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Exploring salivary biomarkers and swallowing perceptions in Sjogren's syndrome:A case-control feasibility study

Rheumatology & Autoimmunity 2022年第3期2卷 129-140页

作者： Veronica H.letawsky Parker J.Holman Caroline T.Nguyen Camilla Dawson joanne Weinberg lynne J.Williams Stacey A.Skoretz Faculty of Medicine School of Audiology and Speech SciencesUniversity of British ColumbiaVancouverBCCanada Department of Cellular and Physiological Sciences University of British ColumbiaVancouverBCCanada Department of Oral Health Sciences University of British ColumbiaVancouverBCCanada National Dental Examining Board of Canada OttawaONCanada Department of Speech and language Therapy University Hospitals Birmingham NHS Foundation TrustBirminghamUK BC Children's Hospital MRI Research Facility BC Children's Hospital Research InstituteVancouverBCCanada Department of Critical Care Medicine University of AlbertaEdmontonABCanada Centre for Heart lung Innovation St.Paul's HospitalProvidence Health CareVancouverBCCanada

Background:The autoimmune disease Sjogren's syndrome(SS)is often characterized by salivary changes that may affect *** known study has investigated the association between salivary biomarkers and perceptions of swallowing in individuals with *** objectives were to explore:(1)the operational feasibility of investigating saliva volume and composition,along with perceptions of swallowing,in those with and without SS;and(2)the relationship between saliva composition and perceptions of oral dryness,swallowing,and quality of ***:We conducted a prospective,case–control feasibility study,collecting feasibility data(recruitment rate and optimal saliva collection methods)and whole mouth saliva samples(unstimulated and stimulated).We measured total protein content and conducted sialochemical(α-amylase,cortisol,C-reactive protein[CRP],and mucins),sialometric(flow rate),and perceptual(oral dryness and swallowing-related quality of life[SWAl-QOl])*** exploratory analyses focused on the main and fixed *** summarized all data descriptively,comparing:(a)outcomes between groups(t tests or Mann–Whitney U)and(b)salivary and perceptual data across participants(partial least-squares correlation[PlSC]).Results:We enrolled 12(N)participants(6 per group),all providing analyzable *** had lower flow rate(p=0.003)and higher total protein,cortisol,and CRP concentrations(pled inverse covariance between sialochemical and SWAl-QOl data across ***:Our study was feasible as *** explored novel relationships between salivary outcomes and participant-reported perceptions,distinguishing individuals with and without *** findings support further study of saliva's role in perceptions of swallowing,specifically analytes with lubricative properties.

关键词： deglutition feasibility studies quality of life saliva Sjogren's syndrome

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白雪公主和七个小矮人

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丛书名：童话盒子·有声双语绘本

2010年

作者： (英) joanne Swan改写

本书内容包括: 白雪公文和七个小矮人 ; 想一想做一做 ; 图画单词表几部分。

ISBN: (纸本)9787513501071;9787880952124

本书内容包括: 白雪公文和七个小矮人 ; 想一想做一做 ; 图画单词表几部分。

关键词：图画故事

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Business English at work

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2000年

作者： Susan Jaderstrom joanne Miller

Includes index.

ISBN: (纸本)0028025385

Includes index.

关键词： English language

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Exosomal glypican-1 is elevated in pancreatic cancer precursors and can signal genetic predisposition in the absence of endoscopic ultrasound abnormalities

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World Journal of Gastroenterology 2022年第31期28卷 4310-4327页

作者： Pedro Moutinho-Ribeiro Ines A Batista Sofia T Quintas Bárbara Adem Marco Silva Rui Morais Armando Peixoto Rosa Coelho Pedro Costa-Moreira Renato Medas Susana lopes Filipe Vilas-Boas Manuela Baptista Diogo Dias-Silva Ana l Esteves Filipa Martins joanne lopes Helena Barroca Fátima Carneiro Guilherme Macedo Sonia A Melo Serviço de Gastrenterologia Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Faculty of Medicine University of PortoPorto 4200Portugal Instituto de Investigacao e Inovacao em Saúde(i3S) Universidade do PortoPorto 4200Portugal IPATIMUP-Institute of Molecular Pathology and Immunology University of PortoPorto 4200Portugal Instituto de Ciencias Biomédicas Abel Salazar(ICBAS) University of PortoPorto 4050Portugal Servico de Cirurgia Geral Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Unidade de Saúde Familiar Serpa Pinto ACeS Porto OcidentalPorto 4250Portugal Serviço de Anatomia Patológica Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal

BACKGROUND Individuals within specific risk groups for pancreatic ductal adenocarcinoma(PDAC)[mucinous cystic lesions(MCls),hereditary risk(HR),and new-late onset diabetes mellitus(NlOD)]represent an opportunity for early cancer *** ultrasound(EUS)is a premium image modality for PDAC screening and precursor lesion *** no specific biomarker is currently clinically available for this purpose,glypican-1(GPC1)is overexpressed in the circulating exosomes(crExos)of patients with PDAC compared with healthy subjects or those harboring benign pancreatic *** To evaluate the capacity of GPC1+crExos to identify individuals at higher risk within these specific groups,all characterized by *** This cross-sectional study with a prospective unicentric cohort included 88 subjects:40 patients with MCl,20 individuals with HR,and 20 patients with NlOD.A control group(CG)was submitted to EUS for other reasons than pancreatic pathology,with normal pancreas and absence of hereditary risk factors(n=8).The inclusion period was between October 2016 and January 2019,and the study was approved by the Ethics Committee of Centro Hospitalar Universitário de São João,Porto,*** patients provided written informed *** and blood tests for quantification of GPC1+crExos by flow cytometry and carbohydrate antigen 19-9(CA 19-9)levels by ElISA were performed in all ***-guided tissue acquisition was done whenever *** statistical analysis,SPSS®27.0(IBM Corp.,Armonk,NY,United States)version was *** graphs were created using GraphPad Prism 7.00(GraphPad Software,San Diego,CA,United States).RESUlTS Half of MCls harbored worrisome features(WF)or high-risk stigmata(HRS).Pancreatic abnormalities were detected by EUS in 10.0%and 35.0%in HR and NlOD individuals,respectively,all considered non-malignant and“harmless.”Median levels of GPC1+crExos were statistically different:MCl[99.4%,interquartile range(IQR):94.9%-99.8%],HR(8

关键词： Glypican-1 Circulating exosomes Endoscopic ultrasound Pancreatic cancer risk groups Pancreatic cancer precursor lesions Genetic predisposition

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local HY5 Activity Mediates Hypocotyl Growth and Shoot-to-Root Communication

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Plant Communications 2020年第5期1卷 64-72页

作者： Yogev Burko Christophe Gaillochet Adam Seluzicki joanne Chory Wolfgang Busch Howard Hughes Medical Institute Salk Institute for Biological StudiesLa JollaCA 92037USA Plant Biology laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Integrative Biology laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA

Plants optimize their growth in fluctuating environments using information acquired by different *** information is then transmitted through the rest of the plant using both short-and long-distance signals,including hormones and mobile *** a few of these signals have been characterized,long-distance signaling is not well understood in ***,the light-regulated transcription factor HY5 was reported to move from the shoot to the root to regulate root *** generated a cell-type specifically expressed HY5 fusion protein that could not be detected outside the tissue in which it was *** expressing this DOF-HY5 protein in specific cell types of the hypocotyl,we showed that its local activity was sufficient to regulate hypocotyl *** also found that,although DOF-HY5 was expressed specifically in the shoot and not detected in the roots,it could rescue hy5 growth defects in primary roots but not in lateral *** therefore conclude that HY5 protein mobility is not required in the hypocotyl or for shoot-to-root *** results indicate that a signal downstream of,or in parallel with,HY5 in the shoot is mobile and links shoot and root growth.

关键词： HY5 shoot-to-root communication hypocotyl root lateral root Arabidopsis

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MAGNETOENCEPHAlOGRAPHY (MEG) IN HUMAN BRAIN MAPPING

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神经解剖学杂志 2001年第B7期17卷 86-87页

作者： Juha H M l INEN joanne Y. GAMElIN Kenneth C. SQUIRES 4-D Neuroimaging Helsinki Finland 4-D Neuroimaging San Diego CA 4-D Neuroimaging San Diego CA

The neurophysiological measurement technique known as magnetoencephalography, or MEG, has been in use since the early 1970's, and applied to clinical populations since the early 1980's. However, it was not until the late 1980's and early 1990's that the technology was advanced to point where effective clinical use was achieved. This presentation will review the basic principles of MEG, discuss the progression of technology development and give an update on the current clinical applications of the technology.

关键词：人类脑电地形图脑磁成像 MEG 临床应用

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死亡并不总是坏事

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上海文学 2023年第12期554卷 71-77页

作者：李家安不详

二〇二三年一月七日,星期六嗨,你好。不要介意,我只是为新年开始写这篇新的日记。新的一年,事情仍然感觉一样。在我以前的日记中,我提到我感觉更加成熟,但事实证明,那只是因为我周围的人。我和父母在一起,和外公外婆在一起,我哥哥关心我... 详细信息

二〇二三年一月七日,星期六嗨,你好。不要介意,我只是为新年开始写这篇新的日记。新的一年,事情仍然感觉一样。在我以前的日记中,我提到我感觉更加成熟,但事实证明,那只是因为我周围的人。我和父母在一起,和外公外婆在一起,我哥哥关心我,但是我感到孤独。就像一种朋友式的孤独,我需要和我年龄相仿的人交谈。

关键词：外公外婆感觉日记

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Combined influence of basal media and fibroblast growth factor on the expansion and differentiation capabilities of adipose-derived stem cells

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Cell Regeneration 2014年第1期3卷 98-105页

作者： Mark Ahearne joanne lysaght Amy P lynch Trinity Centre for Bioengineering Trinity Biomedical Sciences InstituteTrinity College DublinDublinIreland Department of Mechanical and Manufacturing Engineering School of EngineeringTrinity College DublinDublinIreland Department of Surgery Institute of Molecular MedicineTrinity Centre for Health SciencesSt.James’s HospitalDublin 8Ireland.

Background: Interest in adipose-derived stem cells (ASCs) has increased in recent years due to their multi-linagedifferentiation capabilities. While much work has been done to optimize the differentiation media, few studies havefocused on examining the influence of different expansion media on cell behavior. In this study, three basal media(low glucose Dulbecco’s modified Eagle’s medium (DMEM), high glucose DMEM and DMEM-F12) supplementedwith or without fibroblast growth factor 2 (FGF) were examined to assess their suitability for expanding ***: Flow cytometry, colony-forming unit assays (CFU-Fs) and differentiation assays were utilized to study cellbehavior. High glucose media CFU-Fs produced fewest colonies while the addition of FGF increased colony *** passage 2, the majority of cells were positive for CD44, 45, 73, 90 and 105 and negative for CD14, 31 and 45,indicating a mesenchymal phenotype. A sub-population of CD34 positive cells was present among passage 2 cells;however, by passage 4 the cells were negative for CD34. FGF has a negative effective on passage 4 ASC adipogenesisand high glucose media plus FGF-enhanced osteogenic capacity of passage 4 ASCs. FGF supplemented basal mediawere most suitable for chondrogenesis. High glucose media plus FGF appeared to be the most beneficial for primingASCs to induce a keratocyte ***: These findings demonstrate the reciprocal effect FGF and basal media have on ASCs. This research hasimplications for those interested regenerating bone, cartilage, cornea or adipose tissues.

关键词： Cell differentiation Cartilage Bone Adipose Cornea

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Marker-Assisted Breeding of Thermo-Sensitive Genic Male Sterile line 1892S for Disease Resistance and Submergence Tolerance

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Rice science 2021年第1期28卷 89-98页

作者： luo Yanchang Ma Tingchen joanne Teo luo Zhixiang li Zefu Yang Jianbo Yin Zhongchao Temasek life Sciences laboratory 1 Research LinkNational University of SingaporeSingapore 117604Republic of Singapore Key laboratory of Rice Genetics and Breeding Rice Research InstituteAnhui Academy of Agricultural SciencesHefei 230031China Department of Biological Sciences National University of Singapore14 Science Drive 4Singapore 117543Republic of Singapore

Rice line 1892S is an elite thermo-sensitive genic male sterile(TGMS)line for two-line hybrid rice ***,1892S is susceptible to rice blast,bacterial blight and *** we reported the introduction of blast resistance(R)gene Pi9,bacterial blight R gene Xa21 and submergence tolerance gene Sub1A into 1892S genetic background through backcrossing and marker-assisted *** improved TGMS line 31892S and its hybrids conferred disease resistance to rice blast and bacterial blight,and showed submergence tolerance for over 14 d without significant loss of *** sterility-fertility conversion of 31892S was similar to that of 1892S.31892S and its derived hybrid rice had similar agronomic traits and grain quality with 1892S and the control hybrid rice,*** newly developed 31892S provided an improved TGMS line for two-line hybrid rice production with disease resistance to rice blast and bacterial blight,and submergence tolerance with no yield penalty or change in grain quality.

关键词： thermo-sensitive genic male sterility bacterial blight rice blast submergence tolerance disease resistance marker-assisted selection

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Overexpression of the bacterial tryptophan oxidase RebO affects auxin biosynthesis and Arabidopsis development

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Science Bulletin 2016年第11期61卷 859-867页

作者： Yangbin Gao Xinhua Dai Zuyu Zheng Hiroyuki Kasahara Yuji Kamiya joanne Chory David Ballou Yunde Zhao Section of Cell and Developmental Biology University of California San Diego La Jolla CA 92093 USA Plant Biology laboratory Salk Institute for Biological StudiesLa Jolla CA 92037 USA Plant Science Center RIKEN Yokohama Kanagawa 230-0045Japan The Global Innovation Research Organization Tokyo University of Agriculture and Technology Fuchu 183-8509 Japan Department of Biological Chemistry University of MichiganAnn Arbor MI 48109 USA

Both tryptophan(Trp) and auxin are essential for plant growth and Trp is a precursor for auxin *** of Trp and auxin need to be tightly controlled to ensure optimal growth and development. It has been very difficult to study the homeostasis of these two essential and inter-dependent compounds. Auxin is mainly synthesized from Trp via a two-step pathway using indole-3-pyruvate(IPA) as the intermediate. Here we used a bacterial Trp oxidase Reb O, which does not exist in Arabidopsis and which converts Trp to the imine form of IPA,to modulate IPA levels in Arabidopsis. Our results demonstrate that Arabidopsis plants use two strategies to ensure that no excess IPA is made from Trp. IPA is made from Trp by the TAA family of aminotransferases, which we show catalyzes the reverse reaction when IPA level is high. Moreover, excess IPA is converted back to Trp by the VAS1 aminotransferase. We show that the VAS1-catalyzed reaction is very important for Trp homeostasis. This work not only elucidates the intricate biochemical mechanisms that control the homeostasis of Trp, IPA, and auxin,but also provides novel tools for further biochemical studies on Trp metabolism and auxin biosynthesis in plants.

关键词：植物生长素生物合成色氨酸拟南芥氧化酶过量表达细菌微生物控制

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