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Red propolis:Chemical composition and pharmacological activity

Asian Pacific Journal of Tropical Biomedicine 2017年第7期7卷 591-598页

作者： Luciane Corbellini Rufatto Denis Amilton dos Santos Flávio Marinho joao antonio pegas henriques Mariana Roesch Ely Sidnei Moura Laboratory of Biotechnology of Natural and Synthetics Products-Biotechnology Institute University of Caxias do SulBrazil Laboratory of Genomics Proteomics and DNA Repair-Biotechnology InstituteUniversity of Caxias do SulBrazil

Propolis has been used worldwide for years in folk medicine and currently marketed by the pharmaceutical industry. In Brazil, propolis was classified into 13 groups based on their organoleptics and physicochemical characteristics. The 13th type named red propolis has been an important source of investigation since late 90s. Their property comes from the countless compounds, including terpenes, pterocarpans, prenylated benzophenones and especially the flavonoids. This last compound class has been indicated as the responsible for its potent pharmacological actions, highlighting the antimicrobial, antiinflammatory, antioxidant, healing and antiproliferative activities. The red propolis can also be found in other countries, especially Cuba, which has similar features as the Brazilian. Therefore, with the compilation of 80 papers, this review aims to provide a key reference for researchers interested in natural products and discovery of new active compounds, such as from propolis.

关键词： Red propolis Bioactivity Chemical composition Review

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Chemical Characterization and Cytotoxic Activity of Antarctic Macroalgae Extracts against Colorectal Cancer

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Advances in Biological Chemistry 2019年第5期9卷 167-177页

作者： Rafaele Frassini Yeslei Paulino da Silva Sidnei Moura Leonardo Zambotti Villela Aline Paternostro Martins Pio Colepicolo Mutue Toyota Fujii Nair S.Yokoya Claudio Martin Pereira de Pereira Vagner Reinaldo Zingalli Bueno Pereira joao antonio pegas henriques Mariana Roesch-Ely Laboratory of Genomics Proteomics and DNA RepairUniversity of Caxias do SulCaxias do SulRSBrazil Laboratory of Biosynthetic and Natural Products of Caxias do Sul Caxias do SulRSBrazil Laboratory of Biochemistry and Molecular Biology of Algae University of Sao PauloSao PauloSPBrazil Phycologycal Research Institute of BotanySao PauloSPBrazil Laboratory of Lipidomics and Biorganic—LLipidomicaBio Federal University of PelotasPelotasRSBrazil General Hospital University of Caxias do SulCaxias do SulRSBrazil

Background/Aim: Antarctic seaweeds are considered a promising source of compounds with anticancer activity. Colorectal cancer (CRC) is one of the most incident cancers with high mortality rates worldwide. This work aimed to characterize chemically extracts of the Antarctic macroalgae Iridaea cordata, Cystosphaera jacquinotii and Desmarestia anceps and to evaluate the cytotoxic effects against human colon cancer HCT 116 cell line. Materials and Methods: The extracts were obtained by depletion using an ultrasound probe and were identified by High-Performance Liquid Chromatography (HPLC) and Gas Chromatography coupled with Mass Spectrometry (GC-MS). Cell viability was determined by MTT assay. Results: Hexanic and chloroform extracts of the I. cordata and the hexanic, chloroform and methanolic extracts of D. anceps were able to inhibit growth of colorectal cancer cells in the three different incubation times (24, 48 and 72 h). Through GC analysis, 01 compounds were identified in the hexane extract and 02 compounds in the chloroform extract of the algae I. cordata. The hexane extract of D. anceps macroalgae presented 5 compounds, chloroform extract 10 and methanolic extract 3 respectively, with special highlight to fucosterol. Carotenoid analysis by HPLC identified β-carotene in all species, while zeaxanthin was present in the spectrum of I. cordata and C. jacquinotii. Fucoxanthin and violaxanthin were confirmed in the brown seaweeds C. jacquinotii and D. anceps. Conclusion: Extracts of macroalgae I. Cordata and D. anceps may be a source of therapeutic agents against CRC.

关键词： Antarctic Seaweeds Antitumor Activity Colorectal Cancer

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A Review on General Nutritional Compounds and Pharmacological Properties of the Lentinula edodes Mushroom

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Food and Nutrition Sciences 2014年第12期5卷 1095-1105页

作者： Tiane Cristine Finimundy Aldo José Pinheiro Dillon joao antonio Pêgas henriques Mariana Roesch Ely Laboratory of Genomics Proteomics and DNA RepairInstitute of BiotechnologyUniversity of Caxias do SulCaxias do SulBrazil Laboratory of Enzyme and Biomass Institute of BiotechnologyUniversity of Caxias do SulCaxias do SulBrazil

Lentinula edodes?is a macrofungus with great potential for therapeutic applications and serves as a model for investigating functional fungi properties and isolating pure compounds for pharmaceutical use. Mushrooms have a great nutritional value and present medicinal molecules including polysaccharides, terpenoids, sterols and lipids, that participate actively in several human disorders and modulate mechanisms involved in the immune system regulation. This review will focus on general nutritional compounds and pharmacological properties of L. edodes.

关键词： Lentinula edodes β-Glucans Therapeutic Applications Review

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