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Historical fluxes of metal and metalloids in an aquatic ecosystem affected by land-use change and mining activities in northwestern Mexico

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International journal of Sediment Research 2023年第5期38卷 724-738页

作者： Ochoa-Contreras Roberto jara-Marini Martín enrique Ruiz-Fernández Ana Carolina Sanchez-Cabeza joan Albert Meza-Figueroa Diana Pérez-Bernal Libia Hascibe Posgrado en Ciencias Centro de Investigación en Alimentación y Desarrollo Unidad Hermosillo 2. Centro de Investigación en Alimentación y Desarrollo Unidad Hermosillo Unidad Acad emica Mazatlán Instituto de Ciencias del Mar y Limnología Universidad Nacional Autónoma de M exico Departamento de Geología División de Ciencias Exactas y Naturales Universidad de Sonora Rosales y Encinas

Freshwater reservoirs are essential owing because of their ecological, economic, and social *** are particularly vulnerable to contamination, as of metal and metalloids, derived from anthropogenic activities like mining. The temporal variations in trace element concentrations(arsenic(As),mercury(Hg), chromium(Cr), copper(Cu), nickel(Ni), lead(Pb), and zinc(Zn)), enrichment, fluxes, and possible sources were evaluated by studying two sediment cores from the La Angostura(ANG) Reservoir(northwest Mexico), using210Pb geochronology. The enrichment factors showed from null to minor enrichment for most elements, but moderate to severe enrichment of mercury(Hg). Most trace element concentrations had a detrital origin, and notable Hg concentration increases since the past decade were associated with severe drought periods, likely resulting from wildfires. The observed sediment concentrations of As and Hg can cause adverse effects on biota in the ecosystem since they are above the probable effect level(PeL). Development of strategies for metal attenuation in this reservoir is recommended and metals should be controlled until specific ecotoxicological studies are performed.

关键词： Aquatic ecosystems ~(210)Pb geochronology Mining activities Metals Metalloids enrichment factors

Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation

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World journal of Gastroenterology 2015年第26期21卷 8021-8031页

作者： eirini Pantazi Mohamed Bejaoui Mohamed Amine Zaouali emma Folch-Puy Anabela Pinto Rolo Arnau Panisello Carlos Marques Palmeira joan Roselló-Catafau experimental Pathology Department Experimental Hepatic Ischemia-Reperfusion UnitInstitute of Biomedical Research of Barcelona(IIBB-CSIC Department of Life Sciences Faculty of Science and TechnologyUniversity of Coimbra Portugal and Center for Neurosciences and Cell Biology University of Coimbra

AIM: To investigate a possible association between losartan and sirtuin 1(SIRT1) in reduced-size orthotopic liver transplantation(ROLT) in ***: Livers of male Sprague-Dawley rats(200-250 g) were preserved in University of Wisconsin preservation solution for 1 h at 4 ℃ prior to *** an additional group,an antagonist of angiotensin Ⅱ type 1 receptor(AT1R),losartan,was orally administered(5 mg/kg) 24 h and 1 h before the surgical procedure to both the donors and the ***(as an indicator of liver injury),SIRT1 activity,and nicotinamide adenine dinucleotide(NAD+,a co-factor necessary for SIRT1 activity) levels were determined by biochemical *** expression of SIRT1,acetylated Fox O1(ac-Fox O1),NAMPT(the precursor of NAD+),heat shock proteins(HSP70,HO-1) expression,endoplasmic reticulum stress(GRP78,IRe1 a,p-e IF2) and apoptosis(caspase 12 and caspase 3) parameters were determined by Western *** alterations in protein expression of mitogen activated protein kinases(MAPK),such as p-p38 and p-eRK,were also ***,the SIRT3 protein expression and m RNA levels were ***: The present study demonstrated that losartan administration led to diminished liver injury when compared to ROLT group,as evidenced by the significant decreases in alanine aminotransferase(358.3 ± 133.44 vs 206 ± 33.61,P e aminotransferase levels(893.57 ± 397.69 vs 500.85 ± 118.07,P e lessened hepatic injury in case of losartan was associated with enhanced SIRT1 protein expression and activity(5.27 ± 0.32 vs 6.08 ± 0.30,P eased levels of NAD+(0.87 ± 0.22 vs 1.195 ± 0.144,P e co-factor necessary for SIRT1 activity,as well as with decreases in ac-Fox O1 *** treatment also provoked significant attenuation of endoplasmic reticulum stress parameters(GRP78,IRe1 a,p-e IF2) which was consistent with reduced levels of both caspase 12 and caspase 3.

关键词： Losartan Sirtuin 1 endoplasmic reticulumstress Liver ischemia reperfusion injury Angiotensin Ⅱ

engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment

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Bone Research 2019年第2期7卷 157-170页

作者： Nathalie Bock Ali Shokoohmand Thomas Kryza joan Rohl jonelle Meijer Phong A. Tran Colleen C. Nelson judith A. Clements Dietmar W. Hutmacher School of Biomedical Sciences Faculty of Health and Australian Prostate Cancer Research Centre (APCRC-Q)Institute of Health and Biomedical Innovation (IHBI)Queensland University of Technology (QUT)BrisbaneQLD 4000Australia Translational Research Institute (TRI) WoolloongabbaQLD 4102Australia Centre in Regenerative Medicine QUTKelvin GroveQLD 4059Australia Bone and joint Disorders Program School of ChemistryPhysics and Mechanical EngineeringScience and Engineering Faculty (SEF)QUTBrisbaneQLD 4000Australia Australian Research Council (ARC) Training Centre in Additive Biomanufacturing QUTKelvin GroveQLD 4059Australia

While stromal interactions are essential in cancer adaptation to hormonal therapies,the effects of bone stroma and androgen deprivation on cancer progression in bone are poorly ***,we tissue-engineered and validated an in vitro microtissue model of osteoblastic bone metastases,and used it to study the effects of androgen deprivation in this *** model was established by culturing primary human osteoprogenitor cells on melt electrowritten polymer scaffolds,leading to a mineralized osteoblast-derived microtissue containing,in a 3D setting,viable osteoblastic cells,osteocytic cells,and appropriate expression of osteoblast/osteocyte-derived mRNA and proteins,and mineral *** co-culture of androgen receptordependent/ independent cell lines (LNCaP,C4-2B,and PC3) led cancer cells to display functional and molecular features as observed in ***-cultured cancer cells showed increased affinity to the microtissues,as a function of their bone metastatic *** led to alkaline phosphatase and collagen-I upregulation and sclerostin downregulation,consistent with the clinical marker profile of osteoblastic bone *** showed a significant adaptive response under androgen deprivation in the microtissues,with the notable appearance of neuroendocrine transdifferentiation features and increased expression of related markers (dopa decarboxylase,enolase 2).Androgen deprivation affected the biology of the metastatic microenvironment with stronger upregulation of androgen receptor,alkaline phosphatase,and dopa decarboxylase,as seen in the transition towards *** unique microtissues engineered here represent a substantial asset to determine the involvement of the human bone microenvironment in prostate cancer progression and response to a therapeutic context in this microenvironment.

关键词： engineering osteoblastic metastases the adaptive response metastatic microenvironment

文化与幼儿教育的澳大利亚视角:多元文化趋势

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学前教育研究 2004年第7期 13-14页

作者： joan Waters 乔梁世界学前教育组织亚太地区华东师范大学学前教育系

大多数的澳大利亚儿童在5岁左右进入小学之前,会在幼儿园或者学前机构里待上1～2年.30多年前的澳大利亚幼儿园活动,迄今仍能代表澳大利亚学前教育的特点.例如第二次世界大战前,澳洲学前教育的情景是这样的:在家里一个由壁炉、水池、炖... 详细信息

大多数的澳大利亚儿童在5岁左右进入小学之前,会在幼儿园或者学前机构里待上1～2年.30多年前的澳大利亚幼儿园活动,迄今仍能代表澳大利亚学前教育的特点.例如第二次世界大战前,澳洲学前教育的情景是这样的:在家里一个由壁炉、水池、炖锅、刀叉等布置的角落里,儿童摆弄着洋娃娃的小床以及面色粉红的洋娃娃,唱着以袋鼠和树袋熊为主题的歌曲;讲给孩子们的故事大多关于眼前偏远地区的日常生活.

关键词：幼儿教育多元文化教育权利教学评估教学语言

Predictive clinical features of cardioembolic infarction in patients aged 85 years and older

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journal of Geriatric Cardiology 2019年第11期16卷 793-799页

作者： Ana Maria Carbajo-García jonatan Cortés AdriàArboix joan Massons Laura Díez enric Vergés jordi Arboix-Alió Luís García-eroles Cerebrovascular Division Department of NeurologyHospital Universitari del Sagrat CorUniversitat de BarcelonaBarcelonaCataloniaSpain Department of Sports Sciences Ramon Llull UniversityFPCEE BlanquernaBarcelonaCataloniaSpain Director d’Organitzaciói Sistemes d’Informació Gerència Territorial Metropolitana NordInstitut Catalàde la SalutBarcelonaCataloniaSpain

Objective To assess predictive clinical factors of cardioembolic infarction in very old patients(85 years of age and older).Methods Prospective hospital-based stroke registry("The Sagrat Cor Hospital of Barcelona Stroke Registry")is an acute-care teaching hospital in Barcelona,Catalonia,*** 956 first-ever cardioembolic stroke patients included in the stroke registry over a 24-year period,639 were younger than 85 years of age and 317 were 85 years or older(mean age:88.9 years).Demographics,clinical characteristics,risk factors and early outcome were *** of cardioembolic infarction in the oldest age group were assessed by multivariate *** In a logistic regression model based on demographics,risk factors,clinical features and complications,female gender(odds ratio[OR]=1.74,95%confidence interval[CI]:1.27–2.39),heart failure(OR=2.27,95%CI:1.46–3.56),altered consciousness(OR=1.76,95%CI:1.28–2.42),and infectious complications(OR=2.01,95%CI:1.39–2.91)were predictors of cardioembolic stroke in the oldest age *** contrast,heavy smoking,heart valve disease,hypertension,headache,early seizures,sensory deficit,and involvement of the posterior cerebral artery were independently associated with cardioembolic stroke in the younger *** Identification of a differential clinical profile of cardioembolic stroke between patients aged 85 years or more and those younger than 85 years helps clinicians to the optimal management of ischemic infarction in the oldest segment of the population.

关键词： Cardioembolic stroke Clinical features Ischemic infarction Stroke Very old patients

Reproductive Health Needs of Women Living with HIV/AIDS in Yaounde, Cameroon

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World journal of AIDS 2014年第1期4卷 8-14页

作者： Robinson e. Mbu William A. Takang Hortence j. Fouedjio ekane joan Flobert Y. Fouelifack Florence N. Tumasang Rebecca N. Tonye Robert j. I. Leke Department of Obstetrics and Gynecology Faculty of Health Sciences University of Bamenda Bamenda Cameroon Department of Obstetrics and Gynecology Faculty of Medicine and Biomedical Sciences University of Yaounde 1 Yaounde Cameroon Department of Obstetrics and Gynecology Faculty of Medicine and Biomedical Sciences University of Yaounde 1 Yaounde Cameroon Maternity Unit Central Hospital Yaounde Cameroon Maternity Unit Central Hospital Yaounde Cameroon

The population plagued with the HIV/AIDS pandemic in Cameroon is young, a generation that may desire or control fertility. For those who may become pregnant, the desire to have children may not be there. We carried out this study to look at the picture of the reproductive health needs of women living with HIV/AIDS in our setting. In this cross-sectional non-analytic design that lasted for three years, we employed both qualitative and quantitative methods to collect data from them after receiving ethical clearance (N221/CM/2009) from the National ethics Committee. Consenting HIV infected women who were attending the “HIV Day Care” clinics and those who delivered and were in the post partum wards in four of our major hospitals in Yaounde were enrolled. Interviews were individualized. We used both CSPro version 4.1 and Statistical Package for Social Sciences (SPSS) version 19.0 softwares for data analysis. Four hundred and fifteen (415) women were enrolled;the mean age was 29 ± 7.8 years;the most represented age group was 24 -29 years. They were single (36.14%), well educated (5 out of 10 had attained university level of education), 61.20% revealed that their partners knew their HIV status, 82.4% believed that screening for cancer of the cervix was necessary for their status and 47.70% would want to be screened for some or all STIs. About 36.86% had the desire to have children, 57.1% of those who delivered did not plan to have the pregnancies out of which 82% would have wanted a modern method of contraception but did not have (82% unmet needs). Modern contraceptive use was associated with age and individual characteristics such as level of education. It was 64.34% among women who had secondary level of education and below as against 35.66% among those who had high school level of education and above. Contraceptive use was also high among women who were unmarried as against those who were married (89.64% vs 10.36%). The desire to have children decreased as age increased

关键词： Reproductive Health Needs Family Planning Unmet Needs Cancer of the Cervix Sexually Transmitted Infections

Kinetics of <i>Candida albicans</i>and <i>Staphylococcus aureus</i>Biofilm Initiation on Herpes Simplex Virus (HSV-1 and HSV-2) Infected Cells

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Advances in Microbiology 2020年第11期10卷 583-598页

作者： Balbina j. Plotkin Ira M. Sigar Amber Kaminski jessica Kreamer Brent Ito joan Kacmar Department of Microbiology and Immunology Midwestern University Downers Grove USA

This study examines the kinetics of S. aureus and C. albicans adherence as it relates to HSV replication and corresponding dynamic display of shared receptors. HeLa cells infected for various times with HSV-1 gL86 or HSV-2 333gj-(MOI 50) were incubated with S. aureus ATCC 25923 or C. albicans yeast and CFU measured. Over time, S. aureus adherence to HSV-1 infected cells was relatively stable for 45 min then decreased to 0.8 of virus-free control, before cycling at 15-to-30 min intervals. In contrast, staphylococcal adherence to HSV-2 infected cells proceeded at a more gradual rate, increasing to control levels at ~105 min before decreasing to a nadir at 165 min. Yeast adherence to HSV-1 infected cells remained relatively unchanged for the first 75 min then increased 2-fold before returning to its original level. This pattern is repeated over the next 90 min. While a similar pattern with C. albicans and HSV-2 was measured, it occurred more rapidly. Our model shows that while the interaction of both HSV-1 and HSV-2 with S. aureus is both dynamic and inhibitory, C. albicans interaction with HSV-2 is more permissive than HSV-1. However, the interaction of both microbes with HSV-infected cells in this model system appears to be independent of α5B1, CD36 and HSP60 viral-regulated receptor expression. These findings indicate that microbiome interactions across taxonomic kingdoms are more complex than previously thought.

关键词： Polymicrobic Microbiome Biofilm Adherence Herpes Simplex Virus Staphylococcus aureus Candida albicans

exploring Agritourism experience and Perceptions of Pork Production

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Agricultural Sciences 2016年第4期7卷 239-249页

作者： Ann M. Cummins Nicole j. Olynk Widmar Candace C. Croney joan R. Fulton Department of Agricultural economics Purdue University West Lafayette IN USA College of Veterinary Medicine Purdue University West Lafayette IN USA

The interest of consumers in farming activities is evident and agricultural producers have responded to this increasing interest in a number of ways, including inviting visitors to farm operations through tourism or farm visits. Livestock industries, in particular, are interacting with the public in numerous ways, including via marketing channels for their products, interacting with community leaders and community members in regard to location siting and regulations, and inviting people onto their operations via agritourism. An improved understanding of who visits agricultural locations (particularly livestock operations) and consumers’ perceptions about livestock agriculture is needed in order to begin to understand the possible relationships between on-farm experiences and consumers’ perceptions. Thus, it is important to gain a deeper understanding in consumers’ interests, including their levels of concern for production process attributes, such as animal welfare, relative to product attributes like price and taste. This analysis investigates the demographics of consumers who have (and have not) visited various agritourism operations, studies differences in preferences for (or perceptions of) animal welfare relative to other pork attributes between consumers who have or have not visited a livestock operation, as well as amongst consumers with varying levels of involvement in household food production. Indeed the relationships explored are between having visited a livestock operation and the perceptions. This study found that 69% of participants had visited a livestock operation (pig farm, dairy farm, and/or horse farm) at some point. The majority of respondents agreed that agriculture was an important industry, yet, those who had visited livestock operations were more likely to note concerns about the impact of livestock operations on water quality in their county.

关键词： Agritourism Animal Welfare Best-Worst Scaling Pork Production

嗜酸性粒细胞性食管炎：管理进展及面临的困惑

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英国医学杂志中文版 2018年第7期21卷 388-401页

作者： joan W Chen john Y Kao 夏志伟(译) Division of Gastroenterology and Hepatology Department of Internal Medicine University of Michigan Ann Arbor M148109-5362 USA 北京大学第三医院消化内科

嗜酸性粒细胞性食管炎是由过敏原驱动、免疫介导的慢性疾病。近年来，大家逐步认识到该病是成人和儿童发生吞咽困难及上消化道症状的重要原因。时该病的遗传及环境因素、相关的炎症背景、食管改变的远期并发症等方面的资料逐步丰富。本... 详细信息

嗜酸性粒细胞性食管炎是由过敏原驱动、免疫介导的慢性疾病。近年来，大家逐步认识到该病是成人和儿童发生吞咽困难及上消化道症状的重要原因。时该病的遗传及环境因素、相关的炎症背景、食管改变的远期并发症等方面的资料逐步丰富。本文主要总结了成人嗜酸性粒细胞性食管炎的最新进展，讨论通过微侵入的方法替代反复活检来判断疾病的活动程度的尝试，对采用现有方法如阻抗和腔内成像等技术检测黏膜完整性及食管功能改变的研究进行总结，探讨质子泵抑制剂时嗜酸性粒细胞性炎症的疗效差异。一临床治疗研究仍然支持应用局部糖皮质激素和食物剔除疗法作为该病的一线治疗方法。本文还将讨论优化食物剔除疗法以缩短饮食限制时间并降低饮食限制的程度。展望未来，目前对嗜酸性粒细胞性食管炎发病机制的理解已有可能支持进一步研发特异性的生物治疗。

关键词：管理食道曙红