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Does HSP27 injection induce glaucoma damage in mice?

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Neural Regeneration Research 2024年第11期19卷 2347-2348页

作者： Stephanie C.joachim Sabrina Reinehr Experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

In a further aging society,excellent eyesight is an integral part of overall well-being and quality of *** good vision is crucial to maintaining mobility,independence,and mental *** can be several reasons for visual impairment in elderly people,these include age-related macular degeneration,the leading cause of vision loss among older adults,cataract,glaucoma,diabetic retinopathy,retinal detachment,and others.

关键词： HSP27 injection damage

Control of Canine Endoparasites,Especially Isospora spp.,with Procox^(■) in Naturally Infected Puppies:Parasitological,Bacteriological and Health Parameters

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Open Journal of Veterinary Medicine 2013年第2期3卷 121-130页

作者： Barbara Anna Rauscher Sabine Schafer-Somi Monika Ehling-Schulz Karin Mostl Stefanie Handl Barbara Hinney joachim spergser Roland Schaper Anja joachim Institute of Parasitology Department of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Centre for Artificial Insemination and Embryo Transfer Department for Small Animals and HorsesUniversity of Veterinary Medicine ViennaViennaAustria Functional Microbiology IBMHDepartment of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Institute of Virology Department of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Institute of Animal Nutrition Department for Farm Animals and Veterinary Public HealthUniversity of Veterinary Medicine ViennaViennaAustria Clinical Microbiology and Infection Biology IBMHDepartment of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Bayer Animal Health GmbH MonheimGermany

The effect of Procox? (Bayer, emodepside/toltrazuril suspension for dogs) against natural infections with Isospora spp. was investigated. Two groups were treated either with 0.5 ml suspension/kg of body weight (0.45 mg emodepside and 9 mg toltrazuril/kg of body weight) in the 3rd, 5th and 7th week of life (w.o.l.) (Procox? group;n = 28) or with a control anthelminthic (Dewormed Control group;n = 26). Animals were surveyed weekly from the 3rd w.o.l. by coproscopy and clinical examination. Faecal samples were examined microbiologically from the 4th to the 8th w.o.l. and faecal inflammatory markers canine calprotectin and canine S100A12 were measured in the 8th w.o.l. Specific antibody titres were evaluated in serum samples from five litters before and after vaccination against canine distemper virus and canine parvovirus 2. The prevalence of Isospora-positive animals increased to 67% in the Dewormed Control group (n = 15 puppies from four parasite-positive litters), while in the Procox? group (n = 15 puppies) it was less than 34% with significantly lower excretion (p ? was easily applied and effective;adverse effects did not occur. The level of seroconversion or titre increase upon vaccination was higher in parasite-free animals (91%) compared to Procox?-treated puppies (30%) and the Control animals (10%). Animals from parasite-free litters showed significantly different excretion patterns for haemolytic Escherichia coli and Clostridium perfringens, while there was no difference between Procox?-treated and Control animals. In some animals kept under poor hygienic conditions diarrhoea was noted in association with C. perfringens, E. coli or Salmonella. Concentrations of inflammatory markers in the faeces did not significantly differ between the Procox? and the Control group. Adequate control of parasitic and bacterial infections in suckling puppies requires both antiparasitic treatment and hygiene. Even when parasites do not cause overt effects treatment is recommended

关键词： Dog Emodepside Gut Health Isospora Toltrazuril Toxocara Vaccination

Prevalence and intensity of urinary schistosomiasis and soil-transmitted helminths among women of reproductive age in Mwaluphamba,Kwale

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 71-83页

作者： Samuel M.Ngui Joseph M.Mwangangi joachim Richter Josephine W.Ngunjiri Department of Biological Sciences University of EmbuKenya Medical Entomology Kenya Medical Research Institute(KEMRI)Center for Geographic Medicine Research Coast KilifiKenya Institute of International Health Global Health CenterCharitéUniversity MedicineBerlinCorporate Member of Free University and Humboldt University and Berlin Institute of HealthBerlinGermany Swiss Tropical and Public Health Institute BaselSwitzerland Tropical and Infectious Diseases Department of Biological sciencesUniversity of EmbuKenya

Objective:To assess the epidemiology of urinary schistosomiasis and soil-transmitted helminthiasis among women of reproductive age in Mwaluphamba,Kwale County,***:A community-based cross-sectional study design was employed to randomly sample 422 women of reproductive age(15-<50 years)from four villages in Mwaluphamba *** specimens were collected and examined using the Kato-Katz method,while filtration technique was used to analyze urine ***’sociodemographic details were obtained using a standardized ***:Urinary schistosomiasis prevalence was at 4.7%(20/422,95%CI 2.8%-6.9%)while the prevalence of soil-transmitted helminthiasis infection was 4.5%(19/422,95%CI 2.6%-6.7%).The infection intensities of urinary schistosomiasis among the study participants ranged from 1 to 120 eggs/10 mL of urine with median egg count of 18.45 eggs/10 *** patients were diagnosed with light infection,of 56.16 egg/gram and 48.48 egg/gram for Trichuris trichiura and hookworms,*** without latrines had 15.7 times higher risk of having urinary schistosomiasis compared to those with a ***,use of surface water(aOR=1.0,95%CI 0.2-1.4,P=0.010)and crossing the river to go to a place(aOR=1.1,95%CI 0.3-1.6,P=0.009)were statistically significant risk factors for getting urinary *** bivariable regression analysis,defecating around the water source(OR=4.3,95%CI 1.5-12.9)had a statistically significant association with the prevalence of soil-transmitted helminthiasis(P=0.008).Conclusions:This study has given an insight on the prevalence and intensity of urinary schistosomiasis and soil-transmitted helminthiasis in Mwaluphamba location that form a basis for strengthening the control and elimination programmes for these neglected tropical diseases.

关键词： Urinary schistosomiasis Prevalence Soiltransmitted helminths Mwaluphamba

Building Blocks of Nature

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第3期10卷 1226-1303页

作者： Hans joachim Dudek Retired Auf dem Komp Germany

By means of a representation of the elementary objects by the Lagrange density and by the commutators of the communication relations, correlations can be formed using the Fourier transform, which under the conditions of the Hamilton principle, describes correlation structures of the elementary objects with oscillator properties. The correlation structures obtained in this way are characterized by physical information, the essential component of which is the action. The correlation structures describe the physical properties and their interactions under the sole condition of the Hamilton’s principle. The structure, the properties and the interactions of elementary objects can be led back in this way to a fundamental four dimensional structure, which is therefore in their different modifications the building block of nature. With the presented method, an alternative interpretation of elementary physical effects to quantum mechanics is obtained. This report provides an overview of the fundamentals and statements of physical information theory and its consequences for understanding the nature of elementary objects.

关键词： Hamilton Principle as Global Law in Physics Physical Information Generated by Action Correlation Space Mass and Charge Formation Interpretation of Physical Effects

矩形边界限定形式的感应电机低开关频率预测控制研究

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中国电机工程学报 2024年第8期44卷 3278-3286,I0029页

作者：齐昕张家宁 HOLTZ joachim 田柏轩任佳仕王辰宇周珂北京科技大学机械工程学院北京市海淀区100083 伍珀塔尔大学电机与驱动实验室德国伍伯塔尔42119 北京科技大学顺德研究生院广东省佛山市528399 北京科技大学高等工程师学院北京市海淀区100083

圆形边界限定形式预测控制对电流畸变的限定在各方向均相同,无法通过增大边界圆半径进一步降低开关频率。因此,该文提出一种矩形边界限定形式的预测控制方法。首先,深入分析感应电机数学模型,发现感应电机转子子系统的低通物理特性,以... 详细信息

圆形边界限定形式预测控制对电流畸变的限定在各方向均相同,无法通过增大边界圆半径进一步降低开关频率。因此,该文提出一种矩形边界限定形式的预测控制方法。首先,深入分析感应电机数学模型,发现感应电机转子子系统的低通物理特性,以及励磁电流波动对电磁转矩的影响不显著;其次,利用该特性,将限定边界改为矩形,对转矩电流与励磁电流进行独立约束,适度增加励磁电流畸变允许限值,扩大电流轨迹运动范围,延长开关状态切换时长;再次,探究电流矢量梯度同边界约束间的数学关系,提出该方法下电压矢量筛选与寻优准则,筛选出最优矢量;最终,进行实验对比。实验结果证明,在相同系统动态特性和转矩波动下,相较于圆形边界限定策略,矩形边界限定策略可以进一步降低开关频率。

关键词：矩形边界低开关频率预测控制感应电机

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Effect of the Implementation of Emonc in the Reduction of Maternal Deaths in the Department of Collines from 2018 to 2022

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Open Journal of Obstetrics and Gynecology 2024年第2期14卷 259-266页

作者： joachim Aifa Florence Abraham Roger Klikpezo Edgard-Marius Ouendo Badirou Aguemon Faculty of Health Sciences of Cotonou Department of Public Health Cotonou Benin Nursing and Midwifery Training Institute University of Parakou Parakou Benin Assistant in Gynecology-Obstetrics FM-University of Parakou Parakou Benin Full Professor of Public Health and Epidemiology Ouidah Regional Institute of Public Health Ouidah Benin Full Professor of Public Health Faculty of Health Sciences of Cotonou Cotonou Benin

Background: Maternal and neonatal mortality remains a public health problem in Benin. Each year, approximately 1500 maternal deaths and more than 12,000 newborn deaths are recorded there. In order to correct the situation, strategies such as the implementation of Emergency Obstetric and Neonatal Care (EmONC) were initiated. Objective: Determine the rates of maternal deaths in EmONC centers in the Collines department from 2018 to 2022. Framework and Methods: The study took place in Benin precisely in the Collines department. This was a descriptive cross-sectional study. Data collection was carried out during the first two weeks of January 2023 and covered data from the 09 Basic Emergency Obstetric and Neonatal Care centers (BEMONC) and the Obstetric and Neonatal Care centers of Complete Emergency (CEmONC) of the Collines department from 2018 to 2022. An estimate of the ratios of maternal deaths occurring at the level of the EmONC centers of the Collines department from 2018-2022 was carried out followed by constructive suggestions. Results: During the five years (2018 to 2022), the Collines department recorded 42,582 live births with 148 maternal deaths, i.e. a ratio of 348 maternal deaths per 100,000 live births. Between 2018 and 2022, the highest maternal death ratio was recorded in 2019, i.e. 425 maternal deaths per 100,000 live births for all EmONC centers and 607 maternal deaths per 100,000 live births in EmONC centers. The highest maternal death ratio at the BEmONC center level was recorded in 2020, i.e. 129 maternal deaths per 100,000 births. Conclusion: These results suggest that despite the implementation of EmONC in the Collines department, maternal deaths have not decreased. To improve these outcomes for a reduction in maternal deaths, urgent action must be taken.

关键词： Effect BEmONC CEmONC Maternal deaths Department of Collines

Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

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多重挑战时期的货币政策

中国金融 2024年第4期 32-33页

作者：约阿希姆·内格尔芦国荣(译) 德意志联邦银行中国人民银行甘肃省分行

最重要的挑战仍是过高的通胀率在欧元体系货币政策面临的多重挑战中,最重要的就是欧元区通胀率在过长的时期内持续运行在较高水平,为此,欧洲中央银行通过连续加息、缩减中央银行资产负债表等货币政策措施来稳定价格和预期。

关键词：欧洲中央银行欧元区通胀率货币政策加息中央银行资产负债表多重挑战欧元体系

Thermal Efficiency Optimization of a Ground Source Heat Pump System by Assistant Preheating/Precooling: A Case Study on a Heating-Load Dominated Building

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Journal of Thermal Science 2022年第6期31卷 1948-1958页

作者： LUO Jin ZHANG Qi PRIESS Anna ROHN joachim Faculty of Engineering China University of Geosciences(Wuhan)Wuhan 430074China GeoZentrum Nordbayern University of Erlangen-NürnbergSchlossgarten 591054 ErlangenGermany

Operation strategies of Ground Source Heat Pump System(GSHPS) such as continuous or intermittent approaches have been extensively studied. In this work, a novel strategy was proposed to maximize the energy efficiency of GSHPS. In this approach, the buildings was first air-conditioned by the preheating/precooling mode and the rest thermal load was covered by the heat pump(HP) mode. The system performance can then be optimized by considering the combination of these two operating modes. A case study was made to examine the thermal performance of a GSHPS installed in Nuremberg, Germany. Thermal performance of the HP and the preheating/precooling operating modes was examined. The system was optimized by deploying the assistant preheating/precooling approach and over one-year period monitoring showed that the seasonal Coefficient of Performance(COP) of the GSHPS was 4.12 in winter and 5.01 in summer. These COP values are higher than that of the conventional GSHPS. Thus, this proposed strategy could be an efficient way to improve the thermal performance of GSHPS.

关键词： ground source heat pump system ground-air heat exchanger ground temperature response preheating and precooling