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Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi al-Hasani joachim al.schmied.katharina bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

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Ketogenic diets and alzheimer’s disease

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Food Science and Human Wellness 2017年第1期6卷 1-9页

作者： Klaus W.Lange katharina M.Lange Ewelina Makulska-Gertruda Yukiko Nakamura Andreas Reissmann Shigehiko Kanaya joachim Hauser Department of Experimental Psychology University of Regensburg93040 RegensburgGermany Department of Psychology University of WinchesterUK Graduate School of Information Science Nara Institute of Science and TechnologyJapan

alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by decline in cognitive functions and associated with the neuropathological hallmarks of amyloid-peptide plaques and neurofibrillary *** glucose uptake and metabolism deteriorate in AD and this hypometabolism precedes the onset of clinical signs in *** early decline in brain glucose metabolism in AD has become a potential target for therapeutic *** has led to investigations assessing the supplementation of the normal glucose supply with ketone bodies which are produced by the body during glucose deprivation and can be metabolized by the brain when glucose utilization is *** present review provides a synopsis of preclinical studies and clinical trials assessing the efficacy of ketogenic diets in the treatment of *** the direct administration of ketone bodies and the use of high-fat,low-carbohydrate ketogenic diets have been shown to be efficacious in animal models of AD and clinical trials with AD *** mechanism underlying the efficacy of ketogenic diets remains unclear,but some evidence points to the normalization of aberrant energy *** present there is only limited evidence of the usefulness of ketogenic diets in ***,this dietary approach seems to be promising and deserves further clinical investigations.

关键词： alzheimer’s disease Ketone bodies Ketogenic diet Therapy

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Monitoring River Restoration Efforts: Do Invasive alien Plants Endanger the Success? A Case Study of the Traisen River

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Journal of Environmental Protection 2016年第6期7卷 831-843页

作者： katharina Lapin Karl-Georg Bernhardt Elisabeth Mayer Stefanie Roithmayr joachim Neureiter Claudia Horvath Department of Integrative Biology and Biodiversity Research Institute of Botany University of Natural Resources and Life Sciences Vienna Austria

River restoration activities are challenging for the native vegetation and the colonization process. The development of invasive alien plant species (IAS) as well as the development of the pioneer vegetation cover and seed bank were observed in one year prior to construction of a new river bed and within the first two years after construction, along the downstream section of the river Traisen in Austria. One year after completion of the new river channel, the occurrence of IAS above ground decreased while the occurrence of target species increased. Furthermore, no seeds of IAS were detected in the new river bed as a result of proper management of soil movement. Despite the positive impact on the abundance of IAS, the restoration project of the river Traisen shows that the fact that such a restoration activity is a disturbance event must be taken into consideration already during the planning process. Supporting the competitiveness of native plant species is an important tool for reducing the danger of establishment of invasive alien species.

关键词： landscape management Invasive alien plant species vegetation river restoration succession riparian area seed bank

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Coronary Angiography in Patients with and without STEMI Following Out-of-Hospital Cardiac Arrest

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Open Journal of Internal Medicine 2014年第4期4卷 115-122页

作者： Martin Christ katharina Isabel von Auenmueller Wolfgang Dierschke Jan Peter Noelke Thomas Butz Jeanette Liebeton Hans-joachim Trappe Department of Cardiology and Angiology Marienhospital Herne Ruhr-University Bochum Germany

Introduction: Little is known about discrepancies between patients who present with or without STEMI following out-of-hospital cardiac arrest (OHCA). Material and Methods: all patients with OHCA who were admitted to our hospital between January 1st 2008 and December 31st 2013 were classified according to their initial laboratory and electrocardiographic findings into STEMI, NSTEMI or no ACS. Results: Overall, 147 patients [32 STEMI (21.8%), 28 NSTEMI (19.0%) and 87 no ACS (59.2%)] were included with a mean age of 63.7 ± 13.3 years;there were 84 men (57.1%) and 63 (42.9%) women. Of these, 63 patients (51.7%) received coronary angiography [29 STEMI (90.6%), 9 NSTEMI (32.1%) and 38 no ACS (43.7%)] showing a high prevalence of coronary artery disease (CAD) [28 STEMI (96.6%), 9 NSTEMI (100.0%) and 26 no ACS (68.4%)] requiring percutaneous coronary intervention (PCI) in 52 cases [28 STEMI (96.6%), 8 NSTEMI (88.9%) and 16 no ACS (42.1%)]. Discussion: Coronary angiography immediately after hospital admission is feasible if all are prepared for potential further resuscitation efforts during cardiac catheterization. Primary focus on haemodynamic stabilisation may reduce the rates of coronary angiographies in patients following OHCA. altogether, our data support the call for immediate coronary angiography in all patients following OHCA irrespective of their initial laboratory or electrocardiographic findings.

关键词： Out-of-Hospital Cardiac Arrest OHCA Myocardial Infarction STEMI NSTEMI Coronary Angiography Resuscitation

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Are There Age-Related Differences in the In-Hospital Treatment of Victims from Out-of-Hospital Cardiac Arrest?

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International Journal of Clinical Medicine 2015年第6期6卷 431-438页

作者： Martin Christ katharina Isabel von Auenmueller Irini Maria Breker Jeanette Liebeton Michael Brand Jan Peter Noelke Hans-joachim Trappe Department of Cardiology and Angiology Ruhr-University Bochum Bochum Germany

Objective: Hardly anything is known about reasons for age-related differences in surviving out-of-hospital cardiac arrest (OHCA) with worse surviving rates in elderly. Methods: 204 victims from OHCA who were admitted in our hospital between January 1st 2008 and December 31st 2013 were identified. According to their mean age (69.1 ± 14.2 years) we classified those patients (pts) who were younger than mean age minus standard deviation (SD) as young, and those victims from OHCA who were older than mean age plus SD as old. Results: Young victims from OHCA (n = 32 pts) presented more often with an initial shockable rhythm than the elderly (n = 38 pts) (50.0% vs. 21.1%;p = 0.014), received more often coronary angiography (71.9% vs. 18.4%;

关键词： Out-of-Hospital Cardiac Arrest Mild Therapeutic Hypothermia Coronary Angiography Resuscitation Elderly

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