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Human Seroreactivity to Secreted Molecules of Corynebacterium pseudotuberculosis

Advances in Microbiology 2022年第3期12卷 150-158页

作者： Ramon Mendes dos Santos Silvânia Maria Andrade Cerqueira Caio Lopez Borge Andrade Gabriel Saldanha Müller Vitória Costa de Menezes Santos Hévlyn Ribeiro de Araújo Samanta Queiroz Rogério Reis Conceição Luiz Gustavo Freitas Oliveira Marcos Borges Ribeiro Silvana Marchioro Lilia Ferreira de Moura-Costa Fúlvia Soares Campos de Sousa Maria da Conceição Aquino de Sá José Tadeu Raynal rocha Filho Soraya castro Trindade Eduardo Martins Netto Roberto Meyer Songelí Menezes Freire Laboratory of Immunology and Molecular Biology of the Health Sciences Institute of the Federal University of Bahia Bahia Brazil Specialized Hospital Otávio Mangabeira Bahia Brazil Microbiology of the Federal University of Bahia Bahia Brazil Laboratory of Infectology of the University Hospital Complex Professor Edgard Santos Salvador Bahia Brazil

Corynebacterium pseudotuberculosis is an infectious agent that occurs in small ruminants causing caseous lymphadenitis, and more rarely in humans causing lymphadenitis and pneumonia. The breeding small ruminants have great economic importance in Brazil. Rural farm workers and veterinary students who acquired this disease suffered from weakening symptoms for weeks, and the identification of the etiological agent was time-consuming and complex. Due to the low prevalence of case records, there is probably no available commercial diagnostic kit for C. pseudotuberculosis infection in humans. This study aimed to describe human seroreactivity to secreted antigens from C. pseudotuberculosis. Reactivity of serum from farm workers (n = 14), individuals who work with the bacillus at laboratory (n = 8) or individuals without contact (n = 25) was tested with secreted proteins from PAT10 strain of C. pseudotuberculosis by Western blotting. Samples of all (100%) farm workers showed reactivity to 31 kDa, 71 kDa and 164 kDa proteins, while laboratory workers showed 87.5%, 62.5 % and 37.5%, and no-contact 20%, 0% and 16%, respectively. All sera recognized the 275 kDa protein. Our data suggest that C. pseudotuberculosis secreted proteins are antigenic in humans and the recognition profiles allowed the identification of individuals with and without prior contact with this bacillus. This is the first paper which describes human reactivity to C. pseudotuberculosis in serum samples of workers in Brazil.

关键词： Human Immunoreactivity Antigenicity Corynebacterium pseudotuberculosis Secreted Proteins Western Blot

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Risk factors for osteoporosis in inflammatory bowel disease patients

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World Journal of Gastrointestinal Pathophysiology 2015年第4期6卷 210-218页

作者： Carla Andrade Lima Andre castro Lyra Raquel rocha Genoile Oliveira Santana Pos-graduation program in medicine and health Federal University of Bahia department of Gastroenterology Federal University of Bahia department of Sciences of Nutrition School of NutritionFederal University of Bahia

Inflammatory bowel disease(IBD) patients exhibit higher risk for bone loss than the general population. The chronic inflammation causes a reduction in bone mineral density(BMD), which leads to osteopenia and osteoporosis. This article reviewed each risk factor for osteoporosis in IBD patients. Inflammation is one of the factors that contribute to osteoporosis in IBD patients, and the main system that is involved in bone loss is likely RANK/RANKL/osteoprotegerin. Smoking is a risk factor for bone loss and fractures, and many mechanisms have been proposed to explain this loss. Body composition also interferes in bone metabolism and increasing muscle mass may positively affect BMD. IBD patients frequently use corticosteroids, which stimulates osteoclastogenesis. IBD patients are also associated with vitamin D deficiency, which contributes to bone loss. However, infliximab therapy is associated with improvements in bone metabolism, but it is not clear whether the effects are because of inflammation improvement or infliximab use. Ulcerative colitis patients with proctocolectomy and ileal pouches and Crohn's disease patients with ostomy are also at risk for bone loss, and these patients should be closely monitored.

关键词： Bone mineral density Crohn’s disease Osteoporosis

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巴西博物馆--以文化食人主义回应莎士比亚文化之困境

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外国语言与文化 2020年第1期4卷 14-24页

作者：若昂·塞萨尔·德·卡斯特罗·霍夏冯倩(译) 里约热内卢州立大学文学院巴西里约热内卢999074 湖南师范大学外国语学院

莎士比亚文化指的是那些基本上根据外来者的凝视进行自我定义的文化,其自我认知源于他者的凝视。在这种情况下,他者的中心地位来自于构建民族身份时对于模仿冲动的重视,但这会导致在本国文化与外来文化之间摇摆不定,从而催生悖论。拉美... 详细信息

莎士比亚文化指的是那些基本上根据外来者的凝视进行自我定义的文化,其自我认知源于他者的凝视。在这种情况下,他者的中心地位来自于构建民族身份时对于模仿冲动的重视,但这会导致在本国文化与外来文化之间摇摆不定,从而催生悖论。拉美文化产生于他者阴影下,这 (几乎)是一种绝对的模式。

关键词：莎士比亚文化非霸权状态文化食人主义模仿跨文化交际

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