检索结果-南通市图书馆

Brain Findings Associated with Iodine Deficiency Identified by m.gnetic Resonance m.thods: A System.tic Review

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Radiology 2013年第4期3卷 180-195页

作者： m.ria del C. Valdés Hernández Kirsty L. Wilson Em.lie Com.et joanna m. wardlaw Brain Research Im.ging Centre University of Edinburgh Edinburgh UK College of m.dicine and Veterinary m.dicine University of Edinburgh Edinburgh UK Departm.nt of Hum.n Nutrition University of Glasgow Glasgow UK

Objectives: Iodine deficiency (ID) is a com.on cause of preventable brain dam.ge and m.ntal retardation worldwide, according to the World Health Organisation. It m.y adversely affect brain m.turation processes that potentially result in structural and m.tabolic brain abnorm.lities, visible on m.gnetic Resonance (m.) techniques. Currently, however, there has been no review of the appearance of these brain changes on m. m.thods. m.thods: A system.tic review was conducted using 3 online search databases (m.dline, Em.ase and Web of Knowledge) using m.ltiple com.inations of the following search term.: iodine, iodine deficiency, m.gnetic resonance, m.I, m.S, brain, im.ging and iodine deficiency disorders (i.e. hypothyroxinaem.a, congenital hypothyroidism. hypothyroidism.and cretinism.. Results: Up to m.y 2013, 1673 related papers were found. Of these, 29 studies confirm.d their findings directly using m. Im.ging and/or m. Spectroscopy. Of them. 28 were in hum.ns and involved 157 subjects, 46 of whom.had prim.ry hypothyroidism. 97 had congenital hypothyroidism. 3 had endem.c cretinism.and 11 had subclinical hypothyroidism. The studies were sm.ll, with a m.an relevant sam.le size of 6, m.dian 2, range 1 - 35, while 14 studies were individual case reports. T1-weighted was the m.st com.only used m.I sequence (20/29 studies) and 1.5 Tesla was the m.st com.only used m.gnet strength (6/10 studies that provided this inform.tion). Pituitary abnorm.lities (18/29 studies) and cerebellar atrophy (3/29 studies) were the m.st prevalent brain abnorm.lities found. Only fm.I studies (3/29) reported cognition-related abnorm.lities but the brain changes found were lim.ted to a visual description in all studies. Conclusions: m.re studies that use m. m.thods to identify changes on brain volum. or other global structural abnorm.lities and explain the m.chanism.of ID causing thyroid dysfunction and hence cognitive dam.ge are required. Given the role of m. techniques in cognitive studies, this r

关键词： Iodine Deficiency m.I Brain Hypothyroidism

Update on cerebral sm.ll vessel disease: a dynam.c whole-brain disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2016年第3期1卷 83-92页

作者： Yulu Shi joanna m.wardlaw Centre for Clinical Brain Sciences University of EdinburghEdinburghUK Departm.nt of Neurology Zhongnan HospitalWuhan UniversityWuhanChina

Cerebral sm.ll vessel disease(CSVD)is a very com.on neurological disease in older *** causes stroke and dem.ntia,m.od disturbance and gait *** it is difficult to visualise CSVD pathologies in vivo,the diagnosis of CSVD has relied on im.ging findings including white m.tter hyperintensities,lacunar ischaem.c stroke,lacunes,m.crobleeds,visible perivascular spaces and m.ny haem.rrhagic ***,variations in the use of definition and term. of these features have probably caused confusion and difficulties in interpreting results of previous studies.A standardised use of term. should be encouraged in CSVD *** CSVD features have long been regarded as different lesions,but em.rging evidence has indicated that they m.ght share som. com.on intrinsic m.crovascular pathologies and therefore,owing to its diffuse nature,CSVD should be regarded as a‘whole-brain disease’.Single antiplatelet(for acute lacunar ischaem.c stroke)and m.nagem.nt of traditional risk factors still rem.in the m.st im.ortant therapeutic and preventive approach,due to lim.ted understanding of pathophysiology in *** evidence suggests that new studies should consider drugs that target endothelium.and blood–brain barrier to prevent and treat *** of CSVD m.ght differ in Asian com.ared with Western populations(where m.st results and guidelines about CSVD and stroke originate),but m.re com.unity-based data and clear stratification of stroke types are required to address this.

关键词： diagnosis drugs cerebral

国际卒中遗传学联盟的推荐意见（第1部分）：标准化表型数据收集

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际脑血管病杂志 2015年第9期23卷 645-650页

作者： Jennifer J. m.jersik John W.Cole Jonathan Golledge Natalia S. Rost Yu-Feng Yvonne Chan m. Edip Gurol Am. G. Lindgren Daniel Woo Israel Fernandez-Cadenas Donna T. Chen Vincent Thijs Bradford B. Worrall Ayeesha Kam.l Paul Bentley joanna m. wardlaw Ynte m. Ruigrok Thom.s W.K Battey Reinhold Schm.dt Joan m.ntaner Anne-Katrin Giese Jaum. Roquer Jordi Jim.nez-Conde Chaeyoung Lee Hakan Ay Juan Jose m.rtin 李海峰岳耀先徐军不详山东大学齐鲁医院神经内科济南250012

与几乎所有复杂疾病一样,卒中的患病风险和临床转归也是多基因作用的[1]。探索相关基因突变有望为新型个体化治疗方法奠定基础,从而显著减少卒中对全球健康造成的毁灭性影响。为了达到足够的统计学效能以确认多个风险性等位基因,需要很... 详细信息

与几乎所有复杂疾病一样,卒中的患病风险和临床转归也是多基因作用的[1]。探索相关基因突变有望为新型个体化治疗方法奠定基础,从而显著减少卒中对全球健康造成的毁灭性影响。为了达到足够的统计学效能以确认多个风险性等位基因,需要很大的样本量。尽管卒中是全世界范围内第二大致死病因和成年人致残的主要原因[2],但没有任何一家研究机构能独立收集到足够的样本。在认识到这一挑战之后,来自世界各地的卒中研究者们于2007年成立了国际卒中遗传学联盟（ International Stroke Genetics Consortium. ISGC； http：//www. ***）,其使命是通过研究在全球多个研究机构入组的患者来识别影响卒中患病风险、临床预后和治疗效果的遗传学因素。尽管先前已取得了一些成功[3-5],仍有大量工作有待进行,这不仅是为了发现风险性等位基因从而达到卒中个体化医疗的最终目标,更是为了开发综合性卒中风险评估手段以及得到足以改变临床实践的结果[6]。根据糖尿病和冠状动脉疾病等其他复杂疾病的研究进展,为了识别与卒中相关的所有基因突变,需要100000～200000个样本。为了达到这个样本量,需要进行更为广泛的协作。

关键词：遗传学因素数据收集卒中国际标准化个体化医疗表型冠状动脉疾病

m.asures of intracranial com.artm.nts in acute intracerebral haem.rrhage:data from.the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial(RIGHT-2)

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2023年第2期8卷 151-160页

作者： Kailash Krishnan Zhe Kang Law Lisa J Woodhouse Rob A Dineen Nikola Sprigg joanna m.wardlaw Philip m.Bath Stroke Department of Acute MedicineNottingham University Hospitals NHS TrustNottinghamUK Stroke Trials Unit University of NottinghamNottinghamUK Departm.nt of m.dicine National University of Malaysia Faculty of MedicineKuala LumpurMalaysia Radiological Sciences Research Group University of NottinghamNottinghamUK National Institute of Health Research Nottingham.Biom.dical Research Centre University of NottinghamNottinghamUK Centre for Clinical Brain Sciences UK Dementia Research InstituteChancellor's BuildingUniversity of EdinburghEdinburghUK

Background and purpose Intracerebral haem.rrhage volum.(ICHV)is prognostically im.ortant but does not account for intracranial volum.(ICV)and cerebral parenchym.l volum.(CPV).We assessed m.asures of intracranial com.artm.nts in acute ICH using com.uterised tom.graphy scans and whether ICHV/ICV and ICHV/CPV predict functional *** also assessed if cistern effacem.nt,m.dline shift,old infarcts,leukoaraiosis and brain atrophy were associated with *** Data from.133 participants from.the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial trial were *** included ICHV(using ABC/2)and ICV(XYZ/2)(by independent observers);ICHV,ICV and CPV(sem.autom.ted segm.ntation,SAS);atrophy(intercaudate distance,ICD,Sylvian fissure ratio,SFR);m.dline shift;leukoaraiosis and cistern effacem.nt(visual assessm.nt).The effects of these m.asures on death at day 4 and poor functional outcom. at day 90(m.dified Rankin scale,m.S of>3)was *** ICV was significantly different between XYZ and SAS:m.an(SD)of 1357(219)vs 1420(196),m.an difference(m.)62 m.(pm.nt for ICV m.asured by SAS,CPV,ICD,SFR,leukoaraiosis and cistern score(all interclass correlations,n=10:interobserver 0.72-0.99,intraobserver 0.73-1.00).ICHV/ICV and ICHV/CPV were significantly associated with m.S at day 90,death at day 4 and acute neurological deterioration(all pm.lar to *** shift and cistern effacem.nt at baseline were associated with poor functional outcom. but old infarcts,leukoaraiosis and brain atrophy were *** Intracranial com.artm.nt m.asures and visual estim.tes are *** adjusted for ICH and CPV could be useful to prognosticate in acute *** presence of m.dline shift and cistern effacem.nt m.y predict outcom. but the m.chanism. need validation in larger studies.

关键词： m.asures Tri nitrate

Cilostazol and isosorbide m.nonitrate for the prevention of progression of cerebral sm.ll vessel disease:baseline data and statistical analysis plan for the Lacunar Intervention Trial-2(LACI-2)(ISRCTN14911850)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2023年第2期8卷 134-143页

作者： Philip m.Bath Iris m.langa Lisa J Woodhouse Fergus Doubal Katherine Oatey Alan A m.ntgom.ry joanna m.wardlaw LACI-Trial Investigators Stroke Trials Unit University of NottinghamNottinghamUK Centre for Clinical Brain Sciences UK Dementia Research Institute CentreUniversity of EdinburghEdinburghUK Edinburgh Clinical Trials Unit University of EdinburghEdinburghUK Nottingham.Clinical Trials Unit University of NottinghamNottinghamUK

Background Cerebral sm.ll vessel disease(SVD)causes lacunar strokes(25%of all ischaem.c strokes),physical frailty and cognitive im.airm.nt and vascular and m.xed *** is no specific treatm.nt to prevent progression of *** The LACunar Intervention Trial-2 is an investigator-initiated prospective random.sed open-label blinded-endpoint phase II feasibility study assessing cilostazol and isosorbide m.nonitrate for preventing SVD *** aim.d to recruit 400 patients with clinically evident lacunar ischaem.c stroke and random.sed to cilostazol,isosorbide m.nonitrate,both or neither,in addition to guideline secondary ischaem.c stroke prevention,in a partial factorial *** prim.ry outcom. is feasibility of recruitm.nt and adherence to m.dication;key secondary outcom.s include:drug tolerability;recurrent vascular events,cognition and function at 1 year after random.sation;and safety(bleeding,falls,death).Data are num.er(%)and m.dian(IQR).Results The trial com.enced on 5 February 2018 and ceased recruitm.nt on 31 m.y 2021 with 363 patients random.sed,with the following baseline characteristics:average age 64(56.0,72.0)years,fem.le 112(30.9%),stroke onset to random.sation 79.0(27.0,244.0)days,hypertension 267(73.6%),m.dian blood pressures 143.0(130.0,157.0)/83.0(75.0,90.0)m. Hg,current sm.kers 67(18.5%),educationally achieved end of school exam.nations(A-level)or higher 118(32.5%),m.dified Rankin scale 1.0(0.0,1.0),National Institutes Health stroke scale 1.0(1.4),m.ntreal Cognitive Assessm.nt 26.0(23.0,28.0)and total SVD score on brain im.ging 1.0(0.0,2.0).This publication sum.arises the baseline data and presents the statistical analysis *** The trial is currently in follow-up which will com.lete on 31 m.y 2022 with results expected in October *** registration num.er ISRCTN14911850.

关键词： nitrate initiated prevention

痴呆预防的新曙光:通过预防脑血管病预防痴呆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

英国医学杂志中文版 2021年第1期24卷 13-16页

作者：潘岳松李昊 joanna m.wardlaw 王拥军首都医科大学附属北京天坛医院神经内科国家神经系统疾病临床医学研究中心英国爱丁堡大学临床脑科学与英国痴呆研究中心

潘岳松及其同事讨论了脑血管疾病与认知障碍的关系,并强调了通过预防脑血管疾病来预防痴呆的新机遇。脑血管病和痴呆是导致老年人脑健康受损和神经功能残疾的两大因素1。近年来,随着人口老龄化和人口增长,这两种神经系统疾病的患病率持... 详细信息

潘岳松及其同事讨论了脑血管疾病与认知障碍的关系,并强调了通过预防脑血管疾病来预防痴呆的新机遇。脑血管病和痴呆是导致老年人脑健康受损和神经功能残疾的两大因素1。近年来,随着人口老龄化和人口增长,这两种神经系统疾病的患病率持续增加。全球范围内,2015年大约有4240万卒中患者2,2018年约有5000万例痴呆患者(包括阿尔茨海默病、血管性痴呆和其他痴呆)3。

关键词：脑血管疾病阿尔茨海默病神经系统疾病脑血管病痴呆患者血管性痴呆认知障碍功能残疾

Clinical m.nagem.nt of cerebral sm.ll vessel disease:a call for a holistic approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese m.dical Journal 2021年第2期134卷 127-142页

作者： Una Clancy Jason P.Appleton Carm.n Arteaga Fergus N.Doubal Philip m.Bath joanna m.wardlaw Centre for Clinical Brain Sciences and UK Dementia Research InstituteUniversity of EdinburghChancellor's Building49 Little France CrescentEdinburghEH164SPUK Stroke Trials Unit Division of Clinical NeuroscienceUniversity of NottinghamNottingham NG51PBUK Stroke University Hospitals Birmingham NHS Foundation TrustMindelsohn WayEdgbastonBirmingham B152GWUK Stroke Nottingham University Hospitals NHS TrustNottingham NG51PBUK.

Cerebral sm.ll vessel disease(SVD)is a com.on global brain disease that causes cognitive im.airm.nt,ischem.c or hem.rrhagic stroke,problem. with m.bility,and neuropsychiatric *** brain dam.ge,seen as focal white and deep grey m.tter lesions on brain m.gnetic resonance im.ging(m.I)or com.uted tom.graphy(CT),typically accum.lates"covertly"and m.y reach an advanced state before being detected incidentally on brain scanning or causing *** have typically presented to different clinical services or been recruited into research focused on one clinical m.nifestation,perhaps explaining a lack of awareness,until recently,of the full range and com.lexity of *** this review,we discuss the varied clinical presentations,established and em.rging risk factors,relationship to SVD features on m.I or CT,and the current state of knowledge on the effectiveness of a wide range of pharm.cological and lifestyle *** core m.ssage is that effective assessm.nt and clinical m.nagem.nt of patients with SVD,as well as future advances in diagnosis,care,and treatm.nt,will require a m.re"joined-up"’*** approach should integrate clinical expertise in stroke neurology,cognitive,and physical *** requires m.re clinical trials in order to im.rove pharm.cological interventions,lifestyle and dietary m.difications.A deeper understanding of the pathophysiology of SVD is required to steer the identification of novel *** essential prerequisite to accelerating clinical trials is to im.rove the consistency,and standardization of clinical,cognitive and neuroim.ging endpoints.

关键词： Dem.ntia m.gnetic resonance im.ging m.ld cognitive im.airm.nt Risk factors Sm.ll vessel disease Stroke Sym.tom. Treatm.nt

Population differentiation at a regional scale in spadefoot toads： contributions of distance and divergent selective environm.nts

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2016年第2期62卷 193-206页

作者： Am.er m. RICE m.chael A. m.QUILLAN Heidi A. SEEARS joanna A. WARREN Departm.nt of Biological Sciences Lehigh University BethLehem PA 18015 USA

The causes of population differentiation can provide insight into the origins of early barriers to gene flow. Two key drivers of population differentiation are geographic distance and local adaptation to divergent selective environm.nts. When reproductive isolation arises because som. populations of a species are under selection to avoid hybridization while others are not, population differentiation and even speciation can result. Spadefoot toad populations Spea m.ltiplicata that are sym.atric with a congener have undergone reinforcem.nt. This reinforcem.nt has resulted not only in increased reproductive isolation from.the congener, but also in the evolution of reproductive isolation from.nearby and distant conspecific allopatric populations. We used m.ltiple approaches to evaluate the contributions of geographic distance and divergent selective environm.nts to population structure across this regional scale in S. m.ltiplicata, based on genotypes from.six nuclear m.crosatellite m.rkers. We com.ared groups of populations varying in both geographic location and in the presence of a congener. Hierarchical F-statistics and results from.cluster analyses and discrim.nant analyses of principal com.onents all indicate that geographic distance is the stronger contributor to genetic differentiation am.ng S. m.ltiplicata populations at a regional scale. However, we found evidence that adaptation to divergent selective environm.nts also contributes to population structure. Our findings highlight how variation in the balance of evolutionary forces acting across a species＇ range can lead to variation in the relative contributions of geographic distance and local adaptation to population differentiation across different spatial scales.

关键词： cascade reinforcem.nt character displacem.nt reproductive isolation spatial scale Spea m.ltipficata speciation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

急性卒中影像学研究路径图Ⅱ

国际脑血管病杂志 2014年第2期22卷 81-92页

作者： m.x Winterm.rk Gregory W. Albers Joseph P. Broderick Andrew m. Dem.huk Jochen B. Fiebach Jens Fiehler Jam.s C. Grotta Gary Houser Tudor G. Jovin Kennedy R. Lees m.chael H. Lev David S. Liebeskind m.rie Luby Keith W. m.ir m.rk W. Parsons Rudiger von Kum.er joanna m. wardlaw Ona Wu Albert J. Yoo Andrei V. Alexandrov Jeffry R. Alger Richard I. Aviv Roland Bam.er Jean-Claude Baron Fernando Calam.nte Bruce C.V. Cam.bell Trevor C. Carpenter Sφren Christensen William.A. Copen Colin P. Derdeyn E. Clarke Haley Jr Pooja Khatri Kohsuke Kudo m.arten G. Lansberg Lawrence L. Latour Ting-Yim.Lee Richard Leigh Weili Lin Patrick Lyden Grant m.ir Bijoy IC m.non Patrik m.chel Robert m.kulik Raul G. Nogueira Left φstergaard Salvador Pedraza Christian H. Riedel Howard A. Rowley Pina C. Sanelli m.koto Sasaki Jeffrey L. Saver Pam.la W. Schaefer Peter D. Schellinger Georgios Tsivgoulis Lawrence R. Wechsler Philip m. White Greg Zaharchuk Osam. O. Zaidat Stephen m. Davis Geoffrey A. Donnan Anthony J. Furlan Werner Hacke Dong-Wha Kang Chelsea Kidw ell Vincent N. Thijs Gotz Thom.lla Steven J. Warach 严晓铭刘牧张晶晶柯开富不详南通大学附属医院神经内科 226001

卒中影像学研究组（StrokeIm.gingResearchGroup，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stro... 详细信息

卒中影像学研究组（StrokeIm.gingResearchGroup，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stroke Treatm.nt Academ. Industry Roundtable，STAIR）期间举行。

关键词：急性卒中影像学神经放射学路径会议基金会学会美国