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Dynamics of Droplets of Biological Fluids on Smooth Superhydrophobic Surfaces under Electrostatic Actuation

Journal of Bionic Engineering 2016年第2期13卷 220-234页

作者： Ana Sofia Moita Catarina Laurencia joana Anastacio Ramos Duarte Miguel Franca Prazeres Antonio Luis Nobre Moreira IN+ - Center for Innovation Technology and Policy Research Instituto Superior Tecnico Universidade de Lisboa Av. Rovisco Pais 1049-001 Lisboa Portugal iBB - Institute for Bioengineering and Biosciences Department of Bioengineering Instituto Superior Tecnico Universidade de Lisboa Av. Rovisco Pais 1049-001 Lisboa Portugal

This study describes the dynamic behaviour of droplets of biological liquids on hydrophobic surfaces under electrostatic actuation, to devise sample handling in lab-on-chip diagnostic tools. Bovine Serum Albumin （BSA） is taken as a representative biomolecule, since it is often used in adsorption studies. Green Fluorescence Protein （GFP） is also considered, given its natural fluorescence. Several effects such as sample concentration and pH are discussed. The results show negligible effects of proteins concentration in electrowetting, although increased concentrations endorse passive adsorption mechanisms, which alter the local wettability of the substrates precluding droplet motion. Bioinspired surfaces promote the largest spreading diameter, which is beneficial for droplet motion. However, surface roughness promotes energy dissipation limiting the receding droplet motion. Hence, the most effective approach is altering the surface chemistry. The coating is applied to a surface with a mean roughness smaller than 20 nm and does not alter significantly the topography, thus leading to the so-called smooth superhydrophobic surface. This coating also reduces passive proteins adsorption, as confirmed by Confocal Microscopy （CM）, which is beneficial for droplet motion. Evaluating absorption spectra of protein solutions evidences an increase in protein concentration ascribed to droplet evaporation as confirmed by theoretical analysis and time resolved infrared visualization.

关键词： bioinspired surfaces biofluids electrostatic actuation hydrophobicity adsorption evaporation

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Exocrine drainage in pancreas transplantation:Complications and management

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World Journal of Transplantation 2020年第12期10卷 392-403页

作者： joana Ferrer-Fàbrega Laureano Fernández-Cruz HepatoBiliaryPancreatic Surgery and Liver and Pancreas Transplantation Department ICMDMHospital Clinic BarcelonaUniversity of BarcelonaBarcelona Clinic Liver Cancer GroupAugust Pi i Sunyer Biomedical Research InstituteBarcelona 08036BarcelonaSpain Department of Surgery ICMDMHospital Clinic BarcelonaBarcelona 08036BarcelonaSpain

The aim of this minireview is to compare various pancreas transplantation exocrine drainage techniques i.e.,bladder vs *** techniques have different difficulties and *** comparisons have been made in the literature between exocrine drainage techniques throughout the history of pancreas transplantation,detailing complications and their impact on graft and patient *** emphasis has been made on the early postoperative management of these complications and the related surgical infections and their *** light of the results,a number of bladder-drained pancreas grafts required conversion to enteric *** a result of technical improvements,outcomes of the varied enteric exocrine drainage techniques(duodenojejunostomy,duodenoduodenostomy or gastric drainage)have also been discussed i.e.,assessing specific risks vs *** exocrine secretions can be drained to the urinary or intestinal *** the late 1990s the bladder drainage technique was used in the majority of transplant centers due to ease of monitoring urine amylase and lipase levels for evaluation of possible ***,bladder drainage was associated at that time with fewer surgical complications,which in contrast to enteric drainage,could be managed with conservative ***,the most commonly used technique for proper driving of exocrine pancreatic secretions is enteric drainage due to the high rate of urological and metabolic complications associated with bladder *** note,10%to 40%of bladder-drained pancreata eventually required enteric conversion at no detriment to overall graft *** surgical techniques were originally described using the small bowel for enteric anastomosis with Roux-en-Y loop or a direct side-to-side *** the improvements in surgery,enteric drainage complication rates ranging from 2%-20%have been *** depends on the presence of any associated complicati

关键词： Graft survival Patient survival Anastomotic leak Morbidity Infection Surgery

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Ammonia Sensing System Based on Wavelength Modulation Spectroscopy

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Photonic Sensors 2015年第2期5卷 109-115页

作者： Duarte VIVEIROS Joao FERREIRA Susana O. silva joana RIBEIRO Deolinda FLORES Jose L. SANTOS Orlando FRAZAO Jose M. BAPTISTA INESC Porto Rua do Campo Alegre 687 4169-007 Porto Portugal Geology Center of the University of Porto and Department of Geosciences Environment and Spatial Plannings Facultyof Science at University of Porto Rua do Campo Alegre 687 4169-007 Porto Portugal Department of Physics and Astronomy Faculty of Science at University of Porto Rua do Campo Alegre 687 4169-007 Porto Portugal Competence Center of Exact Sciences and Engineering University of Madeira Campus da Penteada 9000-390 Funchal Portugal

A sensing system in the near infrared region has been developed for ammonia sensing based on the wavelength modulation spectroscopy （WMS） principle. The WMS is a rather sensitive technique for detecting atomic/molecular species, presenting the advantage that it can be used in the near-infrared region by using the optical telecommunications technology. In this technique, the laser wavelength and intensity were modulated by applying a sine wave signal through the injection current, which allowed the shift of the detection bandwidth to higher frequencies where laser intensity noise was typically lower. Two multi-pass cells based on free space light propagation with 160 cm and 16 cm of optical path length were used, allowing the redundancy operation and technology validation. This system used a diode laser with an emission wavelength at 1512.21nm, where NH3 has a strong absorption line. The control of the NH3 gas sensing system, as well as acquisition, processing and data presentation was performed.

关键词： Ammonia sensing fiber optic system near infrared region wavelength modulation spectroscopy,environment

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Current perspectives on the antidepressant-like effects of guanosine

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Neural Regeneration Research 2016年第9期11卷 1411-1413页

作者： Luis E.B.Bettio joana Gil-Mohapel Ana Lucia S.Rodrigues Department of Biochemistry Center of Biological Sciences Federal University of Santa Catarina Florianopolis-SC Brazil Division of Medical Sciences and UBC Island Medical Program University of Victoria Victoria BC V8W 2Y2 Canada

Purines have a recognized importance as intercellular mes- sengers. These molecules play an important role in the de- velopment and maintenance of the central nervous system （CNS）, as well as in its response to pathological conditions. Both adenine and guanine-based purines can be released from astrocytes, where they play a relevant role as extracel- lular signaling molecules. Particularly, the nucleoside gua- nosine has been proposed as an extracellular molecule that regulates the response of CNS to damage. Following injury, this nucleoside attains high concentrations in the extracel- lular space, where it activates multiple signaling pathways.

关键词： Current perspectives on the antidepressant-like effects of guanosine

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Fecal marker levels as predictors of need for endoscopic balloon dilation in Crohn's disease patients with anastomotic strictures

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World Journal of Gastroenterology 2017年第35期23卷 6482-6490页

作者： Susana Lopes Patrícia Andrade Eduardo Rodrigues-Pinto joana Afonso Guilherme Macedo Fernando Magro Gastroenterology Department Faculty of MedicineHospital de Sao Joao Department of Pharmacology and Therapeutics University of Porto

AIM To evaluate the accuracy and best cut-off value of fecal calprotectin(FC) and fecal lactoferrin(FL) to predict disease recurrence in asymptomatic patients presenting with anastomotic strictures. METHODS This was a longitudinal single tertiary center study based on prospectively collected data(recorded in a clinical database created for this purpose) performed between March 2010 and November 2014. Crohn's disease(CD) patients with anastomotic stricture who submitted to postoperative endoscopic evaluation were included. Stools were collected on the day before bowel cleaning for FC and FL. Endoscopic balloon dilation(EBD) was performed if the patient presented an anastomotic stricture not traversed by the colonoscope, regardless of patients' symptoms. Successful dilation was defined as passage of the colonoscope through the dilated stricture into the neotermimal *** recurrence was defined as a modified Rutgeerts score of ≥ i2 b. RESULTS In a total of 178 patients who underwent colonoscopy, 58 presented an anastomotic stricture, 86% were asymptomatic, and 48(54% male; median age of 46.5 years) were successfully dilated. Immediate success rate was 92% and no complications were recorded. FC and FL levels correlated significantly with endoscopic recurrence(P < 0.001) with an optimal cut-off value of 90.85 μg/g(sensitivity of 95.5%, specificity of 69.2%, positive predictive value(PPV) of 72.4%, negative predictive value(NPV) of 94.7% and accuracy of 81%] for FC and of 5.6 μg/g(sensitivity of 77.3%, specificity of 69.2%, PPV of 68%, NPV of 78.4% and accuracy of 72.9%) for *** Fecal markers are good predictors of CD endoscopic recurrence in patients with asymptomatic anastomotic stricture. FC and FL may guide the need for EBD in this context.

关键词： Crohn's disease Anastomotic strictures Endoscopic balloon dilation Fecal markers Po stoperative recurrence

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Impact of the timing of capsule endoscopy in overt obscure gastrointestinal bleeding on yield and rebleeding rate-is sooner than 14 d advisable?

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World Journal of Gastrointestinal Endoscopy 2018年第4期10卷 74-82页

作者： Catarina Gomes Rolando Pinho Adélia Rodrigues Ana Ponte joana silva Jaime Pereira Rodrigues Mafalda Sousa Joao Carlos silva Joao Carvalho Department of Gastroenterology Centro Hospitalar Vila Nova de Gaia/EspinhoPorto 4434502Portugal

AIM To evaluate the impact of the timing of capsule endoscopy(CE) in overt-obscure gastrointestinal bleeding(OGIB). METHODS Retrospective, single-center study, including patients submitted to CE in the setting of overt-OGIB between January 2005 and August 2017. Patients were divided into 3 groups according to the timing of CE(≤ 48 h; 48 h-14 d; ≥ 14 d). The diagnostic and therapeutic yield(DY and TY), the rebleeding rate and the time to rebleed were calculated and compared between groups. The outcomes of patients in whom CE was performed before(≤ 48 h) and after 48 h(> 48 h), and before( 48 h groups(P = 0.03).CONCLUSION Performing CE within 48 h from overt-OGIB is associated to a higher TY and a lower rebleeding rate and longer time to rebleed.

关键词： Overt-obscure gastrointestinal bleeding Capsule endoscopy Timing Diagnosis Therapeutic Rebleeding

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Power and Architecture in Portuguese Fascism： Political and Artistic Control and Resistance

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Journalism and Mass Communication 2015年第7期5卷 360-371页

作者： joana Brites University ofCoimbra Coimbra Portugal

This paper analyses the system of artistic and ideological conditioning that architects were subject to during the Portuguese fascism, the so-called ＂New State＂, the longest western European dictatorship of the previous century, that lasted from 1933 to 1974, under the uninterrupted leadership of Ant6nio de Oliveira Salazar until 1968. After a concise exposition of the importance of a major public work campaign to the regime affirmation as well as the aesthetic discourse promoted in its architecture, the standard course of a building project evaluation will be described. Crossing varied legislation and taking into consideration the results of a thorough examination to more than one hundred processes of architectural plans approval, the interaction of the various decision-making bodies will illustrate the existence of an efficient apparatus which progressively depurate designs. Prevention and repression of artistic deviation will be demonstrated. Furthermore, the development and importance of self-censorship will be highlighted. Secondly, a characterization of the atmosphere of ideological surveillance and dissident＇s oppression will be provided. Architects＇ participation in opposition＇s initiatives and strategies will be portrayed. As a conclusion, New State practice of a negotiation and inclusion （both artistic and ideological） tactic in the architectural field will be underlined.

关键词： New State fascism architecture control opposition

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Changes in feeding selectivity of freshwater invertebrates across a natural thermal gradient

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Current Zoology 2018年第2期64卷 231-242页

作者： Timothy A. C. GORDON joana NETO-CEREJEIRA Paula C. FUREY Eoin J. O'GORMAN Imperial College London Silwood Park Campus Buckhurst Road Ascot Berkshire SL5 7PY UK Biosciences College of Life and Environmental Sciences University of Exeter Stocker Road Exeter EX4 4QD UK Department of Biology Saint Catherine University St Paul MN 55105 USA

Environmental warming places physiological constraints on organisms, which may be mitigated by their feeding behavior. Theory predicts that consumers should increase their feeding selectivity for more energetically valuable resources in warmer environments to offset the disproportionate increase in metabolic demand relative to ingestion rate. This may also result in a change in feeding strategy or a shift towards a more specialist diet. This study used a natural warming experiment to investigate temperature effects on the feeding selectivity of three freshwater invertebrate grazers： the snail Radix balthica, the blackfly larva Simulium aureum, and the midgefly larva Eukiefferiella minor. Chesson＇s Selectivity Index was used to compare the proportional abundance of diatom species in the guts of each invertebrate species with corresponding rock biofilms sampled from streams of different tem- perature. The snails became more selective in warmer streams, choosing high profile epilithic diatoms over other guilds and feeding on a lower diversity of diatom species. The blackfly larvae appeared to switch from active collector gathering of sessile high profile diatoms to more passive filter feeding of motile diatoms in warmer streams. No changes in selectivity were observed for the midgefly larvae, whose diet was representative of resource availability in the environment. These results suggest that key primary consumers in freshwater streams, which constitute a major portion of invertebrate biomass, can change their feeding behavior in warmer waters in a range of different ways. These patterns could potentially lead to fundamental changes in the flow of energy through freshwater food webs.

关键词： climate change global warming diet Lymnaea peregra Simuliidae Chironomidae

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The Biotechnological and Seafood Potential of Stichopus regalis

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Advances in Bioscience and Biotechnology 2015年第3期6卷 194-204页

作者： Rita Santos Simaura Dias Susete Pinteus joana silva Celso Alves Carla Tecelao Ana Pombo Rui Pedrosa Department of Geography Environment and Earth Sciences(GEES)Faculty of ScienceUniversity of HullHullUK MARE—Marine and Environmental Sciences Centre ESTMPolytechnic Institute of LeiriaPenichePortugal Linking Landscape EnvironmentAgriculture and Food Research Unit(LEAF)Instituto Superior de AgronomiaUniversity of LisbonTapada da AjudaLisbonPortugal

Sea cucumbers are highly used not only for the production of the bêche-de-mer, but also recent studies have been showing the high potential of these marine invertebrates on the pharmaceutical industry, as they are rich in bioactive compounds with important functions. Stichopus regalis extracts (1 mg·mL-1) were used in antioxidant, antimicrobial and antitumor assays. The lipid profile was also evaluated. No significant antioxidant activity was detected in both methanolic and dichloromethane extracts. The methanolic fraction showed the highest antimicrobial potential against Candida albicans with an IC50 of 475.4 μg·mL-1. In the antitumor assays, the dichloromethane fraction showed a high potential for both cell lines, as revealed by the MTT method. The total fat content was 3.63% ± 0.11% and the fatty acid profile revealed the highest amount in C16:0 (9.43% ± 0.77%), C18:0 (12.43% ± 0.83%), C18:1 ω7 (5.63% ± 0.33%), EPA (12.49% ± 0.15%), DHA (7.35% ± 0.02%), ARA (19.29% ± 0.14%) and a ω3/ω6 ratio of 1.078. These findings led us to suggest the potential use of S. regalis as a new source of bioactive compounds with pharmacological potential and its nutritional benefits for human health.

关键词： Sea Cucumber Antimicrobial Activity Antitumor Activity Marine Natural Compounds Fatty Acid Profile

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BCG Infection after Bladder Cancer Treatment—3 Clinical Case Reports

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Advances in Infectious Diseases 2015年第4期5卷 218-221页

作者： joana Alves Angélica Ramos Teresa Carvalho Susana silva Joao Tiago Guimaraes António Sarmento Infectious Diseases Department Faculty of MedicineUniversity of PortoCentro Hospitalar Sao Joao EPEPortoPortugal Clinical Pathology Department Centro Hospitalar Sao Joao EPEPortoPortugal EPI Unit Institute of Public Health of University of PortoPortoPortugal Biochemistry Department Faculty of MedicineUniversity of PortoPortoPortugal

Immunotherapy with Bacillus Calmette-Guérin (BCG) to treat non-muscle invasive bladder cancer has become an effective and superior alternative to chemotherapy. Intravesical treatment with BCG appears to be relatively safe;however, occasionally BCG infection complicates such treatment. In the present work we describe three patients in whom BCG infection occurred after intravesical BCG therapy. All patients had positive urine culture forMycobacterium tuberculosis complex, using AccuProbe culture identification and then Genotype Mycobacterium MTBC test identified Mycobacterium bovis BCG. The diagnosis is difficult and microbiologic study is usually negative, so high index of suspicion is essential.

关键词： Bacillus Calmette-Guérin Intravesical BCG Therapy BCG Infection Disseminated M.bovis BCG Infection

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