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Clinical outcomes of endoscopic papillectomy of ampullary adenoma: A multi-center study

World Journal of Gastroenterology 2022年第17期28卷 1845-1859页

作者： Seong Ji Choi Hong Sik Lee jiyeong kim Jung Wan Choe Jae Min Lee Jong Jin Hyun Jai Hoon Yoon Hyo Jung kim Jae Seon kim Ho Soon Choi Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University College of MedicineSeoul 02841South Korea Lab of Biostatistical Consulting and Research Medical Research Collaborating CenterIndustry-University Cooperation FoundationHanyang UniversitySeoul 04763South Korea

BACKGROUND Ampullary adenoma is a rare premalignant lesion,but its incidence is *** papillectomy has become the first treatment of choice for ampullary adenomas due to its safety and effectiveness,thereby replacing surgical ***,recurrence rates and adverse events after endoscopic papillectomy were reported in up to 30%of *** To review the long-term outcomes of endoscopic papillectomy and investigate the factors that affect these *** We retrospectively analyzed the data of patients who underwent endoscopic papillectomy for ampullary adenoma at five tertiary hospitals between 2013 and *** evaluated clinical outcomes and their risk *** definitions of outcomes were as follow:(1)curative resection:complete endoscopic resection without recurrence;(2)endoscopic success:treatment of ampullary adenoma with endoscopy without surgical intervention;(3)early recurrence:reconfirmed adenoma at the first endoscopic surveillance;and(4)late recurrence:reconfirmed adenoma after the first endoscopic *** A total of 106 patients were included for *** the included patients,81(76.4%)underwent curative resection,99(93.4%)had endoscopic success,showing that most patients with noncurative resection were successfully managed with *** patients(15.1%)had piecemeal resection,22 patients(20.8%)had shown positive/uncertain resection margin,11 patients(16.1%)had an early recurrence,13 patients(10.4%)had a late recurrence,and 6 patients(5.7%)had a *** multivariate analysis,a positive/uncertain margin[Odds ratio(OR)=4.023,P=0.048]and piecemeal resection(OR=6.610,P=0.005)were significant risk factors for early and late recurrence,*** resection was also a significant risk factor for non-curative resection(OR=5.424,P=0.007).Twenty-six patients experienced adverse events(24.5%).CONCLUSION Endoscopic papillectomy is a safe and effective treatment for ampullary ***

关键词： Endoscopic papillectomy Ampullary adenoma Clinical outcome Recurrence Adverse event

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Comparison of Usage and Effectiveness between Methoxy Polyethylene Glycol Epoetin Beta and Darbepoetin Alfa with Hemodialysis Patients

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Journal of Pharmacy and Pharmacology 2015年第4期3卷 182-190页

作者： jiyeong Yoon Beung Koo Lee Hyesun Gwak Jeongmee kim Youngmee Lee Ewha Graduate School of Clinical Pharmacology 52 Ewhayeodae-gil Seodaemun-gu Seoul KSO13 Korea Samsung Medical Center 81 Irwon-Ro Gangnam-gu Seoul KSO13 Korea

Methoxy polyethylene glycol epoetin beta which has a long half-life is developed to provide stable control of hemoglobin levels at extended administration intervals compared to darbepoetin alfa. The purpose of this study was to compare the patterns of use, efficiency of therapy and cost with undergoing hemodialysis patients. Electronic medical record system was used to examine administration frequency, hemoglobin response rate, achievement of target hemoglobin, drug costs. Administration frequency was once in 4 weeks with methoxy polyethylene glycol epoetin beta group and 3 times in 4 weeks with darbepoetin alfa group. Hemoglobin response rate was 61.5% in methoxy polyethylene glycol epoetin beta at the time of 16 weeks. It was not significantly different from 66.7% in darbepoetin alfa （P = 1.000）. The drug cost for methoxy polyethylene glycol epoetin beta group was little higher than darbepoetin alfa group. However, there was no statistically significant difference （P = 0.164）. Use of methoxy polyethylene glycol epoetin beta is as effective and safe as darbepoetin alfa managing renal anemia in hemodialysis patients. Methoxy polyethylene glycol epoetin beta＇s extended administration interval improve patient＇s compliance and enable effective anemia treatment.

关键词： Methoxy polyethylene glycol epoetin beta erythropoiesis stimulating agent renal anemia hemoglobin.

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