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促进慢性阻塞性肺疾病哮喘患者自我监控空气质量的护理干预措施:整合性综述（英文）

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International Journal of Nursing Sciences 2024年第1期 46-56页

作者： Bruna f.Sebasti?o Raquel M.Hortel?o Sara S.Granadas José M.faria joana R.Pinto Helga Rafael Henriques Nursing School of Lisbon Hospital Center of Central Lisbon CUf Tejo Hospital University Hospital Center of Northern Lisbon Nursing Research Innovation and Development Centre of Lisbon (CIDNUR)

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronic obstructive pulmonary disease overlap,ACO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过... 详细信息

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronic obstructive pulmonary disease overlap,ACO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过系统性综述,寻找证据,以指导制订护理干预措施,促进ACO患者对空气质量的自我管理。方法 2023年3月,系统检索CINAHL、Medline、Academic Search Complete、Scopus、Web of Science、Cochrane图书馆、乔安娜布里格斯研究所(Joanna Briggs Institute,JBI)循证实践数据库,以及Google Scholar。对纳入研究进行数据提取和综合,并对护理干预措施进行分类。采用JBI研究质量评估工具进行方法学质量评估。结果共纳入5篇来自不同国家的研究。促进ACO患者自我监控空气质量的干预措施包括:警觉性干预措施(医务人员定期巡诊、进行症状评估),监测干预措施(监测室内外诱发因素),教育干预措施(空气质量警报、避免接触过敏原),以及相关政策的影响,如无烟政策和改善空气质量的综合战略。尽管这些研究报告了不同的干预措施,方法质量也存在差异,但这些干预措施显示了预防患者病情恶化、尽量减少急诊就诊和住院治疗的潜力。这些关键点可作为护理干预措施的关键组成部分。结论有必要采取全面措施,让护士参与促进患者自我监控空气质量的多学科团队、提高认识、制订和实施护理干预,从而使ACO患者受益。同时,需要进一步开展研究,以扩大证据基础并完善这些干预措施。

关键词：空气质量哮喘哮喘-慢阻肺重叠慢性病慢性阻塞性肺疾病护理自我管理

Resection *** for hepatocellular carcinoma:a never ending challenge

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 443-446页

作者： joana ferrer-fàbrega Jordi Bruix Barcelona Clínic Liver Cancer Group(BCLC) IDIBAPSBarcelonaSpain Hepatic Oncology Unit Hospital ClínicBarcelonaSpain Hepatobiliopancreatic Surgery and Liver and Pancreatic Transplantation Unit Department of SurgeryInstitute Clínic of Digestive and Metabolic Diseases(ICMDiM)Hospital ClínicBarcelonaSpain Department of Medicine and Departament of Surgery University of BarcelonaBarcelonaSpain CIBERehd BarcelonaSpain Liver Unit Institute Clínic of Digestive and Metabolic Diseases(ICMDiM)Hospital ClínicBarcelonaSpain

Liver transplantation(LT)is fully established in conventional clinical care for patients with hepatocellular carcinoma(HCC).The long-term survival of transplanted patients competes with the survival offered by surgical resection and this sets the scene for a debate for which a consensus answer based in evidence is not *** outcomes have steadily improved due a refined selection of patients and the availability of other effective options such as ablation or locoregional approach(chemoembolization or radioembolization)has allowed to avoid its indication as a last effective resource for desperate *** evolution has taken place for LT as it was early shown that if the tumor burden was reduced the survival results would be encouraging(1).

关键词： Hepatocellular carcinoma(HCC) liver resection liver transplantation(LT) survival recurrence

NK cell dysfunction in severe COVID-19:TGf-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity

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Signal Transduction and Targeted Therapy 2022年第2期7卷 346-348页

作者： joana Barros-Martins Reinhold förster Berislav Bošnjak Institute of Immunology Hannover Medical School30625 HannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical School30625 HannoverGermany German Centre for Infection Research(DZIf) Partner site HannoverHannoverGermany

In a recent study published in Nature,Witkowski et *** that in patients with severe forms of coronavirus disease 2019(COVID-19)deranged tumor growth factor-beta(TGf-β)secretion counteracts interferon-alpha(IfN-α)-induced activation of NK cells by decreasing expression of transcription factor ***,NK cells fail to upregulate the adhesion molecule integrin beta-2(-ß2),which impedes their attachment to and killing of SARS-CoV-2 infected cells.

关键词： interferon cytotoxicity

Trophic niche changes associated with the eradication of invasive mammals in an insular lizard: an assessment using isotopes

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Current Zoology 2022年第2期68卷 211-219页

作者： Sara f.NUNES Mario MOTA-f.rreira Marta SAMPAIO joana ANDRADE Nuno OLIVEIRA Rui REBELO Ricardo ROCHA faculty of Sciences Centre for EcologyEvolution and Environmental ChangesUniversity of LisbonLisbon1749-016Portugal CIBI0-lnBI0 Research Center in Biodiversity and Genetic ResourcesUniversity of PortoVairao4485-661Portugal CIBI0-lnBI0 Research Center in Biodiversity and Genetic ResourcesInstitute of AgronomyUniversity of LisbonLisbon1349-017Portugal Sociedade Portuguesa Para o Estudo das Aves Av.Columbano Bordalo Pinheiro873°AndarLisboa1070-062Portugal

Invasive species are a major threat to island biodiversity,and their eradications have substantially contributed to the conservation of island ***,the consequences of eradications on the trophic ecology of native taxa are largely ***,we used the eradication of invasive black rats Rattus rattus and European rabbits Oryctolagus cuniculus from the Berlenga Island,in the western coast of Portugal,as a whole-ecosystem experiment to investigate the effects of the eradication of invasive mammals on the trophic niche and body dimensions of the island-restricted Berlenga wall lizard Podarcis carbonelli berlengensis over a 2-year *** results suggest an expansion of the isotopic niche and an intensification of the sexual dimorphism of the lizard following mammal ***,we found considerable variability in isotopic niche across the island and detected evidence of sex-specific and season-modulated nutritional requirements of this threatened *** findings support that the eradication of 2 of the planets most problematic invasive vertebrates led to changes in the lizard trophic niche and sexual dimorphism in just 2 *** suggests that the ecological pressuresfor example,prey availability and habitat structureto which lizards are exposed have substantially changed *** study emphasizes the scientific value of island eradications as experiments to address a wide range of ecological questions and adds to the increasing body of evidence supporting substantial conservation gains associated with these restoration interventions.

关键词： food-webs invasive species eradication Oryctolagus cuniculus Podarcis carbonelli berlengensis Rattus rattus

Microplastic fiber and drought effects on plants and soil are only slightly modified by arbuscular mycorrhizal fungi

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Soil Ecology Letters 2022年第1期4卷 32-44页

作者： Anika Lehmann Eva fLeifheit Linshan feng joana Bergmann Anja Wulf Matthias C.Rillig freie Universität Berlin Institut für Biologie14195 BerlinGermany Berlin-Brandenburg Institute of Advanced Biodiversity Research 14195 BerlinGermany Leibniz Centre for Agricultural Landscape Research(ZALf) 15374 MünchebergGermany

Microplastics are increasingly recognized as a factor of global change. By altering soil inherentproperties and processes, ripple-on effects on plants and their symbionts can be ***, interactions with other factors of global change, such as drought, can influence theeffect of microplastics. We designed a greenhouse study to examine effects of polyester microfibers,arbuscular mycorrhizal (AM) fungi and drought on plant, microbial and soil responses. We found thatpolyester microfibers increased the aboveground biomass of Allium cepa under well-watered anddrought conditions, but under drought conditions the AM fungal-only treatment reached the highestbiomass. Colonization with AM fungi increased under microfiber contamination, however, plantbiomass did not increase when both AM fungi and fibers were present. The mean weight diameter ofsoil aggregates increased with AM fungal inoculation overall but decreased when the system wascontaminated with microfibers or drought stressed. Our study adds additional support to themounting evidence that microplastic fibers in soil can affect the plant–soil system by promoting plantgrowth, and favoring key root symbionts, AM fungi. Although soil aggregation is usually positivelyinfluenced by plant roots and AM fungi, and microplastic promotes both, our results show that plasticstill had a negative effect on soil aggregates. Even though there are concerns that microplastic mightinteract with other factors of global change, our study revealed no such effect for drought.

关键词： Arbuscular mycorrhizal fungi Microplastic Soil aggregation Organic matter decomposition Drought Root traits

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Red deer as a disperser of native,but not invasive plants’seeds

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Integrative Zoology 2023年第5期18卷 859-866页

作者： fernanda GARCIA António ALVES DA SILVA Ruben HELENO JoséPaulo SOUSA joana ALVES Centre for functional Ecology(CfE) TERRA Associate LaboratoryDepartment of Life SciencesUniversity of CoimbraCoimbraPortugal

INTRODUCTION Seed dispersal is a key process in the life cycle of most plants,with ecological and evolutionary consequences that go beyond vegetation dynamics and cascade to entire ecosystem functioning and stability(Traveset et al.2014).Seed dispersal largely constrains plant recruitment and the distribution of future plant cohorts,thus playing a critical role in the restoration of disturbed sites(Cain et al.2000;Higgins et al.2003).It can also threaten plant diversity by facilitating plant invasions(Vavra et al.2007;Heleno 2020).

关键词： consequences disperse disturbed

Recalcitrant cell wall of Ulva lactuca seaweed is degraded by a single ulvan lyase from family 25 of polysaccharide lyases

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Animal Nutrition 2022年第2期9卷 184-192页

作者： Monica M.Costa Luís B.Pio Pedro Bule Vania A.Cardoso Marlene Duarte Cristina M.Alfaia Diogo f.Coelho joana A.Bras Carlos M.G.A.fontes Jose A.M.Prates CIISA-Centro de Investigaçao Interdisciplinar em Sanidade Animal Faculdade de Medicina Veterinari1Universidade de Lisbo1Alto da Ajud11300-477 Lisbo1Portugal NZYTech-Genes and Enzymes Estrada do Paço do LumiarCampus do LumiarEdifício E1649-038 Lisbo1Portugal

Green macroalgae,e.g.,Ulva lactuca,are valuable bioactive sources of nutrients;but algae recalcitrant cell walls,composed of a complex cross-linked matrix of polysaccharides,can compromise their utilization as feedstuffs for monogastric *** study aimed to evaluate the ability of pre-selected Carbohydrate-Active enZymes(CAZymes)and sulfatases to degrade *** cell walls and release nutritive compounds.A databank of 199 recombinant CAZymes and sulfatases was tested in vitro for their action towards *** cell wall *** enzymes were incubated with the macroalga,either alone or in combination,to release reducing sugars and decrease fluorescence intensity of Calcofluor White stained cell *** individual action of a polysaccharide lyase family 25(PL25),an ulvan lyase,was shown to be the most efficient in cell wall *** ulvan lyase treatment,in triplicate measures,promoted the release of 4.54 g/L(Pf 11.4 and 11.2 mmol/100 g of dried alga(Pf 41.7%(Pfluorescence,in comparison to *** ability of ulvan lyase treatment to promote the release of nutritional compounds from alga biomass was also evaluated.A release of some monounsaturated fatty acids was observed,particularly the health beneficial 18:1c9(Pficant release of total fatty acids(P>0.05),proteins(P?0.861)or pigments(P>0.05)was *** results highlight the capacity of a single recombinant ulvan lyase(PL25 family)to incompletely disrupt *** cell *** enzyme could enhance the bioaccessibility of *** bioactive products with promising utilization in the feed industry.

关键词： Macroalga Ulva lactuca Carbohydrate-active enzyme Ulvan lyase Cell wall degradation

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Exocrine drainage in pancreas transplantation:Complications and management

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World Journal of Transplantation 2020年第12期10卷 392-403页

作者： joana ferrer-fàbrega Laureano fernández-Cruz HepatoBiliaryPancreatic Surgery and Liver and Pancreas Transplantation Department ICMDMHospital Clinic BarcelonaUniversity of BarcelonaBarcelona Clinic Liver Cancer GroupAugust Pi i Sunyer Biomedical Research InstituteBarcelona 08036BarcelonaSpain Department of Surgery ICMDMHospital Clinic BarcelonaBarcelona 08036BarcelonaSpain

The aim of this minireview is to compare various pancreas transplantation exocrine drainage techniques i.e.,bladder vs *** techniques have different difficulties and *** comparisons have been made in the literature between exocrine drainage techniques throughout the history of pancreas transplantation,detailing complications and their impact on graft and patient *** emphasis has been made on the early postoperative management of these complications and the related surgical infections and their *** light of the results,a number of bladder-drained pancreas grafts required conversion to enteric *** a result of technical improvements,outcomes of the varied enteric exocrine drainage techniques(duodenojejunostomy,duodenoduodenostomy or gastric drainage)have also been discussed i.e.,assessing specific risks vs *** exocrine secretions can be drained to the urinary or intestinal *** the late 1990s the bladder drainage technique was used in the majority of transplant centers due to ease of monitoring urine amylase and lipase levels for evaluation of possible ***,bladder drainage was associated at that time with fewer surgical complications,which in contrast to enteric drainage,could be managed with conservative ***,the most commonly used technique for proper driving of exocrine pancreatic secretions is enteric drainage due to the high rate of urological and metabolic complications associated with bladder *** note,10%to 40%of bladder-drained pancreata eventually required enteric conversion at no detriment to overall graft *** surgical techniques were originally described using the small bowel for enteric anastomosis with Roux-en-Y loop or a direct side-to-side *** the improvements in surgery,enteric drainage complication rates ranging from 2%-20%have been *** depends on the presence of any associated complicati

关键词： Graft survival Patient survival Anastomotic leak Morbidity Infection Surgery

Lanthanide complexes with β-diketones and coumarin derivates:synthesis,thermal behaviour,optical and pharmacological properties and immobilisation

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Journal of Rare Earths 2010年第S1期28卷 66-74页

作者： Maria Milanova joana Zaharieva Iliya Manolov Miroslava Getzova Dimitr To dorovsky Department of Inorganic Chemistry University of SofiaBulgaria 1J. Bourc hier Blvd.1164 SofiaBulgaria Department of Organic Chemistry Medical Un iversity2Dunav Str.1000 SofiaBulgaria

The paper presents the results of the synthesis of complexes of the ty pe Eu(DBM) 3 and Eu(DBM) 3·Q(DBM-dibenzoylmethane,Q-1,10-phenantroline or 4,7-d iphenyl-1,10-phenantroline) and of Tb-and Nd-complexes with the newly-synthesis ed coumarin derivates 3,3’-[(4-chlorphenyl) methylene) bis(4-hydroxy-2H-chromen-2-one) ,3,3’-[(3,5-dimethoxy-4-hydroxy) methylene) bis(4-hydroxy-2H-chromen-2-one) ,etc. Elemental and thermogravimetric analysis,IR,UV,NMR and fluorescence spe ctroscopy and X-ray analysis were applied for characterisation of the complexes. Some peculiarities of the synthetic procedures for both types of complexes were discussed and the influence of the synthetic approach,pH of the reaction mediu m,temperature of synthesis and drying of the complexes on the composition,stab ility and optical properties was reported. The immobilisation of the complexes i n thin films based on sol-gel produced SiO2 and on polymethylmethacrylate was st udied. The optimal conditions for preparation of the matrices(composition of th e starting system,temperature and time of sol aging,etc.) were recommended. Th e film morphology was evaluated by fluorescence,scanning electron and atomic fo rce microscopy. The interaction of the lanthanide ions with the matrices and the influence of their nature,the effect of the in-situ polymerisation and other f actors on photoluminescent excitation and emission spectra and excited state lif e-times of the complexes were followed. The effect of the second ligand on the p hotoluminescence properties of the immobilised diketonates was further elucidate d. Processes involved in the thermal decomposition of the complexes and microcom posites produced on their base were proposed. Preliminary results on the pharmac ological properties of the coumarin complexes reported showed unambiguously high er cytotoxicity of the Nd complex in comparison with that of the respective ligand.

关键词： rare earths complexes thin films β-diketones coumarin derivates optical properties pharmacological properties morphology

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