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Research in Cold and Arid Regions 2022年第4期14卷 235-238页

作者： Sang Yeob Kim Won-taek Hong jong-Sub Lee School of Civil Environmental and Architectural EngineeringKorea UniversitySeoul 02841Republic of Korea Department of Civil&Environmental Engineering Gachon UniversitySeongnam-si 13120Republic of Korea

Portable in-situ devices have been used for characterizing low accessible field,such as the railway *** this study,the automated cone penetrometer(ACP)was designed for the application on the railway *** is composed of the cone tip,driving rod,and hydraulic hammer *** hydraulic motor lifts and drops the 294.3 N hammer from a height of 200 mm such that the potential energy of 58.9 N m impacts the driving *** N-value(NACP)from the ACP test was compared with the dynamic cone penetration index(DCPI)from the dynamic cone penetrometer(DCP)*** test results show that the NACP and DCPI profiles show opposite trend owing to the inverse concept of the *** the correlation of DCPI and NACP,the limitation of DCPI reveals owing the minimum manually measured value of 1 mm/***,the evaluation of the deflection modulus(EFWD)using NACP is more efficient than that using *** on the result of this study,we suggest that ACP can be used for strength and stiffness evaluation of railway subgrade rapidly and reliably.

关键词： Automated cone penetrometer DCPI E_(FWD )N_(ACP) Railway subgrade

Endoscopic radial incision and cutting technique for treatment-naive stricture of colorectal anastomosis:Two case reports

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World journal of Gastrointestinal Surgery 2020年第11期12卷 460-467页

作者： taek-Gu Lee Soon Man Yoon Sang-Jeon Lee Department of Surgery Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Internal medicine Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea

BACKGROUND Anastomotic stenosis(AS)after colorectal surgery was treated with balloon dilation,endoscopic procedure or *** endoscopic procedures including dilation,electrocautery incision,or radial incision and cutting(RIC)were preferred because of lower complication rates than surgery and are less *** RIC has a greater success rate than dilation *** reports showed that repeated RICs were needed to maintain patency of the *** report that single session RIC was applied only to treatment-naive patients with *** SUMMARY Two female patients presented with *** patient had advanced rectal cancer and the other had a refractory stenosis following surgery for endometriosis at sigmoid *** endoscopic RIC procedure was performed as follows.A single small incision was carefully made to increase the view of the proximal colon and the incision was expanded until the surgical stapling ***,we made a further circumferential excision with endoscopic knife along the inner border of the surgical staple *** the end of the procedure,the standard colonoscope was able to pass freely through the widened *** patients showed improved AS after a single session of RIC without immediate or delayed procedure-related ***-up colonoscopy at 7 and 8 mo after endoscopic RIC revealed intact anastomotic sites in both *** treatment-related adverse events or recurrence of the stenosis was demonstrated during follow-up periods of 20 and 23 *** The endoscopic RIC may play a role as one of treatment options for treatmentnaive AS with short stenotic lengths.

关键词： Colorectal surgery Anastomosis Stenosis Endoscopy Radial incision Case report

Impact of adolescent complex regional pain syndrome on the psychopathology of young men ahead of military service: A retrospective cohort analysis of Korean conscription data

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Military Medical Research 2021年第3期8卷 363-372页

作者： Shin-Heon Lee Myeong-Jin Ko taek-Kyun Nam Jeong-Taik Kwon Yong-Sook Park Department of Neurosurgery College of MedicineChung-Ang UniversitySeoul 06973South Korea

Background: The relationship between physical and psychopathological features in complex regional pain syndrome(CRPS) has been a subject of constant interest, but no data are available in adolescents. Therefore, we aimed to identify the factors associated with psychopathology in adolescents with CRPS ahead of military ***: We retrospectively reviewed all conscription examinees who had completed a Military Personality Inventory(MPI) during a period between February 2013 and December 2016. A total of 63 persons with a history of CRPS(19-years of age for all) were enrolled. Basic demographic and pain-related data were analyzed to examine their association with MPI results. The mean FGR score as well as the 8 subdomain scores were compared between those with pain duration at <15 months(n=30) vs. ≥15 months(n=33). Binary MPI results(normal-abnormal) were also compared between the two ***: In multivariate analysis, abnormal MPI was associated with pain duration, with an odds ratio(OR) at 1.05 for every 1-month increase [95% confidence interval(CI) 1.02–1.08;P=0.002]. Subjects with pain duration at ≥15 months have lower faking good response score(P<0.001 vs. those with pain duration at <15 months), and higher abnormal MPI result rate, faking bad response, inconsistency, anxiety, depression, somatization, paranoid, personality disorder cluster A, and personality disorder cluster B scores(P<0.05). Pain duration was significantly associated with the MPI ***: Pain duration is associated with psychopathology in adolescents with CRPS. Psychopathologic features increased as the disease duration increased. A comprehensive understanding of time-dependent psychopathological factors could support the planning of multimodal approaches for managing adolescent CRPS.

关键词： Chronic pain Complex regional pain syndromes Psychopathology Personality inventory Adolescent Military personnel

Phytoglycoprotein isolated from Dioscorea batatas Decne promotes intestinal epithelial wound healing

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Chinese journal of Natural Medicines 2020年第10期18卷 738-748页

作者： KIM Ji-Yun LEE Young-Min PARK jong-Pil LIM Kye-taek LEE Sei-Jung Department of Pharmaceutical Engineering Daegu Haany UniversityGyeongsan 38610Republic of Korea Department of Food Science and Technology Chung-Ang UniversityAnseong 17546Republic of Korea Division of Animal Science Chonnam National UniversityGwangju61186Republic of Korea

Dioscorea batatas Decne(DBD)has been used to heal various illnesses of the kidney and intestine as an herbal medicine in *** a source of therapeutic agents,many glycoproteins have been isolated from mushrooms and plants,but the functional role of glycoprotein in intestinal epithelial wound healing has not been understood *** the present study,we investigated the wound healing potentials of the 30 kDa glycoprotein(DBD glycoprotein)isolated from DBD in human intestinal epithelial(INT-407)*** found that DBD glycoprotein(100μg·mL^-1)significantly increased the motility of INT-407 cells for 24 h by activating protein kinase C(PKC).DBD glycoprotein stimulated the activation of p38 mitogen-activated protein kinase(MAPK),which is responsible for the phosphorylation of NF-κB inhibitorα(IκBα).DBD glycoprotein increased the level of profilin-1(PFN1),α-actinin and F-actin expression via activation of transcription factor,nuclear factor-kappa B(NF-κB)during its promotion of cell *** mouse colitis was induced by adding dextran sulfate sodium(DSS)to the drinking water at a concentration of 4%(W/V)for 7 *** figured out that administration of DBD glycoprotein(10 and 20 mg·kg-1)lowers the levels of disease activity index and histological inflammation in DSS-treated ICR *** this regard,we suggest that DBD glycoprotein has ability to promote the F-actin-related migration signaling events via activation of PKC and NF-κB in intestinal epithelial cells and prevent inflammatory bowel disease.

关键词： Cell migration Dioscorea batatas Decne(DBD)glycoprotein Intestinal epithelial cells p38 MAPK F-actin Mouse colitis

Suppression of DRR1 results in the accumulation of insoluble ubiquitinated proteins,which impairs drought stress tolerance

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journal of Integrative Plant Biology 2021年第3期63卷 431-437页

作者： Seong Gwan Yu Na Hyun Cho jong Hum Kim Tae Rin Oh Woo taek Kim Department of Systems Biology and Division of Life Science Yonsei UniversitySeoul 03722Korea Institute of Life Science and Biotechnology Yonsei UniversitySeoul 03722Korea

Drought stress has detrimental effects on *** the abscisic acid(ABA)-mediated drought response is well established,defensive mechanisms to cope with dehydration-induced proteotoxicity have been rarely ***1 was identified as an Arabidopsis drought-induced gene encoding an ER-localized RING-type E3 Ub *** of DRR1 markedly reduced tolerance to drought and proteotoxic stress without altering ABA-mediated germination and stomatal *** dehydration-induced insoluble ubiquitinated protein accumulation was more obvious in DRR1 loss-of-function plants than in wild-type *** results suggest that DRR1 is involved in an ABA-independent drought stress response possibly through the mitigation of dehydration-induced proteotoxic stress.

关键词： Arabidopsis drought stress E3 ligase proteotoxicity ubiquitination

Biochemical Characterization of Soluble Acid and Alkaline Invertases from Shoots of Etiolated Pea Seedlings

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journal of Integrative Plant Biology 2010年第6期52卷 536-548页

作者： Donggiun Kim So Yun Park Youngjae Chung jongbum Park Sukchan Lee taek-Kyun Lee Department of Biological Science Silla University South Sea Environment Research Department Korea Ocean Research and Development Institute Department of Life Science and Biotechnology Shin Gyeong University Department of Genetic Engineering Sungkyunkwan University

Soluble invertase was purified from pea （Pisum sativum L.） by sequential procedures entailing ammonium sulfate precipitation, DEAE-Sepharose column, Con-A- and Green 19-Sepharose affinity columns, hydroxyapatite column, ultra-filtration, and Sephacryl 300 gel filtration. The purified soluble acid （SAC） and alkaline （SALK） invertases had a pH optimum of 5.3 and 7.3, respectively. The temperature optimum of two invertases was 37 ℃. The effects of various concentrations of Tris-HCI, HgCI2, and CuSO4 on the activities of the two purified enzymes were examined. Tris-HCI and HgCI2 did not affect SAC activity, whereas 10 mM Tris-HCI and 0.05 mM HgCI2 inhibited SALK activity by about 50%. SAC and SALK were inhibited by 4.8 mM and 0.6 mM CuSO4 by 50%, respectively. The enzymes display typical hyperbolic saturation kinetics for sucrose hydrolysis. The Kms of SAC and SALK were determined to be 1.8 and 38.6 mM, respectively. The molecular masses of SAC shown by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting were 22 kDa and 45 kDa. The molecular mass of SALK was 30 kDa. Iso-electric points of the SAC and SALK were estimated to be about pH 7.0 and pH 5.7, respectively.

关键词： SAC Biochemical Characterization of Soluble Acid and Alkaline Invertases from Shoots of Etiolated Pea Seedlings

Repair of a large patellar cartilage defect using human umbilical cord blood-derived mesenchymal stem cells:A case report

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World journal of Clinical Cases 2022年第34期10卷 12665-12670页

作者： Jun-Seob Song Ki-taek Hong Ki Jeon Song Seok Jung Kim Department of Orthopedic Surgery Gangnam JS HospitalSeoul 06053South Korea Department of Orthopedic Surgery Uijeongbu Street Mary’s HospitalCollege of MedicineThe Catholic University of KoreaUijeongbu 11765GyeonggidoSouth Korea

BACKGROUND Patellar dislocation may cause cartilage defects of various *** defects commonly require surgical treatment;however,conventional treatments are *** SUMMARY A 15-year-old male with a large patellar cartilage defect due to patellar dislocation was treated via human umbilical cord blood-derived mesenchymal stem cell(hUCB-MSC)*** our knowledge,this is the first report of this treatment for this *** patient recovered well as indicated by good visual analog scale,International Knee Documentation Committee and McMaster Universities Osteoarthritis Index *** resonance imaging showed cartilage regeneration 18 mo *** Umbilical cord blood-derived hUCB-MSCs may be a useful treatment option for the repair of large patellar cartilage defects.

关键词： Cartilage defect Umbilical cord Mesenchymal stem cells Patellar dislocation Magnetic resonance imaging Case report

Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization:State-of-the-art in bone and associated tissue regeneration

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Bioactive Materials 2023年第10期28卷 284-310页

作者： Sayan Deb Dutta Tejal V.Patil Keya Ganguly Aayushi Randhawa Ki-taek Lim Department of Biosystems Engineering Kangwon National UniversityChuncheon24341Republic of Korea Institute of Forest Science Kangwon National UniversityChuncheon24341Republic of Korea Interdisciplinary Program in Smart Agriculture Kangwon National UniversityChuncheon24341Republic of Korea

Macrophage-assisted immunomodulation is an alternative strategy in tissue engineering, wherein the interplay between pro-inflammatory and anti-inflammatory macrophage cells and body cells determines the fate of healing or inflammation. Although several reports have demonstrated that tissue regeneration depends on spatial and temporal regulation of the biophysical or biochemical microenvironment of the biomaterial, the underlying molecular mechanism behind immunomodulation is still under consideration for developing immunomodulatory scaffolds. Currently, most fabricated immunomodulatory platforms reported in the literature show regenerative capabilities of a particular tissue, for example, endogenous tissue (e.g., bone, muscle, heart, kidney, and lungs) or exogenous tissue (e.g., skin and eye). In this review, we briefly introduced the necessity of the 3D immunomodulatory scaffolds and nanomaterials, focusing on material properties and their interaction with macrophages for general readers. This review also provides a comprehensive summary of macrophage origin and taxonomy, their diverse functions, and various signal transduction pathways during biomaterial-macrophage interaction, which is particularly helpful for material scientists and clinicians for developing next-generation immunomodulatory scaffolds. From a clinical standpoint, we briefly discussed the role of 3D biomaterial scaffolds and/or nanomaterial composites for macrophage-assisted tissue engineering with a special focus on bone and associated tissues. Finally, a summary with expert opinion is presented to address the challenges and future necessity of 3D bioprinted immunomodulatory materials for tissue engineering.

关键词： Macrophage Immunomodulation Biomaterials 3D bioprinting Tissue engineering

FAK and Pyk2 in disease

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Frontiers in Biology 2016年第1期11卷 1-9页

作者： James M. Murphy Hyeonsoo Park Ssang-taek Steve Lim Department of Biochemistry and Molecular Biology College of Medicine University of South Alabama Mobile Alabama 36688 USA

Focal adhesion kinase （FAK） and proline-rich tyrosine kinase 2 （Pyk2） are non-receptor protein tyrosine kinases that are involved in cell proliferation, migration and survival. Current research of FAK and Pyk2 is greatly focused in cancer biology and several small molecule inhibitors are being tested under clinical development. Like cancer, certain chronic diseases such as cardiovascular disease, bone disease, fibrosis, rheumatoid arthritis, and neurological disorders, share malignant characteristics of cancer. Accumulating evidence has demonstrated that FAK and Pyk2 contribute to other proliferative and degenerative diseases. Thus, the goal of this review is to briefly highlight studies that have implicated FAK and Pyk2 as players in disease progression.

关键词： FAK Pyk2 FRNK disease

Application of a nondestructive method to evaluate the active layer in a cold region

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Research in Cold and Arid Regions 2017年第3期9卷 213-220页

作者： Won-taek Hong jong-Sub Lee School of Civil Environmental and Architectural Engineering Korea University

To provide a safe transportation system in an extremely cold region,evaluation needs to be conducted of the thickness and the volumetric water content of the active layer,as they significantly affect frost *** objective of this study was to evaluate the dielectric constant(κ)of the active layer using ground-penetrating radar(GPR)and a dynamic cone penetrometer(DCP);this evaluation was then used to estimate the thickness and the volumetric water content of the active layer.A field located in midwest Alaska was selected as the study site.A GPR survey and two DCP tests were conducted on the surface of the ground,and the ground temperature was *** the GPR survey,travel times of the electromagnetic wave in the active layer were *** addition,the thickness of the active layer was determined by using the dynamic cone penetration index(DCPI)and ground *** using the travel time and travel distance of the electromagnetic wave in the active layer,dielectric constants were calculated as 26.3 and 26.4 for two DCP *** the mean dielectric constant,the volumetric water content was estimated to be 40%~43%,and the thickness of the active layer was evaluated along the GPR survey *** spatial-scaled GPR image showed that the thickness of the active layer varied from 520 mm to 700 mm due to the presence of a puddle,which accelerated the heat *** results show that evaluation of the dielectric constant using the GPR survey and the DCP test can be effectively used to estimate the thickness and the volumetric water content of the active layer.

关键词： active layer dielectric constant dynamic cone penetrometer (DCP) extremely cold region ground-penetrating radar (GPR)