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Expression of c-kit receptor in human cholangiocarcinoma and in vivo treatment with imatinib mesilate in chimeric mice

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World Journal of Gastroenterology 2006年第10期12卷 1583-1590页

作者： Thomas Kamenz Karel Caca Thilo Blüthner Andrea Tannapfel joachim mssner marcus Wiedmann Department of Internal medicine Ⅱ University of Leipzig Philipp-Rosenthal-Str.2704103 LeipzigGermany Institute of Pathology University of Leipzig Liebigstr.2604103 LeipzigGermany

AIm： To investigate the c-kit expression in biliary tract cancer cell lines and histological sections from patients with extrahepatic cholangiocarcinoma （CC） and to evaluate the efficacy of in vitro and in vitro treatment with imatinib mesilate. mETHODS： The protein expression of c-kit in the human biliary tract cancer cell lines mz-ChA-2 and EGI-1 and histological sections from 19 patients with extrahepatic CC was assessed by immunoblotting, immunocytochemistry, and immunohistochemistry. The anti-proliferative effect of imatinib mesilate on biliary tract cancer cell lines mz-ChA-2 and EGI-1 was studied in vitro by automated cell counting. In addition, immunodeficient NmRI mice （Taconic^Tm） were subcutaneously injected with 5 × 10^6 cells of cell lines mzChA-2 and EGI-1. After having reached a tumour volume of 200 mm^3, daily treatment was started intraperitoneally with imatinib mesilate at a dose of 50 mgikg or normal saline （NS）. Tumor volume was calculated with a Vernier caliper. After 14 d, mice were sacrificed with tumors excised and tumor mass determined.RESULTS： Immunoblotting revealed presence of c-kit in mz-ChA-2 and absence in EGI-1 cells. Immunocytochemistry with c-kit antibodies displayed a cytoplasmatic and membraneous localization of receptor protein in mz-ChA-2 cells and absence of c-kit in EGI-1 cells, c-kit was expressed in 7 of 19 （37%） extrahepatic humanCC tissue samples, 2 showed a moderate and 5 a rather weak immunostaining. Imatinib mesilate at a low concentration of 5 μmoliL caused a significant growth inhibition in the c-kit positive cell line mz-ChA-2 （31%）, but not in the c-kit negative cell line EGI-1 （0%）（P〈0.05）. Imatinib mesilate at an intermediate concentration of 10 μmoliL inhibited cellular growth of both cell lines （51% vs 57%）. Imatinib mesilate at a higher concentration of 20 μmoliL seemed to have a general toxic effect on both cell lines. The IC50 values were 9.7 μmoliL and 11 μmoliL, respectively. After 14 d of in vitro treat

关键词： Cholangiocarcinoma Imatinib Tyrosine kinase inhibitor c-kit Chimeric mice

Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis

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World Journal of Gastroenterology 2005年第44期11卷 7001-7006页

作者： Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia morgenstern joachim m(o|¨)ssner Stephan Schreiber maurizio Vecchi Alberto malesci max Reinshagen Robert L(o|¨)fberg Evangelisches Krankenhaus Kalk medizinische Klinik für Hepatologie und Gastroenterologie medizinische Klinik und Poliklinik Ⅱ medizinische Klinik Dep of Int medicine IRCCS Ospedale Policlinico Istituto Clinico Humanitas Innere medizin Karolinska Institute at the IBD unit

AIm： To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy. mETHODS： An open label multicenter study was carried out in 39 patients with active ulcerative colitis （CAI 6-8） despite continuous use of steroids （a minimum total dose of 400 mg prednisone within the last 4 wk）. Patients received a total of five aphereses using a granulocyte adsorptive technique （Adacolumn, Otsuka Pharmaceutical Europe, UK）. Assessments at wk 6 and during follow-up until 4 mo comprised clinical （CAI） and endoscopic （EI） activity index, histology, quality of life （IBDQ）, and laboratory tests. RESULTS： Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 （37.1%） patients achieved clinical remission and 10/35 （28.6%） patients had endoscopic remission （CAI〈4, EI〈4）. Quality of life （IBDQ） increased significantly （24 points, P〈0.01） at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia. CONCLUSION： In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/ monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent.

关键词： Steroid Refractory colitis Ulcerative colitis Granulocyte Apheresis

In memory of joachim messing,a Pioneer in molecular Genetics and Genomics

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molecular Plant 2019年第11期12卷 1419-1421页

作者： Students and Postdocs of joachim messing 机构不祥

We grieve the passing of our beloved and respected mentor,colleague,and friend,***(Jo)messing,a Distinguished University Professor and director of the Waksman Institute of *** made pioneering contributions that underpin the modern fields of molecular genetics and *** invented the,lshotgunn DNA sequencing method along with a set of toolkits for molecular cloning,which he sent out worldwide for free,advancing the genomic era of *** endeavors guided the directions of both fundamental and applications-based research in agriculture,biofuel,and medicine.

关键词： Pioneer passing directions

Automatic Detection of Atrial Fibrillation from Single-Lead ECG Using Deep Learning of the Cardiac Cycle

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Biomedical Engineering Frontiers 2022年第1期3卷 159-170页

作者： Alina Dubatovka joachim m.Buhmann Department of Computer Science ETH ZurichZurichSwitzerland

Objective and Impact *** fibrillation(AF)is a serious medical condition that requires effective and timely treatment to prevent *** explore deep neural networks(DNNs)for learning cardiac cycles and reliably detecting AF from single-lead electrocardiogram(ECG)*** are widely used for diagnosis of various cardiac dysfunctions including *** huge amount of collected ECGs and recent algorithmic advances to process time-series data with DNNs substantially improve the accuracy of the AF ***,however,are often designed as general purpose black-box models and lack interpretability of their *** design a three-step pipeline for AF detection from ***,a recording is split into a sequence of individual heartbeats based on R-peak *** heartbeats are then encoded using a DNN that extracts interpretable features of a heartbeat by disentangling the duration of a heartbeat from its ***,the sequence of heartbeat codes is passed to a DNN to combine a signal-level representation capturing heart ***,the signal representations are passed to a DNN for detecting *** approach demonstrates a superior performance to existing ECG analysis methods on AF ***,the method provides interpretations of the features extracted from heartbeats by DNNs and enables cardiologists to study ECGs in terms of the shapes of individual heartbeats and rhythm of the whole *** considering ECGs on two levels and employing DNNs for modelling of cardiac cycles,this work presents a method for reliable detection of AF from single-lead ECGs.

关键词： recording Deep enable

Impact of renewable energies on the operation and economicsituation of coal fired power stations： Actual situation of coalfired power stations in Germany

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Frontiers in Energy 2017年第2期11卷 119-125页

作者： Hans-joachim KRAUTZ Alexander LISK joachim POSSELT Christian KATZER Department for Power Plant Technology Brandenburg University of Technology Cottbus-Senftenberg 03046 Cottbus Gemany

Due to the fluctuating character of the renewable energy sources the demand of conventional power plants for flexibility is increasing. In the recent years, in Germany there has been a fast rise of production capacity of renewable energies, especially from wind turbines, photovoltaic installations, and biomass plants. The installed nominal power of wind turbines is actually (December 2016) 42 GW and of photovoltaic installations 40?GW. The renewable electric energy production in Germany is about 190?TWh/a, which represents a share of 33% of the yearly demand. The increased need for flexibility affects both the power gradients as well as the minimum load of conventional power plants. Due to this flexibility behaviour, conventional power plants are faced with problems concerning the durability of power plant components, corrosion, more maintenance effort and consequently the overall life expectancy. Another consequence of the increasing share of renewable energies is the decreasing full load operating hours, especially of coal fired and gas power plants. Along with decreasing revenues from the energy exchange market, coal fired power plants are faced with new economically challenges.

关键词： flexible load operation minimal load power gradients power plant maintenance corrosion life expectancy

Combinatorial Dyson-Schwinger equations and inductive data types

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Frontiers of physics 2016年第3期11卷 179-193页

作者： joachim Kock Departament de matemhtiques Universitat Autdnoma de Barcelona Spain

The goal of this contribution is to explain the analogy between combinatorial Dyson-Schwinger equations and inductive data types to a readership of mathematical physicists. The connection relies on an interpretation of combinatorial Dyson-Schwinger equations as fixpoint equations for polynomial functors （established elsewhere by the author, and summarised here）, combined with the now-classical fact that polynomial functors provide semantics for inductive types. The paper is expository, and comprises also a brief introduction to type theory.

关键词： Dyson-Schwinger equations type theory inductive types bialgebras polynomialfunctors

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Efficiency of sample-based indices for spatial pattern recognition of wild pistachio(Pistacia atlantica) trees in semi-arid woodlands

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Journal of Forestry Research 2016年第3期27卷 583-594页

作者： Yousef Erfanifard joachim Saborowski Kerstin Wiegand Katrin m.meyer Department of Natural Resources and Environment College of Agriculture Shiraz University Department of Ecosystem modelling University of Goettingen

The efficiency of sample-based indices proposed to quantify the spatial distribution of trees is influenced by the structure of tree stands, environmental heterogeneity and degree of aggregation. We evaluated 10 commonly used distance-based and 10 density-based indices using two structurally different stands of wild pistachio trees in the Zagros woodlands, Iran, to assess the reliability of each in revealing stand structure in woodlands. All trees were completely stem-mapped in a nearly pure（40 ha） and a mixed（45 ha） stand. First, the inhomogeneous pair correlation function [g（r）] and the Clark-Evans index（CEI） were used as references to reveal the true spatial arrangement of all trees in these stands. The sampled data were then evaluated using the 20 *** was undertaken in a grid based on a square lattice using square plots（30 m 9 30 m） and nearest neighbor distances at the sample points. The g（r） and CEI statistics showed that the wild pistachio trees were aggregated in both stands, although the degree of aggregation was markedly higher in the pure stand. Three distance- and six density-based indices statistically verified that the wild pistachio trees were aggregated in both stands. The distance-based Hines and Hines statistic（ht） and the densitybased standardised morisita（Ip）, patchiness（IP） and Cassie（CA） indices revealed aggregation of the trees in the two structurally different stands in the Zagros woodlands and the higher clumping in the pure stand, whereas the other indices were not sensitive enough.

关键词： Density-based indices Distance-basedindices Pattern recognition Wild pistachio Woodland

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Geochronological constraints on the metamorphic sole of the Semail ophiolite in the United Arab Emirates

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Geoscience Frontiers 2016年第4期7卷 609-619页

作者： Nick m.W.Roberts Robert J.Thomas joachim Jacobs NERC Isotope Geosciences Laboratory British Geological SurveyKeyworthNG12 5GGUK Council for Geoscience P.O.Box 572Bellville 7535South Africa University of Bergen.Department of Earth Science PB 78035020 BergenNorway Norwegian Polar Institute Fram Centre9296 TromsoNorway

The Semail ophiolite of Oman and the United Arab Emirates （UAE） provides the best preserved large slice of oceanic lithosphere exposed on the continental crust, and offers unique opportunities to study processes of ocean crust formation, subduction initiation and obduction. metamorphic rocks exposed in the eastern UAE have traditionally been interpreted as a metamorphic sole to the Semail ophiolite. However, there has been some debate over the possibility that the exposures contain components of older Arabian continental crust. To help answer this question, presented here are new zircon and futile U-Pb geochronological data from various units of the metamorphic rocks. Zircon was absent in most samples. Those that yielded zircon and futile provide dominant single age populations that are 95-93 ma, partially overlapping with the known age of oceanic crust formation （96.5-94.5 ma）, and partially overlapping with cooling ages of the metamorphic rocks （95 90 ma）. The data are interpreted as dating high-grade metamorphism during subduction burial of the sediments into hot mantle lithosphere, and rapid cooling during their subsequent exhumation. A few discordant zircon ages, interpreted as late Neoproterozoic and younger, represent minor detrital input from the continent. No evidence is found in favour of the existence of older Arabian continental crust within the metamorphic rocks of the UAE.

关键词： Semail ophiolite United Arab Emirates metamorphic sole U-Pb geochronology Zircon Rutile

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A Fresh Look at Dickinsonia:Removing It from Vendobionta

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Acta Geologica Sinica(English Edition) 2006年第5期80卷 636-642页

作者： joachim REITNER Geowissenschaftliches Zentrum Abteilung Geobiologie Universitt Gttingen 37077 Gttingen Germany

The Ediacaran Dickinsonia is well-known for being the only fossil to be assigned to many phyla,ranging from lichens,Cnidaria,Platyhelminthes,Annelida,and a phylum of its own to a nonmetazoan kingdom.A new specimen from the Ediacaran fine-grained sandstone on the Winter Coast of the White Sea in northern Russia,which has an age of ~555 million years ago,preserved convincing internal anatomies of definite animals,comparable with meridional canals of extant ctenophores(comb jellies).Additionally,we reconsidered Dickinsonia as a biradially symmetrical animal rather than a bilateral one as previously *** animal nature of Dickinsonia is,thus,well established and its affinities are most probably allied to *** research is not only removing Dickinsonia from Vendobionta,but also bringing the fossil record of ctenophores forward to 20 million years before the Cambrian “explosion”.

关键词： Dickinsonia Ctenophora Vendobionta metazoan Ediacara biota Ediacaran