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Correction:Microglial Depletion does not Affect the Laterality of Mechanical Allodynia in Mice

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Neuroscience Bulletin 2023年第11期39卷 1745-1746页

作者： Quan Ma Dongmei Su Jiantao Huo Guangjuan Yin Dong Dong Kaifang Duan Hong Cheng Huiling Xu Jiao Ma Dong Liu Bin Mou jiyun peng Longzhen Cheng School of Life Science and Technology Harbin Institute of TechnologyHarbin 150001China Shenzhen Key Laboratory of Gene Regulation and Systems Biology School of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China Department of Biology Brain Research CenterSouthern University of Science and TechnologyShenzhen 518055China Institute of Life Science Nanchang UniversityNanchang 330031China Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Shenzhen 518055China

The original version of this article unfortunately contained one *** authors found that in the middle panel of Fig.2A,the example traces recorded from a contralateral dorsal horn neuron of the capsaicin-treated mouse ... 详细信息

关键词： does record wrong

Microglial brain-derived neurotrophic factor regulates neurogenesis in epilepsy

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Microglial brain-derived neurotrophic factor regulates neuro...

中国神经科学学会第十二届全国学术会议

作者： Mingshu Mo Ukpong B.Eyo jiyun peng Pingyi Xu Long-Jun Wu Department of Neurology First Affiliated Hospital of Guangzhou Medical University Department of Cell Biology and Neuroscience Rutgers University Deparment of Neurology Mayo Clinic

The microglia activation, neurogenesis and mossy sprouting fiber（MSF） in dentate gyrus（DG） increase after epilepsy. Recent studies showed that microglia regulate synaptic pruning and release brain-derived neurotrophic factor（BDNF） to promote synapse formation in brain development. However, the interaction between microglia and neurogenesis, MSF after epilepsy in adult remains unclear. To address this question, we used CX3CR1 Cre ER/+:R26 i DTR/+ mice for microglia conditional ablation. With these mice, we can induce diphtheria toxin（DT） receptors on microglia by tomoxifen and deplete the microglia by DT injection. Using kainic acid（KA） induced epilepsy model, we confirmed that the number of doublecortin（DCX）, DCX+/Ki67+, DCX+/Brdu+ cells in DG and their sprouting fiber projected to CA3 increased significantly, as well as microglia activation in granular layers. After microglia ablation, the increased DCX+ cells and their sprouting fiber in epilepsy were dramatically inhibited. Furthermore, using CX3CR1 Cre ER/+:BDNFfl/fl mice for conditional manipulation of BDNF expression from microglia, we found that the increase of DCX+, DCX+/Ki67+, DCX+/Brdu+ and their sprouting fiber in epilepsy were also significantly inhibited. Our study suggested that BDNF released form microglia promotes the neurogenesis after epilepsy.

关键词： Brain-derived neurotrophic factor Microglia Neurogenesis Epilepsy

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钛细化过共晶高铬铸铁的研究

稀有金属材料与工程 2008年第1期37卷 101-104页

作者：智小慧韩彦军彭纪云邢建东高义民西安交通大学金属材料强度国家重点实验室陕西西安710049

研究了不同的含Ti量对4C-20Cr(质量分数,%)过共晶高铬铸铁显微组织的影响。结果表明,随着含Ti量的增加,初生碳化物和总的碳化物(初生碳化物和共晶碳化物)均逐渐细化;TiC的体积分数也随含Ti量的增加而增加,但TiC出现长大和团聚现象。Ti... 详细信息

研究了不同的含Ti量对4C-20Cr(质量分数,%)过共晶高铬铸铁显微组织的影响。结果表明,随着含Ti量的增加,初生碳化物和总的碳化物(初生碳化物和共晶碳化物)均逐渐细化;TiC的体积分数也随含Ti量的增加而增加,但TiC出现长大和团聚现象。Ti细化过共晶高铬铸铁的机理为:弥散分布的TiC可能作为初生碳化物的异质形核质点;TiC颗粒阻碍初生碳化物的长大;生成TiC的反应消耗一部分C而降低过共晶高铬铸铁的过共晶程度。

关键词：过共晶钛细化高铬铸铁

Spinal Long-term Potentiation Underlies Chronic Pain

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Spinal Long-term Potentiation Underlies Chronic Pain

Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus

中国神经科学学会第十二届全国学术会议

作者： Li-Jun Zhou jiyun peng Madhuvika Murugan Yong Liu Ukpong B.Eyo Zhi Tan Xiao Wei Xian-Guo Liu Long-Jun Wu Department of Physiology and Pain Research Center Zhongshan School of MedicineSun Yat-sen University Department of Cell Biology and Neuroscience Rutgers University

Spinal long-term potentiation（LTP） at C-fiber synapses induced by injury or electrical high frequency stimulation（HFS） of peripheral nerve is believed to underlie chronic pain. However, the evidence demonstrating the causal link between spinal LTP and chronic pain is still lacking. Here we reported that LTP-inducible HFS that did not cause physical nerve injury triggered pain hypersensitivity lasting for at least 3 weeks in mice and rats. HFS activated spinal microglia via colony stimulating factor 1（CSF1） signaling and induced CGRP afferent sprouting in the dorsal horn. Genetic ablation of resident microglia prevented the HFS-induced long lasting synaptic potentiation, CGRP afferent sprouting and chronic pain. Using transgenic mice with specific deletion of microglial BDNF, we further delineated that microglial BDNF promotes HFS-and CSF1-induced sprouting of CGRP primary afferents. Together, the results dissect an intriguing neuronal CSF1 to microglial BDNF signaling cascade in chronic pain generated directly by LTP-inducible electrical stimulation. Therefore, our study demonstrates a causal link between spinal LTP and chronic pain, and provides novel insights into the microglial mechanism underlying acute to chronic pain transition after intensive noxious stimulation of the peripheral nerve.

关键词： Long-term potentiation spinal dorsal horn microglia CGRP primary afferents colony stimulating factor 1 BDNF

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Microglial proliferation and monocyte infiltration contribut...

中国解剖学会2019年年会

作者： Lijie Feng Madhuvika Murugan Dale B.Bosco Yong Liu jiyun peng Gregory A.Worrell Hai-long Wang Lauren E.Ta Yuxian Shen Long-jun Wu School of Basic Medical Sciences Anhui Medical University Department of Cell Biology and Neuroscience School of Arts and SciencesRutgers University Department of Neurology Mayo Clinic

Microglial activation has been recognized as a major contributor to inflammation of the epileptic *** are commonly accompanied by remarkable microgliosis and loss of *** this study,we utilize the CX3CR1CCR2genetic mouse model,in which CX3CR1～+resident microglia and CCR2 monocytes are labeled with GFP and RFP,*** a combination of time-lapse two-photon

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《数据库原理及应用》教学与实践的改革

电脑学习 2008年第2期 50-51页

作者：彭积云曾晓亮江西应用技术职业学院信息系讲师赣州341000 不详

提出了《数据库原理及应用》课程教学改革的建议与注意问题。

关键词：人才需求数据库原理及应用教学改革

Microglial Depletion does not Afect the Laterality of Mechanical Allodynia in Mice

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神经科学通报:英文版 2023年第8期39卷 1229-1245页

Mechanical allodynia(MA),including punctate and dynamic forms,is a common and debilitating symptom suffered by millions of chronic pain *** peripheral injuries result in the development of bilateral MA,while most injuries usually led to unilateral *** date,the control of such laterality remains poorly ***,to study the role of microglia in the control of MA laterality,we used genetic strategies to deplete microglia and tested both dynamic and punctate forms of MA in ***,the depletion of central microglia did not prevent the induction of bilateral dynamic and punctate ***,in dorsal root ganglion-dorsal root-sagittal spinal cord slice preparations we recorded the low-threshold Aβ-fiber stimulation-evoked inputs and outputs of superficial dorsal horn *** with behavioral results,microglial depletion did not prevent the opening of bilateral gates for Aβpathways in the superficial dorsal *** study challenges the role of microglia in the control of MA laterality in *** studies are needed to further understand whether the role of microglia in the control of MA laterality is etiology-or species-specific.

关键词： Microglia Mechanical allodynia Laterality Spinal dorsal horn Aβ Dynamic allodynia Punctate allodynia

A Comparative Study on the Performance of Typical Types of Bionic Groove Dry Gas Seal based on Bird Wing

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Journal of Bionic Engineering 2016年第2期13卷 324-334页

作者： Jinbo Jiang Xudong peng jiyun Li Yuan Chen School of Mechanical Engineering Zhejiang University of Technology Hangzhou 310014 China

A series of bionic grooves based on bird wing, such as cluster spiral groove, multi-array spiral groove and flow-split spiral groove, are introduced to improve the film stiffness and sealing properties of dry gas seal. A theoretical model solved with Finite Difference Method （FMD） is developed to study the static sealing performance, such as film stiffness and leakage rate of these bionic groove dry gas seals. Then, a performance comparative study between the bionic groove dry gas seals and common spiral groove dry gas seal with different groove geometry parameters such as groove depth ratio, spiral angle and micro groove number under different average linear velocity at seal ring face and seal pressure is carried out. The closing force, film thickness and leakage rate of dry gas seals with bionic grooves and common spiral groove are measured experimentally. Results show that cluster spiral groove and multi-array spiral groove dry gas seals have superiority in the film stiffness and stiffness-leakage ratio compared with common spiral groove under the condition of high-speed and low-pressure, while flow-split spiral groove dry gas seal has no obvious advantages of performance. Film stiffness of cluster spiral groove dry gas seal and stiffness-leakage ratio of multi-array spiral groove dry gas are 20% and 50% larger than that of common spiral groove dry gas seal, respectively, which are verified by the experimental results.

关键词： bionic groove dry gas seal film stiffness performance comparison

Experiment on Wear Behavior of High Pressure Gas Seal Faces

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Chinese Journal of Mechanical Engineering 2014年第6期27卷 1287-1293页

作者： XU Jing peng Xudong BAI Shaoxian MENG Xiangkai LI jiyun MOE Engineering Research Center of Process Equipment and Its Remanufacture Zhejiang University of Technology School of Mechanical Engineering Hangzhou Dianzi University

Current researches show that mechanical deformation of seal ring face makes fluid film clearance decrease at high pressure side, thus a divergent clearance is formed and face wear occurs more seriously at the high pressure side than that on the low pressure side. However, there is still lack of published experimental works enough to prove the theoretical results. In this paper, a spiral groove dry gas seal at high pressures is experimentally investigated so as to prove the face wear happened at the high pressure side of seal faces due to the face mechanical deformation, and the wear behavior affected by seal ring structure is also studied. The experimental results show that face wear would occur at the high pressure side of seal faces due to the deformation, thus the leakage and face temperature increase, which all satisfies the theoretical predictions. When sealed pressure is not less than 5 MPa, the pressure can provide enough opening force to separate the seal faces. The seal ring sizes have obvious influence on face wear. Face wear, leakage and face temperature of a dry gas seal with the smaller cross sectional area of seal ring are less than that of a dry gas seal with bigger one, and the difference of leakage rate between these two sizes of seal face width is in the range of 24%–25%. Compared with the effect of seal ring sizes, the effect of secondary O-ring seal position on face deformation and face wear is less. The differences between these two types of dry gas seals with different secondary O-ring seal positions are less than 5.9% when the rotational speed varies from 0 to 600 r/min. By linking face wear and sealing performance changes to the shift in mechanical deformation of seal ring, this research presents an important experimental method to study face deformation of a dry gas seal at high pressures.

关键词： dry gas seal structures face wear high pressure mechanical deformation