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Ultrastructure of oval cells in children with chronic hepatitis B,with special emphasis on the stage of liver fibrosis:The first pediatric study

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World Journal of Gastroenterology 2007年第21期13卷 2918-2922页

作者： maria Elzbieta Sobaniec-lotowska joanna maria lotowska Dariusz Marek Lebensztejn Department of Clinical Pathomorphology Medical University of BialystokPoland IIIrd Department of Pediatrics Medical University of BialystokPoland

AIM:To investigate the ultrastructure of oval cells in children with chronic hepatitis B,with special emphasis on their location in areas of collagen fibroplasia. METHODS:Morphological investigations were conducted on biopsy material obtained from 40 children,aged 3-16 years with chronic hepatitis B. The stage of fibrosis was assessed histologically using the arbitrary semiquantitative numerical scoring system proposed by Ishak et al. The material for ultrastructural investigation was fixed in glutaraldehyde and paraformaldehyde and processed for transmission-electron microscopic analysis. RESULTS:Ultrastructural examination of biopsy specimens obtained from children with chronic hepatitis B showed the presence of two types of oval cells,the hepatic progenitor cells and intermediate hepatic-like cells. These cells were present in the parenchyma and were seen most commonly in areas of intense periportal fibrosis (at least stage 2 according to Ishak et al) and in the vicinity of the limiting plate of the lobule. The activated nonparenchymal hepatic cells,i.e. transformed hepatic stellate cells and Kupffer cells were seen in close proximity to the intermediate hepatic-like cells. CONCLUSION:We found a distinct relationship between the prevalence of oval cells (hepatic progenitor cells and intermediate hepatocyte-like cells) and fibrosis stage in pediatric patients with chronic hepatitis B.

关键词： Pediatric patients, Oval cells Ultrastructural study Chronic hepatitis B Liver biopsy Fibrosis

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Pediatric non-alcoholic steatohepatitis:The first report on the ultrastructure of hepatocyte mitochondria

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World Journal of Gastroenterology 2014年第15期20卷 4335-4340页

作者： joanna M lotowska maria E Sobaniec-lotowska Sylwia B Bockowska Dariusz M Lebensztejn Department of General Pathomorphology Medical University of Bialystok15269 BialystokPoland Department of Medical Pathomorphology Medical University of Bialystok15269 BialystokPoland Department of Laboratory Diagnostics Maria Sklodowska-Curie Memorial Bialystok Oncology Center15027 BialystokPoland Department of Pediatrics Gastroenterology and AllergologyMedical University of Bialystok15274 BialystokPoland

AIM: To investigate the ultrastructure of abnormal hepatocyte mitochondria, including their cellular and hepatic zonal distribution, in bioptates in pediatric non-alcoholic steatohepatitis (NASH).

关键词： Pediatric non-alcoholic steatohepatitis Hepatocyte ultrastructure Megamitochondria with crystalline inclusions Foamy cytoplasm of hepatocytes

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