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An easy approach to assess the susceptibility of a landslide by utilizing simple raster overlay methods: A case study on Huangtupo landslide(P.R. China)

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Journal of Mountain Science 2016年第10期13卷 1701-1710页

作者： Christian DUMPERTH joachim ROHN Alexander FLEER WANG Jin-ge XIANG Wei Karsten ZIMMERMANN University of Erlangen-Nuremberg Department of Geology and Mineralogy Chair of Applied Geology Exploration and Geosurvey DMT Gmb H & Co. KG Department of Geosciences Chair of Soil Science and Geomorphology University of Tübingen Department of Geotechnical Engineering and Engineering Geology China University of GeosciencesWuhan

Semi qualitative index based methods using rankings and ratings are commonly used in susceptibility estimations over a wide area. However, generalized ranking and ratings are not applicable for one single landslide. This paper gives an easy and transferable approach to a susceptibility assessment of Huangtupo landslide(P.R. China), using raster addition without taking account for ranking and ratings. Slope, aspect, curvature, location and drainage buffer distance raster data sets have been obtained out of open source digital elevation models using ESRI's Arc GIS. These conditioning factor raster data sets have been translated into raster data sets including simple yes or no criteria, referring to triggering or not. Subsequently they have been added by raster math to acquire a simple raster overlay *** that this map is compared to initial displacement measurements, obtained by using a ground based synthetic aperture radar device. Acquired data is recalculated to a raster data set using the same spatial extent, to provide the possibility of comparison of the two raster data sets. The results reveal, that 76.35% of all measured movements occur in areas where raster cells include three or more conditioning factors, indicating that easy raster math operations can lead to satisfying results in local scale.

关键词： Landslide susceptibility Geographical Information System(GIS) Raster overlay Huangtupo Radar interferometry

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CONTROLLING THE 3D NANOSCALE ORGANIZATION OF BULK HETEROJUNCTION POLYMER SOLAR CELLS

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Chinese Journal of Polymer Science 2009年第1期27卷 85-92页

作者： Svetlana S.van Bavel Erwan Sourty Gijsbertus de With joachim Loos Laboratory of Materials and Interface Chemistry Soft Matter Cryo-TEM Research UnitEindhoven University of TechnologyP.O.Box 513NL-5600 MB EindhovenThe Netherlands Dutch Polymer Institute P.O.Box 902NL-5600 AX EindhovenThe Netherlands Laboratory of Materials and Interface Chemistrt Soft Matter Cryo-TEM Research UnitEindhoven University of TechnologyP.O.Box 513NL-5600 MB EindhovenThe Netherlands FEI Company Achtseweg Noord 5NL-565I GG EindhovenThe Netherlands

In this study,the three dimensional nanoscale organization in the photoactive layers of poly(3-hexylthiophene) (P3HT) and a methanofullerene derivative (PCBM) is revealed by transmission electron *** annealing treatment,either at elevated temperature or during slow solvent evaporation,nanoscale interpenetrating networks are formed with high crystalline order and favorable concentration gradients of both components through the thickness of the photoactive *** a tailored morphology account...

关键词： Polymer solar cells Morphology Electron tomography Device performance

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Behavioral assessment of hippocampal function following dietary intervention

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Food Science and Human Wellness 2018年第3期7卷 229-233页

作者： Klaus W.Lange Ewelina Stollberg Yukiko Nakamura joachim Hauser Department of Experimental Psychology University of Regensburg93040 RegensburgGermany

Pattern separation keeps items distinct in memory and is mediated by the hippocampus.A relationship between hippocampal function and diet quality has been suggested by findings in both humans and *** the present study,rats were fed over seven generations a diet containing increased amounts of sugar and saturated fatty acids,reduced levels of polyunsaturated fatty acids and an increased ratio of omega-6/omega-3 fatty acids(“Western”diet).Spatial pattern separation(or local discrimination)performance of these animals was compared with that of rats fed a standard diet.A separation-dependent difference between the standard and Western diet groups was found in the number of discriminations performed in the pattern separation task,with rats of the“Western”group performing fewer *** present results suggest that behavioral assessment of spatial pattern separation can detect effects of dietary interventions in rats and that pattern separation can be impaired by transgenerational administration of a“Western”*** studies should determine which components of this diet induce the memory impairments related to the *** translational relevance of these findings in regard to mental disorders such as dementia and depression needs to be investigated.

关键词： Memory Hippocampus Western diet Fatty acids Sugar

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A Coupled Approach for Fluid Dynamic Problems Using the PDE Framework Peano

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Communications in Computational Physics 2012年第6期12卷 65-84页

作者： Philipp Neumann Hans-joachim Bungartz Miriam Mehl Tobias Neckel Tobias Weinzierl Chair of Scientific Computing Faculty of InformaticsTechnische Universitat MunchenBoltzmannstr.381545 GarchingGermany

We couple different flow models,i.e.a finite element solver for the Navier-Stokes equations and a Lattice Boltzmann automaton,using the framework Peano as a common *** new coupling strategy between the meso-and macroscopic solver is presented and validated in a 2D channel flow *** results are in good agreement with theory and results obtained in similar works by Latt et *** addition,the test scenarios show an improved stability of the coupledmethod compared to pure Lattice Boltzmann simulations.

关键词： Spatial coupling Lattice Boltzmann Navier-Stokes Peano

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Chapter model systems in heterogeneous catalysis at the atomic level: a personal view

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Science China Chemistry 2020年第4期63卷 426-447页

作者： Hans-joachim Freund Markus Heyde Helmut Kuhlenbeck Niklas Nilius Thomas Risse Thomas Schmidt Shamil Shaikhutdinov Martin Sterrer Fritz Haber Institute of the Max Planck Society Faradayweg 4-6Berlin D-14195Germany Fakultat V-Mathematik und Naturwissenschaften Carl von Ossietzky Universitat OldenburgGermany Institut fur Chemie und Biochemie Freie UniversitatBerlinGermany Institute of Physics University of GrazGrazAustria

The review presents an overview of studies in the surface science of oxide and related surfaces with an emphasis of the studies performed in the authors’ group. Novel instruments and technique developments, as well as their applications are reported, in an attempt to cover studies on model systems of increasing complexity, including some of the key ingredients of an industrially applied heterogeneous catalyst and its fabrication. The review is intended to demonstrate the power of model studies in understanding heterogeneous catalysis at the atomic level. The studies include those on supported nano-particles, both, prepared in vacuum and from solution, interaction of surfaces and the underlying bulk with molecules from the gas phase, strong metal support interaction, as well as the first attempt to include studies on reactions in confined spaces.

关键词： model catalysts oxide surfaces structure and spectroscopy supported nanoparticles reactions in the confined space

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Expression of c-kit receptor in human cholangiocarcinoma and in vivo treatment with imatinib mesilate in chimeric mice

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World Journal of Gastroenterology 2006年第10期12卷 1583-1590页

作者： Thomas Kamenz Karel Caca Thilo Blüthner Andrea Tannapfel joachim Mssner Marcus Wiedmann Department of Internal Medicine Ⅱ University of Leipzig Philipp-Rosenthal-Str.2704103 LeipzigGermany Institute of Pathology University of Leipzig Liebigstr.2604103 LeipzigGermany

AIM： To investigate the c-kit expression in biliary tract cancer cell lines and histological sections from patients with extrahepatic cholangiocarcinoma （CC） and to evaluate the efficacy of in vitro and in vitro treatment with imatinib mesilate. METHODS： The protein expression of c-kit in the human biliary tract cancer cell lines Mz-ChA-2 and EGI-1 and histological sections from 19 patients with extrahepatic CC was assessed by immunoblotting, immunocytochemistry, and immunohistochemistry. The anti-proliferative effect of imatinib mesilate on biliary tract cancer cell lines Mz-ChA-2 and EGI-1 was studied in vitro by automated cell counting. In addition, immunodeficient NMRI mice （Taconic^TM） were subcutaneously injected with 5 × 10^6 cells of cell lines MzChA-2 and EGI-1. After having reached a tumour volume of 200 mm^3, daily treatment was started intraperitoneally with imatinib mesilate at a dose of 50 mgikg or normal saline （NS）. Tumor volume was calculated with a Vernier caliper. After 14 d, mice were sacrificed with tumors excised and tumor mass determined.RESULTS： Immunoblotting revealed presence of c-kit in Mz-ChA-2 and absence in EGI-1 cells. Immunocytochemistry with c-kit antibodies displayed a cytoplasmatic and membraneous localization of receptor protein in Mz-ChA-2 cells and absence of c-kit in EGI-1 cells, c-kit was expressed in 7 of 19 （37%） extrahepatic humanCC tissue samples, 2 showed a moderate and 5 a rather weak immunostaining. Imatinib mesilate at a low concentration of 5 μmoliL caused a significant growth inhibition in the c-kit positive cell line Mz-ChA-2 （31%）, but not in the c-kit negative cell line EGI-1 （0%）（P〈0.05）. Imatinib mesilate at an intermediate concentration of 10 μmoliL inhibited cellular growth of both cell lines （51% vs 57%）. Imatinib mesilate at a higher concentration of 20 μmoliL seemed to have a general toxic effect on both cell lines. The IC50 values were 9.7 μmoliL and 11 μmoliL, respectively. After 14 d of in vitro treat

关键词： Cholangiocarcinoma Imatinib Tyrosine kinase inhibitor c-kit Chimeric mice

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TLR3-dependent immune regulatory functions of human mesangial cells

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Cellular & Molecular Immunology 2012年第4期9卷 334-340页

作者： Monika Merkle Andrea Ribeiro Simone Koppel joachim Pircher Hanna Mannell Maximilian Roeder Markus Wornle Medizinische Poliklinik--Campus Innenstadt Klinikum der LMU Munich Germany Walter-Brendel-Centre of Experimental Medicine University of Munich MunichGermany

In glomerulonephritis, the migration of inflammatory cells into the glomerulus is an important step in disease initiation and progression. The viral receptor Toll-like receptor 3 （TLR3） is known to play a role in virus-associated glomerulonephritis. Based on this knowledge, this study aimed to define the effects of the TLR3 ligand polyriboinosinic：polyribocytidylic acid （poly（hC）） on the expression of adhesion molecules and macrophage colony-stimulating factor （M-CSF） on resident glomerular cells. Experiments in MCs demonstrated that the activation of viral receptors by poly（I.C） leads to a time- and dose-dependent induction of intercellular adhesion molecule 1 （ICAM-1）, vascular cell adhesion molecule 1 （VCAM-1） and M-CSF at both the mRNA and protein levels; these results were confirmed by incubating MCs with HCV RNA. As shown in knockdown experiments, this effect is specifically mediated by TLR3. The prestimulation of MCs with proinfiammatory cytokines increases the effects of poly（hC）, except for its induction of VCAM-I. Tumor-necrosis factor （TNF）-a, likewise, induces ICAM-1, VCAM-1 and M-CSF, and amplifies the mesangial response to poly（hC）. These results were confirmed by incubating MCs with HCV RNA. We thus provide evidence that human MCs represent a potential target of the leukocytes and monocytes that infiltrate the glomerulus in viral disease-associated GN, highlighting the possibility that MCs may act as resident antigen-presenting cells.

关键词： adhesion molecules glomerulonephritis hepatitis C Toll-like receptor 3

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Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood,bone marrow and peritoneal lavage of pancreatic carcinoma patients

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World Journal of Gastroenterology 2007年第2期13卷 257-263页

作者： Katrin Hoffmann Christiane Kerner Wolfgang Wilfert Marc Mueller joachim Thiery Johann Hauss Helmut Witzigmann Department of Visceral Transplantation Thoracic and Vascular Surgery University of Leipzig Germany Institute of Laboratory Medicine Clinical Chemistry and Molecular Diagnostics University of Leipzig Germany

AIM： To evaluate the diagnostic potential of cytokeratin-19 （CK-19） mRNA for the detection of disseminated tumor cells in blood, bone marrow and peritoneal lavage in patients with ductal adenocarcinoma of the pancreas. METHODS： Sixty-eight patients with pancreatic cancer （/7 = 37）, chronic pancreatitis （n = 16）, and non-pancreatic benign surgical diseases （/7 = 15, control group） were included in the study. Venous blood was taken preoperatively, intraoperatively and at postoperative d 1 and 10. Preoperative bone marrow aspirates and peritoneal lavage taken before mobilization of the tumor were analyzed. All samples were evaluated for disseminated tumor cells by CK-19-specific nested-PCR and quantitative fluorogenic RT-PCR. RESULTS： CK-19 mRNA expression was increased in 24 （64%） blood samples and 11 （30%） of the peritoneal lavage samples in the patients with pancreatic cancer. In 15 （40%） of the patients with pancreatic cancer, disseminated tumor cells were detected in venous blood and bone marrow and/or peritoneal lavage. In the peritoneal lavage, the detection rates were correlated with the tumor size and the tumor differentiation. CK-19 levels were increased in pT3/T4 and moderately/poorly differentiated tumors （G2/G3）. Pancreatic cancer patients with at least one CK-19 mRNA-positive sample showed a trend towards shorter survival. Pancreatic cancer patients showed significantly increased detection rates of disseminated tumor cells in blood and peritoneal lavage compared to the controls and the patients with chronic pancreatitis. CONCLUSION： Disseminated tumor cells can be detected in patients with pancreatic ductal adenocarcinorna by CK-19 fluorogenic RT-PCR. In peritoneal lavage, detection rate is correlated with tumor stage and differentiation. In the clinical use, CK-19 is suitable for the distinction between malignant and benign pancreatic disease in combination with other tumor-specific markers.

关键词： Tumor cell dissemination Pancreatic cancer Cytokeratin-19

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Gastro esophageal reflux disease is associated with absence from work: Results from a prospective cohort study

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World Journal of Gastroenterology 2005年第45期11卷 7148-7151页

作者： Andreas Leodolter Marc Nocon Michael Kulig Stefan N Willich Peter Malfertheiner joachim Labenz Department of Gastroenterology Institute of Social Medicine Ev.Jung-Stilling-Krankenhaus

AIM： To study the association of gastro-esophageal reflux disease （GERD） with the absence from work and to estimate the extent of loss in gross domestic product due to inability to work. METHODS： Analysis was based on the prospectively gathered data of a large European cohort study involving 6 215 symptomatic GERD patients （ProGERD）. Among these patients, 2 871 were initially employed. The calculation of the loss of gross domestic product was based on the assumption that the prevalence of GERD was about 15% in Germany. According to the German Federal Statistical Office, the mean gross wage of employees was 150 E/d in 2002. RESULTS： The data of 2 078 employed patients who were prospectively followed up for over 2 years were analyzed. At study entry, the patients reported a mean of 1.8 d per year of inability to work. During the prospective follow-up under routine clinical care, the proportion of patients reporting days with inability to work decreased from 14% to 6% and the mean number of days per year with inability to work decreased to 0.9 d. Assuming a prevalence of troublesome GERD of 15% in the employed German population, the loss of gross domestic product amounted to 668 million E/year in Germany. CONCLUSION： GERD causes a relevant impairment on the national economics by absence from work. The presented data demonstrate the importance of GERD, not only for patients and health insurance companies, but also for the community at large.

关键词： Gastro-esophageal reflux Sick leave Medicale conomics

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Alterations of attention and impulsivity in the rat following a transgenerational decrease in dietary omega-3 fatty acids

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Food Science and Human Wellness 2018年第1期7卷 49-56页

作者： joachim Hauser Ewelina Stollberg Andreas Reissmann Ivo Kaunzinger Klaus W.Lange Department of Experimental Psychology University of Regensburg93040 RegensburgGermany

Polyunsaturated fatty acids(PUFAs),particularly the omega-3 PUFAs,are thought to be involved in neuronal processes,to play a role in neurodevelopmental disorders and to be important for the integrity of central nervous system *** present study investigated the effects of nutritional omega-3 PUFAs on attentional functions and impulsive behavior in Wistar *** this purpose,female Wistar rats were fed an omega-3 deficient diet over several generations,and the dams of the seventh generation were randomly assigned to two diet groups and fed an omega-3 deficient or an omega-3 sufficient *** addition,a group of previously untreated dams was fed an omega-3 sufficient *** male offspring of these three diet groups were tested using an established paradigm for the assessment of attention and impulsive behavior,i.e.a modified version of the five-choice-serial-reaction-time task(5CSRTT).The present data show that the deficiency of omega-3 PUFAs over generations led to substantial changes in attentional processes and impulsive *** impairments associated with an omega-3 deficiency were partly corrected by treatment with the omega-3 sufficient diet in the last generation of the omega-3 deficient group which showed substantial improvements in attention *** there were no significant effects of dietary modifications on psychomotor activity levels,there was some evidence for changes in impulsive *** conclusion,transgenerational dietary changes in the availability of omega-3 PUFAs led to changes in attentional processes and impulsive behavior in rats,supporting the hypothesis that omega-3 PUFAs play a role in cognitive and behavioral *** present findings offer a promising approach in the investigation of the role of omega-3 PUFAs in a variety of cognitive and behavioral domains.

关键词： Omega-3 fatty acid Polyunsaturated fatty acids Attention Impulsivity Activity Rat Neurodevelopmental disorders Psychiatric disorders

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