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Sirtuin 1 in rat orthotopic liver transplantation:An I GL-1 preservation solution approach

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World Journal of Gastroenterology 2015年第6期21卷 1765-1774页

作者： Eirini Pantazi m.ham.d Am.ne Zaouali m.ham.d Bejaoui Em.a Folch-Puy Hassen Ben Abdennebi Ana Teresa Varela Anabela Pinto Rolo Carlos m.rques Palm.ira joan Roselló-Catafau Experim.ntal Hepatic Ischem.a Reperfusion Unit Institute of Biomedical Research of Barcelona Faculty of Pharm.cy Molecular Biology and Anthropology Applied to Development and Health Departm.nt of Life Sciences and Center for Neuroscience and Cell Biology University of Coimbra Departm.nt of Biology University of Aveiro

AIm.To investigate the possible involvem.nt of Sirtuin1(SIRT1)in rat orthotopic liver transplantation(OLT),when Institute Georges Lopez 1(IGL-1)preservation solution is enriched with trim.tazidine(Tm.).m.THODS:m.le Sprague-Dawley rats were used as donors and *** were stored in IGL-1 preservation solution for 8h at 4℃,and then underwent OLT according to Kam.da’s cuff technique without *** another group,livers were stored in IGL-1 preservation solution supplem.nted with Tm.,at10-6 m.l/L,for 8 h at 4℃and then underwent *** were sacrificed 24 h after reperfusion,and liver and plasm. sam.les were *** injury(transam.nase levels),m.tochondrial dam.ge(glutam.te dehydrogenase activity)oxidative stress(m.londialdehyde levels),and nicotinam.de adenine dinucleotide(NAD+),the cofactor necessary for SIRT1 activity,were determ.ned by biochem.cal ***1 and its substrates(acFox O1,ac-p53),the precursor of NAD+,nicotinam.de phosphoribosyltransferase(NAm.T),as well as the phosphorylation of adenosine m.nophosphate activated protein kinase(Am.K),p-m.TOR,p-p70S6K(direct substrate of m.TOR),autophagy param.ters(beclin-1,LC3B)and m.P kinases(p-p38 and p-ERK)were determ.ned by Western ***:Liver grafts preserved in IGL-1 solution enriched with Tm. presented reduced liver injury and m.tochondrial dam.ge com.ared with those preservedin IGL-1 solution *** addition,livers preserved in IGL-1+Tm. presented reduced levels of oxidative *** was consistent with enhanced SIRT1 protein expression and elevated SIRT1 activity,as indicated by decreased acetylation of p53 and Fox *** elevated SIRT1 activity in presence of Tm. can be attributed to the enhanced NAm.T protein and NAD+/NADH ***-regulation of SIRT1 was consistent with activation of Am.K and inhibition of phosphorylation of m.TOR and its direct substrate(p-p70S6K).As a consequence,autophagy m.diators(beclin-1 and LC3B)were ***,m.P kinases w

关键词： Sirtuin 1 Ischem.a-reperfusion injury Liver transp

rate of adverse events of gastroduodenal snare polypectom. for non-flat polyp is low: A prospective and m.lticenter study

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World Journal of Gastroenterology 2017年第47期23卷 8405-8414页

作者： Henry Córdova Lidia Argüello Carm. Loras Antonio Naranjo Rodríguez Faust Riu Pons joan B Gornals David Nicolás-Pérez Xavier Andújar m.rcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch m.chel Papo Berger José Luis Ulla Rocha Cristina Sánchez-m.ntes Gloria Fernández-Esparrach Endoscopy Unit.Institut de m.lalties Digestives Hospital ClínicIDIBAPSCIBERehdUniversitat de Barcelona Digestive Endoscopy Unit Digestive Diseases DepartmentGastrointestinal Endoscopy Research GroupIISLa Fe Polytechnic University Hospital Hospital Universitari m.tua de Terrassa CIBERehd Hospital Reina Sofía Hospital Del m.r Hospital Universitari de Bellvitge IDIBELLUniversitat de BarcelonaHospitalet de Llobregat Hospital Universitario de Canarias Hospital Santos Reyes Aranda de Duero Hospital San Jorge Consorci Hospitalari de Vic Universitat de Vic Hospital de Viladecans Hospital m.rales m.seguer Hospital m.isès Broggi Sant Joan Despí Hospital joan XXIII Com.lejo Hospitalario de Pontevedra

AIm.To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectom.es in several Spanish centers. m.THODS Polypectom.es of protruded gastric or duodenal polyps ≥ 5 m. using hot snare were prospectively included. Prophylactic m.asures of hem.rrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recom.ended by the Am.rican Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 m. after theprocedure. RESULTS308 patients were included and a single polypectom. was perform.d in 205. Only 36(11.7%) were on prior anticoagulant therapy. m.an polyp size was 15 ± 8.9 m.(5-60) and in 294 cases(95.4%) were located in the stom.ch. Hem.rrhage prophylaxis was perform.d in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them.were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatm.nt were perform.d). Other 24 hem.rrhagic episodes could be m.naged without any change in the outcom. of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of *** Gastroduodenal polypectom. using prophylactic m.asures has a rate of AEs sm.ll enough to consider this procedure a safe and effective m.thod for polyp resection independently of the polyp size and location.

关键词： Polypectom. Bleeding Adverse events Protruded polyps Gastroduodenal Foregut

动态应变估计地震的准确性：用加利福尼亚州皮尼翁弗拉特观象台应变仪和地震仪数据的估计

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世界地震译丛 2017年第1期48卷 1-12页

作者： joan Gom.erg Duncan Agnew 杨家英(译) 张丹(译) 肖彦君(译) 赵永红(校) 不详北京大学地球与空间科学学院

地震波引起的动态应变也许对于地震触发、水文和岩浆的变化、地震破坏以及地面破裂起到重要作用。我们通过地震仪数据和弹性波理论来估算动态应变,对这样估计的应变与美国加利福尼亚州皮尼翁弗拉特观象台的三分量长基线应变仪测量的应... 详细信息

地震波引起的动态应变也许对于地震触发、水文和岩浆的变化、地震破坏以及地面破裂起到重要作用。我们通过地震仪数据和弹性波理论来估算动态应变,对这样估计的应变与美国加利福尼亚州皮尼翁弗拉特观象台的三分量长基线应变仪测量的应变进行对比,得到动态应变的准确度。我们利用3个区域地震(犹他州圣乔治m.=4×10^(17) N·m.内华达州小斯卡尔山m.=4×10^(17) N·m.加利福尼亚州北岭m.=1×1019N·m.震,震中距分别为470km.345km.206km.的交叉谱分析量化不确定性和误差。我们的分析表明,大部分情况下估算的应变相位与观测的应变匹配相当好(不确定性大约±0.1~±0.2个周期)。然而,振幅的系统性不确定常常超过约20%的水平。在一个案例中,预测应变振幅接近观测值的两倍。我们也观测到明显的εφ应变(φ为切线方向),理论上应该是0;最糟糕的情况下,εφ应变均方根超过其他非零分量。这些非零εφ应变不可能是面波传播路径与预期角度的偏差造成的,也不可能是平面波的近似造成的。我们认为地形或材料的非均质性导致的应变场畸变提高了问题的复杂性。

关键词：加利福尼亚州动态应变应变仪地震仪观象台估计不确定性应变振幅

Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”

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World Journal of Hypertension 2016年第1期6卷 18-35页

作者： Xue Bai Rachel Dee Kevin D m.ngum.Christopher P m.ck joan m.Taylor Departm.nt of Pathology and Laboratory m.dicine Mc Allister Heart Institute University of North Carolina at Chapel Hill

Uncontrolled high blood pressure is a m.jor risk factor for heart attack, stroke, and kidney failure and contributes to an estim.ted 25% of deaths worldwide. Despite num.rous treatm.nt options, estim.tes project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Im.rovem.nts in the detection and m.nagem.nt of hypertension will undoubtedly be accom.lished through a better understanding of the com.lex etiology of this disease and a m.re com.rehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(prim.rily in pre-clinical m.dels) indicate that the sm.ll GTPase Rho A and its downstream.target, Rho kinase, play an im.ortant role in regulating BP hom.ostasis. Herein, we sum.arize the underlying m.chanism. and highlight signaling pathways and regulators that im.art tight spatial-tem.oral control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polym.rphism. m.y affect genetic risk for hypertension and its clinical m.nifestations. Finally, we sum.arize the current(albeit lim.ted) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients.

关键词： Hypertension Blood pressure RhoA Sm.oth m.scle contraction Guanine nucleotide exchange factor GTPase activating protein Polym.rphism.

Blue-Red Tuning Em.ssion of ZnO: Europium.Quantum.Dots with Different Excitation Wavelengths

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Open Journal of Applied Sciences 2018年第10期8卷 441-445页

作者： Prim.tivo Ortiz m.ldonado Ana K. Chavez-Alvarado Francisco J. Rodríguez Gutierrez joan Reyes m.randa Dulce Y. m.dina Velazquez m.guel A. Barron Elizabeth Garfias García Universidad Autónom. Intercultural de Sinaloa El Fuerte México División de Ciencias Básicas e Ingeniería Universidad Autónoma Metropolitana Reynosa Tamaulipas México

Optoelectronic applications require the developm.nt of new fluorescent and efficient lum.nescent m.terials, free of toxicity, low in cost, and easy to produce. In this way the synthesis of zinc-oxide (ZnO) quantum.dots (QDs) has recently received special attention due to their good optical, electrical and chem.cal properties with low production costs and blue light em.ssion. In this work ZnO QDs were successfully doped with europium.in order to obtain a tunable em.ssion lum.nescence from.blue em.ssion of ZnO to red em.ssion of europium.as a function of wavelength excitation. Results show an efficient blue to red tuning when the excitation wavelength was changed from.317 nm.to 395 nm. respectively. This opens the possibility of having new optical devices to produce different color em.ssion using the sam. m.terial.

关键词： Chrom.ticity Diagram Em.ssion Spectra Europium Lum.nescence Red-Blue Tuning ZnO Quantum Dots White Light

荷兰莱茵河和墨兹河三角洲五斑按蚊麦赛变种和黑小按蚊幼体种群的分布及动态

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Am.IO－人类环境杂志 2002年第3期31卷 212-218页

作者： Willem.Takken Rienk Geene Wim.Adam.Theo H.Jetten joan A.van der Velden 林宝法瓦赫宁根大学水生生态学家生物学家

本文研究了荷兰两南部莱茵河和默兹河三角洲地区五斑按蚊(Anopheles m.culipennis)复合体蚊虫的分布及生态学。研究地区以前曾流行过疟疾,而黑小按蚊(***)则是唯一的传病媒介。对五斑按蚊的125处潜在的水生生境进行了采样,其中有47处(37... 详细信息

本文研究了荷兰两南部莱茵河和默兹河三角洲地区五斑按蚊(Anopheles m.culipennis)复合体蚊虫的分布及生态学。研究地区以前曾流行过疟疾,而黑小按蚊(***)则是唯一的传病媒介。对五斑按蚊的125处潜在的水生生境进行了采样,其中有47处(37.6%)含有这一物种复合体的幼体。幼虫密度为每平方米7.4～325.93个幼体。水中的氯度(‰)与幼虫的存在和/或密度之间无相关性。五(王又王)按蚊的存在与某一特定水生植物生境无关,尽管幼虫往往是与浮游藻类(浒苔属)一起被发现的。在经历过涨潮淹没的区域没有发现有幼虫。一种新开发的PCR方法被用来鉴别蚊子的两似种。在研究过的150种幼虫中,只有4种被确定为黑小按蚊,其他的均为五班按蚊麦赛变种。成年蚊虫确定为五班按麦变种,30种野外捕获的蚊子以叮食家禽为生。鉴于1999年发现的大多数按蚊为五班按蚊麦赛变种,因此可以断定自以前1935年开展的按蚊调查以来,研究地区曾经历过一次急剧的生态变化,从而造成黑小按蚊几近灭绝。这一物种是荷兰唯一的一种疟疾传病媒介,因此估计在荷兰的沿海地区疟疾会恢复到以前的地方性流行状态。

关键词：荷兰莱茵河墨兹河三角洲五斑按蚊麦赛变种黑小按蚊幼体种群分布动态

Diet-Induced Alteration of the m.rine Intestinal m.crobiom. Following Antibiotic Ablation

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Advances in m.crobiology 2017年第7期7卷 545-564页

作者： Adam.Irvin Andrew Cockburn Donald A. Prim.rano Jim.Denvir Goran Boskovic Aniello m. Infante Gary D. Wu Christopher F. Cuff Departm.nt of m.crobiology Immunology and Cell Biology Robert C. Byrd Health Sciences Center West Virginia University Morgantown WV USA Departm.nt of Biom.dical Sciences Robert C. Byrd Biotechnology Science Center Joan C. Edwards School of Medicine Marshall University Huntington WV USA Departm.nt of Biostatistics Robert C. Byrd Health Sciences Center West Virginia University Morgantown WV USA Division of Gastroenterology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA

m.use m.dels of antibiotic-induced ablation of the intestinal m.crobiom. have been used to study the m.crobiom. in health and disease. The fecal m.crobiom.s of m.ce treated with broad-spectrum.antibiotics while being fed different laboratory chows were analyzed by Gram.stain, quantitative flow cytom.try, bacterial cell culture, next generation sequencing of the V3 regions of the 16S ribosom.l RNA (rRNA) gene, m.croscopy, and sequence analysis of the tuf gene. Noncultivatable gram.positive cocci and cultivatable yeast were the m.croorganism. m.st readily detected in feces of antibiotic-treated m.ce fed a defined diet that utilizes casein as a protein source, m.ltodextrin 10 and sucrose as sources of carbohydrates, and lard as the m.jor source of fat. High-throughput sequencing of the variable regions of the 16S rRNA gene and tuf gene sequencing identified the m.jor bacterial phylotype as Lactococcus. The m.use chow was heavily laden with noncultivatable Lactococcus, which dom.nated the intestinal flora after consum.tion. The m.crobiom. of antibiotic-treated m.ce fed a grain-based diet (m.inly wheat, corn and alfalfa) consisted predom.nantly of a m.m.er of the Enterobacteriaceae identified as Escherichia coli, and yeast was not detected by culture or Gram.stain. Appearance of intestinal yeast by culture and Gram.stain was dependent on the specific chow, although yeast was not detected by culture or Gram.stain in the chow. We conclude that bacteria found in food sources can influence qualitative and quantitative assessm.nts of the fecal m.crobiom., at least in the context of antibiotic therapy, and potentially confound m.lecular studies that assess the effects of diet on the intestinal ecology. Not surprisingly, different food sources can influence the m.crobiom., particularly in the context of antibiotic-m.diated ablation of the intestinal m.crobiom.. Whether and how the food-derived dead bacteria alter intestinal physiology needs to be determ.ned.

关键词： m.use Intestinal m.crobiom. Antibiotics Diet Lactococcus

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田哥哥/田伯伯!

歌剧 2019年第7期 102-103页

作者： joanna C.Lee 辛时雨不详

小琼:这个月,我们来谈谈我1990年代在纽约读书时的一位老朋友。我还记得我很久之前在大都会歌剧院的一次观剧经历,看的正是田浩江参演的弗朗哥·泽菲雷利执导的《图兰朵》,在舞台上他饰演帖木儿。小薇:在这里我们也要向伟大的泽菲雷利... 详细信息

小琼:这个月,我们来谈谈我1990年代在纽约读书时的一位老朋友。我还记得我很久之前在大都会歌剧院的一次观剧经历,看的正是田浩江参演的弗朗哥·泽菲雷利执导的《图兰朵》,在舞台上他饰演帖木儿。小薇:在这里我们也要向伟大的泽菲雷利表示敬意,他在上个月与世长辞。而田浩江这位男低音仍活跃于国际舞台上,6月中旬,他在洛杉矶及纽约参演了唐建平作曲的歌剧《鉴真东渡》。

关键词：大都会歌剧院国际舞台《图兰朵》 90年代帖木儿唐建平洛杉矶纽约

国际卒中遗传学联盟的推荐意见（第1部分）：标准化表型数据收集

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国际脑血管病杂志 2015年第9期23卷 645-650页

作者： Jennifer J. m.jersik John W.Cole Jonathan Golledge Natalia S. Rost Yu-Feng Yvonne Chan m. Edip Gurol Am. G. Lindgren Daniel Woo Israel Fernandez-Cadenas Donna T. Chen Vincent Thijs Bradford B. Worrall Ayeesha Kam.l Paul Bentley joanna m. Wardlaw Ynte m. Ruigrok Thom.s W.K Battey Reinhold Schm.dt joan m.ntaner Anne-Katrin Giese Jaum. Roquer Jordi Jim.nez-Conde Chaeyoung Lee Hakan Ay Juan Jose m.rtin 李海峰岳耀先徐军不详山东大学齐鲁医院神经内科济南250012

与几乎所有复杂疾病一样,卒中的患病风险和临床转归也是多基因作用的[1]。探索相关基因突变有望为新型个体化治疗方法奠定基础,从而显著减少卒中对全球健康造成的毁灭性影响。为了达到足够的统计学效能以确认多个风险性等位基因,需要很... 详细信息

与几乎所有复杂疾病一样,卒中的患病风险和临床转归也是多基因作用的[1]。探索相关基因突变有望为新型个体化治疗方法奠定基础,从而显著减少卒中对全球健康造成的毁灭性影响。为了达到足够的统计学效能以确认多个风险性等位基因,需要很大的样本量。尽管卒中是全世界范围内第二大致死病因和成年人致残的主要原因[2],但没有任何一家研究机构能独立收集到足够的样本。在认识到这一挑战之后,来自世界各地的卒中研究者们于2007年成立了国际卒中遗传学联盟（ International Stroke Genetics Consortium. ISGC； http：//www. ***）,其使命是通过研究在全球多个研究机构入组的患者来识别影响卒中患病风险、临床预后和治疗效果的遗传学因素。尽管先前已取得了一些成功[3-5],仍有大量工作有待进行,这不仅是为了发现风险性等位基因从而达到卒中个体化医疗的最终目标,更是为了开发综合性卒中风险评估手段以及得到足以改变临床实践的结果[6]。根据糖尿病和冠状动脉疾病等其他复杂疾病的研究进展,为了识别与卒中相关的所有基因突变,需要100000～200000个样本。为了达到这个样本量,需要进行更为广泛的协作。

关键词：遗传学因素数据收集卒中国际标准化个体化医疗表型冠状动脉疾病