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Asian pacific Journal of Tropical medicine 2010年第1期3卷 25-28页

作者： okoye TC Akah pa omeke CP Department of Pharmacology and Toxicology Faculty of Pharmaceutical SciencesUniversity of Nigeria

objective:To investigate the potentials of the root bark of Annona（A.） senegalensis in the control of seizure and related hypnotic and motor incoordination effects in mice using experimental ***:The methanol extract（me） of the root bark of *** was studied in mice using pentylenetetrazole（PTZ） induced convulsions,phenobarbitone induced sleeping time and motor coordination test on rota-rod *** toxicity and lethality（LD50） lest as well as phytochemical analysis were also carried ***:The extract（200,400,800 mg/ kg） exhibited a non- dose dependent significant（Ponset of both tonic and clonic phases of seizure induced by PTZ（60 mg/kg,s.c.） as well as offered a 100%protection （200 mg/kg） in mice from PTZ induced *** extract significantly（Pon of phenobarbitone induced sleeping *** 200 mg/kg, the extract exhibited a significant（Potor *** acute toxicity test revealed an oral LD50 of 1 2%mg/kg,while the phytochemical studies showed the presence of alkaloids, resins,glycosides,carbohydrate,reducing sugar,flavonoids,terpenoids,saponins and tannins. Conclusion:The extract of A senegalensis possessed anticonvulsant activity with pronounced hypnotic and muscle relaxant effects.

关键词： Annona senegalensis Hypnosis Anticonvulsant Muscle relaxant

Antimicrobial and antispasmodic activity of leaf extract and fractions of Stachytarpheta cayennensis

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Asian pacific Journal of Tropical medicine 2010年第3期3卷 189-192页

作者： okoye TC Akah pa okoli Co Ezike AC Mbaoji FN Department of Pharmacology & Toxicology Faculty of Pharmaceutical SciencesUniversity of Nigeria

objective:To investigate the antimicrobial activity of the methanol leaf extract(me),n-hexane fraction(HF),ethylacetate fraction(EF) and methanol fraction(MF),of Stachytarpheta cayennensis ***(verbenaceae) as well as to ascertain the antispasmodic effects of the me and the various fractions(HF,EF and MF) on acetylcholine(Ach) and histamine(H) induced contractions on isolated guinea pig ***:The in vitro agar well diffusion method was used for the antimicrobial studies while the isolated tissue method was employed for the antispasmodic test. organisms used were all clinical isolates of Bacillus subtilis,Staphylococcus aureus,Pseudomonas aeruginosa,Salmonella paratyphi,Candida albicans and Aspergillus ***:The extract and fractions exhibited dose dependent inhibition against all the bacteria tested and also exhibited insignificant antifungal activity against Candida albicans and Aspergillus *** minimum inhibitory concentration(MIC) of the extract and fractions(mg/mL) on Bacillus subtilis, Staphylococcus aureus,Pseudomonas aeruginosa and Salmonella paratyphi respectively were me 5.62,14.12,22.38,2.11;EF 1.25,6.30,9.40,9.40 and MF 3.98,8.81,39.80,*** n-hexane fraction exhibited MIC of 1.07 mg/mL against only Bacillus *** extract and fractions exhibited significant(Pose dependent attenuation of contractions induced by acetylcholine and histamine on isolated guinea pig *** of the extract and fractions(μg/mL) which evoked 50%inhibition of maximal response exhibited by Ach were me 0.64,HF 0.16,EF 0.08 and MF 0.15,while that of histamine included me 5.12,HF 0.16,EF 0.04 and MF *** phytochemical studies on the extract and fractions indicated the presence of carbohydrates,alkaloids,saponins,flavonoids,steroids and ***: The extract and fractions of Stachytarpheta cayennensis possessed both antibacterial and antispasmodic effects confirming the claimed use in folkloric medicine

关键词： Antimicrobial Antispasmodic Stachytarpheta cayennensis Acetylcholine Histamine

Liver retransplantation: indications and outcomes

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Hepatobiliary & pancreatic Diseases International 2004年第2期3卷 175-178页

作者： Zi-Fa Wang and Chang Liu Pittsburgh, USA Department ot Surgery, University of Pittsburgh me- dical Center, Pittsburgh, pa 15213, USA Division of Hepa- tobiliary Surgery . First Hospital, Xi’ an Jiaotong University , Xi’ an 710061, China Department of Surgery University of Pittsburgh NW607 Montefiore University Hospital 3459 Fifth Avenue Pittsburgh PA 15213 USA. ziw3@pitt.edu

BACKGRoUND: Liver transplantation is a life-saving the- rapeutic modality for patients with end-stage liver diseases. After liver transplantation, however, more than 10% pa- tients may lose the grafts caused by a variety of reasons. This review covers the most frequent indications for liver retransplantation as well as the results and specific problems with each indication. DATA RESoURCES: Searching meDLINE (1997-2003) for articles on liver retransplantation. RESULTS: The most frequent indications of liver retrans- plantation are primary non-function, hepatic artery throm- bosis, graft rejection and recurrent diseases. The results af- ter liver retransplantation remain inferior to those after first transplantation. CoNCLUSIoN: Liver retransplantation, which is the only means of prolonging survival in those patients whose initial graft has failed, makes an important contribution to overall survival.

关键词： liver retransplantation primary non-function hepatic artery thrombosis rejection recurrent diseases

Comparison of long-term outcome between patients aged 〈 65 years vs. ≥ 65 years after atrial fibrillation ablation

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Journal of Geriatric Cardiology 2017年第9期14卷 569-574页

作者： Zsuzsanna Kis Anna me Noten Mihran Martirosyan Astrid A Hendriks Rohit Bhagwandien Tamas Szili-Torok Department of Cardiology Erasmus MC University Medical Center Rotterdam the Netherlands

Background Atrial fibrillation （AF） is the most frequent arrhythmia, and its prevalence is increasing with aging. We aimed to com-pare the long-term outcome data of patients 〈 65 years vs.≥ 65 years who underwent catheter ablation （CA） for drug-refractory AF. methodsConsecutive patients with primary pulmonary vein isolation performed between March 2001 and December 2011, and those who completeda five-year of follow-up were divided into two groups： patients aged 〈 65 years into group 1, and patients aged ≥ 65 into group 2. Long-termoutcome data concerning mortality, thromboembolic events （TE） and success rates were compared between these groups. Results A totalnumber of 390 patients were included, group 1 contained 310 patients, and 80 patients in group 2. In group 2, patients had more often impairedrenal function （P 〈 0.001） and thyroid disease （P = 0.047）. A total of fifteen patients died during the 6.63 ± 2.1 years of follow-up, with a sig-nificantly higher incidence in the older group （8/80 vs. 7/310 patients, P = 0.004）. The majority of fatal outcome was due to cancerous dis-eases in both groups. No difference was observed concerning the long-term TE rate （12/310 vs. 4/80 patients, P = 0.75）. Rhythm controlfailed in 25.9% of the patients, with no difference between the groups： 26.4% in group 1 vs. 23.7% in group 2 （P = 0,67）, ConclusionsDespite growing prevalence of AF in aging population, the elderly patients are underrepresented in CA procedures. Similar clinical successand TE complication rate are observed between the age-groups. our data suggest more liberal criteria might be applied while selecting pa-tients for AF ablation.

关键词： Atrial fibrillation Catheter ablation Clinical outcome The elderly Thromboembolic complication

Geochemistry and mineralogy of platinum-group elements(PGE)in chromites from CentralnoyeⅠ,Polar Urals,Russia

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Geoscience Frontiers 2011年第1期2卷 81-85页

作者： Jan paava Ilja Knésl Anna Vymazalová Ivan Vavrín Ludmila Ivanovna Gurskaya Leonid Ruslanovich Kolbantsev Czech Geological Survey Geologicka 6152 00 Praha 5Czech Republic All Russia Geological Research Institute(VSEGEI) 74 Srechy Pr.199 106 St.PetersburgRussia

The Polar Urals region of northern Russia is well known for large chromium （Cr）-bearing massifs with major chromite orebodies, including the Centralnoye I deposit in the Ray-Iz ultramafic massif of the Ural ophiolite belt. New data on platinum （Pt）-group elements （PGE）, geochemistry and mineralogy of the host dunite shows that the deposit has anomalous iridium （Ir） values. These values indicate the predominance of ruthenium--osmium--iridium （Ru--os--Ir）-bearing phases among the platinum-group mineral （PGM） assemblage that is typical of mantle-hosted chromite ores. Low Pt values in chromites and increased Pt values in host dunites might reflect the presence of cumulus PGM grains. The most abundant PGM found in the chromite is erlichmanite （up to 15 μm）. Less common are cuproiridsite （up to 5 μm）, irarsite （up to 4--5 μm）, and laurite （up to 4 μm）. The predominant sulfide is heazlewoodite, in intergrowth with Ni--Fe alloys, sporadically with pentlandite, and rarely with pure nickel. Based on the average PGE values and esti- mated Cr-ore resources, the Centralnoye I deposit can be considered as an important resource of PGE.

关键词： Platinum-group elements Platinum-group minerals Chromite ophiolites Centralnoye I deposit Polar Urals

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《英国非酒精性脂肪性肝炎肝移植指南》导读

胃肠病学 2012年第6期17卷 379-380页

作者：张舒宜丁晓东范建高上海交通大学医学院附属新华医院消化内科 200092

非酒精性脂肪性肝炎（non—alcoholicsteatohepatitis，NASH）现已成为肝移植愈来愈重要的基础肝病。鉴于晚期NASH患者常并存多种影响肝移植转归的临床问题，而至今尚无针对NASH患者进行肝移植的评估和治疗指南，为此英国移植学会（Brit... 详细信息

非酒精性脂肪性肝炎（non—alcoholicsteatohepatitis，NASH）现已成为肝移植愈来愈重要的基础肝病。鉴于晚期NASH患者常并存多种影响肝移植转归的临床问题，而至今尚无针对NASH患者进行肝移植的评估和治疗指南，为此英国移植学会（British Transplant Society，BTS）邀请相关专家制定了指南，以指导肝移植前后NASH患者的处理。

关键词：非酒精性脂肪性肝炎肝硬化肝移植指南英国

The Ray Wu Society for Life Sciences

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Chinese Science Bulletin 2003年第8期48卷 839-840页

作者： MA Hong Department of Biology and The Huck Institute for Life Sciences, The Pennsylvania State University, 315 Wartik Laboratory, University park, pa 16802, USA (e-mail: Hxm16@psu.edu) Penn State Univ Dept Biol Wartik Lab 315 University Pk PA 16802 USA Penn State Univ Huck Inst Life Sci Wartik Lab 315 University Pk PA 16802 USA

The Ray Wu Society for Life Sciences (RWS) is a non-profit professional society of Chinese-American and Chinese life scientists with the goal to promote scientific communication among the scientists between USA and China and the life science research in China. The members of the RWS, now numbered more than 300, are a group of elite biologists who have reached the level of assistant professor or equivalent in their careers and are experts of their respective fields including molecular biology and genetics, cell and developmental biology, me- dicine, pharmacology, plant biology, and biotechnology. RWS was founded in early 1998 by a group of life scientists who have come from China during the last 22 years. With the encouragement of Dr. Chris Tan, the Director of the Molecular Biology Institute in Singapore, who proposed to set up a fund in the name of Prof. Ray Wu of Cornell University to recognize his contribution to the academic exchange between China and the USA. A quick positive response was reflected from American Chinese scholars with a further proposal of forming a professional society. This initiative spread rapidly and widely throughout the existing networks of Chinese life-science professionals.

关键词：生命科学中国美国学术交流科学研究

Systematic review of anorectal leiomyosarcoma: Current challenges and recent advances

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World Journal of Gastrointestinal Surgery 2019年第8期11卷 334-341页

作者： Mohammed o Nassif Razan A Habib Luai Z Almarzouki Nora H Trabulsi Department of Surgery King Abdulaziz University

BACKGRoUND The anorectal leiomyosarcoma (LMS) is an aggressive malignant neoplasm. owing to the rarity of LMSs, an optimal treatment modality has yet to be determined. AIM To collect all published data on anorectal LMS characteristics, explore current treatment options, and review recent cases of postradiation LMS. meTHoDS A literature search of the Pubmed electronic database was conducted using the meSH terms "rectal neoplasms","anus neoplasms" and "gastrointestinal neoplasms" combined with "leiomyosarcoma". The search was limited to English language and human studies. All available case reports and case series of anal or rectal LMSs that were published from the beginning of January 1996 to May 2017 were included if the diagnosis of LMS had been confirmed by histopathologic examination. Data were analyzed using simple statistics (mean, median, and standard deviation). Independent sample t-test was used to compare means for continuous variables. RESULTS A total of 27 articles reporting on 51 cases of anorectal LMS were identified. Among these cases, 11.7% had undergone previous pelvic radiotherapy (developing LMS at 13-35 years afterwards). Anorectal LMS affected the rectum in 92.2% of the cases, and no sex-based predominance was observed. Surgical resection with negative margins remains the mainstay of treatment, which can be accomplished with wide local excision or radical resection. The local recurrence rate was higher among cases who received wide local excision (30%), as compared to radical resection (20%);however, the overall rate of metastasis was 51.61% regardless of the treatment approach. The use of neoadjuvant radiation lowers the risk of local recurrence compared to adjuvant radiotherapy, and facilitates R0 resection of the tumor. Cases treated with adjuvant chemotherapy showed better rates of distant recurrence and overall survival. Nonetheless, multidisciplinary team discussion is necessary to determine the optimal management plan whilst considering pa

关键词： Leiomyosarcoma Rectal neoplasms Anal neoplasms Gastrointestinal neoplasms Soft tissue neoplasms

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《弟吴宗教源流》(吐蕃史)译注(四)

西藏研究 2019年第1期 43-53页

作者：弟吴贤者阿贵 <西藏大学学报>编辑部西藏拉萨850000

《弟吴宗教源流》是一部约成书于12世纪的重要宗教史籍,藏文原名为《弟吴贤者所著印、藏教法源流详本》。本译文为《弟吴宗教源流》第五节"吐蕃佛教史"的第四部分有关惹萨佛殿等内容,主要讲述了惹萨幻化佛殿的修建情况,王室后人、王妃... 详细信息

《弟吴宗教源流》是一部约成书于12世纪的重要宗教史籍,藏文原名为《弟吴贤者所著印、藏教法源流详本》。本译文为《弟吴宗教源流》第五节"吐蕃佛教史"的第四部分有关惹萨佛殿等内容,主要讲述了惹萨幻化佛殿的修建情况,王室后人、王妃、庶民修建佛殿,吞弥创制藏文以及贡松、芒松、杜松和赤德祖赞梅阿聪的历史等内容。本次译文以西藏人民出版社2010年12月第2次版的藏文版为蓝本,为藏文版第262页至第285页的内容。

关键词：惹萨幻化佛殿吞弥创制藏文贡松芒松杜松赤德祖丹梅阿聪译注

慢性乙型肝炎肝纤维化患者实时剪切波弹性成像的应用价值分析

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世界华人消化杂志 2018年第15期26卷 932-938页

作者：么晓伟李晓永义乌市中医医院超声科浙江省义乌市322000 唐山市传染病医院河北省唐山市063000

目的探讨实时剪切波弹性成像技术(shear wave elastography,S W E)与常规超声检查在评估慢性乙型肝炎患者肝纤维化中的应用价值.方法回顾性分析唐山市传染病医院在2015-08/2017-06收治的慢性乙型肝炎患者87例,分别进行常规超声和S W E检... 详细信息

目的探讨实时剪切波弹性成像技术(shear wave elastography,S W E)与常规超声检查在评估慢性乙型肝炎患者肝纤维化中的应用价值.方法回顾性分析唐山市传染病医院在2015-08/2017-06收治的慢性乙型肝炎患者87例,分别进行常规超声和S W E检查,以病理穿刺活检结果为金标准,分析常规超声、SWE与肝纤维化病理分期的相关性,评估常规超声、SWE诊断肝纤维化各分期的RoC曲线下面积,比较常规超声与SWE在诊断肝纤维化各分期的诊断效能.结果 (1)常规超声积分在肝纤维化相邻分期之间(S0-S1vs S2,S2 vs S3,S3 vs S4)比较差异无统计学意义(P=0.451,0.639,0.103);但不相邻分期(S0-S1 vs S3,S0-S1vs S4,S2 vs S4)之间常规超声评分比较差异具有统计学意义(P=0.001,0.000,0.000);SWE在不同肝纤维化分期的弹性模量值分别为(S0=5.625 kpa±1.221 kpa,S1=7.172 k pa±1.818 k pa,S2=10.295 kpa±3.122kpa,S3=15.541 kpa±4.340 kpa,S4=23.918 kpa±5.697 kpa),肝脏弹性模量在相邻及不相邻分期之间比较差异均具有统计学意义(P均oC曲线下面积分别为0.766,0.891,0.764;SWE值在诊断肝纤维化S≥2、S≥3和S4期的RoC曲线下面积分别为0.941,0.948,0.952;SWE的诊断效能高于常规超声(P<0.05).结论相比于常规超声,SWE技术在评估慢性乙型肝炎患者肝纤维化程度方面具有更高的应用价值,可重复性好,具有较高的潜在临床价值.

关键词：常规超声弹性成像慢性乙型肝炎肝纤维化