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Efficacy,safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart:A pilot study

World Journal of Diabetes 2025年第1期16卷 65-73页

作者： na Yang Lu Lv Shu-Meng Han Li-Yun He Zi-Yi Li Yu-Cheng Yang Fan Ping Ling-Ling Xu Wei Li Hua-Bing Zhang Yu-Xiu Li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient data from the Chinese *** To demonstrate the efficacy,safety,and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus(T2DM).METHODS In this 12-week open-label,non-randomized,single-center,pilot study,patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin *** doses,hemoglobin A1c(HbA1c)levels,fasting blood glucose(FBG),hypoglycemic events,a Diabetes Treatment Satisfaction Questionnaire,and other parameters were assessed at baseline and *** This study included 21 participants.A marked enhancement was observed in the FBG level(P=0.02),daily total insulin dose(P=0.03),and overall diabetes treatment satisfaction(P<0.01)in the participants who switched to *** was a decrease in HbA1c levels(7.6±1.1 vs 7.4±0.9,P=0.31)and the frequency of hypoglycemic events of those who switched to IDegAsp decreased,however,there was no statistically significant *** The present findings suggest that treatment with IDegAsp enhances clinical outcomes,particularly FBG levels,daily cumulative insulin dose,and overall satisfaction with diabetes treatment.

关键词： Insulin degludec/aspart Type 2 diabetes management Basal-bolus insulin therapy Pre-mixed insulin Diabetes treatment satisfaction questionnaire

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BOUNDS ON AVERAGE CONTROLLED DIRECT EFFECTS WITH AN UNOBSERVED RESPONSE VARIABLE

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Journal of Systems Science & Complexity 2011年第6期24卷 1154-1164页

作者： na SHAN Jianhua GUO Key Laboratory for Applied Statistics of Ministry of Education School of Mathematics and Statistics Northeast Normal University Changchun 130024 China School of Basic Science Changchun University of Technology Changchun 130012 China

This paper considers the problem of estimating the bounds on the average controlled direct effects （ACDEs） of a treatment variable on an unobserved response variable in the presence of unobserved confounders between an intermediate variable and the response variable. When the response variable is observed, Cai, et al.（2008） derived the formulas for the sharp bounds on the ACDEs. When the response variable is unobserved, the authors propose a graphical criterion for selecting variables affected by the response variable to derive the formulas for the bounds on the ACDEs, which is an extension of the result of Kuroki（2005） to ACDEs. The results enable us not only to judge from the graph structure whether the bounds on the ACDEs can be expressed through observed variables when the response variable is unobserved, but also to provide their formulas when the answer is affirmative.

关键词： Average controlled direct effect causal network d-separation

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Chaotification of a Continuous Stable Complex Network via Impulsive Control

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Journal of Systems Science & Complexity 2015年第6期28卷 1271-1278页

作者： LIU na GUAN Zhihong School of Electric and Information Engeering Zhengzhou University of Light Industry

A method is proposed to chaotify a class of complex networks via impulsive control, when the orbits of the impulsive systems are confined in a bounded area. Based on computing the largest Lyapunov exponent, theoretical results and algorithmic analysis are given in details. Finally, numerical simulations are presented to illustrate the effectiveness of the method.

关键词： Chaotification complex network impulsive control largest Lyapunov exponent

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CRABP1-mediated non-canonical retinoic acid signaling in motor neurons and neural stem cells

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Neural Regeneration Research 2024年第6期19卷 1169-1170页

作者： Li-na Wei Department of Pharmacology University of Minnesota Medical SchoolMinneapolisMNUSA

Retinoic acid(RA),the active metabolite of vitamin A(the retinoids),elicits a wide spectrum of biological activities critical to the development and health of most of the organ systems including the nervous systems(Corcoran et al.,2002).The effects of RA are mediated by two very distinct pathways;the first is manifested in the nucleus by binding to a large family of nuclear RA receptors(RARs)to regulate proper expression of RAtargeted genes.

关键词： canonical spectrum critical

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Cooling of hybrid stars with spin down compression

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Research in Astronomy and Astrophysics 2009年第12期9卷 1351-1358页

作者： Miao Kang Xiao-Dong Wang na-na Pan College of Physics and Electronics Henan University Kaifeng 475004 China College of Mathematics and Physics Chongqing University of Posts and TelecommunicationsChongqing 400065 China

We study the cooling of hybrid stars coupled with spin-down. Due to the spindown of hybrid stars, the interior density continuously increases and different neutrino reactions may be triggered （from the modified Urca process to the quark and nucleon direct Urca process） at different stages of evolution. We calculate the rate of neutrino emissivity of different reactions and simulate the cooling curves of the rotational hybrid stars. The results show that the cooling curves of hybrid stars clearly depend on a magnetic field if the direct Urca reactions occur during the spin-down. Comparing the results of the rotational star model with the transitional static model, we find the cooling behavior of the rotational model is more complicated; the temperature of the star is higher, especially when direct Urca reactions appear in the process of rotation. Then, we find that the predicted temperatures of some rotating hybrid stars are compatible with the pulsar＇s data which are in contradiction with the results of the transitional method.

关键词： dense matter -- stars: rotation -- equation of state

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第01期 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol na J.Jay Liu Young-Ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

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Entire Solution of the Degenerate Fisher Equation

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Acta Mathematicae Applicatae Sinica 2017年第1期33卷 75-82页

作者： Li-na WANG School of Science Beijing Technology and Business University Beijing 100048 China

This paper deals with the solutions defined for all time of the degenerate Fisher equation. Some solutions are obtained by considering two traveling fronts with critical speed that come from both sides of the X-axis and mix. Unfortunately, the entire solutions which behave as two opposite wave fronts with non-critical speed approaching each other from both sides of the X-axis can not be obtained, because the essential difficulty originates from the algebraic decay rate of the fronts with non-critical speed.

关键词： entire solution degenerate Fisher traveling front

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Conditional Symmetries and Solutions to a Class of Nonlinear Diffusion-Convection Equations

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Communications in Theoretical Physics 2006年第4X期46卷 668-674页

作者： JI Li-na Center for Nonlinear Studies Northwest University Xi'an 710069 China Department of Mathematics Northwest University Xi'an 710069 China Information and Management Science College Henan Agricultural University Zhengzhou 450002 China

The present paper discusses a class of nonlinear diffusion-convection equations with source. The method that we use is the conditional symmetry method. It is shown that the equation admits certain conditional symmetri... 详细信息

关键词： symmetry nonlinear diffusion-convection equation conditional symmetry exact solution

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Analytical Structure Matching and Very Precise Approach to the Coulombic Quantum Three—Body Problem

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Communications in Theoretical Physics 2001年第1期35卷 71-77页

作者： TANShi－na InstituteofTheoreticalPhysicsAcademiaSinica P.O.Box2735Beijing100080China

A powerful approach to solve the Coulombic quantum three-body problem is proposed. The approach is exponentially convergent and more efficient than the hyperspherical coordinate method and the correlation-function hyperspherical harmonic method. This approach is numerically competitive with the variational methods, such as that using the Hylleraas-type basis functions. Numerical comparisons are made to demonstrate the efficiency of this approach, by calculating the nonrelativistic and infinite-nuclear-mass limit of the ground state energy of the helium atom. The exponential convergency of this approach is due to the full matching between the analytical structure of the basis functions that are used in this paper and the true wavefunction. This full matching was not reached by most other methods. For example, the variational method using the Hylleraas-type basis does not reflects the logarithmic singularity of the true wavefunction at the origin as predicted by Bartlett and Fock. Two important approaches are proposed in this work to reach this full matching: the coordinate transformation method and the asymptotic series method. Besides these, this work makes use of the least square method to substitute complicated numerical integrations in solving the Schr?dinger equation without much loss of accuracy, which is routinely used by people to fit a theoretical curve with discrete experimental data, but here is used to simplify the computation.

关键词： quantum three-body problem analytical structure matching the least square method asymptotic series Bartlett-Fock expansion

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Analysis of survival probability based on superasymmetric reaction systems

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Chinese Physics C 2020年第9期44卷 95-102页

作者： na-na Li Xiao-Jun Bao Department of Physics Collaborative Innovation Center for Quantum Effectsand Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of EducationHunan Normal UniversityChangsha 410081China

The survival probability of an excited compound nucleus was studied using two different approaches of the washing out of shell effects with excitation energy based on a superasymmetric reaction *** estimated evaporation residue cross sections based on the two different methods are compared with the available experimental *** methods are in agreement with the experimental data to a certain extent for some specific reactions and emission channels.

关键词： survival probability superasymmetric reaction systems two different approaches shell effect washing out with excitation energy

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