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Polyethylene glycol 35 ameliorates pancreatic inflammatory response in cerulein-induced acute pancreatitis in rats

World Journal of Gastroenterology 2020年第39期26卷 5970-5982页

作者： Ana Ferrero-Andrés Arnau Panisello-Roselló joan Roselló-Catafau Emma Folch-Puy Experimental Pathology Department Institut d'Investigacions Biomèdiques de Barcelona-Consejo Superior de Investigaciones científicasBarcelona 08036CataloniaSpain Experimental Pathology Department Institut d'Investigacions Biomèdiques de Barcelona-Consejo Superior de Investigaciones científicasCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasInstitut d'Investigacions Biomèdiques August Pi i SunyerBarcelona 08036CataloniaSpain

BACKGROUND Acute pancreatitis(AP)is a sudden inflammatory process of the pancreas that may also involve surrounding tissues and/or remote *** and parenchymal cell death are common pathological features of this condition and determinants of disease *** glycols(PEGs)are nonimmunogenic,non-toxic water-soluble polymers widely used in biological,chemical,clinical and pharmaceutical *** To evaluate the protective effect of a 35-kDa molecular weight PEG(PEG35)on the pancreatic damage associated to cerulein-induced acute pancreatitis in vivo and in *** Wistar rats were assigned at random to a control group,a cerulein–induced AP group and a PEG35 treatment *** was induced by five hourly intraperitoneal injections of cerulein(50μg/kg/bw),while the control animals received saline ***35 was administered intraperitoneally 10 minutes before each cerulein injection in a dose of 10 mg/*** AP induction,samples of pancreatic tissue and blood were collected for ***42J pancreatic acinar cells were treated with increasing concentrations of PEG35 prior to exposure with tumor necrosis factorα(TNFα),staurosporine or *** severity of AP was determined on the basis of plasma levels of lipase,lactate dehydrogenase activity,pancreatic edema and histological *** evaluate the extent of the inflammatory response,the gene expression of inflammation-associated markers was determined in the pancreas and in AR42J-treated ***-induced cell death was also measured in models of in vivo and in vitro pancreatic *** Administration of PEG35 significantly improved pancreatic damage through reduction on lipase levels and tissue edema in cerulein-induced AP *** increased associated inflammatory response caused by cerulein administration was attenuated by a decrease in the gene expression of inflammation-related cytokines and inducible nitric oxide synthase enzyme in the *** contr

关键词： Acute pancreatitis Inflammation Polyethylene glycols Cytokines AR42J cells Cell death

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Complementary examinations other than neuroimaging and neurosonology in acute stroke

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World Journal of Clinical Cases 2017年第6期5卷 191-202页

作者： Adrià Arboix Víctor Obach Maria José Sánchez joan Massons Cerebrovascular Division Department of Neurology Hospital Universitari del Sagrat Cor University of Barcelona Acute Stroke Unit Department of Neurology Hospital Clínic University of Barcelona

The etiologic diagnosis of cerebrovascular diseases requires non-routine complementary examinations to be performed. Thus, in specific cases, after neuroimaging(computed tomography/magnetic resonance imaging cerebral scan sequences) and neurosonology(Doppler test of the supra-aortic trunks, transcranial echography and echocardiography), which academically allow us to classify the patients according to their etiologic stroke subtype, further examinations must be used to make a correct etiologic diagnostic. The present review aims to update knowledge about the usefulness of the different tests of blood and urine, plain chest radiography, X-ray of the spine, skull and abdomen, lumbar puncture, electroencephalography, evoked potentials, polysomnography, and pathologic examination after biopsy of the artery, skin, muscles, nerves, meninges, and brain, in the management of patients who have suffered an acute stroke.

关键词： Complementary examinations Cerebrovascular disorders Acute stroke Diagnostic techniques Blood biochemistry Polysomnography

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Improving the Quality of Care in Chinese Family Planning Programme

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China Population Today 1994年第5期11卷 5-8页

作者： Jiang Yiman Geng Qian joan Haffey Elaine Douglas

The project is afecting in a positive way the quality of care in the family planning programme in man *** 1992,approximately 40,000 family planning workers and volunteers at the county,township and village levels have been trained in IPC/C knowledge and ***-workshop evaluation shows that these workers understand what"informed choice"is and why counseling is important to a family planning *** from regular monitoring visits and a mid-term evaluation shows that they also have begun using their newly acquired IPC/C skills in their daily work to help clients choose contracep-tive methods that are appropriate to their unique situations.

关键词： Family

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Real-Time Streaming Relay Mechanism for P2P Conferences on Hierarchical Overlay Networks

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Journal of Electronic Science and Technology 2019年第3期17卷 242-251页

作者： Hui-Kai Su Jian-Ting Pan Kim-joan Chen Marek R.Ogiela Hsing-Chung Chen the Department of Electrical Engineering National Formosa UniversityYunlin 632 Dray Tec Corporation Hsinchu 30041 the Department of Electrical Engineering National Chung Cheng UniversityChiayi 621 Akademia Gorniczo-Hutnicza University of Science and Technology Krakow 30-059 the Department of Computer Science and Information Engineering and the Department of Bioinformatics and Medical Engineering Asia UniversityTaichung 41354 the Department of Medical Research China Medical UniversityTaichung 40402

A peer-to-peer (P2P) multimedia conferencing service is operating that users share their resources to each other on the Internet. It can solve the problem in the centralized conferencing architecture, such as the centralized loading, single point error, and expensive infrastructure. However, P2P networks have the problem that a peer has a difference between the physical location and logical location in the overlay network. In the viewpoint of P2P networks, the nearest conference resource may be far away geographically. The P2P-session initiation protocol (P2P-SIP) multimedia conference is to construct an application-based logical multicast network efficiently according to physical network information. Thus, this paper proposes a real-time streaming relay mechanism for P2P conferences on hierarchical overlay networks. The real-time streaming relay mechanism can improve the transportation efficiency of conferencing stream exchange well based on the application-layer multicast (ALM) structure and the hierarchical overlay networks.

关键词： Application-layer conferences hierarchical networks multimedia conferences path recovery peer-to-peer(P2P) session initiation protocol(SIP)

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How to protect liver graft with nitric oxide

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World Journal of Gastroenterology 2011年第24期17卷 2879-2889页

作者： Hassen Ben Abdennebi Mohamed Amine Zaoualí Izabel Alfany-Fernandez Donia Tabka joan Roselló-Catafau Laboratory of Human Physiology Faculty of PharmacyUniversity of Monastir Unit of Experimental Hepatic IschemiaReperfusion Institut of d'Investigacions Biomèdiques de BarcelonaConsejo Superior de Investigaciones Científicas Unitat de Transplantament de Fetge i Viabilitat de l'Empelt Institut d'Investigacions Biomèdiques August Pi i Sunyer

Organ preservation and ischemia reperfusion injury associated with liver transplantation play an important role in the induction of graft injury. One of the earliest events associated with the reperfusion injury is endothelial cell dysfunction. It is generally accepted that endothelial nitric oxide synthase （e-NOS） is cell-pro- tective by mediating vasodilatation, whereas inducible nitric oxide synthase mediates liver graft injury after transplantation. We conducted a critical review of the literature evaluating the potential applications of regulating and promoting e-NOS activity in liver preservation and transplantation, showing the most current evidence to support the concept that enhanced bioavailability of NO derived from e-NOS is detrimental to ameliorate graft liver preservation, as well as preventing subse- quent graft reperfusion injury. This review deals mainly with the beneficial effects of promoting ＂endogenous＂ pathways for NO generation, via e-NOS inducer drugs in cold preservation solution, surgical strategies such as ischemic preconditioning, and alternative ＂exogenous＂ pathways that focus on the enrichment of cold storage liquid with NO donors. Finally, we also provide a basic bench-to-bed side summary of the liver physiology and cell signalling mechanisms that account for explaining the e-NOS protective effects in liver preservation and transplantation.

关键词： Cold ischemia reperfusion injury Endotheli-al nitric oxide synthase Nitric oxide Liver graft preser-vation Ischemic preconditioning Liver transplantation

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STUDENTS’ PROCESSING OF AND ATTITUDES TOWARDS FEEDBACK ON THEIR WRITTEN WORK

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Chinese Journal of Applied Linguistics 1996年第1期19卷 94-102页

作者： joan Fleming Kong Dehui joan Fleming Yang Yuchen Northeast Normal University

IntroductionThe aim of our Pre-Service Senior Middle School Teacher Training (PRESET SMSTT) project,whichis now in its second year,is to introduce more communicative teaching methodology and materialsinto the first an... 详细信息

关键词：月池男犯

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A Journey Through AIDS With My Daughter

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英语学习 1998年第12期 13-18页

作者： joan Hurley

It was a beautiful springmorning full of thepromise of another lovelyMelbourne day.I had not sleptvery much at all that night,as Iwas extremely worried about mydaughter Caroline’s ***,Frank(a senior patholo-gist at t... 详细信息

关键词：艾滋病 A Journey Through AIDS With My Daughter

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Role of microfluctuations in accommodation: a novel approach to reduce non-accommodative noise

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 681-684页

作者： Núria Lupón joan Gispets Genis Cardona Alba Tàpia Hector Abril Department of Optics and Optometry Universitat Politècnica de Catalunya Applied Optics and Image Processing Research Group Universitat Politècnica de Catalunya

Accommodative response and its possible role in myopia development has been explored through the study of the microfluctuations(MFs) of accommodation, which are commonly divided in high(1.0 to 2.3 Hz) and low(0.1 to 0.6 Hz) frequency components. Previous research efforts have evidenced that a certain percentage of the amplitude of MFs seems not to originate in the accommodative response. We aimed to develop and test a new approach to reduce this non-accommodative noise. For this purpose, ten healthy participants were enrolled to determine the difference between the amplitude of MFs at near and distance for each range of frequencies, which was defined as the relative amplitude of MFs. The findings support the exploration of the relative rather than absolute values of the amplitude of MFs to better understand the contribution of both accommodative and non-accommodative factors to MFs.

关键词： accommodation cycloplegia microfluctuations myopia photorefraction

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The Significance of Proper Pour Point Depressant Selection when Formulating Engine Oils to Meet the ILSAC GF-5 Specification

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润滑油 2011年第2期26卷 30-35页

作者： joan Souchik Evonik RohMax USA

Pour point depressants(PPDs),also know as wax crystal modifiers,are polymeric materials that when added to a mineral based lubricant can significantly improve the low temperature low shear properties or pumpability of an *** many years the lubricant industry has set requirements for pumpability of engine oils,with the most well known requirement being the ASTM D4684 MRV TP-1 specification within SAE *** has gone a step further in their GF-4 and GF-5 specifications by requiring these generations of oil to be tested for pumpability after severe *** the number and severity of pumpability tests increase the need for proper PPD selection becomes very *** paper will present a brief history of pumpability and the tests used to measure low temperature shear viscosity,including the new ROBO test for aged *** will be presented to show that,with proper PPD selection,an oil can easily be formulated to meet all the low temperature low shear requirements of SAE and ILSAC.

关键词： PPD ROBO MRV TP-1

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Mallory-Denk body pathogenesis revisited

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World Journal of Hepatology 2010年第8期2卷 295-301页

作者： Samuel W French Fawzia Bardag-Gorce Barbara A French joan Oliva Department of Pathology Harbor-UCLA Medical Center

This editorial reviews the recent evidence showing that Mallory-Denk bodies(MDBs)form in hepatocytes as the result of a drug-induced shift from the 26s proteasome formation to the immunoproteasome *** shift is the result of changes in gene expression induced in promoter activation,which is induced by the IFNγ and TNFa signaling *** activates TLR 2 and 4 *** TLR signaling pathway stimulates both the induction of a cytokine proinflammatory response and an up regulation of growth *** MDB-forming hepatocytes proliferate as a result of the increase in growth factor expression by the MDBforming cells,which selectively proliferate in response to drug *** of these mechanisms are induced by drug toxicity,and are prevented by feeding the methyl donors SAMe and betaine,supporting the epigenetic response of MDB formation.

关键词： Toll-like receptor Proinflammatory Methyl donors Epigenetic processes Drug toxicity 26s Proteasome Immunoproteasome

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