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Asian Journal of Andrology 2014年第6期16卷 838-844页

作者： Zaida Sarrate Francesca vidal joan Blanco Unitat de Biologia Cel.lular Facultat de Biociencies Universitat Autonoma de Barcelona Bellaterra (Cerdanyola del Valles) 08193 Spain.

The aim of this study was to look in depth at the relationship between meiotic anomalies and male infertility, such as the determination of the chromosomes involved or the correlation with patient features. For this purpose, a total of 31 testicular tissue samples from individuals consulting for fertility problems were analyzed. Metaphase I cells were evaluated using a sequential methodology combining Leishman stained procedures and multiplex fluorescence in situ hybridization protocols. The number of chromosomal units and chiasmata count per bivalent were established and a hierarchical cluster analysis of the individuals was performed. The relationship of the seminogram and the karyotype over recombination were evaluated using Poisson regression models. Results obtained in this study show a significant percentage of infertile individuals with altered meiotic behavior, mostly specified as a reduction in chiasmata count in medium and large chromosomes, the presence of univalents, and the observation of tetraploid metaphases. Moreover, the number and the type of anomalies were found to be different between cells of the same individual, suggesting the coexistence of cell lines with normal meiotic behavior and cell lines with abnormalities. In addition, chromosomal abnormalities in metaphase I are significantly associated with oligozoospermia and/or polymorphic karyotype variants.

关键词： chiasmata count human spermatocytes multiplex fluorescence in situ hybridization polymorphic karyotype seminalparameters

Non-invasive brain stimulation to promote motor and functional recovery following spinal cord injury

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Neural Regeneration Research 2017年第12期12卷 1933-1938页

作者： Aysegul Gunduz John Rothwell joan vidal Hatice Kumru Department of Neurology Cerrahpasa School of Medicine Istanbul University Istanbul Turkey Sobell Department of Motor Neuroscience and Movement Disorders Institute of Neurology Queen Square University College London London UK Institut Guttmann Institut Universitari de Neurorehabilitaci6 adscrit a la UAB Badalona-Barcelona Spain Universidad Autonoma de Barcelona Bellaterra (Cerdanyola del Valles) Spain Fundacio Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol Badalona Barcelona Spain

We conducted a systematic review of studies using non-invasive brain stimulation（NIBS： repetitive transcranial magnetic stimulation（r TMS） and transcranial direct current stimulation（t DCS）） as a research and clinical tool aimed at improving motor and functional recovery or spasticity in patients following spinal cord injury（SCI） under the assumption that if the residual corticospinal circuits could be stimulated appropriately, the changes might be accompanied by functional recovery or an improvement in spasticity. This review summarizes the literature on the changes induced by NIBS in the motor and functional recovery and spasticity control of the upper and lower extremities following SCI.

关键词： spinal cord injury non-invasive brain stimulation transcranial magnetic stimulation transcranialdirect current stimulation functional improvement spasticity neuropathic pain

Re： Is number of chiasmata an etiological factor of male infertility？

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Asian Journal of Andrology 2014年第6期16卷 921-921页

作者： Zaida Sarrate Francesca vidal joan Blanco Unitat de Biologia Cel-lular Facultat de Biociencies Universitat Autonoma deBarcelona Bellaterra (Cerdanyola del Valles) 08193 Spain.

We would like to thank Kurpisz and Olszewska for their commentary on our article2 and we welcome the opportunity to discuss some of the issues addressed by our colleagues.

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COVID-19 mental health care toolkit:an international collaborative effort by Early Career Psychiatrists section

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General Psychiatry 2020年第5期33卷 352-355页

作者： Frances Adiukwu Laura Orsolini Drita Gashi Bytyçi Samer El Hayek Jairo M Gonzalez-Diaz Amine Larnaout Paolo Grandinetti Marwa Nofal Victor Pereira-Sanchez Mariana Pinto da Costa Ramdas Ransing Andre Luiz Schuh Teixeira Mohammadreza Shalbafan joan Soler-vidal Zulvia Syarif Ganesh Kudva Kundadak Rodrigo Ramalho Department of Neuropsychiatry University of Port Harcourt Teaching HospitalChobaRiversNigeria Department of Clinical Neurosciences/DIMSC School of MedicinePolytechnic University of MarcheAnconaMarcheItaly Mental Health Center Prizren Hospital and University Clinical Service of KosovoPrizrenKosovo Department of Psychiatry American University of BeirutBeirutLebanon CERSAME School of Medicine and Health SciencesUniversidad del Rosario-Clinica Nuestra Senora de la PazBogotaColombia Psychiatry Department D Razi Hospitalfaculty of Medicine of TunisTunis El Manar UniversityTunisTunisia Addictions Service(SerD) Department of Territorial AssistanceASL TeramoTeramoItaly Helwan Mental Health Hospital CairoEgypt Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNew YorkUSA Unit for Social and Community Psychiatry(WHO Collaborating Centre for Mental Health Services Development) Queen Mary University of LondonLondonUK Institute of Biomedical Sciences Abel Salazar University of PortoPortoPortugal Hospital de Magalhaes Lemos PortoPortugal Department of Psychiatry BKL Walawalkar Rural Medical CollegeSawardeRatnagiriIndia Department of Childhood and Adolescent Psychiatry Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil Mental Health Research Center Department of PsychiatrySchool of MedicineIran University of Medical SciencesTehranIran(the Islamic Republic of) Fidmag Research Foundation Hermanas HospitalariasBarcelonaSpain Department of Psychiatry Tarakan General HospitalJakartaIndonesia Early Psychosis Intervention Programme Institute of Mental HealthSingapore Department of Social and Community Health School of Populatin HealthUniversity of AucklandAucklandNew Zealand

The collaborative effort of an international research team from the Early Career Psychiatrists section of the World Psychiatry Association has brought about an easy-to-use,quick and stepwise mental health care toolkit for the identification and appropriate referral of those in need of mental health care during the *** simple guide can be applied in the general outpatient setting and is catered for all healthcare professionals,regardless of their expertise within the mental health field with minimal *** is our hope that by incorporating this toolkit into our daily clinical care during the pandemic for high-risk patients and patients with non-specific complaints,we will be able to bridge the mental health gap present in our society.

关键词： Psychiat section clinical

A comprehensive analysis of chromosomal anomalies in metaphase II spermatocytes from infertile patients

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Asian Journal of Andrology 2018年第1期20卷 105-106页

作者： Zaida Sarrate joan Blanco Oliver Valero Francesca vidal Genetics of Male Fertility Group Unitat de Biologia Cel.lular Departament de Biologia Cel.lular Fisiologia i Immunologia Facultat de Biociencies Universitat Autonoma de Barcelona Bellaterra (Cerdanyola del Valles) 08193 Spain Servei d'Estadistica Aplicada Universitat Autonoma de Barcelona Bellaterra (Cerdanyola del Valles) 08193 Spain

Dear Editor, The scarce number of secondary spermatocytes in human seminiferous tubules and the complexity of analyzing chromosomes at metaphase II are the main causes of the limited knowledge we have about chromosome characteristics at this stage. In this study, we have performed a comprehensive analysis of meiotic abnormalities in metaphase II spermatocytes combining Leishman＇s staining protocols and multiplex fluorescent in situ hybridization procedures. Results indicated that infertile individuals showed different susceptibilities to meiotic abnormalities in secondary spermatocytes without a preferentially effect on any particular chromosome.

关键词： MEIOTIC ABNORMALITIES SISTER CHROMATIDS ANEUPLOIDY MEIOSIS SEPARATION OOCYTES MALES

Unpaired sex chromosomes in metaphase I human spermatocytes locally modify autosomal bivalents positioning

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Asian Journal of Andrology 2018年第6期20卷 626-628页

作者： Carla Mayans joan Blanco Oliver Valero Francesca vidal Zaida Sarrate Genetics of Male Fertility Group Unitat de Biologia Cel.lularDepartament de Biologia Cel.lularFisiologia i ImmunologiaFacultat de BiocienciesUniversitat Autbnoma de BarcelonaBellaterra（Cerdanyola del Vall~s）08193Spain Servei d＇Estadistica Aplicada Universitat AutOnoma de BarcelonaBetlaterra（Cerdanyola del Valles）08193Spain.

Dear Editor, In interphase nuclei, chromosomes occupy specific localizations called chromosome territories （CTs）. Distribution of CTs has been related to chromosome size and gene density and is known to influence gene expression.~ This pattern of organization appears to be a widespread nuclear feature, both in somatic and germ ceils.

关键词： ABNORMALITIES

Endorectal Magnetic Resonance Imaging and Spectroscopy Are Useful for Selecting Candidates for Biopsy among Patients with Persistently Elevated Prostate Specific Antigen

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Open Journal of Urology 2012年第3期2卷 198-205页

作者： Josep Comet-Batlle Carles Barceló-vidal joan Carles Vilanova-Busquets Roger Boix-Orri Albert Maroto-Genover joan Areal-Calama Margarita Osorio-Fernandez Ferran Perez-Bueno Nuria Fuertes-Izquierdo Department of Computer Science and Applied Mathematics University of Girona Catalonia Spain Pathology Department Hospital Dr. Josep Trueta Catalonia Spain Radiology Department Hospital Dr. Josep Trueta Catalonia Spain Ressonància Girona Catalonia Spain Urology Department Hospital Dr. Josep Trueta Catalonia Spain Urology Department Hospital Trias Pujol Catalonia Spain

Objective: To evaluate the efficacy of endorectal Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spetroscopic Imaging (MRSI) combined with total prostate-specific antigen (tPSA) and free prostate-specific antigen (fPSA) in selecting candidates for biopsy. Subjects and Methods: 246 patients with elevated tPSA (median: 7.81 ng/ml) underwent endorectal MRI and MRSI before Transrectal Ultrasound (TRUS) biopsy (10 peripheral + 2 central cores);patients with positive biopsies were treated with radical intention;those with negative biopsies were followed up and underwent MRSI before each additional biopsy if tPSA rose persistently. Mean follow-up: 27.6 months. We compared MRI, MRSI, tPSA, and fPSA with histopathology by sextant and determined the association between the Gleason score and MRI and MRSI. We determined the most accurate combination to detect prostate cancer (PCa) using receiver operating curves;we estimated the odds ratios (OR) and calculated sensitivity, specificity, and positive and negative predictive values. Results: No difference in tPSA was found between patients with and without PCa (p = 0.551). In the peripheral zone, the risk of PCa increased with MRSI grade;patients with high-grade MRSI had the greatest risk of PCa over time (OR = 328.6);the model including MRI, MRSI, tPSA, and fPSA was more accurate (Area under Curve: AUC = 95.7%) than MRI alone (AUC = 85.1%) or fPSA alone (AUC = 78.1%), but not than MRSI alone (94.5%). In the transitional zone, the model was less accurate (AUC = 84.4%). The association (p = 0.005) between MRSI and Gleason score was significant in both zones. Conclusions: MRSI is useful in patients with elevated tPSA. High-grade MRSI lesions call for repeated biopsies. Men with negative MRSI may forgo further biopsies because a significantly high Gleason lesion is very unlikely.

关键词： Endorectal MRI Spectroscopy Prostate Cancer Diagnosis Prostate Specific Antigen (PSA) Free to Total PSA Ratio (F/T PSA)

CD300a inhibits CD16-mediated NK cell effector functions in HIV-1-infected patients

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Cellular & Molecular Immunology 2019年第12期16卷 940-942页

作者： joana Vitallé Iñigo Terrén Ane Orrantia Raquel Pérez-Garay Francesc vidal JoséA.Iribarren Carmen Rodríguez Ana M.López Lirola Enrique Bernal Olatz Zenarruzabeitia Francisco Borrego Immunopathology Group Biocruces Bizkaia Health Research InstituteBarakaldoSpain Hospital Universitari de Tarragona joan XXIII IISPVUniversitat Rovira i VirgiliTarragonaSpain Servicio de Enfermedades Infecciosas Hospital Universitario DonostiaInstituto de Investigación Sanitaria BiodonostiaDonostia-San SebastiánSpain Centro Sanitario Sandoval Hospital Clínico San CarlosInstituto de Investigación Sanitaria San CarlosMadridSpain Hospital Universitario de Canarias Santa Cruz de TenerifeSpain Department of Clinical Medicine Universidad de Murcia and Hospital General Universitario Reina SofíaMurciaSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain

Natural killer(NK)cell-mediated antibody-dependent cellular cytotoxicity(ADCC)through CD16 plays a critical role in antihuman immunodeficiency virus(HIV)responses.1–3 CD300a is a surface receptor highly expressed on NK cells that has the capacity to inhibit NK cell-mediated cytotoxicity in healthy donors.4 The CD300a molecule has been related to several viral infections and is able to diminish the NK cell killing of pseudorabies-infected cells through interactions with its ligands phosphatidylserine and phosphatidylethanolamine.5 In addition,CD300a expression on B and CD4+T lymphocytes is altered during HIV-1 infection,and combined antiretroviral therapy(cART)does not restore nonpathological expression levels.5,6 However,the expression and function of CD300a on NK cells during HIV-1 infection is still *** have determined the surface expression of CD300a on different NK cell subsets and the capacity of this receptor to inhibit CD16-induced NK cell effector functions in healthy and HIV-1 infected individuals.

关键词： CD16 CD30 ADCC