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Mercury in sediments and vegetation in a moderately contaminated salt marsh (Tagus Estuary, Portugal)

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Journal of Environmental Sciences 2010年第8期22卷 1151-1157页

作者： joao Canário Carlos Vale Laurier Poissant Marta Nogueira Martin Pilote Vasco Branco INRB I.P./IPIMAR Av. Brasília Environment Canada Science and Technology Branch

Depth variations of total mercury （Hg） and methylmercury （MeHg） concentrations were studied in cores from non-colonized sediments, sediments colonized by Halimione portulacoides, Sarcocornia fruticosa and Spartina maritima and belowground biomass, in a moderately contaminated salt marsh （Tagus Estuary, Portugal）. Concentrations in belowground biomass exceeded up to 3 （Hg） and 15 （MeHg） times the levels in sediments, and up to 198 （Hg） and 308 （MeHg） times those found in aboveground parts. Methylmercury in colonized sediments reached 3% of the total Hg, 50 times above the maximum values found in non-colonized sediments. The absence of correlations between total Hg concentrations in sediments and the corresponding MeHg levels suggested that methylation was only dependent on the environmental and microbiological factors. The analysis of belowground biomass at high-depth resolution （2 cm） provided evidence that Hg and MeHg were actively absorbed from sediments, with higher enrichment factors at layers where higher microbial activity was probably occurring. The results obtained in this study indicated that the biotransformation of Hg to the toxic MeHg could increase the toxicity of plant-colonized sediments.

关键词： mercury methylmercury salt marshes Tagus Estuary Portugal

Pulmonary amyloidosis and multiple myeloma mimicking lymphoma in a patient with Sjogren’s syndrome:A case report

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World Journal of Clinical Cases 2022年第3期10卷 1016-1023页

作者： joa Kim Yun Sung Kim Hee Jeong Lee Sang Gon Park Department of Internal Medicine RheumatologyChosun University HospitalGwangju 501-717South Korea Department of Internal Medicine Chosun University HospitalGwangju 501-717South Korea Department of Internal Medicine Hemato-OncologyChosun University HospitalGwangju 501-717South Korea

BACKGROUND Sjogren’s syndrome(SS),which affect salivary gland function,is an autoimmune *** may involve extraglandular *** 10 to 20 percent of SS patients have clinically significant lung disease,but presentation of pulmonary amylodosis is extremly *** incidence of benign monoclonal gammopathy in SS patients is high,but multiple myeloma is *** case involving the simultaneous occurrence of two rare diseases,pulmonary amyloidosis and multiple myeloma,in the same patient with SS has been reported so *** SUMMARY A 41-year-old male patient was referred to our hematology department due to incidentally detected gastric *** had been diagnosed with SS four years *** miliary nodules,ground glass opacity in both lung fields,and enlargement of both inguinal lymph nodes was observed on chest and abdomen computer *** on the pathological findings of lung and lymph node biopsied specimens,the patient was diagnosed with pulmonary amyloidosis and multiple *** amyloidosis and multiple myeloma associated with SS has rarely been *** This is an extremely rare case of simultaneous pulmonary amyloidosis and multiple myeloma in the same patient with SS.

关键词： Case report Sjogren’s syndrome Amyloidosis Multiple myeloma Plasmacytoma

Thin films as an emerging platform for drug delivery

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Asian Journal of Pharmaceutical Sciences 2016年第5期11卷 559-574页

作者： Sandeep Karki Hyeongmin Kim Seon-Jeong Na Dohyun Shin Kanghee joa Jaehwi Lee Pharmaceutical Formulation Design Laboratory College of PharmacyChung-Ang UniversitySeoul 06974Republic of Korea Bio-Integration Research Center for Nutra-Pharmaceutical Epigenetics Chung-Ang UniversitySeoul 06974Republic of Korea Center for Metareceptome Research Chung-Ang UniversitySeoul 06974Republic of Korea

Pharmaceutical scientists throughout the world are trying to explore thin films as a novel drug delivery tool. Thin films have been identified as an alternative approach to conventional dosage forms. The thin films are considered to be convenient to swallow, selfadministrable, and fast dissolving dosage form, all of which make it as a versatile platform for drug delivery. This delivery system has been used for both systemic and local action via several routes such as oral, buccal, sublingual, ocular, and transdermal routes. The design of efficient thin films requires a comprehensive knowledge of the pharmacological and pharmaceutical properties of drugs and polymers along with an appropriate selection of manufacturing processes. Therefore, the aim of this review is to provide an overview of the critical factors affecting the formulation of thin films, including the physico-chemical properties of polymers and drugs, anatomical and physiological constraints, as well as the characterization methods and quality specifications to circumvent the difficulties associated with formulation design. It also highlights the recent trends and perspectives to develop thin film products by various companies.

关键词： Thin film Film-forming polymer Mechanical properties Manufacturing Characterization

Novel ACLV1 Mutation Identified in Late Onset Hereditary Hemorrhagic Telangiectasia

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International Journal of Otolaryngology and Head & Neck Surgery 2016年第4期5卷 157-173页

作者： Cory Patrick Kaitlin McIntyre Jeremy Ramidial Sano joa Vijaykumar Dinsukhlal Zaveri Damien Hansra Miller School of Medicine University of Miami Miami FL USA Jackson Memorial Hospital Miami FL USA Mercy Hospital Miami FL USA Oncology and Radiation Associates Miami FL USA

Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant disorder with variable expressivity. We present a 62-year-old patient with a rare, late-onset disease course featuring a novel mutation in ACVRL1, a... 详细信息

关键词： Hereditary Hemorrhagic Telaniectasia Osler-Weber-Rendu Syndrome Anemia Mutation

Patients’ Experiences of Trust in the Patient-Nurse Relationship——A Systematic Review of Qualitative Studies

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Open Journal of Nursing 2015年第3期5卷 195-209页

作者： Kristine Rortveit Britt Satre Hansen Ingrid Leiknes Inge joa Ingelin Testad Elisabeth Severinsson Stavanger University Hospital StavangerNorway Department of Health Studies Faculty of Social SciencesUniversity of StavangerStavangerNorway Centre for Movement Disorders Stavanger University HospitalStavangerNorway Division of Psychiatry Regional Centre for Clinical Research in PsychosisStavanger University HospitalStavangerNorway Regional Centre for Age-Related Medicine(SESAM) Stavanger University HospitalStavangerNorway Department of Research Stavanger University HospitalStavangerNorway

Aims and Objectives: To report a synthesis of the literature on the meaning of trust in the context of patients’ experiences of nursing. The review question was “How do patients describe the meaning of trust in the nursing relationship?” Background: Trust is essential in nursing as it has the potential to create opportunities for the human being to gain faith, hope and meaning in life as well as open up for new experiences. Trust is an interpersonal and essential element of all patient-nurse relationships and requires nurses to create a trusting relationship with the patients. Design: Systematic qualitative literature review. Methods: Systematic searches were conducted for the period January 2002 to December 2012, updated in January 2014. 20 papers were included. Results: Four categories emerged: Attitudes related to trust, indicating that trust is fundamental and existential;Experiences of trust, concerning how trust can be sensed;The patient-nurse relationship, revealing the qualities of the person who creates trust;and Where trust occurs, illuminating the contextual relevancies of trust. Conclusions: Patients’ experiences of trust in nursing are dependent on the nurses’ knowledge, level of commitment in the dialogue to creating and developing the relationship and contextual issues. Implications for nursing practice: Reflection on a trusting relationship with the patient is necessary for a deeper conceptual understanding of trust in nursing. Clinical nurse researchers nurse supervisors, managers and nurse educatorsshould discuss different areas of trust during nursing supervision and focus-group meetings as well as with nursing graduates to ensure that nurses develop knowledge of how to create a trusting patient-nurse relationship.

关键词： Patient-Nurse Relationship Patient Experience Qualitative Literature Review Trust

感受宁静与质朴 Malapascua Exotic潜水度假

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摄影之友 2014年第11期 178-179页

作者：水水 joa Lofstrom

如果你已经厌烦了在十一黄金周假期中去感受人山人海,那么请随我来,前往一个美丽的小岛—妈妈拍丝瓜。这里有最为质朴亲切的当地居民,还有一个美丽的度假村—Exotic(奇异岛潜水度假村),让你可以充分感受潜水的乐趣,充分享受这里的每一... 详细信息

如果你已经厌烦了在十一黄金周假期中去感受人山人海,那么请随我来,前往一个美丽的小岛—妈妈拍丝瓜。这里有最为质朴亲切的当地居民,还有一个美丽的度假村—Exotic(奇异岛潜水度假村),让你可以充分感受潜水的乐趣,充分享受这里的每一天。神奇岛屿"妈妈拍丝瓜"妈妈拍丝瓜是Malapascua的音译文字,也因为其独特而有趣的发音,让人们很容易就记住了这个美丽的地方,并且亲切的称之为妈妈岛。妈妈岛是一个很小的海岛,位于宿务的最北端,想要前往这里,需要坐螃蟹船。

关键词：长尾鲨潜水装备社交网络异国风情潜水设备最大光圈手机浏览海洋生物资源传输功能防压

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抽象几何的色彩演绎

设计 2014年第10期27卷 120-123页

作者： msright joa Herrenknecht

年轻的设计师琼海瑞克（joa HERRENKNECHT）生于加拿大,但已经在不同的城市,像伦敦、纽约和悉尼等大城市工作生活过。海瑞克说：“我的父母喜欢旅行,所以我也经常旅行,我猜我是继承了他们的旅行基因吧,迄今为止我生命中的大部分时光都... 详细信息

年轻的设计师琼海瑞克（joa HERRENKNECHT）生于加拿大,但已经在不同的城市,像伦敦、纽约和悉尼等大城市工作生活过。海瑞克说：“我的父母喜欢旅行,所以我也经常旅行,我猜我是继承了他们的旅行基因吧,迄今为止我生命中的大部分时光都是在德国南部度过的,我在接近法国瑞士的边境线长大,然后在卡尔斯鲁厄设计学院（HOCHSCHULE FüR GESTALTUNG IN KARLSRUHE）学习产品设计。”

关键词：演绎色彩几何抽象城市工作设计学院产品设计设计师

小切口开窗术治疗腰间盘突出症合并腰椎管狭窄的临床研究

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中国当代医药 2018年第13期25卷 98-100页

作者：廖强江西省萍乡市人民医院脊柱外科江西萍乡337055

目的探究小切口开窗术治疗腰间盘突出症合并腰椎管狭窄的临床效果。方法选取2016年11月~2017年11月我院收治的82例腰间盘突出症合并腰椎管狭窄患者,采用随机数字表法将其分为参照组、研究组,每组41例。参照组采用常规治疗方法,研究组行... 详细信息

目的探究小切口开窗术治疗腰间盘突出症合并腰椎管狭窄的临床效果。方法选取2016年11月~2017年11月我院收治的82例腰间盘突出症合并腰椎管狭窄患者,采用随机数字表法将其分为参照组、研究组,每组41例。参照组采用常规治疗方法,研究组行小切口开窗术治疗,将两组治疗后的总有效率、VAS及joa评分实施对比分析。结果研究组患者的治疗总有效率明显高于参照组,差异有统计学意义(Pjoa评分高于参照组,差异均有统计学意义(P<0.05)。结论同常规治疗方式比较,对腰间盘突出症合并腰椎管狭窄患者来讲,小切口开窗术,可以起到更好的治疗效果,腰椎神经恢复速度更快、疼痛度更低。

关键词：小切口开窗术腰间盘突出腰椎管狭窄临床研究

颈椎动态稳定器治疗颈椎间盘突出症的早期临床疗效

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中华骨科杂志 2012年第1期32卷 26-31页

作者：高延征司文腾余正红高坤陈书连张广泉河南省人民医院骨科郑州450003 郑州市骨科医院

目的探讨应用颈椎动态稳定器（dynamic cervical implant，DCI）治疗颈椎间盘突出症的安全性及早期临床疗效。方法2009年9月至2010年12月，应用颈前路DCI治疗31例颈椎间盘突出症患者，记录并统计分析手术时间和出血量；采用颈椎残障功... 详细信息

目的探讨应用颈椎动态稳定器（dynamic cervical implant，DCI）治疗颈椎间盘突出症的安全性及早期临床疗效。方法2009年9月至2010年12月，应用颈前路DCI治疗31例颈椎间盘突出症患者，记录并统计分析手术时间和出血量；采用颈椎残障功能指数（neck disability index，NDI）、日本矫形外科协会（Japanese Orthopaedic Association，joa）评分评价神经功能改善情况，评估患者手术前后的疼痛视觉模拟评分（visual analogue scale，VAS）。在x线片上测量术前和末次随访时植人节段的运动范围、手术节段脊柱功能单位（functionalspineunit，FSU）高度与上位椎体高度比值（H／h）等的差异。结果31例患者的手术时间为（45-15）min，出血量为（100-30）ml。术后随访6-20个月，平均14个月。术前与末次随访时植入节段的运动范围（9．6°±4．2°VS．6．9°±5．3°，P〉0．05）、H／h（2．6±0．1vs2．5±0．1，P〉O．05）和FSU的角度（2．6°±5．2°VS．1．7°±2．9°，P〉0．05）差异无统计学意义；而术前与末次随访时NDI（50．5±16．2 vs 19．6±4．3，P〈0．05）、joa评分（12．3±1．6 vs 13．9±1．8，P〈0．05）及颈痛VAS（6．3±2．6vs3．1±2．2，P〈0．05）差异有统计学意义。结论应用DCI非融合技术治疗颈椎间盘突出症，手术时间短，出血少，可以早期保留手术节段的运动功能，维持了椎间高度，早期临床效果满意。

关键词：颈椎椎间盘移位假体和植入物治疗结果