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Disorders of Consciousness in China

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Neuroscience Bulletin 2018年第4期34卷 605-614页

作者： jizong zhao China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical University

With the development of modern international medicine, the subject of disorders of consciousness （DOCs） has begun to be raised in China's Mainland. Much progress has been made to date in several specialties related to the management of chronic DOC patients in China. In this article, we briefly review the present status of DOC studies in China, specifically concerning diagnosis, prognosis, therapy, and rehabilitation. The development of DOC- related scientific organizations and activities in China are introduced. Some weaknesses that need improvement are also noted. The current program provides a good foundation for future development.

关键词： China Disorders of consciousness Diagno-sis Therapy

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对21世纪网络神经外科临床实践的思考

空军军医大学学报 2024年第4期45卷 361-363页

作者：赵继宗国家神经系统疾病临床医学研究中心首都医科大学附属北京天坛医院北京100070

百年神经外科发展史可以划分为三个时期,即经典神经外科时期、显微神经外科时期和微创神经外科时期。进入21世纪,现代医学科学迅猛发展,神经外科跨入网络神经外科新时期。网络神经外科是以脑网络的拓扑特性为基础,以多模态智能神经功能... 详细信息

百年神经外科发展史可以划分为三个时期,即经典神经外科时期、显微神经外科时期和微创神经外科时期。进入21世纪,现代医学科学迅猛发展,神经外科跨入网络神经外科新时期。网络神经外科是以脑网络的拓扑特性为基础,以多模态智能神经功能影像和微创手术技术为手段,在诊治神经系统疾患过程中,使患者脑功能网络得到保护或重塑,藉此提高难治性神经系统疾患诊治水平,它将成为脑科学转化研究的纽带。

关键词： 21世纪网络神经外科学神经网络脑解剖与功能医学影像医疗器械脑机接口

Excitatory amino acid changes in the brains of rhesus monkeys following selective cerebral deep hypothermia and blood flow occlusion

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Neural Regeneration Research 2013年第2期8卷 143-148页

作者： Jun Pu Xiaoqun Niu jizong zhao Department of Neurosurgery Beijing Tiantan Hospital of Capital Medical University Department of Respiratory Medicine Second Hospital of Kunming Medical University

Selective cerebral deep hypothermia and blood flow occlusion can enhance brain tolerance to ischemia and hypoxia and reduce cardiopulmonary complications in monkeys. Excitotoxicity induced by the release of a large amount of excitatory amino acids after cerebral ischemia is the major mechanism underlying ischemic brain injury and nerve cell death. In the present study, we used selective cerebral deep hypothermia and blood flow occlusion to block the bilateral common carotid arteries and/or bilateral vertebral arteries in rhesus monkey, followed by reperfusion using Ringer＇s solution at 4~C. Microdialysis and transmission electron microscope results showed that selective cerebral deep hypothermia and blood flow occlusion inhibited the release of glutamic acid into the extracellular fluid in the brain frontal lobe and relieved pathological injury in terms of the ultrastructure of brain tissues after severe cerebral ischemia. These findings indicate that cerebral deep hypothermia and blood flow occlusion can inhibit cytotoxic effects and attenuate ischemic/ hypoxic brain injury through decreasing the release of excitatory amino acids, such as glutamic acid.

关键词： neural regeneration brain injury selective deep hypothermia microdialysis rhesus monkey glutamic acid excitatory amino acids brain protection high performance liquid chromatogram ultrastructure grants-supported paper photographs-containing paper neuroregeneration

Brain-Computer Interfaces in Disorders of Consciousness

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Neuroscience Bulletin 2023年第2期39卷 348-352页

作者： Qiheng He Jianghong He Yi Yang jizong zhao Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Chinese Institute for Brain Research Beijing 100010China Beijing Institute of Brain Disorders Beijing 100069China China National Clinical Research Center for Neurological Diseases Beijing 100070China

The development of brain-computer interfaces(BCIs)has established a new communication channel between the brain and external devices for information transmission that requires no muscular signals[1].BCIs have been preliminarily studied to improve motor functions in patients with severe motor disabilities,especially lock-in *** present,the application of BCIs has been extensively validated.

关键词： communication Interfaces channel

Gene expression profiles in intracranial aneurysms

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Neuroscience Bulletin 2014年第1期30卷 99-106页

作者： Lanbing Yu Jinghan Fan Shuo Wang Dong Zhang Rong Wang Yuanli zhao jizong zhao Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University

In this study, we extracted total RNA from 15 intracranial aneurysms and 17 superficial temporal artery samples, then performed genome-wide expression profiling using the Affymetrix U133 Plus 2.0 GeneChip. Genes that were differentially expressed between intracranial aneurysms and arterial samples were identified using significance analysis for microarrays, and the expression patterns of three randomly-selected genes were verified by real-time polymerase chain reaction analysis. We identified 3 736 differentially-expressed genes out of the 47 000 assayed transcripts. A total of 179 genes showed a 〉10-fold change in expression between the aneurysms and the arterial samples. Genes involved in the proliferation, migration, and apoptosis of vascular muscle cells, atherosclerosis, extracellular matrix disruption, and inflammatory reactions were associated with the formation of intracranial aneurysms. There were no significant differences in gene expression profile between unruptured and ruptured aneurysms.

关键词： intracranial aneurysms microarray gene expression profiles

Enhancement Expression of bFGF in Chinese Patients with Moyamoya Disease

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Biomedical and Environmental Sciences 2011年第1期24卷 74-80页

作者： ZOU DeWei zhao jizong ZHANG Dong WANG Shuo WANG KeDa ZHANG Yan Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Objective To detect the content of the basic fibroblast growth factor in blood samples of patients with Moyamoya disease, and investigate the relationship between Moyamoya disease and the basic fibroblast growth factor. Methods This tissue microarray study included 24 cases of superficial temporal artery samples, 15 cases of Moyamoya disease, and 9 cases of normal arteries as control, and bFGF immunofluorescence assay was applied to test the samples. The number of positive cells and total cells of the muscular layer and the endothelium layer were counted separately in every picture, the positive rates were calculated, and the experimental data were analyzed statistically. Results The bFGF immunofluorescence staining of smooth muscular layer cells, intima cells and endothelial cells from the moyamoya disease group were obviously stronger than that from the control group （P0.01）. Conclusion The enhancement expression of bFGF in the Moyamaya disease group implicates that bFGF plays an important part in the pathogenesis of Moyamoya disease.

关键词： Moyamoya disease bFGF Pathogenesis Superficial temporal artery Immunofluorescence

Imbalance of matrix metalloproteinase-9 and matrix metalloproteinase tissue inhibitor-1 may contribute to hemorrhage in cerebellar arteriovenous malformations

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Neural Regeneration Research 2012年第19期7卷 1513-1519页

作者： Fei Di Tongyan Chen Hongli Li jizong zhao Shuo Wang Yuanli zhao Dong Zhang Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Laboratory Medicine Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Pathology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

In this study, we determined the expression levels of matrix metalloproteinase-2 and -9 and matrix metalloproteinase tissue inhibitor-1 and -2 in brain tissues and blood plasma of patients undergoing surgery for cerebellar arteriovenous malformations or primary epilepsy （control group）. Immunohistochemistry and enzyme-linked immunosorbent assay revealed that the expression of matrix metalloproteinase-9 and matrix metalloproteinase tissue inhibitor-1 was significantly higher in patients with cerebellar arteriovenous malformations than in patients with primary epilepsy. The ratio of matrix metalloproteinase-9 to matrix metalloproteinase tissue inhibitor-1 was significantly higher in patients with hemorrhagic cerebellar arteriovenous malformations compared with those with non-hemorrhagic malformations. Matrix metalloproteinase-2 and matrix metalloproteinase tissue inhibitor-2 levels were not significantly changed. These findings indicate that an imbalance of matrix metalloproteinase-9 and matrix metalloproteinase tissue inhibitor-I, resulting in a relative overabundance of matrix metalloproteinase-9, might be the underlying mechanism of hemorrhage of cerebellar arteriovenous malformations.

关键词： cerebellar arteriovenous malformations hemorrhage matrix metalloproteinase-2 matrixmetalloproteinase-9 tissue matrix metalloproteinase inhibitor-1 tissue matrix metalloproteinaseinhibitor-2 immunohistochemistry enzyme-linked immunosorbent assay neural regeneration

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储能用钠离子电池及电池模块的开发应用

电源技术 2024年第10期48卷 2052-2057页

作者：徐国平李海涛钟良亮邵栋栋赵纪宗金迪天津中电新能源研究院有限公司天津300381 中电科蓝天科技股份有限公司天津300384 国网宁波供电公司浙江宁波315000

设计了一款储能用电池模块,模块采用新型钠离子电池,具有较高的充放电能量效率、宽温域放电性能、倍率性能好、长循环、高安全等优点。经测试,单体电芯0.33 C充放电能量效率为97.18%,-40℃下1 C放电容量为常温容量的89.79%,5 C放电容量... 详细信息

设计了一款储能用电池模块,模块采用新型钠离子电池,具有较高的充放电能量效率、宽温域放电性能、倍率性能好、长循环、高安全等优点。经测试,单体电芯0.33 C充放电能量效率为97.18%,-40℃下1 C放电容量为常温容量的89.79%,5 C放电容量为0.33 C容量的90.49%,40℃下30天存储后恢复容量保持率为98.34%,0.5 C下常温循环2000次后容量保持率为86.65%,可顺利通过过充、挤压、针刺、过放、短路等安全测试;电池模块在25℃、0.33 C充放电条件下,能量效率为96.3%;在25℃、0.33P充放电条件下,能量效率为95.75%;在5℃、0.33P充放电条件下,与25℃条件下测试相比,能量效率为90.08%。该模块采用风冷散热,模块内电芯温差可控制在3℃以内,可满足储能系统要求。

关键词：钠离子电池低温高安全能量效率储能

Intraoperative hemodynamic parameters of middle cerebral artery and other artery aneurysms utilizing transcranial Doppler ultrasonography

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Neural Regeneration Research 2010年第11期5卷 874-880页

作者： Jianjun Sun Shuo Wang Yuanli zhao Dong Zhang Yoko Kato O Isabelle Liu O jizong zhao Department of Neurosurgery Third Hospital Peking University Beijing 100191 China Department of Neurosurgery Tiantan Hospital Affiliated to Capital Medical University Beijing 100050 China Department of Neurosurgery Fujita Health University Toyoake Aichil 470-1192 Japan Washington University in St Louis School of Medicine St Louis MO 63110 USA

BACKGROUND： Hemodynamic changes accompany the initiation, development and rupture of middle cerebral artery （MCA） aneurysms. The complexity of the intraaneurysmal hemodynamic factors has not been completely clarified by the indirect measures and methods used in previous studies. OBJECTIVE： To evaluate correlations of intraoperative hemodynamic factors to initiation and rupture of MCA aneurysms. DESIGN, TIME AND SETTING： A case-control study was performed at the Department of Neurosurgery, Tiantan Hospital Affiliated to Capital Medical University, China between March and October 2008. PARTICIPANTS： A total of 12 consecutive patients diagnosed with MCA aneurysms （MCA aneurysms group） and five patients without middle cerebral artery aneurysms （with aneurysms located at other arteries, control group） were enrolled at the Department of Neurosurgery, Tiantan Hospital Affiliated to Capital Medical University, China. METHODS： The proximal and distal arteries of MCA aneurysms were exposed visibly in the MCA aneurysm group. The M1 segment of MCA without the aneurysm and the aneurysm on other arteries were also exposed visibly in the control group. Hemodynamic indices were then measured using an intraoperative 16 MHz probe installed in a Multi-Dop TCD8X4 device. MAIN OUTCOME MEASURES： Mean （time-averaged velocity） difference, maximum mean, pulsatility index difference, maximum pulsatility index, resistance index difference, maximum resistance index; correlation of development and rupture of MCA aneurysms to intraoperative hemodynamic factors of the parent artery. RESULTS： A total of 12 patients underwent microsurgery for treatment to occlude 15 MCA aneurysms. Of the 15 MCA aneurysms, 12 were located at the bifurcation, two at the M1 segment and one at the M3 segment; eight of the aneurysms were unruptured and seven were ruptured. The whole indices with combination mean difference, maximum mean, and maximum pulsatility index of the aneurysms were important factors influencing t

关键词： aneurysms middle cerebral artery intraoperative hemodynamics impingement force rupture brain injury neural regeneration