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Immunomodulatory activity of polycaprolactone nanoparticles with calcium phosphate salts against Leishmania infantum infection

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 359-368页

作者： Kübra Kelleci Adil Allahverdiyev Melahat Bağırova Murat Ihlamur EmrahŞefik Abamor Department of Bioengineering Yildiz Technical UniversityIstanbulTurkey V.Akhundov National Scientific Research Medical Prophylactic Institute BakuAzerbaijan Department of Electronics and Automation Biruni UniversityIstanbulTurkey

Objective:To prepare and characterize polycaprolactone(PCL)nanoparticles loaded with sonicator fragmented(SLA)and freeze-thaw Leishmania antigens(FTLA)and to investigate the in vitro immunogenicity of antigen-encapsulated nanoparticles with calcium phosphate ***:The water/oil/water binary emulsion solvent evaporation method was used to synthesize antigen-loaded PCL *** were characterized by scanning electron microscopy and zeta potential *** cytotoxicity in J774 macrophages in vitro was determined by MTT *** addition,the amount of nitric oxide and the level of cytokines produced by macrophages were determined by Griess reaction and ELISA method,*** protective effect of the developed formulations was evaluated by determining the infection index percentage in macrophages infected with Leishmania ***:Compared to the control group,SLA PCL and FTLA PCL nanoparticles with calcium phosphate adjuvant induced a 6-and 7-fold increase in nitric oxide,***,the vaccine formulations promoted the production of IFN-γand *** PCL and FTLA PCL nanoparticles combined with calcium phosphate adjuvant caused an approximately 13-and 11-fold reduction in infection index,respectively,compared to the control ***:The encapsulation of antigens obtained by both sonication and freeze-thawing into PCL nanoparticles and the formulations with calcium phosphate adjuvant show strong in vitro immune stimulating ***,PCL-based antigen delivery systems and calcium phosphate adjuvant are recommended as a potential vaccine candidate against leishmaniasis.

关键词： Leishmaniasis Calcium phosphate Polycaprolactone Nanoparticle Antigen delivery system Adjuvant Vaccine design

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Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato joão B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

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Potential risk genes for primary Sjogren's syndrome from a meta-analysis by linear regression and random forest classification

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Genes & Diseases 2024年第3期11卷 128-131页

作者： Tomas Cerdo Teresa torres Moral Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Reina Sofia University HospitalUniversity of CordobaCordoba 14004Spain Centre for Rheumatology Research Division of MedicineUniversity College LondonLondon W1T 4JFUK Faculty of Computer Sciences Multimedia and TelecommunicationUniversitat Oberta de CatalunyaBarcelona 08018Spain Dermatology Department Melanoma UnitAugust Pi i Sunyer Biomedical Research Institute(IDIBAPS)and Hospital ClinicBarcelona 08036Spain Center for Networked Biomedical Research on Rare Diseases(CIBERER) Carlos II Health InstituteMadrid 28029Spain

Primary Sjogren's syndrome(psS)is one of the most widespread autoimmune diseases with unknown origin,characterized by a lymphocytic infiltrate of the exocrine glands and the production of anti-SSA/Ro and anti-SSB/La antibodies that cause dysfunction and destruction mainly of salivary and lachrymal glands,leading to dry eyes and dry *** the absence of a standardized evidence-based screening tool to decide which patients with dry eye must be referred for study of this pathology.

关键词： Sjogren lymphocytic salivary

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Semiosic Translation:a Bayesian-heuristic theory of translation and translating

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Language and Semiotic Studies 2024年第2期10卷 167-202页

作者： Sergio torres-Martínez Universidad de Antioquia Cll.67#53–108MedellínAntioquiaColombia

In the context of Semiosic Translation,two elements are essential for a translation to emerge:the body–brain–context interface(extended mind)and the sign systems making up a translation *** this paper,I explain how a renewed view of the body as a Bayesian-heuristic Semiotic Prior helps to understand in a more holistic manner the motivations and agentive character of translation,defined herein as a phenomenological grasp of the *** to the present proposal is the idea that bodily self-stabilization(homeostasis)and brain-driven correction(allostasis)provide translator-agents with maps of action upon the world that are semiotic in *** this occurs thanks to information weighing(Bayesian)and cue-driven(heuristic)types of inference whereby exteroceptive(exogenous)and interoceptive(inner-body)signals converge to create a sense of bodily awareness responsible for the construction of the symbolic persona(the translator-agent).

关键词： embodiment Bayesian semiosis heuristic semiosis semiotics Semiosic Translation translator-agents

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Could mammalian inorganic polyphosphate be a crucial signaling molecule in neurological disorders?

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Neural Regeneration Research 2024年第4期19卷 701-702页

作者： Renata torres Da Costa Maria E.Solesio Rutgers University Department of BiologyCamdenNJUSA

Since the early stages of life on earth,cellular metabolism has evolved to adapt to fluctuations in nutrient and oxygen *** this context,mammals,which are probably the organisms that show one of the highest levels of metabolic complexity,have developed an elegant system that uses constant and rechargeable energy sources of modulate their *** homeostasis is especially important in the central nervous system,as neurons and other cells in the brain are highly susceptible to fluctuations in nutrients and oxygen availability.

关键词： metabolism homeostasis neurological

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Impact of solar reflectivity and infrared emissivity on the thermal performance of metal and concrete roofs in cloudy warmhumid climate

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Frontiers of Architectural Research 2024年第4期13卷 842-857页

作者： Jefferson torres-Quezada Antonio Isalgué Helena Coch CONSISO Lab Universidad Católica de CuencaCuenca 010102Ecuador Architecture Energy and EnvironmentPolytechnic University of CataloniaBarcelona 08028Spain

Regions near latitude 0are characterized by warm-humid climate and also by high *** these regions,metal roofs has been the most widely used ***,in the last decades,the use of heavy concrete roofs has increased *** its material characteristics,this roof typology offers a higher thermal resistance and thermal mass than a metal *** strategies focus on the use of these characteristics,as well as the use of high reflectivity and ***,the impact of cloudiness on the effectiveness of these strategies has been little *** research focuses on the impact of reflectivity and emissivity change on the thermal performance of these two roofs in a cloudy warm-humid *** achieve this objective,simulations validated with measurements were *** results show that the efficiency of reflectivity and emissivity is lower in this region compared to other *** impact of these properties is further reduced with increasing thermal mass or decreasing thermal transmittance,so the effectiveness of reflectivity and emissivity is minimal on the concrete ***,this study supports that a metal roof with a reflectivity and emissivity above 0.70 can offer lower daily average temperatures than a concrete roof.

关键词： Concrete roof Metal roof Radiative properties Simulations Measurements

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Selective and Adaptive Incremental Transfer Learning with Multiple Datasets for Machine Fault Diagnosis

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Computers, Materials & Continua 2024年第1期78卷 1363-1379页

作者： Kwok Tai Chui Brij B.Gupta Varsha Arya Miguel torres-Ruiz School of Science and Technology Hong Kong Metropolitan UniversityHong Kong999077China Department of Computer Science and Information Engineering Asia UniversityTaichung41354Taiwan Center for Advanced Information Technology Kyung Hee UniversitySeoul02447Korea Symbiosis Centre for Information Technology Symbiosis International UniversityPuneMaharashtra411042India Department of Electrical and Computer Engineering Lebanese American UniversityBeirut1102Lebanon School of Computing Skyline University CollegeSharjah1797United Arab Emirates Department of Business Administration Asia UniversityTaichung41354Taiwan Center for Interdisciplinary Research University of Petroleum and Energy StudiesDehradun248007India Department of Computer Science&Engineering Chandigarh UniversityChandigarh160036India Centro de Investigación en Computación Instituto Politécnico NacionalUPALM-ZacatencoMexico City07320Mexico

The visions of Industry 4.0 and 5.0 have reinforced the industrial *** have also made artificial intelligence incorporated as a major *** machine faults has become a solid foundation for automatically recognizing machine failure,and thus timely maintenance can ensure safe *** learning is a promising solution that can enhance the machine fault diagnosis model by borrowing pre-trained knowledge from the source model and applying it to the target model,which typically involves two *** response to the availability of multiple datasets,this paper proposes using selective and adaptive incremental transfer learning(SA-ITL),which fuses three algorithms,namely,the hybrid selective algorithm,the transferability enhancement algorithm,and the incremental transfer learning *** is a selective algorithm that enables selecting and ordering appropriate datasets for transfer learning and selecting useful knowledge to avoid negative *** algorithm also adaptively adjusts the portion of training data to balance the learning rate and training *** proposed algorithm is evaluated and analyzed using ten benchmark *** with other algorithms from existing works,SA-ITL improves the accuracy of all *** studies present the accuracy enhancements of the SA-ITL,including the hybrid selective algorithm(1.22%-3.82%),transferability enhancement algorithm(1.91%-4.15%),and incremental transfer learning algorithm(0.605%-2.68%).These also show the benefits of enhancing the target model with heterogeneous image datasets that widen the range of domain selection between source and target domains.

关键词： Deep learning incremental learning machine fault diagnosis negative transfer transfer learning

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Porphyrinic Acceptors forFullerene-Free MolecularPhotovoltaics

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CCS Chemistry 2024年第2期6卷 276-296页

作者： Jorge Labella Juan Laforga-Martin Tomás torres Department of Organic Chemistry Universidad Aut´onoma de Madrid28049 Madrid Institute for Advanced Research in Chemical Sciences Universidad Aut´onoma de MadridMadrid IMDEA—Nanociencia 28049 Madrid

Over the past few years,the development of nonfullerene acceptors(NFAs)has become a prominent focus in both organic and perovskite solar cell(OSCs and PSCs,respectively)research *** this context,porphyrinoids,compounds structurally related to porphyrins,have emerged as promising solar cell *** contrast to the widely used fullerene acceptors,porphyrinoids exhibit strong,broad absorption properties across the UV–vis/NIR spectrum,which can be easily tuned through chemical ***,they can be prepared and derivatized using cost-effective and straightforward methodologies,allowing for convenient adjustments in thin-film morphology,processability,supramolecular organization,and energy ***,these compounds offer higher thermal and photochemical stability,resulting in longer device lifetimes compared to their fullerene-based *** this review,we outline the utilization of porphyrinoids as NFAs in OSCs and PSCs,discussing essential aspects such as design guidelines,molecular properties,and device *** goal is to inspire and further promote the development of n-type porphyrinoids,which have not yet fully unleashed their potential.

关键词： fullerene-free molecular photovoltaics nonfullerene acceptors porphyrinic acceptors n-type porphyrinoids organic and perovskite solar cells

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Hydrochar and synthetic natural gas co-production for a full circular economy implementation via hydrothermal carbonization and methanation:An economic approach

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Journal of Environmental Sciences 2024年第6期140卷 69-78页

作者： Judith González-Arias Guillermo torres-Sempere Miriam González-Castaño Francisco MBaena-Moreno Tomás RReina Inorganic Chemistry Department and Materials Sciences Institute University of Seville-CSICSevilleSpain Materials Sciences Institute(ICMSE) CSIC-University of SevilleSevilleSpain Department of Chemistry and Chemical Engineering Chalmers University of TechnologyGothenburgSE 41296Sweden

Herein we study the economic performance of hydrochar and synthetic natural gas coproduction from olive tree *** process entails a combination of hydrothermal carbonization and *** a previous work,we evidenced that standalone hydrochar production via HTC results ***,we propose a step forward on the process design by implementing a methanation,adding value to the gas effluent in an attempt to boost the overall process techno-economic *** different plant capacities were analyzed(312.5,625 and 1250 kg/hr).The baseline scenarios showed that,under the current circumstances,our circular economy strategy in *** analysis of the revenues shows that hydrochar selling price have a high impact on NPV and subsidies for renewable coal production could help to boost the profitability of the *** the contrary,the analysis for natural gas prices reveals that prices 8 times higher than the current ones in Spain must be achieved to reach *** seems unlikely even under the presence of a strong subsidy *** costs analysis suggests that a remarkable electricity cost reduction or electricity consumption of the HTC stage could be a potential strategy to reach profitability ***,significant reduction of green hydrogen production costs is deemed instrumental to improve the economic performance of the *** results show the formidable techno-economic challenge that our society faces in the path towards circular economy societies.

关键词： Hydrothermal carbonization CO_(2)waste valorization Methanation Profitability analysis

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Optimal Design of Hybrid Microgrid in Isolated Communities of Ecuador

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 488-499页

作者： Luis A.Pesantes Ruben Hidalgo-León Johnny Rengifo Miguel torres Jorge Aragundi JoséCordova-Garcia Luis F.Ugarte Facultad de Ingeniería en Electricidad y Computación of Escuela Superior Politécnica del Litoral(ESPOL)University GuayaquilEcuador Department of Electrical Engineering at Universidad Técnica Federico Santa María SantiagoChile IEEE

In rural territories, the communities use energy sources based on fossil fuels to supply themselves with electricity, which may address two main problems: greenhouse gas emissions and high fuel prices. Hence, there is an opportunity to include renewable resources in the energy mix. This paper develops an optimization model to determine the optimal sizing, the total annual investment cost in renewable generation, and other operating costs of the components of a hybrid microgrid. By running a k-means clustering algorithm on a meteorological dataset of the community under study, the hourly representative values become input parameters in the proposed optimization model. The method for the optimal design of hybrid microgrid is analyzed in six operating scenarios considering:(1) 24-hour continuous power supply;(2) load shedding percentage;(3) diesel power generator(genset) curtailment;(4) the worst meteorological conditions;(5) the use of renewable energy sources including battery energy storage systems(BESSs);and(6) the use of genset. A mathematical programming language(AMPL) tool is used to find solutions of the proposed optimization model. Results show that the total costs of microgrid in the scenarios that cover 100% of the load demand(without considering the scenario with 100% renewables) increase by over 16% compared with the scenario with genset operation limitation. For the designs with power supply restrictions, the total cost of microgrid in the scenario with load shedding is reduced by over 27% compared with that without load shedding.

关键词： Battery energy storage system(BESS) isolated community microgrid renewable energy optimization

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