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Adherence to Mediterranean diet and advanced glycation endproducts in patients with diabetes

World journal of Diabetes 2021年第11期12卷 1942-1956页

作者： Marko Grahovac Marko Kumric Marino Vilovic Dinko Martinovic Ante Kreso Tina Ticinovic Kurir josip Vrdoljak Karlo Prizmic joško božić Department of Pharmacology University of Split School of MedicineSplit 21000Croatia Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Endocrinology University Hospital of SplitSplit 21000Croatia

BACKGROUND in recent years,American Diabetes Association started to strongly advocate the Mediterranean diet(MD)over other diets in patients with diabetes mellitus(DM)because of its beneficial effects on glycemic control and cardiovascular(CV)risk *** levels of advanced glycation endproducts(AGEs)emerged as an indicator of CV risk in *** biopsy being invasive,the use of AGE Reader has been shown to reflect tissue AGEs *** To examine the association between adherence to MD and AGEs in patients with DM type *** This cross-sectional study was conducted on 273 patients with DM type ii.A survey questionnaire was composed of 3 separate *** first part of the questionnaire included general data and the habits of the *** second part aimed to assess the basic parameters of participants’diseases and associated *** third part of the questionnaire was the Croatian version of the 14-item MD service score(MDSS).AGEs levels and associated CV risk were measured using AGE Reader(DiagnOptics Technologies BV,Groningen,The Netherlands).RESULTS A total of 27(9.9%)patients fulfilled criteria for adherence to MD,with a median score of 8.0(6.0-10.0).Patients with none/limited CV risk had significantly higher percentage of MD adherence in comparison to patients with increased/definite CV risk(15.2%vs 6.9%,P=0.028),as well as better adherence to guidelines for nuts(23.2%vs 12.6%,P=0.023)and legumes(40.4%vs 25.9%,P=0.013)*** number of patients with glycated hemoglobin(HbA1c)ients with HbA1c>7%(14.9%vs 7.3%,P=0.045).Moreover,those patients followed the MDSS guidelines for eggs(33.0%vs 46.8%,P=0.025)and wine(15.6%vs 29.8%,P=0.006)consumption more *** score had significant positive correlation with disease duration(r=0.179,P=0.003)and negative correlation with body mass index(BMi)values(r=-0.159,P=0.008).in the multiple linear regression model,BMi(β±SE,-0.09±0.04,P=0.037

关键词： Mediterranean diet Cardiovascular disease Diabetes mellitus Advanced glycation endproducts Dietary habits Atherosclerosis

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Brain age estimation:premise,promise,and problems

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Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron Ji Hyun ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

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Security Strategy of Digital Medical Contents Based on Blockchain in Generative Ai Model

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Computers, Materials & Continua 2025年第1期82卷 259-278页

作者： Hoon ko Marek R.Ogiela Division of Computer Science and Engineering Sunmoon UniversityAsan31460Republic of Korea AGH University of Krakow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study presents an innovative approach to enhancing the security of visual medical data in the generative Ai environment through the integration of blockchain *** combining the strengths of blockchain and generative Ai,the research team aimed to address the timely challenge of safeguarding visual medical *** participating researchers conducted a comprehensive analysis,examining the vulnerabilities of medical Ai services,personal information protection issues,and overall security *** multi faceted exploration led to an indepth evaluation of the model’s performance and ***,the correlation between accuracy,detection rate,and error rate was *** analysis revealed insights into the model’s strengths and limitations,while the consideration of standard deviation shed light on the model’s stability and performance *** study proposed practical improvements,emphasizing the reduction of false negatives to enhance detection rate and leveraging blockchain technology to ensure visual data integrity in medical *** blockchain to generative Ai-created medical content addresses key personal information protection *** utilizing the distributed ledger system of blockchain,the research team aimed to protect the privacy and integrity of medical data especially medical *** approach not only enhances security but also enables transparent and tamperproof ***,the use of generative Ai models ensures the creation of novel medical content without compromising personal information,further safeguarding patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,particularly in securing sensitive medical data and protecting patient *** proposed approach,combining blockchain and generative Ai,offers a promising direction toward more robust and secure medical content *** research and advancements

关键词： Digitalmedical content medical diagnostic visualization security analysis generativeAi blockchain vulnerability pattern recognition

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Cutting force signal pattern recognition using hybrid neural network in end milling

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中国有色金属学会会刊：英文版 2009年第B09期19卷 209-214页

作者： Song-Tae SEONG ko-Tae jo Young-Moon LEE Research and Development Department Gyeongbuk Hybrid Technology Institute School of Mechanical Engineering Yeongnam University School of Mechanical Engineering Kyungpo ok National University

Under certain cutting conditions in end milling, the signs of cutting forces change from positive to negative during a revolution of the tool. The change of force direction causes the cutting dynamics to be unstable which results in chatter vibration. Therefore, cutting force signal monitoring and classification are needed to determine the optimal cutting conditions and to improve the efficiency of cut. Artificial neural networks are powerful tools for solving highly complex and nonlinear problems. it can be divided into supervised and unsupervised learning machines based on the availability of a teacher. Hybrid neural network was introduced with both of functions of multilayer perceptron (MLP) trained with the back-propagation algorithm for monitoring and detecting abnormal state, and self organizing feature map (SOFM) for treating huge datum such as image processing and pattern recognition, for predicting and classifying cutting force signal patterns simultaneously. The validity of the results is verified with cutting experiments and simulation tests.

关键词：切削力信号混合神经网络模式识别铣床人工神经网络切削条件信号监测监督学习

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Tribological properties of hierarchical micro-dimples produced on a cylindrical surface by dual-frequency texturing

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Friction 2023年第2期11卷 246-258页

作者： Saood ALi Rendi KURNiAWAN Park Gun CHUL Tae jo ko School of Mechanical Engineering Yeungnam UniversityGyeongsan-si 712749Republic of Korea

An experimental investigation was performed for investigating the tribological performance of micro-dimple surface texture patterns on a cylindrical surface in a realistic operating environment of starved lubrication. Micro-dimples were generated by a dual-frequency surface texturing method, in which a high-frequency (16.3 kHz) three-dimensional (3D) vibration and a low-frequency (230 Hz) one-dimensional (1D) vibration were applied at the tool tip simultaneously, resulting in the generation of the hierarchical micro-dimples in a single step. Rotating cylinder-on-pin tribological tests were conducted to compare the tribological performance of the non-textured reference specimen and micro-dimple samples. The effect of surface textures generated with various shape parameters (long drop and short drop), dimension parameters (length and surface texture density), and operation parameters (load and sliding velocity) on the tribological performance was evaluated. Stribeck curves indicate that the hierarchical micro-dimples exhibit a lower coefficient of friction than the reference specimen in the high contact-pressure regions. it is also observed that variation in the length of a micro-dimple, the shape effect, is the major factor affecting the friction response of the textured surfaces. The generation of additional hydrodynamic pressure and lift effect by hierarchical structures is the main reason for the improved performance of hierarchical micro-dimple surfaces.

关键词： dual-frequency surface texturing hierarchical surfaces tribology starved lubrication three-dimensional elliptical vibration transducer

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COMMON FiXED POiNT THEOREMS FOR MULTi-VALUED MAPS

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Acta Mathematica Scientia 2012年第2期32卷 818-824页

作者： boško Damjanovic Bessem Samet Calogero Vetro Department of Mathematics Faculty of AgricultureNemanjina 6BelgradeSerbia Universitéde Tunis Département de MathématiquesEcole Supérieure des Sciences et Techniques de Tunis Department of Mathematics and informatics University of PalermoVia Archirafi3490123 PalermoItaly

We establish some results on coincidence and common fixed points for a twopair of multi-valued and single-valued maps in complete metric spaces. Presented theorems generalize recent results of Gordji et al [4] and sev... 详细信息

关键词： Coincidence point common fixed point multi-valued maps

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Approximation of thermoelasticity contact problem with nonmonotone friction

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Applied Mathematics and Mechanics(English Edition) 2010年第1期31卷 77-86页

作者： ivan ESTAK boko S. joVANOVi Faculty of Mine and Geology University of Belgrade Faculty of Mathematics University of Belgrade

The paper presents the formulation and approximation of a static thermoelasticity problem that describes bilateral frictional contact between a deformable body and a rigid foundation. The friction is in the form of a nonmonotone and multivalued law. The coupling effect of the problem is neglected. Therefore, the thermic part of the problem is considered independently on the elasticity problem. For the displacement vector, we formulate one substationary problem for a non-convex, locally Lipschitz continuous functional representing the total potential energy of the body. All problems formulated in the paper are approximated with the finite element method.

关键词： static thermoelastic contact nonmonotone multivalued friction hemivari-ational inequality substationary problem finite element approximation

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The Blue Cave in the Vis Archipelago Paradise,Croatia’s First UNESCO Geopark in the Adriatic

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journal of Tourism and Hospitality Management 2022年第2期10卷 51-63页

作者： joško božanić University of Split SplitCroatia

The island of Vis in the Adriatic Sea(Croatia)is a central Adriatic *** is a small island(89.72 km^(2))but it has a large maritime zone(6,601 km^(2))featuring geologically very attractive open-sea islets known for having rich fishing *** Vis Archipelago was officially declared a UNESCO Geopark on April 18th *** was the first area of the Croatian Adriatic to be included in the Global UNESCO Geopark *** paper presents the world-known monument of nature in the Adriatic Sea-the Blue Cave,a sea grotto of exceptional beauty on a small islet of Biševo in the Vis Archipelago *** author links the Blue Cave’s discovery to the beginning of tourism in Dalmatia,and he presents a few interesting commentaries and impressions of the Blue Cave by various visitors,especially in comparison to the more widely known Grotta Azzurra on the island of Capri near Naples(italy).

关键词： Blue Cave island of Vis UNESCO Adriatic Sea island of Biševo 10 last paradises of the Mediterranean Geopark Vis Archipelago

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Role of small leucine zipper protein in hepatic gluconeogenesis and metabolic disorder

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journal of Molecular Cell Biology 2021年第5期13卷 361-373页

作者： Minsoo Kang Sun Kyoung Han Suhyun Kim Sungyeon Park Yerin jo Hyeryung Kang Jesang ko Division of Life Sciences Korea UniversitySeoul 02841South Korea

Hepatic gluconeogenesis is the central pathway for glucose generation in the *** imbalance between glucose synthesis and uptake leads to metabolic diseases such as obesity,diabetes,and cardiovascular *** leucine zipper protein(sLZiP)is an isoform of LZiP and it mainly functions as a transcription *** sLZiP is known to regulate the transcription of genes involved in various cellular processes,the role of sLZiP in hepatic glucose metabolism is not *** this study,we investigated the regulatory role of sLZiP in hepatic gluconeogenesis and its involvement in metabolic *** found that sLZiP expression was elevated during glucose starvation,leading to the promotion of phosphoenolpyruvate carboxylase and glucose-6-phosphatase expression in ***,sLZiP knockdown suppressed the expression of the gluconeogenic enzymes under low glucose *** also enhanced glucose production in the human liver cells and mouse primary hepatic ***-induced cyclic adenosine monophosphate impeded sLZiP *** of glucose and pyruvate tolerance tests showed that sLZiP transgenic mice exhibited abnormal blood glucose *** findings suggest that sLZiP is a novel regulator of gluconeogenic enzyme expression and plays a role in blood glucose homeostasis during starvation.

关键词： gluconeogenic enzymes hepatic gluconeogenesis hyperglycemia transcription factor

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Comparative analysis of radiofrequency ablation and resection for resectable colorectal liver metastases

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World journal of Gastroenterology 2014年第2期20卷 525-531页

作者： Sanghwa ko Hongjae jo Seongpil Yun Eunyoung Park Suk Kim Hyung-il Seo Department of Surgery Biomedical Research InstitutePusan National University HospitalBusan 602-739South Korea Department of Radiology Biomedical Research InstitutePusan National UniversityBusan 602-739South Korea

AiM:To evaluate the therapeutic efficacy of radiofrequency ablation(RFA)for resectable colorectal liver metastases(CRLM)compared with that of ***:Between June 2004 and June 2009,we retrospectively analyzed 29 patients with resectable CRLMs;17 patients underwent RFA,and 12 underwent hepatic *** of the patients were informed about the treatment modalities and were allowed to choose either of *** including an intraoperative approach was performed by a radiologist;otherwise,hepatic resection was performed by a *** analysis of the two groups was performed,including comparisons of gender,age,and clinical outcomes,such as primary tumor stage and survival ***:The mean tumor size was significantly larger in the resection group(3.59 cm vs 2.02 cm,Pival(OS)rate for all patients was 44.7%.There was no difference in the 5-year OS rates between the RFA and resection groups(37.8%vs66.7%).Univariate analysis indicated significantly lower5-year OS rates for patients with a tumor size>*** 5-year disease-free survival(DFS)rates were17.6%and 22.2%in the RFA and resection groups,respectively(P=0.119).Univariate analysis revealed that in cases of male gender,age>65 years,T stageic metastasis,and tumor size>3 cm,RFA resulted in significantly inferior 5-year DFS rates compared with surgical ***:Surgical resection revealed superior outcomes in the treatment of resectable CRLMs,particularly in cases with a hepatic tumor size>3 cm.

关键词： Colorectal neoplasm Metastasis Radiofrequency Hepatectomy Survival

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