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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 97-102页

作者： cheng-Li Du Shen-Yu wei Yun-Hao chen Kang-Jie chen Division of Thoracic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Zhejiang University School of Medicine Hangzhou 310003China Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor:Hepatocellular carcinoma(HCC)is an aggressive malignancy with poor long-term prognosis[1].Liver cancer stem cell(CSC)can drive the metastasis,drug resistance,and recurrence of HCC[2].The regulatory mechanisms about liver cancer stemness have been investigated,which encouraged the identification and characterization of novel prognostic and therapeutic strategies for HCC[3].

关键词： cancer prognosis Liver

Low cost and low density chloride solid electrolyte for all solid state cathode with high active material ratio

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Nano Research 2024年第10期17卷 8826-8833页

作者： Hao-Yuan Tan mei-Yu Zhou Zhongyuan Huang Jin-Da Luo Jing-Tian Yang Jian-Ping Wang Ye-Chao Wu Xiao-Bin cheng Zi-wei Wang Xu-Dong Hao Linjun Wang Ke Gong Yi-chen yin yinguo Xiao Hong-Bin Yao Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Department of Applied Chemistry University of Science and Technology of ChinaHefei 230026China School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhen 518055China

Chloride solid electrolytes(SEs)have attracted widespread attention due to their high room-temperature ionic conductivity and excellent cathode ***,the conventionally selected central metal elements(e.g.,In,Y and Ta)are usually rare and heavy,inevitably causing the high cost and high density of the obtained chloride ***,by choosing abundant and light Mg and Al as central metal elements,we develop a cheap and low density Li_(1.2)Mg_(0.95)Al_(0.3)Cl_(4)SE for high active material ratio in all solid state *** replacement of Mg^(2+)by Al^(3+)in the framework yields vacancies and lowers the non-lithium metal ions occupancy at Mg/Li co-occupied 16d site,effectively relieving the blocking effects by Mg^(2+)in the pristine spinel Li_(2-2x)Mg_(1+x)Cl_(4).Thus,a significantly improved room-temperature conductivity of 3.08×10^(-4)S·cm^(-1)is achieved,two orders of magnitude higher than that of Li_(1.2)Mg_(1.4)Cl_(4).More attractively,its low density of only 1.98 g·cm-3 enables low SE mass ratio in cathodes(only 16 wt.%)with still effective electrolyte/cathode contact and lithium-ion conduction *** charged to potential of 4.30 V,the asfabricated Li_(1.2)Mg_(0.95)Al_(0.3)Cl_(4)-based solid lithium battery with uncoated NCM523 cathode can be cycled for over 100 cycles with a capacity retention of 86.68%at room temperature.

关键词： chloride solid electrolytes low cost low density Li+conductivities

An intermittent lithium deposition model based on CuMnbimetallic MOF derivatives for composite lithium anode with ultrahigh areal capacity and current densities

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Nano Research 2024年第4期17卷 2763-2769页

作者： Tao wei Yanyan Zhou cheng Sun Xingtong Guo Shoudong Xu Daifen chen Yongfu Tang School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China State Key Laboratory of Metastable Materials Science and Technology(MMST) Hebei Key Laboratory of Applied ChemistryYanshan UniversityQinhuangdao 066004China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China

Recently,three-dimensional(3D)conductive frameworks have been chosen as the host for composite lithium(Li)metal anode because of their exceptional electrical conductivity and remarkable thermal and electrochemical ***,Li tends to accumulate on the top of the 3D frameworks with homogenous lithiophilicity and Li dendrite still *** work firstly designed a bimetallic metal-organic framework(MOF)(CuMn-MOF)derived Cu_(2)O and Mn_(3)O_(4) nanoparticles decorated carbon cloth(CC)substrates(CC@Cu_(2)O/Mn_(3)O_(4))to fabricate a composite Li *** to the synergistic effects of lithiophilic Cu_(2)O and Mn_(3)O_(4),the CC@Cu_(2)O/Mn_(3)O_(4)@Li symmetrical cell can afford a prolonged cycling lifespan(1400 h)under an ultrahigh current density and areal capacity(6 mA·cm^(-2)/6 mAh·cm^(-2)).When coupled with the LiFePO_(4)(LFP)cathode,the LFP||CC@Cu_(2)O/Mn_(3)O_(4)@Li full cell demonstrated a superior performance of 89.7 mAh·g^(-1) even at an extremely high current density(10 C).Furthermore,it can also be matched well with LiNi_(0.5)Co^(0).2Mn_(0.3)O_(2)(NCM523)***,to explain the excellent performances of the CC@Cu_(2)O/Mn_(3)O_(4)@Li composite anode,an intermittent model was also *** study offers a novel model that can enhance our comprehension of the Li deposition behavior and pave the way to attain stable and safe Li metal anodes by employing bimetallic MOF-derived materials to construct 3D frameworks.

关键词： lithium metal anode(LMA) three-dimensional(3D)frameworks intermittent lithiophilic model high areal capacity bimetallic metal-organic frameworks(MOFs)

Tet methylcytosine dioxygenase 2(TET2)deficiency elicits EGFR-TKI(tyrosine kinase inhibitors)resistance in non-small cell lung cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1706-1720页

作者： Jian Zhang Kejia Zhao Wenjing Zhou Ran Kang Shiyou wei Yueli Shu cheng Yu yin Ku Yonghong Mao Hao Luo Juqin Yang Jiandong mei Qiang Pu Senyi Deng Zhengyu Zha Gang Yuan Shensi Shen Yaohui chen Lunxu Liu Department of Thoracic Surgery and Institute of Thoracic Oncology West China Hospital of Sichuan UniversityChengdu 610097China Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer Sichuan UniversityChengdu 610097China Biobank of West China Hospital Sichuan UniversityChengdu 610041China

Despite epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(TKl)have shown remarkable efficacy in patients with EGFR-mutant non-small cell lung cancer(NSCLC),acquired resistance inevitably develops,limiting clinical *** found that TET2 was poly-ubiquitinated by E3 ligase CUL7^(FBXW11) and degraded in EGFR-TKI resistant NSCLC *** perturbationof TET2 rendered parental cells more tolerant to TKI ***2 was stabilized by MEK1 phosphorylation at Ser 1107,while MEK1 inactivation promoted its proteasome degradation by enhancing the recruitment of CUL7^(FBXW11),Loss of TET2 resulted in the upregulation of TNF/NF-kB signaling that confers the EGFR-TKI *** or pharmacological inhibition of NF-kB attenuate the TKI resistance both in vitro and in *** findings exemplified how a cell growth controlling kinase MEK1 leveraged the epigenetic homeostasis by regulating TET2,and demonstrated an alternative path of non-mutational acquired EGFR-TKI resistance modulated by TET2 ***,combined strategy exploiting EGFR-TKI and inhibitors of TET2/NF-κB axis holds therapeutic potential for treating NSCLC patients who suffered from this resistance.

关键词： TET2 TKI resistance

Main controlling factor and mechanism of gas-in-place content of the Lower Cambrian shale from different sedimentary facies in the western Hubei area, South China

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Petroleum Science 2024年第3期21卷 1488-1507页

作者： Gang Li Xian-Ming Xiao Bo-wei cheng chen-Gang Lu Yue Feng Dong-Sheng Li School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Frontiers Science Center for Deep-time Digital Earth China University of Geosciences(Beijing)Beijing100083 China

The Lower Cambrian shale gas in the western Hubei area,South China has a great resource prospect,but the gas-in-place(GIP)content in different sedimentary facies varies widely,and the relevant mechanism has been not well *** the present study,two sets of the Lower Cambrian shale samples from the Wells YD4 and YD5 in the western Hubei area,representing the deep-water shelf facies and shallowwater platform facies,respectively,were investigated on the differences of pore types,pore structure and methane adsorption capacity between them,and the main controlling factor and mechanism of their methane adsorption capacities and GIP contents were *** results show that the organic matter(OM)pores in the YD4 shale samples are dominant,while the inorganic mineral(IM)pores in the YD5 shale samples are primary,with underdeveloped OM *** pore specific surface area(SSA)and pore volume(PV)of the YD4 shale samples are mainly from micropores and mesopores,respectively,while those of the YD5 shale samples are mainly from micropores and macropores,*** methane adsorption capacity of the YD4 shale samples is significantly higher than that of the YD5 shale samples,with a maximum absolute adsorption capacity of 3.13 cm^(3)/g and 1.31 cm^(3)/g in average,*** with the shallow-water platform shale,the deep-water shelf shale has a higher TOC content,a better kerogen type and more developed OM pores,which is the main mechanism for its higher adsorption *** GIP content models based on two samples with a similar TOC content selected respectively from the Wells YD4 and YD5 further indicate that the GIP content of the deep-water shelf shale is mainly 34 m^(3)/t within a depth range of 1000—4000 m,with shale gas exploration and development potential,while the shallow-water platform shale has normally a GIP content of1 m^(3)/t,with little shale gas *** the geological and geochemical conditions of shale gas formation a

关键词： Lower Cambrian shale Deep-water shelf facies Shallow-waterplat form facies Pore structure Methane adsorption Gas-in-place content Controlling factor

Quantification of Central and Eastern China's atmospheric CH_(4) enhancement changes and its contributions based on machine learning approach

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Journal of Environmental Sciences 2024年第4期138卷 236-248页

作者： Xinyue Ai cheng Hu Yanrong Yang Leying Zhang Huili Liu Junqing Zhang Xin chen Guoqiang Bai wei Xiao College of Biology and the Environment Joint Center for sustainable Forestry in Southern ChinaNanjing Forestry UniversityNanjing 210037China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science&TechnologyNanjing 210044China Guang’an Vocational&Technical College Guangan 638550China HuaNan Meteorological Administration Huanan 154400China

Methane is the second largest anthropogenic greenhouse gas,and changes in atmospheric methane concentrations can reflect the dynamic balance between its emissions and ***,the monitoring of CH_(4) concentration changes and the assessment of underlying driving factors can provide scientific basis for the government’s policy making and *** is the world’s largest emitter of anthropogenic ***,due to the lack of ground-based observation sites,little work has been done on the spatial-temporal variations for the past decades and influencing factors in China,especially for areas with high anthropogenic emissions as Central and Eastern *** to quantify atmospheric CH_(4) enhancements trends and its driving factors in Central and Eastern China,we combined the most up-to-date TROPOMI satellite-based column CH_(4)(xCH_(4))concentration from 2018 to 2022,anthropogenic and natural emissions,and a random forest-based machine learning approach,to simulate atmospheric xCH_(4) enhancements from 2001 to *** results showed that(1)the random forest model was able to accurately establish the relationship between emission sources and xCH_(4) enhancement with a correlation coefficient(R^(2))of 0.89 and a root mean-square error(RMSE)of 11.98 ppb;(2)The xCH_(4) enhancement only increased from 48.21±2.02 ppb to 49.79±1.87 ppb from the year of 2001 to 2018,with a relative change of 3.27%±0.13%;(3)The simulation results showed that the energy activities and waste treatment were the main contributors to the increase in xCH_(4) enhancement,contributing 68.00% and 31.21%,respectively,and the decrease of animal ruminants contributed-6.70% of its enhancement trend.

关键词： TROPOMI Methane column concentrations Anthropogenic sources Random Forest model

Visual test paper based on Au/δ-MnO_(2) hollow nanosphere oxidase-like activity regulation using hexavalent chromium as a smart switch

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Rare Metals 2024年第2期43卷 711-722页

作者： Wen-Chang zhuang Hai-Yue Zhang Zhen-Yang chen Wen-Jing cheng wei-Dan Na Zhao Li Lin Tian School of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhou221018China School of Chemistry and Environmental Science Yili Normal UniversityYining835000China

Paper-based sensing platform is a point of need analytical toolkit for safety ***,the sensitivity,specificity,and simplicity are still ***,we report a novel strategy(Au/δ-MnO_(2) hollow nanosphere and 3,3′,5,5′-tetramethylbenzidine(TMB)induced test strips for signal-on detection)that can be utilized for hexavalent chromium(Cr^(6+))***,Cr^(6+)(CrO_(4)^(2−)) as a smart switch can remarkably enhance the oxidase-like activity of Au/δ-MnO_(2) hollow *** presence of Cr^(6+) can regulate the surface electronic redistribution of Au/δ-MnO_(2) and adjust the geometric configuration,which leads to the improvement in oxidase-like activity of Au/δ-MnO_(2).As a proof-of-concept application,a visual paper-based sensing platform of Cr^(6+) along with quantitative analysis by the test strips was successfully *** paper-based sensing platform exhibits a linear range with excellent selectivity for other interfering substances and lower limit of detection of 0.09μmol·L^(−1),providing a promising toolkit at-home Cr^(6+) measurement and environmental monitoring.

关键词： Point of need Colorimetric biosensing platform Au/δ-MnO_(2) hollow nanosphere Test strip Cr^(6+)

Theoretical Exploration of Alloying Effects on Stabilities and Mechanical Properties ofγʹPhase in Novel Co–Al–Nb-Base Superalloys

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1238-1248页

作者： Guan-cheng Gu Zhao-Jing Han Ze-Yu chen Zhao-Xuan Li Sheng-Bao Xia Zheng-Ning Li Hua Jin wei-wei Xu Xing-Jun Liu Shenzhen Research Institute of Xiamen University School of Aerospace EngineeringXiamen UniversityXiamen361005China Institute of Materials Genome and Big Data Harbin Institute of TechnologyShenzhen518055China

The new developedγ/γʹCo–Al–Nb-base alloys show great potentials as high-temperature ***,finding appropriate compositions to improve performance of alloys still poses a great challenge to the development of Co–Al–Nb-base *** by the lack of alloying effects on fundamental properties of criticalγʹphase,we systematically performed a theoretical investigation on the effect of alloying elements TM(TM:Ti,V,Cr,Zr,Mo,Ta,W,Re,and Ru)on phase stabilities and mechanical properties of L1_(2)-typeγʹ(Co,Ni)_(3)(Al,Nb).By analyzing the stability ofγʹphase with respect to its competitive B2 and D0_(19) phases,the results shown that Ti,V,and Cr enhance the L1_(2) stability and widen the L1_(2)–D0_(19) energy barrier,in which V yields the maximum *** analysis of electronic structure indicated that the alternation of valence electrons at fermi level would be the atomic origin for doping TM inγʹ*** calculated results of mechanical properties shown that V and Cr are expected to be optimal dopant for enhancing the strength and the ductility ofγʹ*** addition of Ta is also beneficial for enhancing the strength at the slight expense of ductility ofγʹ*** drawing the mechanical maps,the preferred composition range for the phases with desired properties is roughly demarcated in theory for the multi-addition of V/Cr and V/Ta inγʹ*** findings would be useful for optimizing the performance of novelγ/γʹCo–Al–Nb-base superalloys.

关键词： Co-Al-Nb-base superalloys γ/γʹdual-phase Phase stability Mechanical properties First-principle methods

Pien Tze Huang Inhibits Migration and Invasion of Hepatocellular Carcinoma Cells by Repressing PDGFRB/YAP/CCN2 Axis Activity

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Chinese Journal of Integrative Medicine 2024年第2期30卷 115-124页

作者： LUO Zhi-yi TIAN Qi cheng Niang-mei LIU Wen-han YANG Ye chen wei ZHANG Xiang-zhi ZHENG Xiao-yuan chen Ming-sheng zhuANG Qiu-yu ZHAO Bi-xing LIU Cong-sheng LIU Xiao-long LI Qin WANG ying-chao The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development Zhangzhou Pien Tze Huang Pharmaceutical Co.Ltd.ZhangzhouFujian Province(363099)China College of Biological Science and Engineering and Mengchao Med-X Center Fuzhou UniversityFuzhou(350116)China Department of Internal Medicine Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China

Objective:To investigate the effects of Pien Tze Huang(PZH) on the migration and invasion of HCC cells and underlying molecular ***:Cell counting kit-8(CCK-8) was applied to evaluate the cell viabilities of SMMC-7721,SK-Hep-1,C3A and HL-7702(6 × 10^(3)cells/well) co-incubated with different concentrations of PZH(0,0.2,0.4,0.6,0.8 mg/mL) for 24 ***,wound healing assay,CCK-8and Annexin V-FITC/PI staining were conducted to investigate the effects of PZH on the migration,invasion,proliferation and apoptosis of SK-Hep-1 and SMMC-7721 cells(650 μg/mL for SK-Hep-1 cells and 330 μg/mL for SMMC-7721 cells),*** vivo,lung metastasis mouse model constructed by tail vein injection of HCC cells was used for evaluating the anti-metastasis function of ***-Hep-1 cells(10^(6)cells/200 μL per mice) were injected into B-NDG mice via tail *** 8 mice were randomly divided into PZH and control groups,4 mice in each *** 2-d inoculation,mice in the PZH group were administered with PZH(250 mg/kg,daily) and mice in the control group received only vehicle(PBS) from the 2nd day after xenograft to day *** analysis based on RNA-seq was subsequently used for deciphering anti-tumor mechanism of *** real-time polymerase chain reaction(qRT-PCR) and Western blot were applied to verify RNA-seq *** reporter assay was performed to examine the transcriptional activity of yes-associated protein(YAP).Results:PZH treatment significantly inhibited the migration,invasion,proliferation and promoted the apoptosis of HCC cells in vitro and in vivo(P2),N-cadherin,vimentin and matrix metallopeptidase 2(MMP2,P<0.01).Meanwhile,the phosphorylatio

关键词： PienTzeHuang hepatocellular carcinoma RNA-seq Hippo yes-associated protein

2-APQC,a small-molecule activator of Sirtuin-3(SIRT3),alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2748-2764页

作者： Fu Peng Minru Liao Wenke Jin wei Liu Zixiang Li Zhichao Fan Ling Zou Siwei chen Lingjuan zhu Qian Zhao Gu Zhan Liang Ouyang cheng Peng Bo Han Jin Zhang Leilei Fu West China School of Pharmacy and Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese MedicineSchool of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China School of Pharmaceutical Sciences Health Science CenterShenzhen UniversityShenzhen 518060China School of Traditional Chinese Materia Medica Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China

Sirtuin 3(SIRT3)is well known as a conserved nicotinamide adenine dinucleotide^(+)(NAD^(+))-dependent deacetylase located in the mitochondria that may regulate oxidative stress,catabolism and ATP *** evidence has recently revealed that SIRT3 plays its critical roles in cardiac fibrosis,myocardial fibrosis and even heart failure(HF),through its deacetylation ***,discovery of SIRT3 activators and elucidating their underlying mechanisms of HF should be urgently ***,we identified a new small-molecule activator of SIRT3(named 2-APQC)by the structure-based drug designing strategy.2-APQC was shown to alleviate isoproterenol(ISO)-induced cardiac hypertrophy and myocardial fibrosis in vitro and in vivo rat ***,in SIRT3 knockout mice,2-APQC could not relieve HF,suggesting that 2-APQC is dependent on SIRT3 for its protective ***,2-APQC was found to inhibit the mammalian target of rapamycin(mTOR)-p70 ribosomal protein S6 kinase(p70S6K),c-jun N-terminal kinase(JNK)and transforming growth factor-β(TGF-β)/small mother against decapentaplegic 3(Smad3)pathways to improve ISO-induced cardiac hypertrophy and myocardial *** upon RNA-seq analyses,we demonstrated that SIRT3-pyrroline-5-carboxylate reductase 1(PYCR1)axis was closely assoiated with *** activating PYCR1,2-APQC was shown to enhance mitochondrial proline metabolism,inhibited reactive oxygen species(ROS)-p38 mitogen activated protein kinase(p38MAPK)pathway and thereby protecting against ISO-induced mitochondrialoxidative ***,activation of SIRT3 by 2-APQC could facilitate AMP-activated protein kinase(AMPK)-Parkin axis to inhibit ISO-induced ***,our results demonstrate that 2-APQC is a targeted SIRT3 activator that alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis,which may provide a new clue on exploiting a promising drug candidate for the future HF therapeutics.

关键词： SIRT3 homeostasis metabolism