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Correspondence amongst the PENO Test Battery Cognitive Results and Hippocampal Lesions in Alzheimer’s Disease

Advances in Aging Research 2014年第3期3卷 239-251页

作者： Rojas Karla Diaz Alfonso Espinosa Blanca Montano Luis Felipe Dilhuydy Hugo Geraux Francine joanette yves Robitaille yves Guevara Jorge Laboratorio Experimental de Enfermedades Neurodegenerativas Instituto Nacional de Neurologia y Neurocirugia“M.V.S.”Mexico DFMexico Departamento de Farmacia Facultad de Ciencias QuimicasBUAPPueblaMexico Departamento Bioquimica INERMexico DFMexico Departamento de Biologia Celular y Tisular Facultad de MedicinaUNAMMexico DFMexico Centre de Recherche Institut Universitaire de Geriatrie de MontrealMontrealCanada Departament de Pathologie Hopital Ste-JustineMontrealCanada Departamento de Bioquimica Facultad de MedicinaUNAMMexico DFMexico

Alzheimer’s disease (AD) is characterized by a decline of cognitive functions. Distinctive histopathological hallmarks are neuritic plaques, neurofibrillary tangles, and synaptic alterations. Abnormally enlarged synaptic structures called “Meganeurite clusters” have been linked to plasticity changes. The aims of this study were to determine if cognitive impairment was related to specific neuritic and synaptic degeneration processes in patients with AD, and if the results of a cognitive test could be correlated with the histopathological damage. The neuropsychological evaluation obtained by the Protocole d’evaluation neuropsychologique optimal (PENO) test battery was used in live AD and control individuals. The histopathological evaluation of their brain after their death was carried out with specific polyclonal and monoclonal antibodies to Aβ, pTau protein, synaptophysin, and GAP-43. Images were obtained by confocal microscopy. The results showed a significant difference between healthy controls and Alzheimer’s patients in neuropsychological evaluation and histopathological hallmarks expression. The most significant positive correlation in AD patients was between memory and language results with the PENO test and the presence of Aβ +pTau+ plaques in the hippocampus. An interesting negative correlation was between cognitive impairment and the presence of Meganeuritic clusters, considered as “plasticity” markers. These results strongly supported the use of the PENO battery test to evaluate the progression of cognitive impairment in AD prone individuals and patients due to the strong correlation of the test results with histopathological brain lesions characteristic of Alzheimer’s disease.

关键词： Cognitive Decline Neuropsychological Evaluation Synapsis Plasticity Alzheimer’s Disease

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