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Clinical/Behavioral Monitoring of Rodents and Rabbits Undergoing Scientific Experiments

open journal of Veterinary Medicine 2024年第5期14卷 91-109页

作者： Luiz Cesar Cavalcanti Pereira Jhônata Willy Rocha Coelho Hyago da Silva Medeiros Elidio Rita de Cássia dos Passos Ferraz Da Silva joão gab.iel regis sob.al Bárbara alves de Brito Soledade Leandro Thomaz Vilela Isabele Barbieri Dos Santos Institute of Science and Technology in Biomodels (ICTB) Oswaldo Cruz Foundation (FIOCRUZ) Rio de Janeiro Brazil Laboratory Animal Facility of the Carlos Chagas Pavilion of the Animal Experimentation Center (CEA) Oswaldo Cruz Institute (IOC) Oswaldo Cruz Foundation (FIOCRUZ) Rio de Janeiro Brazil

Background: We currently have international and national guidelines regarding the assessment and monitoring of clinical signs and humane endpoints in animals used in teaching and research, which make the performance of these activities mandatory for any experiment and professional working in this area. Assigning the severity of a research experiment is the result of an analysis of records of observations of the animal’s behavior, and clinical signs. The aim of this study was to describe the importance of carrying out a severity assessment associated with clinical and behavioral monitoring of rodents and rabbits during experimentation to maintain the welfare of these animals undergoing scientific research. Methods: The literature search was carried out using the following terms: “Monitoring”;“Humane endpoints”;“Animal welfare”, “Rodents”;“Rabbits”, and as connectors “and”;“or”, in the following databases: PubMed;LILACS/BIREME and Scielo. Results: A total of 987 articles were identified in the databases, and 20 of these studies were included in this review. Conclusions: Humane endpoint protocols and procedure severity tables are of the utmost importance, both from an ethical point and to refine the results of research conducted on laboratory animals. They should be drawn up jointly by the teams responsible for the project and the maintenance of the animals during the research period, and the data obtained should be published so that the scientific community can have access to it, helping to disseminate these practices, as well as helping to draw up new procedures. Monitoring and evaluating the welfare and clinical condition of animals undergoing scientific research procedures is the responsibility of the professors, researchers, veterinarians, and animal facility coordinators. The Ethics Committee on the Use of Animals must monitor all the activities conducted with the animals, by inspecting the experimental procedures and the physical environment of the laboratory an

关键词： Monitoring Humane Endpoints Animal Welfare Experimental Design Laboratory Animals’ Investigations

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Major Approaches on the Piezoelectric Device, Drills and Saws to orthognathic Surgery: A Systematic Review

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Health 2019年第6期11卷 783-791页

作者： Diego César Marques Vanessa gab.iela Gonzáles Pinto Rogério Luiz de Araújo Vian regis Manzini Leandro Aparecido Irrazabal Priscilla Janaína de Lima Borelli Bovo Idiberto josé Zotarelli Filho Elias Naim Kassis University Center North Paulista (Unorp) S&#227 o josé do Rio Preto (SP) Brazil Post Graduate and Continuing Education (Unipos) S&#227 o josé do Rio Preto (SP) Brazil Cristo Redentor Hospital Iporá Goáis Brazil Santa Casa de Misericórdia Hospital Servi&#231 o de Cirurgia e Traumatologia Bucomaxilofacial Ribeir&#227 o Preto (SP) Brazil Universida de Federal do Pampa (Unipampa) Campus Uruguaiana (RS) Brazil

Introduction: The incidence of lesions of sensory and motor nerves associated with oral and maxillofacial surgery is often underestimated, representing around 32.0% of all lesions, and orthognathic surgery contributes 12.3% to these lesions. Thus, the use of piezosurgery (PiZCi) has been indicated in several procedures within oral and maxillofacial surgery due to a number of advantages over conventional drill and saw techniques. objective: to analyze the main literature on the use of the piezoelectric device in relation to the use of drills and to orthognathic surgery in dentistry. Methods: A total of 41 articles were found involving orthognathic Surgery, Piezoelectric Device, Drills Device, Saws Device, and Efficiency. Initially, it was held the exclusion existing title and duplications following the interest described this work. After this process, the summaries were evaluated, and a new exclusion was held. 29 articles were included and discussed in this study. Initially, the keywords were determined by searching the DeCS tool (Descriptors in Health Sciences, BIREME base) and later verified and validated by MeSh system (Medical Subject Headings, the US National Library of Medicine). Results and conclusion: It was concluded that the piezoelectric device has excelled with an effective surgical technique, being able to be indicated in the most diverse areas of the oral surgery, providing accurate, clean and minimally traumatic osteotomies for the soft tissues, intraoperative bleeding, when compared to conventional surgery using drills and/or saws.

关键词： orthognathic Surgery Piezoelectric Device Drills Device Saws Device Efficiency

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Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey

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World journal of Gastroenterology 2009年第1期15卷 86-94页

作者： Ho Gak Kim Jimin Han Myung-Hwan Kim Kyu Hyun Cho Im Hee Shin Gwang Ha Kim Jae Seon Kim Jin Bong Kim Tae Nyeun Kim Tae Hyeon Kim Tae Hyo Kim Jae Woo Kim Ji Kon Ryu Young-Soo Moon jong Ho Moon Sung Jae Park Chan Guk Park Sung-jo Bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu Taek Lee Dong Ki Lee Byung Seok Lee Sang Soo Lee Seung ok Lee Woo Jin Lee Chang Min Cho Young-Eun joo gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon Department of Internal Medicine Catholic University of Daegu School of Medicine Daegu 705-718 South Korea Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul 138-736 South Korea Department of Medical Statistics Catholic University of Daegu School of Medicine Daegu 705-718 South Korea Department of Internal Medicine Pusan National University School of Medicine Busan 602-739 South Korea Department of Internal Medicine Korea University College of Medicine Seoul 136-705 South Korea Department of Internal Medicine Hallym University College of Medicine Chuncheon 200-704 South Korea Department of Internal Medicine Yeungnam University College of Medicine Daegu 705-717 South Korea Department of Internal Medicine Wonkwang University College of Medicine Iksan Jeonbuk 570-711 South Korea Department of Internal Medicine Gyeongsang National University School of Medicine Jinju Gyeongnam 660-702 South Korea Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Gangwon 220-701 South Korea Department of Internal Medicine Seoul National University College of Medicine Seoul 110-799 South Korea Department of Internal Medicine lnje University College of Medicine Seoul 139-713 South Korea Department of Internal Medicine Soonchunhyang University College of Medicine Bucheon Gyunggi 420-767 South Korea Department of Internal Medicine Inje University College of Medicine Busan 614-735 South Korea Department of Internal Medicine Chosun University College of Medicine Gwangju Jeonbuk 501-717 South Korea Department of Internal Medicine Ulsan University Hospital University of Ulsan College of Medicine Ulsan 681-714 South Korea Department of Internal Medicine Dongguk University College of Medicine Gyeongju Gyeongbuk 791-707 South Korea Department of Internal Medicine Hallym University College of Medicine Anyang Gyeonggi 431-070 South Korea Department of Internal Medicine Ajou University School of Medicine Suwon

AIM： To investigate prevalence of C/onorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. METHoDS： Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire. RESULTS： of 3080 patients with gastrointestinal diseases, 396 （12.9%） had clonorchiasis and 1140 patients （37.2%） had a history of eating raw freshwater fish. of those with a history of raw freshwater fish ingestion, 238 （20.9%） patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than nonnfected patients [34/396 （8.6%） vs 145/2684 （5.4%）, P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation （P = 0.008）. Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis. CoNCLUSIoN： Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite.

关键词： Clonorchis sinensis Epidemiology Cholangiocarcinoma Korea Multicenter study Clonorchiasis

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