreira Marcela Costa ferreira Mario Cesar de Aguiar Eder Pereira Miguel Eraldo Aparecido Trondoli Matricardi Alba Valeria Rezende Department of Forestry Faculty of TechnologyUniversity of Brası´liaBrası´lia 70910-900Brazil

Individual tree models(ITMs)are classified as growth and production models for projecting current and future forest *** are more complex than other growth and production models,show a higher level of detail and,consequently,produce a better modeling ***,the accuracy and efficiency of ITMs have not been properly assessed to *** this study,we estimated the growth in height,diameter,and individual tree volume of a Eucalyptus urophylla plantation by applying an *** used a continuing forest inventory dataset in which 1554 individual trees within 29 permanent plots were measured in the field over a 6-year period(24 to 72 months).Each individual tree volume was estimated for future tree *** achieve this,we adjusted the model to predict the height and diameter growth,and the probability of mortality as a function of the competition *** ITM accuracy was assessed based on the analysis of variance results and,subsequently,the multiple mean comparison test at the 5%significance *** tree volumes predicted by the ITM for the forest stand aged 72 months,beginning at ages 24,36,48,and 60 months,were compared to the field measured tree volume acquired from the 72-month forest inventory that was used as the reference *** and observed tree volumes were similar when the estimation was based on the 48-month forest *** results might help to reduce financial costs of forest inventory because the ITM produces accurate future predictions of forest stand *** estimated ITM for Eucalyptus plantations using measurement intervals up to 2 years is recommended because it significantly reduced the projected volume discrepancy compared to the field measurements.

关键词： Competition index Forest production Forest site Simulation models Tree mortality

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Investigation of Galactic open cluster remnants： the case of NGC 7193

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Research in Astronomy and Astrophysics 2017年第1期17卷 31-54页

作者： Mateus de Souza Angelo joao Francisco Coelho dos Santos Jr Wagner Jose Barbosa Corradi Francisco ferreira de Souza Maia Andres Eduardo Piatti Departamento de Fisica ICEx Universidade Federal de Minas Gerais Av. Antonio Carlos 6627 31270-901 Belo Horizonte MG Brazil Observatorio Astronomico Universidad Nacional de Cordoba Laprida 854 5000 Cordoba Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas Av. Rivadavia 1917 C1033AAJ Buenos AiresArgentina

Galactic open clusters （OCs） that survive the early gas-expulsion phase are gradually de- stroyed over time by the action of disruptive dynamical processes. Their final evolutionary stages are characterized by a poorly populated concentration of stars called an open cluster remnant （OCR）. This study is devoted to assessing the real physical nature of the OCR candidate NGC 7193. GMOS/Gemini spectroscopy of 53 stars in the inner target region were obtained to derive radial velocities and at- mospheric parameters. We also employed photometric and proper motion data. The analysis method consists of the following steps：（i） analysis of the statistical resemblance between the cluster and a set of field samples with respect to the sequences defined in color-magnitude diagrams （CMDs）; （ii） a 5-dimensional iterative exclusion routine was employed to identify outliers from kinematical and posi- tional data; （iii） isochrone fitting to thes× （J - Ks） CMD of the remaining stars and the dispersion of spectral types along empirical sequences in the （J - H） × （H - Ks） diagram were checked. A group of stars was identified for which the mean heliocentric distance is compatible with that obtained via isochrone fitting and whose metallicities are compatible with each other. Fifteen of the member stars observed spectroscopically were identified together with another 19 probable members. Our results indi- cate that NGC 7193 is a genuine OCR, of a once very populous OC, for which the following parameters were derived： d = 501±46 pc, t = 2.5±1.2 Gyr, （[Fe/H]） = -0.17±0.23 and E（B-V） = 0.05±0.05. Its luminosity and mass functions show depletion of low mass stars, confirming the OCR is in a dynam- ically evolved state.

关键词： open cluster remnants - Galactic open clusters

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