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Preventive Effects of Ananas comosus Juice on Obesity Risk Factors in Female Wistar Rats

Open Journal of Applied Sciences 2020年第8期10卷 534-542页

作者： Judith F. Ahounou Aïkpe André Hamadou Lamou Bonoy Analbert T. Kotinan joachim D. gbenou Pierre H. Dansou Research Unit in Exercise Physiology (URPEF) University of Abomey Calavi Porto-Novo Bénin Laboratory of Pharmacognosy and Essential Oils (LAPHE) University of Abomey Calavi Cotonou Benin Laboratory of Biology Physical Activity National Institute of Youth and Sports (NIYS) Yaoundé Cameroon

The present study aim was to assess the preventive effects of Ananas comosus juice consumption on the risk factors of obesity in female Wistar rats. 108 rats were tested for 90 days. After randomization, they were shared out into six groups including four experimental groups (GTc, GPlp, GEns and GBrS) and two control groups (). The control group consumed 1.20 ml of distilled water, the experimental rats received in oral, 1.20 ml of drinks made from the different parts of Ananas comosus fruit. The measurements of morphometric and biochemical parameters were carried out on Day 0 (D0), Day 30 (D30), Day 60 (D60) and Day 90 (D90). The analysis showed that compared to the positive control rats, the consumption of the various drinks slowed down significantly (P

关键词： Obesity Ananas comosus Morphometric Biochemical Parameters

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Analysis of Cardiovascular Risk Factors in Hypertensive Farmers and Non-Farmers in the Zou Region of Central Benin

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Journal of Biosciences and Medicines 2023年第12期11卷 362-375页

作者： Fidele Sonounameto Marcelin Agbo Colette Azandjeme Santorin Seton Mansouratou Betira Jean-Baptiste Amagbegnon Fresnel Cachon Maximin Senou Casmir Akpovi Alphonse Sezan Camille Dossou Lamine Baba-Moussa joachim gbenou Omedine Koukoui Laboratory of Research in Medical and Pharmaceutic Biotechnology (LaRBiMeP) Research Unit of Animal Physiology Cell Signaling and Pharmacology (U-PASCPharm) ENSBBA/UNSTIM Dassa-Zoumé Benin Department of Health Promotion IRSP/UAC Ouidah Benin Laboratory of Research in Medical and Pharmaceutic Biotechnology (LaRBiMeP) Unit of Experimental and Clinical Biology (U-BEC) ENSBBA/UNSTIM Dassa-Zoumé Benin Laboratory of Applied Biology Research Research Unit on Non-Communicable Diseases and Cancer EPAC/UAC Cotonou Benin Laboratory of Pharmacology and Improved Traditional Medicines Department of Animal Physiology FAST/UAC Cotonou Benin Laboratory of Molecular Biology and Typing in Microbiology Department of Biochemistry and Cell Biology FAST/UAC Abomey Calavi Benin Laboratory of Pharmacognosy and Essential Oils FAST/UAC Cotonou Benin

The heavy use of chemicals, pesticides, cosmetics and plastic packaging coincides with a resurgence of cardiovascular disease, in particular hypertension, which is affecting younger and younger populations. The aim of this study was to analyze the cardiovascular risk factors in hypertensive farmers compared with hypertensive non farmers. This was a prospective case-control study that included 239 hypertensive farmers and non farmers aged 25 to 65 with blood pressure ≥ 140 mmHg and 90 mmHg. Hypertensive farmers (101) represented 42.25% of the population versus hypertensive non farmers (138) 57.74%. The median ages were 47 ± 11.3 years for farmers and 51.45 ± 9.77 years for non farmers. Biochemical analysisand screening for major cardiovascular disease risk factors such as metabolic syndrome were performed. Metabolic syndrome was defined according to the new definition of the International Diabetes Federation. Our results revealed higher blood glucose levels in farmers (47.77%) than in non farmers (27.20%) (p = 0.0132). Dyslipidemia was more frequent in non farmerswith high level of LDL cholesterol and total cholesterol. Farmers presented a high level of tryglycerides. The prevalence of obesity was higher in non farmers 51 (36.96%) than farmers 18 (17.82%). The prevalence of metabolic syndrome was 106 (44.35%) in our study population. There was not an important difference between farmers (39.60%) and non farmers (47.82%). However, the variation of metabolic syndrome according to age and sex showed a higher prevalence in young male farmers aged 25 to 45 whereas non farmers presented an increasing prevalence of metabolic syndrome according to age and the absence of metabolic syndrome between age 25 and 35. Our results showed that the cardiovascular risk appeared early in young farmers compared with non farmers suggesting a possible role of pesticides in the onset of this risk.

关键词： Chemicals Farmers Metabolic Syndrome Hypertension

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LC-MS Identification and Preliminary Pharmacological Study of the Aqueous and Ethanol Extracts from Combretum glutinosum Perr ex DC.(Combretaceae)

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Clinical Complementary Medicine and Pharmacology 2023年第4期3卷 49-59页

作者： Placide Mahougnan Toklo Mathias Amour Ahomadegbe Durand Dah-Nouvlessounon Jean-Bosco Jouda Billy Toussie Tchegnitegni Steven Collins Njonte Wouamba Djidénou Ahoton Mahoudo Fidèle Assogba Joseph Tchamgoue Bruno Ndjakou Lenta Simeon Fogue Kouam Lamine Baba-Moussa Eléonore Chikani Yayi Ladekan joachim Djimon gbenou Laboratoire de Pharmacognosie et des Huiles Essentielles Département de ChimieFacultés des Sciences et TechniquesISBAUniversitéd’Abomey CalaviCotonou 01 BP:918Benin Laboratoire de Biologie et de Typage Moléculaire en Microbiologie Facultédes Sciences et TechniquesUniversitéd’Abomey-CalaviCotonou 01 BP:526Benin Department of Chemical Engineering School of Chemical Engineering and Mineral IndustriesNgaoundéréP.O.Box 454Cameroon Department of Chemistry Faculty of ScienceUniversity of DschangDschangP.O.Box 67Cameroon Department of Chemistry Higher Teacher Training CollegeUniversity of Yaounde I4124 YaoundeP.O.Box 47Cameroon Département de Chimie Facultés des Sciences et TechniquesUniversitéNationale des SciencesTechnologiesIngénierie et MathématiquesGoho Abomey BP:2282Benin

Background:Combretum glutinosum is a plant whose leaves are consumed as a vegetable and used in traditional medicine for the treatment of microbial ***:The present study was designed to identify the compounds in *** leaves extracts,and evaluate its antimicrobial activity,antioxidant ability and its toxicity in Artemia salina larvae in ***:The aqueous and ethanol extracts obtained from the leaves of the plant as well as known compounds previously isolated and characterized from the leaves of *** were tested on eleven different microbial *** antioxidant activity of the extracts was evaluated by the Ferric Reducing Antioxidant Power method and the larval toxicity on Artemia salina larvae was also *** screening and HPLC-DAD-HRESI-MS analysis were performed on the extracts to characterize its chemical ***:When tested at a concentration of 20 mg‧mL^(−1),the extracts of *** leaves strongly inhibited the growth of the bacterial strains with an inhibition diameter ranging from 7.25 mm to 44 mm,superior to those of the positive controls(tetracycline at 30μg‧mL^(−1)and amikacin at 30μg‧mL^(−1)),inhibition diameters from 15 mm to 33 *** evaluated larval toxicity demonstrated that it had no harmful effects on Artemia salina *** extracts present a good antioxidant activity at a concentration of 0.17 and 1.33 mmol ascorbic acid(per gram of extract)for the aqueous and ethanol extracts,***,none of the compounds tested at 500μg‧mL^(−1)were able to show good activity on the 11 reference *** analysis revealed the presence of alkaloids,polyphenols,steroids,triterpenoids,reducing compounds,*** both *** HPLC-DAD-HRESI-MS analyses revealed 18 compounds in the ethanol extract,from which 3 were identified,15 compounds in the aqueous extract from which 5 could be ***:The present work has shown that *** extracts can

关键词： Combretum glutinosum HPLC-DAD-HRESI-MS Antimicrobial activity Antioxidant activity Larval toxicity

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