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Nanomedicines for the treatment of rheumatoid arthritis:State of art and potential therapeutic strategies

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1158-1174页

作者： Qin Wang Xianyan Qin jiyu fang Xun Sun Key Laboratory of Advanced Technologies of Materials Ministry of Education and School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Advanced Materials Processing and Analysis Center and Department of Materials Science and Engineering University of Central FloridaOrlandoFL 32816USA Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacySichuan UniversityChengdu 610041China

Increasing understanding of the pathogenesis of rheumatoid arthritis(RA)has remarkably promoted the development of effective therapeutic regimens of ***,the inadequate response to current therapies in a proportion of patients,the systemic toxicity accompanied by longterm administration or distribution in non-targeted sites and the comprised efficacy caused by undesirable bioavailability,are still unsettled problems lying across the full remission of *** far,these existing limitations have inspired comprehensive academic researches on nanomedicines for RA treatment.A variety of versatile nanocarriers with controllable physicochemical properties,tailorable drug release pattern or active targeting ability were fabricated to enhance the drug delivery efficiency in RA *** review aims to provide an up-to-date progress regarding to RA treatment using nanomedicines in the last 5 years and concisely discuss the potential application of several newly emerged therapeutic strategies such as inducing the antigen-specific tolerance,pro-resolving therapy or regulating the immunometabolism for RA treatments.

关键词： Nanomedicines Rheumatoid arthritis Targeted drug delivery Liposome Micelle Stimulus-responsive delivery systems Immune tolerance Inflammation resolution

Targeting the resolution pathway of inflammation using Ac2–26 peptide-loaded PEGylated lipid nanoparticles for the remission of rheumatoid arthritis

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Asian Journal of Pharmaceutical Sciences 2021年第4期16卷 483-493页

作者： Xianyan Qin Liming He Donghao Fan Wenlang Liang Qin Wang jiyu fang Key Laboratory of Advanced Technologies of Materials Ministry of Education and School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Advanced Materials Processing and Analysis Center and Department of Materials Science and Engineering University of Central FloridaFlorida 32816United State

Rheumatoid arthritis(RA)is a common autoimmune disease characterized by joint inflammation and immune *** various therapeutic approaches have been utilized for the treatment of RA in clinical applications,the low responsiveness of RA patients and undesired systemic toxicity are still unresolved *** the resolution pathway of inflammation with pro-resolving mediators would evoke the protective actions of patient for combating the ***2–26,a 25-amino acid peptide derived from Annexin A(a pro-resolving mediator),has shown good efficacy in the treatment of inflammatory ***,the low bioavailability of Ac2–26 peptides hinders their efficacy in *** this paper,we formed PEGylated lipid nanoparticles(LDNPs)by the co-assembly of l-ascorbyl palmitate(L-AP)and N-(carbonyl methoxypolyethylene glycol-2000)-1,2-distearoyl-sn–glycero-3-phosphoethanolamine(DSPE-PEG 2 k)to encapsulate and deliver Ac2–26 peptides to the arthritic *** showed good stability and *** being intravenously administrated,Ac2–26 peptide-loaded PEGylated lipid nanoparticles(ADNPs)showed the prolonged in vivo circulation time and enhanced accumulation in inflamed *** vivo therapeutic evaluations revealed that ADNPs could attenuate synovial inflammation and improve joint ***,the pro-resolving therapeutic strategy using ADNPs is effective in RA treatment.

关键词： Pegylated lipid nanoparticles Drug delivery Pro-resolving therapy Ac2–26 peptide Rheumatoid arthritis

Interaction of Surfactants and Polyelectrolyte-Coated Liquid Crystal Droplets

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Journal of Materials Science and Chemical Engineering 2014年第11期2卷 1-7页

作者： Tanmay Bera jiyu fang Department of Materials Science and Engineering University of Central Florida Orlando USA

It is known that the adsorption of surfactants at the liquid crystal (LC)/aqueous interface can induce a bipolar-to-radial director configuration of LC droplets dispersed in aqueous solution. In this paper, we study the effect of charged polyelectrolyte-coating on the interaction of surfactants and LC droplet cores by observing the director configuration of the LC droplet cores as a function of surfactant concentrations. It is found that surfactants can penetrate into the polyelectrolyte coating and react with the LC droplet cores to induce the bipolar-to-radial transition of the LC inside the droplet cores. However, the concentration of charged surfactants required to induce the configuration transition of the LC droplet cores is affected by the charged polyelectrolyte coating. The effect is significantly enlarged with decreasing the alkyl chain length of charged surfactants. Our results highlight the possibility of engineering polyelectrolyte coatings to tune the interaction of LC droplets with analysts, which is critical towards designing LC droplet based sensors.

关键词： Liquid Crystals Droplets Polyelectrolyte Coatings Surfactants Configuration Transitions

Templated J-Aggregate Nanotubes for the Detection of Dopamine

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Journal of Materials Science and Chemical Engineering 2017年第1期5卷 142-154页

作者： Samuel Rhodes Xiaochen Wang Wenlang Liang Hyoung Jin Cho jiyu fang Department of Materials Science and Engineering University of Central Florida Orlando USA Department of Mechanical and Aerospace Engineering University of Central Florida Orlando USA

J-aggregates of dye molecules are a unique supramolecular structure, which shows great promise in photoelectric devices due to its remarkable optical and transport properties. In this paper, we report the templated formation of J-aggregate nanotubes by the adsorption of 3,3’-diethylthiacarbocyanine iodide on the self-assembled nanotubes of lithocholic acid. The optical and electronic properties of the templated J-aggregate nanotubes are studied. A sensor platform is fabricated by depositing the J-aggregate nanotubes on interdigitated gold electrodes for the detection of dopamine (DA). We find that the current change of the J-aggregate nanotube-based sensor platform in response to DA is linear in the concentration range from 10 nM to 70 nM, giving the detection limit of 0.27 nM.

关键词： Cyanine Dyes Bile Acids J-Aggregate Nanotubes Dopamine Detection

单玻璃基板与各向异性聚合物膜的IPS-LCD的应用

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现代显示 2006年第10期 7-12页

作者： Yi-Hsin Lin Hongwen Ren Sebastian Gauza Yung-Hsun Wu Yue Zhao jiyu fang Shin-Tson Wu 夏明哲（译）美国电气和电子工程师协会学生会员美国电气和电子工程师协会会员不详深圳天马微电子有限公司

介绍了一种使用单片玻璃基板和各向异性聚合物膜的轻型、共面转换液晶显示(IPS-LCD)技术。液晶分子由伸长的聚合物膜内的颗粒排列。各向异性聚合物膜的取向性能与聚酰亚胺(PI)摩擦层相当。良好的液晶取向性能使新器件的对比度(514:1)、... 详细信息

介绍了一种使用单片玻璃基板和各向异性聚合物膜的轻型、共面转换液晶显示(IPS-LCD)技术。液晶分子由伸长的聚合物膜内的颗粒排列。各向异性聚合物膜的取向性能与聚酰亚胺(PI)摩擦层相当。良好的液晶取向性能使新器件的对比度(514:1)、驱动电压和响应时间都能够与双玻璃基板LCD相比拟。这种各向异性膜也能作为拓宽视角的相位补偿膜来使用。该技术特别引人注目之处在于制作单基板显示器,同时它也具有实现双层宾主显示和IPS-LCD柔性显示的潜在应用。

关键词：各向异性聚合物膜面内切换单基板液晶显示

miR-210的红细胞系相关下游靶基因预测

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山东医药 2017年第3期57卷 20-24页

作者：施继禹刘芳丁谨曹艳李文俊青海大学医学院西宁810001

目的利用生物信息学方法预测miR-210的红细胞系(以下简称红系)相关下游靶基因。方法利用NCBI比对分析miR-210成熟序列在各哺乳动物之间的保守性。运用基因数据库筛选miR-210的下游靶基因。采用Cytoscape中的BINGO插件对预测的miR-210下... 详细信息

目的利用生物信息学方法预测miR-210的红细胞系(以下简称红系)相关下游靶基因。方法利用NCBI比对分析miR-210成熟序列在各哺乳动物之间的保守性。运用基因数据库筛选miR-210的下游靶基因。采用Cytoscape中的BINGO插件对预测的miR-210下游靶基因进行GO分类富集分析。筛选参与红系增殖、分化、凋亡的miR-210下游靶基因,采用DAVID和KEGG数据库进行信号转导通路富集分析后,预测miR-210的红系相关下游靶基因。利用Targetscan在线工具验证靶基因与miR-210的相互作用关系。结果 miR-210成熟序列在多物种间具有高度保守性。筛选出416个与miR-210相关性较高的预测靶基因,其分子功能集中在蛋白结合、离子跨膜运输活动、酶结合等,参与的生物学过程集中在细胞信号转导、突触传导等,参与构成的细胞组分主要有突触小泡、细胞质、细胞器等。筛选出26个与红系增殖、分化、凋亡密切相关的miR-210下游靶基因,参与调控的信号通路主要集中于癌症信号通路、PI3K-Akt信号通路等。初步确定Smad3、Mapk10、Stat5a、Ywhag、Ctgf、Kitl6基因与红系增殖、分化密切相关,其中Smad3、Mapk10、Stat5a、Ywhag、Kitl可能受miR-210的直接调控,Ctgf可能受miR-210的间接调控。结论初步筛选出miR-210的红系相关下游靶基因Smad3、Mapk10、Stat5a、Ywhag、Ctgf、Kitl6,这些靶基因可能与红系的增殖、分化有关。

关键词：微小RNA miR-210 红细胞系靶基因生物信息学

顾及大数据流式处理技术的电子监察系统业务权限模型构建

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国外电子测量技术 2019年第2期38卷 5-9页

作者：王玮方继宇王伟民贵州电网有限责任公司信息中心贵阳550002

提出了运用大数据流式处理技术对电子监察系统业务权限进行分析的模型,探讨了在进行电子监察系统业务权限模型构建时,所采用的函数和对各个自变量的权重分配,并且运用大数据流式处理技术(LDFPTA)来确定电子监察系统业务权限模型的权重... 详细信息

提出了运用大数据流式处理技术对电子监察系统业务权限进行分析的模型,探讨了在进行电子监察系统业务权限模型构建时,所采用的函数和对各个自变量的权重分配,并且运用大数据流式处理技术(LDFPTA)来确定电子监察系统业务权限模型的权重。以电子监察系统业务数据为例进行验证。研究结果表明,该电子监察系统业务权限模型较好地解决了复杂系统多维动态监察问题,并在国内多领域电子监察系统中得到应用,取得了较好的效果。

关键词：电子监察系统业务权限大数据流式处理技术稳定性

土壤不同镉水平对马缨丹生长及其抗氧化酶活性的影响

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西北植物学报 2013年第9期33卷 1838-1844页

作者：贾永霞张世熔张春梅黄添杨胡欣方继宇四川农业大学资源环境学院四川温江611130

采用盆栽试验方法,分别设置0(对照,不添加镉)、30、60、90、120、150、180、210mg·kg-1共8个土壤镉处理水平,研究土壤不同镉水平对马缨丹(Lantana comara L.)生长及其抗氧化酶活性的影响,以探讨马缨丹对镉胁迫的生理响应机制。结果显示... 详细信息

采用盆栽试验方法,分别设置0(对照,不添加镉)、30、60、90、120、150、180、210mg·kg-1共8个土壤镉处理水平,研究土壤不同镉水平对马缨丹(Lantana comara L.)生长及其抗氧化酶活性的影响,以探讨马缨丹对镉胁迫的生理响应机制。结果显示:(1)随着土壤镉处理浓度的升高,马缨丹干重呈先升高后降低的趋势,30mg·kg-1镉处理能促进植株的生长,而浓度高于60mg·kg-1时显著抑制马缨丹的生长。(2)马缨丹叶片和根系中O-·2产生速率、H2O2和MDA含量及电解质渗漏率均随土壤镉处理浓度的升高和胁迫时间的延长逐渐升高,胁迫90d时,叶片和根系中O-·2产生速率、H2O2和MDA含量及电解质渗漏率分别在镉浓度高于60和30mg·kg-1时显著低于对照。(3)叶片和根系抗氧化酶SOD、POD、APX和CAT活性随着土壤镉处理浓度的增加大体呈先升高后降低的趋势,并在镉浓度分别高于90和60mg·kg-1时,叶片和根系抗氧化酶活性显著低于对照。研究表明,低浓度镉处理土壤能促进马缨丹植株生长,而高浓度镉处理土壤显著降低了马缨丹体内抗氧化酶活性,导致活性氧大量积累,引起严重的膜脂过氧化伤害,从而显著抑制马缨丹植株的生长。

关键词：镉马缨丹抗氧化酶

An Overview of Wireless Communication Technology Using Deep Learning

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China Communications 2021年第12期18卷 1-36页

作者： jiyu Jiao Xuehong Sun Liang fang Jiafeng Lyu School of Physics and Electronic-Electrical Engineering Ningxia UniversityNingxia 750021China School of Information Engineering Ningxia UniversityNingxia 750021China

with the development of 5G,the future wireless communication network tends to be more and more *** the face of new service de-mands of communication in the future such as super-heterogeneous network,multiple communication sce-narios,large number of antenna elements and large bandwidth,new theories and technologies of intelli-gent communication have been widely studied,among which Deep Learning(DL)is a powerful technology in artificial intelligence(AI).It can be trained to con-tinuously learn to update the optimal *** paper reviews the latest research progress of DL in in-telligent communication,and emphatically introduces five scenarios including Cognitive Radio(CR),Edge Computing(EC),Channel Measurement(CM),End to end Encoder/Decoder(EED)and Visible Light Com-munication(VLC).The prospect and challenges of further research and development in the future are also discussed.

关键词： artificial intelligence wireless communi�cation deep learning cognitive radio edge comput�ing channel measurement end-to-end encoder and decoder visible light communication