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Long-term results of endoscopic balloon dilatation of lower gastrointestinal tract strictures in Crohn's disease:A prospective study

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World Journal of Gastroenterology 2009年第21期15卷 2623-2627页

作者： Klaus Stienecker Daniel Gleichmann Ulrike Neumayer H joachim Glaser Carolin Tonus Department of Gastroenterology Herz-Jesu-Hospital Fulda Department of Visceral Surgery Herz-Jesu-Hospital Fulda

AIM:To examine the long-term results of endoscopic treatment in a prospective study conducted over a period of 10 years,1997 to January ***:A total of 25 patients(20 female and five male:aged 18-75 years),with at least one symptom of stricture not passable with the standard colonoscope and with a confirmed scarred Crohn's stricture of the lower gastrointestinal tract,were included in the *** main symptom was abdominal *** endoscopic balloon dilatation was performed with an 18 mm balloon under endoscopic and radiological ***:Eleven strictures were located in the colon,13 at the anastomosis after ileocecal resection,three at the Bauhin valve and four in the *** patients had two strictures and one patient had three *** the 31 strictures,in 30 was balloon dilatation successful in a single endoscopic session,so that eventually the strictures could be passed easily with the standard *** one patient with a long stricture of the ileum involving the Bauhin valve and an additional stricture of the ileum which were 15 cm apart,sufficient dilatation was not *** patient therefore required *** of abdominal symptoms was achieved in all cases which had technically successful balloon dilatation,althoughin one case perforation occurred after dilatation of a recurrent *** follow-up was in the range of 54-118 mo(mean of 81 mo).The relapse rate over this period was 46%,but 64% of relapsing strictures could be successfully dilated *** in four patients was surgery required during this follow-up ***:We conclude from these initial results that endoscopic balloon dilatation,especially for short strictures in Crohn's disease,can be performed with reliable *** is a rare *** is our opinion that in the long-term,the relapse rate is probably higher than after surgery,but usually a second endoscopic treatment can be performed successfully,leading to

关键词： Crohn's disease strictures Balloon dilatation Endoscopy Morbidity Mortality

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History and present status of pulmonary metastasectomy in colorectal cancer

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World Journal of Gastroenterology 2014年第40期20卷 14517-14526页

作者： Tom Treasure Miel Miloevi Francesca Fiorentino joachim Pfannschmidt Clinical Operational Research Unit University College London London WC1E 6BT United Kingdom Clinic for Thoracic Surgery Institute for Pul-monary Diseases of Vojvodina University of Novi Sad Novi Sad 402920 Serbia Department of Cardiothoracic Surgery National Heart and Lung Institute Imperial College London W12 0NN United Kingdom HELIOS Klinikum Emil von Behring Lungenklinik Heckeshorn 14165 Berlin Germany

Clinical practice with respect to metastatic colorectal cancer differs from the other two most common cancers,breast and lung,in that routine surveillance is recommended with the specific intent of detecting liver and lung metastases and undertaking liver and lung resections for their *** trace the history of this approach to colorectal cancer by reviewing evidence for effectiveness from the 1950s to the present *** sources included published citation network analyses,the documented proposal for randomised trials,large systematic reviews,and meta-analysis of observational *** present consensus position has been adopted on the basis of a large number of observational studies but the randomised trials proposed in the 1980s and 1990s were either not done,or having been done,were not *** opinion is the mainstay of current practice but in the absence of randomised trials there remains a possibility of selection *** controlled trials(RCTs)are now routine before adoption of a new practice but RCTs are harder to run in evaluation of already established *** such trial is recruiting and shows that controlled trial are possible.

关键词： Colorectal cancer Metastasectomy Liver resection Pulmonary metastasectomy Oligometastatic state

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基于等效黏弹性模型获取土体最大动剪模量的计算方法

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岩石力学与工程学报 2013年第S2期32卷 4082-4090页

作者：项伟江洎洧 joachim Rohn 中国地质大学教育部长江三峡库区地质灾害研究中心湖北武汉430074 长江科学院水利部岩土力学与工程重点实验室湖北武汉430010 爱尔兰根纽伦堡大学应用地质系

土动力特性参数中,最大动剪切模量Gmax是定量描述土动力学本构最重要的参量之一,现有研究方法通常需较多参量及工程经验方能对其进行半定量的计算,但天然状态条件下土体的Gmax真值是唯一且确定的。为此,结合对土体动力学特性广泛适用性... 详细信息

土动力特性参数中,最大动剪切模量Gmax是定量描述土动力学本构最重要的参量之一,现有研究方法通常需较多参量及工程经验方能对其进行半定量的计算,但天然状态条件下土体的Gmax真值是唯一且确定的。为此,结合对土体动力学特性广泛适用性的基于等效黏弹性理论的修正Davidenkov模型,基于土动三轴试验,提出对该模型中的3个参量多元回归和对Gmax自适应逼近迭代的反分析算法,用于求取Gmax并得到本构方程中所需系数。研究表明:该算法在同时满足Davidenkov模型曲线三参数对测试数据拟合以及反算Gmax残差最小的双重计算约束条件下,对3类土样的动三轴测试数据进行拟合,在规避直接获取Gmax存在困难的情况下,顺利得到各测试样本的动本构模型。

关键词：土力学修正Davidenkov模型最大动剪模量Gmax 自适应逼近算法动力三轴测试

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克立格估计的分析解释与协方差函数的代数确定

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地球科学（中国地质大学学报） 2000年第2期25卷 195-200页

作者：边少锋 joachim Menz 中国科学院测量与地球物理研究所武汉430077 TU Bergakade mie Freiberg

首先引入利用旋转面作为基函数的函数逼近概念 ,在此基础上经过复杂的矩阵推导证明泛克立格法可表示为传统的带权最小二乘多项式拟合与以旋转面作为基函数的函数逼近 ,并在一定条件下 (随机场高度连续无块金效应 )论证了协方差 (即旋转... 详细信息

首先引入利用旋转面作为基函数的函数逼近概念 ,在此基础上经过复杂的矩阵推导证明泛克立格法可表示为传统的带权最小二乘多项式拟合与以旋转面作为基函数的函数逼近 ,并在一定条件下 (随机场高度连续无块金效应 )论证了协方差 (即旋转面 )的参数可通过数学分析的方法确定 ,给出了以高斯函数为例确定协方差函数的两个准则 .

关键词：克立格估计协方差函数地质统计学代数确定

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Is correction of severe hypoalbuminemia necessary in the critically ill？

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Chinese Medical Journal 2008年第22期121卷 2360-2362页

作者： joachim Boldt Department of Anesthesiology and Intensive Care Medicine Klinikum der Stadt Ludwigshafen Bremserstr. 79 D-67063 Ludwigshafen Germany

The rationale for using albumin in the critically ill intensive care unit （ICU） patient showing hypoalbuminemia is to increase colloid oncotic pressure （COP） to prevent extravasation of fluid from the intra- to the extravascular space. Correction of low albumin plasma levels is also justified by the role of albumin for binding and transportation of drugs and for its possibly beneficial role as an oxygen radical scavenger.

关键词： hypoalbuminemia critically ill volume replacement hydroxyethyl starch hypovolemia

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Theory of superfluidity and drag force in the one-dimensional Bose gas

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Frontiers of physics 2012年第1期7卷 54-71页

作者： Alexander Yu. Cherny (1) Jean-Sébastien Caux (2) joachim Brand (3) 1. Bogoliubov Laboratory of Theoretical Physics Joint Institute for Nuclear Research 141980 Dubna Moscow region Russia2. Institute for Theoretical Physics Science Park 904 University of Amsterdam 1090 GL Amsterdam The Netherlands3. Centre for Theoretical Chemistry and Physics and New Zealand Institute for Advanced Study Massey University Private Bag 102904 North Shore Auckland 0745 New Zealand

The one-dimensional Bose gas is an unusual superfluid. In contrast to higher spatial dimensions, the existence of non-classical rotational inertia is not directly linked to the dissipationless motion of infinitesimal impurities. Recently, experimental tests with ultracold atoms have begun and quanti- tative predictions for the drag force experienced by moving obstacles have become available. This topical review discusses the drag force obtained from linear response theory in relation to Lan- dau＇s criterion of superfluidity. Based upon improved analytical and numerical understanding of the dynamical structure factor, results for different obstacle potentials are obtained, including single impurities, optical lattices and random potentials generated from speckle patterns. The dynamical breakdown of superfluidity in random potentials is discussed in relation to Anderson localization and the predicted superfluid-insulator transition in these systems.

关键词： Lieb-Liniger model Tonks-Girardeau gas Luttinger liquid drag force superfluidity,dynamical structure factor

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Formation of crystalline particles from phase change emulsion： Influence of different parameters

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Chinese Journal of Chemical Engineering 2016年第7期24卷 929-936页

作者： Javed Iqbal Zulfiqar Ali Murid Hussain Rizwan Sheikh Khaliq Majeed Asad Ullah Khan joachim Ulrich COMSATS Institute of Information Technology Department of Chemical Engineering Defence Road Off Raiwind Road Lahore Pakistan Martin-Luther-Universitat Halle-Wittenberg Zentrum fur Ingenieurwissenschaften Verfahrenstechnik/TVT D-06099 Halle (Saale) Germany

Solidification or crystallization of phase change emulsion in the form of fine emulsion drops in a direct contact coolant at temperatures below their freezing point was studied. This work is mainly focused on the size and shape of the generated partides from phase change emulsified fats. Size of the particles is the major or key factor being considered during their formation, however, other factors that govern the particle size and shape were also observed. The operating parameters of the process were optimized in order to obtain particles of smaller size ranges in the window of current operating conditions. The crystallization of complex emulsion maffices is very difficult to control in the bulk at desired requirement. Hence, the emulsion drop to particle formation has advan- tage in comparison with the bulk solidification or crystallization. The main objective of this work is to achieve spherical emulsion particles in a direct contact cooling system. Parameters like： stat）ility, characterization, viscos- ity, and the effect of different energy inputs were examined. Moreover, the effects of the capillary size, interracial tension, temperature of the emulsion on the particle size were also monitrored.

关键词： EmulsionParticle formationSizePhase changeInterracial tension

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Liver Fat Scores for Noninvasive Diagnosis and Monitoring of Nonalcoholic Fatty Liver Disease in Epidemiological and Clinical Studies

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1212-1227页

作者： Mona Reinshagen Stefan Kabisch Andreas F.H.Pfeiffer joachim Spranger Department of Endocrinology and Metabolism Campus Benjamin FranklinCharitéUniversity MedicineBerlinGermany Deutsches Zentrum für Diabetesforschung e.V. Geschäftsstelle am Helmholtz-Zentrum MünchenNeuherbergGermany

Nonalcoholic fatty liver disease(NAFLD)is strongly associated with the metabolic syndrome and type 2 diabetes and independently contributes to long-term *** often asymptomatic but reversible,it would require population-wide screening,but direct diagnostics are either too invasive(liver biopsy),costly(MRI)or depending on the examiner’s expertise(ultrasonography).Hepatosteatosis is usually accommodated by features of the metabolic syndrome(***,disturbances in triglyceride and glucose metabolism),and signs of hepatocellular damage,all of which are reflected by biomarkers,which poorly predict NAFLD as single item,but provide a cheap diagnostic alternative when integrated into composite liver fat *** liver index,NAFLD LFS,and hepatic steatosis index are common and accurate indices for NAFLD prediction,but show limited accuracy for liver fat *** indices are rarely *** fibrosis scores are commonly used in clinical practice,but their mandatory reflection of fibrotic reorganization,hepatic injury or systemic sequelae reduces sensitivity for the diagnosis of simple ***-induced liver fat changes are poorly reflected by liver fat indices,depending on the intervention and its specific impact of weight loss on *** limited validity in longitudinal settings stimulates research for new ***,hepatokines,markers of cellular integrity,genetic variants but also simple and inexpensive routine parameters might be potential ***,liver fat indices lack precision for NAFLD prediction or monitoring in individual patients,but in large cohorts they may substitute nonexistent imaging data and serve as a compound biomarker of metabolic syndrome and its cardiometabolic sequelae.

关键词： NAFLD Liver fat indices Fatty liver index Prediction Dietary intervention

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Calcium-Dependent Protein Kinase CPK21 Functions in Abiotic Stress Response in Arabidopsis thaliana

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Molecular Plant 2011年第1期4卷 83-96页

作者： Sandra Franz Britta Ehlert Anja Liese joachim Kurth Anne-Claire Cazale Tina Romeis Department of Plant Biochemistry Institute for Biology Freie Universitat Berlin Koenigin-Luise-Str. 12-16 14195 Berlin Germany Department of Plant Microbe Interactions Max-Planck-lnstil:ute for Plant Breeding Research Carl-von-Linne-Weg 10 50935 Cologne Germany Present address: Laboratoire des Interactions Plantes Micro-organismes (LIPM) UMR CNRS-INRA 25941441 31320 Castanet-Tolosan France

Calcium-dependent protein kinases （CDPKs） comprise a family of plant serine/threonine protein kinases in which the calcium sensing domain and the kinase effector domain are combined within one molecule. So far, a biological function in abiotic stress signaling has only been reported for few CDPK isoforms, whereas the underlying biochemical mechanism for these CDPKs is still mainly unknown. Here, we show that CPK21 from Arabidopsis thaliana is biochemically activated in vivo in response to hyperosmotic stress. Loss-of-function seedlings of cpk21 are more tolerant to hyperosmotic stress and mutant plants show increased stress responses with respect to marker gene expression and metabolite accumulation. In transgenic Arabidopsis complementation lines in the cpk21 mutant background, in which either CPK21 wildtype, or a full-length enzyme variant carrying an amino-acid substitution were stably expressed, stress responsitivity was restored by CPK21 but not with the kinase inactive variant. The biochemical characterization of in planta synthesized and purified CPK21 protein revealed that within the calcium-binding domain, N-terminal EF1- and EF2-motifs compared to C-terminal EF3- and EF4-motifs differ in their contribution to calcium-regulated kinase activity, suggesting a crucial role for the N-terminal EF-hand pair. Our data provide evidence for CPK21 contributing in abiotic stress signaling and suggest that the N-terminal EF-hand pair is a calcium-sensing determinant controlling specificity of CPK21 function.

关键词： Abiotic/environmental stress calcium signaling/transport Arabidopsis CDPK EF-hand.

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Paraesophageal hernia and iron deficiency anemia:Mechanisms,diagnostics and therapy

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World Journal of Gastrointestinal Surgery 2021年第3期13卷 222-230页

作者： Christoph G Dietrich Dolores Hübner joachim W Heise Department of Internal Medicine Bethlehem Center of HealthStolberg D-52222Germany Department of Radiology Bethlehem Center of HealthStolberg D-52222Germany Department of General and Abdominal Surgery Bethlehem Health CenterStolberg D-52222Germany

There is ample clinical evidence suggesting that the presence of large axial or paraesophageal hernias may lead to iron deficiency ***-called Cameron lesions,as well as other small mucosa erosions,in the sliding area of these diaphragmatic hernias lead to invisible chronic blood loss and consequently to iron *** the spectrum of symptoms in these patients is large,anemia is often not the only indication and typically not the primary indication for surgical correction of diaphragmatic *** treatment with proton pump inhibitors and iron substitution can alleviate anemia,but this is not always *** exclude other possible bleeding sources in the gastrointestinal tract,a comprehensive diagnostic program is necessary and reviewed in this ***,we discuss controversies in the surgical management of paraesophageal hernias.

关键词： Iron deficiency anemia Paraesophageal hernia Upside-down stomach Cameron lesions

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