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Mercury in sediments and vegetation in a moderately contaminated salt marsh (Tagus Estuary, Portugal)

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Journal of Environmental Sciences 2010年第8期22卷 1151-1157页

作者： joa.o Canário Carlos Vale laurier Poissant Marta Nogueira Martin Pilote Vasco Branco INRB I.P./IPIMAR Av. Brasília Environment Canada Science and Technology Branch

Depth variations of total mercury （Hg） and methylmercury （MeHg） concentrations were studied in cores from non-colonized sediments, sediments colonized by Halimione portulacoides, Sarcocornia fruticosa and Spartina maritima and belowground biomass, in a moderately contaminated salt marsh （Tagus Estuary, Portugal）. Concentrations in belowground biomass exceeded up to 3 （Hg） and 15 （MeHg） times the levels in sediments, and up to 198 （Hg） and 308 （MeHg） times those found in aboveground parts. Methylmercury in colonized sediments reached 3% of the total Hg, 50 times above the maximum values found in non-colonized sediments. The absence of correlations between total Hg concentrations in sediments and the corresponding MeHg levels suggested that methylation was only dependent on the environmental and microbiological factors. The analysis of belowground biomass at high-depth resolution （2 cm） provided evidence that Hg and MeHg were actively absorbed from sediments, with higher enrichment factors at layers where higher microbial activity was probably occurring. The results obtained in this study indicated that the biotransformation of Hg to the toxic MeHg could increase the toxicity of plant-colonized sediments.

关键词： mercury methylmercury salt marshes Tagus Estuary Portugal

Pulmonary amyloidosis and multiple myeloma mimicking lymphoma in a patient with Sjogren’s syndrome:A case report

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World Journal of Clinical Cases 2022年第3期10卷 1016-1023页

作者： joa.Kim Yun Sung Kim Hee Jeong lee Sang Gon Park Department of Internal Medicine RheumatologyChosun University HospitalGwangju 501-717South Korea Department of Internal Medicine Chosun University HospitalGwangju 501-717South Korea Department of Internal Medicine Hemato-OncologyChosun University HospitalGwangju 501-717South Korea

BACKGROUND Sjogren’s syndrome(SS),which affect salivary gland function,is an autoimmune *** may involve extraglandular *** 10 to 20 percent of SS patients have clinically significant lung disease,but presentation of pulmonary amylodosis is extremly *** incidence of benign monoclonal gammopathy in SS patients is high,but multiple myeloma is *** case involving the simultaneous occurrence of two rare diseases,pulmonary amyloidosis and multiple myeloma,in the same patient with SS has been reported so *** SUMMARY A 41-year-old male patient was referred to our hematology department due to incidentally detected gastric *** had been diagnosed with SS four years *** miliary nodules,ground glass opacity in both lung fields,and enlargement of both inguinal lymph nodes was observed on chest and abdomen computer *** on the pathological findings of lung and lymph node biopsied specimens,the patient was diagnosed with pulmonary amyloidosis and multiple *** amyloidosis and multiple myeloma associated with SS has rarely been *** This is an extremely rare case of simultaneous pulmonary amyloidosis and multiple myeloma in the same patient with SS.

关键词： Case report Sjogren’s syndrome Amyloidosis Multiple myeloma Plasmacytoma

Thin films as an emerging platform for drug delivery

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Asian Journal of Pharmaceutical Sciences 2016年第5期11卷 559-574页

作者： Sandeep Karki Hyeongmin Kim Seon-Jeong Na Dohyun Shin Kanghee joa.Jaehwi lee Pharmaceutical Formulation Design laboratory College of PharmacyChung-Ang UniversitySeoul 06974Republic of Korea Bio-Integration Research Center for Nutra-Pharmaceutical Epigenetics Chung-Ang UniversitySeoul 06974Republic of Korea Center for Metareceptome Research Chung-Ang UniversitySeoul 06974Republic of Korea

Pharmaceutical scientists throughout the world are trying to explore thin films as a novel drug delivery tool. Thin films have been identified as an alternative approach to conventional dosage forms. The thin films are considered to be convenient to swallow, selfadministrable, and fast dissolving dosage form, all of which make it as a versatile platform for drug delivery. This delivery system has been used for both systemic and local action via several routes such as oral, buccal, sublingual, ocular, and transdermal routes. The design of efficient thin films requires a comprehensive knowledge of the pharmacological and pharmaceutical properties of drugs and polymers along with an appropriate selection of manufacturing processes. Therefore, the aim of this review is to provide an overview of the critical factors affecting the formulation of thin films, including the physico-chemical properties of polymers and drugs, anatomical and physiological constraints, as well as the characterization methods and quality specifications to circumvent the difficulties associated with formulation design. It also highlights the recent trends and perspectives to develop thin film products by various companies.

关键词： Thin film Film-forming polymer Mechanical properties Manufacturing Characterization

Novel AClV1 Mutation Identified in late Onset Hereditary Hemorrhagic Telangiectasia

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International Journal of Otolaryngology and Head & Neck Surgery 2016年第4期5卷 157-173页

作者： Cory Patrick Kaitlin McIntyre Jeremy Ramidial Sano joa.Vijaykumar Dinsukhlal Zaveri Damien Hansra Miller School of Medicine University of Miami Miami FL USA Jackson Memorial Hospital Miami FL USA Mercy Hospital Miami FL USA Oncology and Radiation Associates Miami FL USA

Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant disorder with variable expressivity. We present a 62-year-old patient with a rare, late-onset disease course featuring a novel mutation in ACVRl1, a... 详细信息

关键词： Hereditary Hemorrhagic Telaniectasia Osler-Weber-Rendu Syndrome Anemia Mutation

Patients’ Experiences of Trust in the Patient-Nurse Relationship——A Systematic Review of Qualitative Studies

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Open Journal of Nursing 2015年第3期5卷 195-209页

作者： Kristine Rortveit Britt Satre Hansen Ingrid leiknes Inge joa.Ingelin Testad Elisabeth Severinsson Stavanger University Hospital StavangerNorway Department of Health Studies Faculty of Social SciencesUniversity of StavangerStavangerNorway Centre for Movement Disorders Stavanger University HospitalStavangerNorway Division of Psychiatry Regional Centre for Clinical Research in PsychosisStavanger University HospitalStavangerNorway Regional Centre for Age-Related Medicine(SESAM) Stavanger University HospitalStavangerNorway Department of Research Stavanger University HospitalStavangerNorway

Aims and Objectives: To report a synthesis of the literature on the meaning of trust in the context of patients’ experiences of nursing. The review question was “How do patients describe the meaning of trust in the nursing relationship?” Background: Trust is essential in nursing as it has the potential to create opportunities for the human being to gain faith, hope and meaning in life as well as open up for new experiences. Trust is an interpersonal and essential element of all patient-nurse relationships and requires nurses to create a trusting relationship with the patients. Design: Systematic qualitative literature review. Methods: Systematic searches were conducted for the period January 2002 to December 2012, updated in January 2014. 20 papers were included. Results: Four categories emerged: Attitudes related to trust, indicating that trust is fundamental and existential;Experiences of trust, concerning how trust can be sensed;The patient-nurse relationship, revealing the qualities of the person who creates trust;and Where trust occurs, illuminating the contextual relevancies of trust. Conclusions: Patients’ experiences of trust in nursing are dependent on the nurses’ knowledge, level of commitment in the dialogue to creating and developing the relationship and contextual issues. Implications for nursing practice: Reflection on a trusting relationship with the patient is necessary for a deeper conceptual understanding of trust in nursing. Clinical nurse researchers nurse supervisors, managers and nurse educatorsshould discuss different areas of trust during nursing supervision and focus-group meetings as well as with nursing graduates to ensure that nurses develop knowledge of how to create a trusting patient-nurse relationship.

关键词： Patient-Nurse Relationship Patient Experience Qualitative literature Review Trust

感受宁静与质朴 Malapascua Exotic潜水度假

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摄影之友 2014年第11期 178-179页

作者：水水 joa.lofstrom

如果你已经厌烦了在十一黄金周假期中去感受人山人海,那么请随我来,前往一个美丽的小岛—妈妈拍丝瓜。这里有最为质朴亲切的当地居民,还有一个美丽的度假村—Exotic(奇异岛潜水度假村),让你可以充分感受潜水的乐趣,充分享受这里的每一... 详细信息

如果你已经厌烦了在十一黄金周假期中去感受人山人海,那么请随我来,前往一个美丽的小岛—妈妈拍丝瓜。这里有最为质朴亲切的当地居民,还有一个美丽的度假村—Exotic(奇异岛潜水度假村),让你可以充分感受潜水的乐趣,充分享受这里的每一天。神奇岛屿"妈妈拍丝瓜"妈妈拍丝瓜是Malapascua的音译文字,也因为其独特而有趣的发音,让人们很容易就记住了这个美丽的地方,并且亲切的称之为妈妈岛。妈妈岛是一个很小的海岛,位于宿务的最北端,想要前往这里,需要坐螃蟹船。

关键词：长尾鲨潜水装备社交网络异国风情潜水设备最大光圈手机浏览海洋生物资源传输功能防压

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抽象几何的色彩演绎

设计 2014年第10期27卷 120-123页

作者： msright joa.Herrenknecht

年轻的设计师琼海瑞克（joa.HERRENKNECHT）生于加拿大,但已经在不同的城市,像伦敦、纽约和悉尼等大城市工作生活过。海瑞克说：“我的父母喜欢旅行,所以我也经常旅行,我猜我是继承了他们的旅行基因吧,迄今为止我生命中的大部分时光都... 详细信息

年轻的设计师琼海瑞克（joa.HERRENKNECHT）生于加拿大,但已经在不同的城市,像伦敦、纽约和悉尼等大城市工作生活过。海瑞克说：“我的父母喜欢旅行,所以我也经常旅行,我猜我是继承了他们的旅行基因吧,迄今为止我生命中的大部分时光都是在德国南部度过的,我在接近法国瑞士的边境线长大,然后在卡尔斯鲁厄设计学院（HOCHSCHUlE FüR GESTAlTUNG IN KARlSRUHE）学习产品设计。”

关键词：演绎色彩几何抽象城市工作设计学院产品设计设计师

癫痫持续状态患者发生多器官功能障碍的危险因素分析

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中华流行病学杂志 2006年第7期27卷 618-622页

作者：陈春富郎森阳贾海燕夏程王湘庆煤炭总医院神经内科北京100028 解放军总医院神经内科海军总医院神经内科

目的分析成年人癫痫持续状态患者中发生多器官功能障碍(MODS)的危险因素。方法1988-2004年连续住院的317例全身惊厥性癫痫持续状态(GCSE)患者,其中资料完整的共137例。疾病组为41例癫痫持续状态继发MODS的患者,对照组96例为同期住院未发... 详细信息

目的分析成年人癫痫持续状态患者中发生多器官功能障碍(MODS)的危险因素。方法1988-2004年连续住院的317例全身惊厥性癫痫持续状态(GCSE)患者,其中资料完整的共137例。疾病组为41例癫痫持续状态继发MODS的患者,对照组96例为同期住院未发生MODS的癫痫持续状态患者。病例和对照采用统一的调查表,用Microsoft Access 2003建立数据库,共53个主项内容,部分主项设有下属分项。对研究资料先进行单因素分析,然后进行多因素非条件logistic回归模型分析。结果经分析筛选出癫痫状态持续时间(OR=14．965)、GCSE持续抽搐发作类型(OR=3．836)、GCSE治疗时机(OR=2．404)、持续发热(OR=1．539)、年龄(OR=1．324)等5个因素为癫痫持续状态继发MODS的独立危险因素。结论癫痫状态继发MODS与抽搐持续时间、GCSE持续抽搐发作类型、治疗时机关系最为密切,持续发热、患者高龄也可促发MODS。

关键词：癫痫全身惊厥性癫痫持续状态多器官功能障碍危险因素非条件logistic回归分析

Satellite-enabled enviromics to enhance crop improvement

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Molecular Plant 2024年第6期17卷 848-866页

作者： Rafael T.Resende lee Hickey Cibele H.Amaral lucas l.Peixoto Gustavo E.Marcatti Yunbi Xu Universidade Federal de Goia´s(UFG) Agronomy DepartmentPlant Breeding SectorGoiania(GO)74690-900Brazil TheCROP a Precision-Breeding Startup:EnviromicsPhenomicsand GenomicsNo Zip-codeOperating VirtuallyGoiania(GO)and Sete Lagoas(MG)Brazil Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneQLDAustralia Earth lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Environmental Data Science Innovation&Inclusion lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Universidade Federal de Sa˜o joa.o del-Rei Forest Engineering DepartmentCampus Sete LagoasSete Lagoas(MG)35701-970Brazil Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Peking University Institute of Advanced Agricultural Sciences WeifangShandong 261325China BGI Bioverse Shenzhen 518083China

Enviromics refers to the characterization of micro-and macroenvironments based on large-scale environmental *** providing genotypic recommendations with predictive extrapolation at a site-specific level,enviromics could inform plant breeding decisions across varying conditions and anticipate productivity in a changing ***-based integration of statistics,envirotyping(i.e.,determining environmental factors),and remote sensing could help unravel the complex interplay of genetics,environment,and *** support this goal,exhaustive envirotyping to generate precise environmental profiles would significantly improve predictions of genotype performance and genetic gain in ***,informatics management platforms aggregate diverse environmental datasets obtained using optical,thermal,radar,and light detection and ranging(liDAR)sensors that capture detailed information about vegetation,surface structure,and *** wealth of information,coupled with freely available climate data,fuels innovative enviromics *** enviromics holds immense potential for breeding,a few obstacles remain,such as the need for(1)integrative methodologies to systematically collect field data to scale and expand observations across the landscape with satellite data;(2)state-of-the-art AI models for data integration,simulation,and prediction;(3)cyberinfrastructure for processing big data across scales and providing seamless interfaces to deliver forecasts to stakeholders;and(4)collaboration and data sharing among farmers,breeders,physiologists,geoinformatics experts,and programmers across research *** these challenges is essential for leveraging the full potential of big data captured by satellites to transform 21st century agriculture and crop improvement through enviromics.

关键词： envirotyping precision breeding genotype-environment interactions remote sensing predictive models enviromic information