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Chemical Research in Chinese Universities 2024年第1期40卷 145-152页

作者： wu Jun LI Yongzhi QIN Hanjiao GAO Ying YANG Bing SHENG jiyao ZHANG Xuewen Department of Hepatobiliary and Pancreatic Surgery the Second Hospital of Jilin UniversityChangchun130022P.R.China Department of Radiation Oncology the Second Hospital of Jilin UniversityChangchun130022P.R.China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun130012P.R.China

In this study,we synthesized an organic material with near-infrared emission capabilities:4-(2-(4-(9-(4-(diphenylamino)phenyl)naphtho[2,3-c][1,2,5]thiadiazol-4-yl)phenyl)-1H-phenol-1-ylidene)malononitrile(TPA).Furthermore,TPA-PEG2000 fluorescent nanoparticles were prepared via coating the shells with PEG2000.TPA-PEG2000 exhibited strong near-infrared emission near 700 nm,with a photoluminescence quantum yield of 15.09%,indicating a high emission efficiency.Molecular biology experiments have confirmed its low toxicity and excellent biocompatibility.Increased cholesterol and phospholipid levels in liver cancer cell membranes with low sensitivity or high drug resistance lead to increased rigidity,reduced membrane fluidity,reduced endocytic efficiency,and reduced uptake.Therefore,the uptake of TPA-PEG2000 nanoparticles into cells and the near-infrared fluorescence intensity can be used to evaluate the sensitivity of systemic liver cancer treatment in a simple and efficient manner.

关键词： Nanoparticle Near-infrared Fluorescence Systemic treatment sensitivity Cell membrane fluidity

circSVIL regulates bovine myoblast development by inhibiting STAT1 phosphorylation

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Science China(Life Sciences) 2022年第2期65卷 376-386页

作者： Binglin Yue Haiyan Yang jiyao wu Jian Wang Wenxiu Ru Jie Cheng Yongzheng Huang Xianyong Lan Chuzhao Lei Hong Chen Key laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China

Circular RNAs(circRNAs),a novel class of non-coding RNAs with a loop structure,have recently been shown to participate in various pathophysiological processes.However,the precise role of circRNAs in myoblasts remains unclear.In this report,circSVIL was screened and identified from our previous sequencing analysis;we then performed gain-and loss-of-function experiments on bovine myoblasts by CCK8,EdU,flow cytometry,qRT-PCR,and Western blotting.The results indicate that circSVIL facilitates bovine myoblast proliferation and inhibits cell apoptosis.Using mechanism assays such as bioinformatics prediction,RNA immunoprecipitation(RIP),and cytoplasmic separation,we demonstrate that circSVIL could interact with STAT1 and inhibit STAT1 phosphorylation,thereby restraining STAT1’s nuclear translocation and affecting its downstream signal cascade.Our results may elucidate a new regulatory pathway for bovine skeletal muscle development.

关键词： circSVIL STAT1 skeletal muscle

Expert consensus on difficulty assessment of endodontic therapy

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International Journal of Oral Science 2024年第1期16卷 15-25页

作者： Dingming Huang Xiaoyan Wang Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Xinmei Chen jiyao Li Ling Ye Lei Cheng Xin Xu Tao Hu Hongkun wu Bin Guo Qin Su Zhi Chen Lihong Qiu Wenxia Chen Xi Wei Zhengwei Huang Jinhua Yu Zhengmei Lin Qi Zhang Deqin Yang Jin Zhao Shuang Pan Jian Yang Jiayuan wu Yihuai Pan Xiaoli Xie Shuli Deng Xiaojing Huang Lan Zhang Lin Yue Xuedong Zhou State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Operative Dentistry and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghuaSchool of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhanChina Department of Operative Dentistry&Endodontics School of StomatologyThe Fourth Military Medical UniversityXi’anChina Department of Endodontics Beijing Stomatological HospitalSchool of StomatologyCapital Medical UniversityBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Preventive Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Geriatric dentistry West China Hospital of Stomatology

Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy(RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics.

关键词： anatomy difficulty treatment

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基于M估计算法的三维点云平面拟合方法研究

电子测量技术 2024年第5期47卷 70-76页

作者：杨少舟龙东平陈继尧吴士旭徐先懂湖南科技大学机电工程学院湘潭411201 难加工材料高效精密加工湖南省重点实验室湘潭411201 长沙视浪科技有限公司长沙410006 韶关学院智能工程学院韶关512005

通过激光传感器获取的三维点云难免混入噪声和异常点,导致点云平面的拟合精度降低。为解决该问题,本文提出了一种结合M估计样本一致性(MSAC)算法和主成分分析(PCA)法拟合点云平面的方法。该方法首先通过MSAC算法去除点云数据中的异常点... 详细信息

通过激光传感器获取的三维点云难免混入噪声和异常点,导致点云平面的拟合精度降低。为解决该问题,本文提出了一种结合M估计样本一致性(MSAC)算法和主成分分析(PCA)法拟合点云平面的方法。该方法首先通过MSAC算法去除点云数据中的异常点,获得较为理想的点云平面,然后使用PCA方法对保留的点云数据进行平面拟合,以获取更加精确的点云平面参数。使用电池托盘作为被测物,应用3D线激光轮廓传感器扫描被测物并将点云数据传输到计算机进行处理。通过设定的仿真数据和电池托盘点云数据进行实验,发现本文方法与随机采样一致性(RANSAC)结合PCA、最小平方中值(LMedS)结合PCA的方法相比,在耗时接近的情况下,能够显著降低异常点对点云平面拟合的影响,获得更精确的平面拟合参数。对两个部分的电池托盘点云滤波处理后进行平面拟合时,能够发现本文方法与其他两种方法相比,标准差分别降低了28.6%和22.5%%、24.0%和29.0%,该方法具有较高的平面拟合精度和实用性。

关键词：点云数据异常点平面拟合 M估计主成分分析方法

Cause of winter gravity wave spectrum saturation

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Science China Earth Sciences 2005年第10期48卷 1802-1808页

作者： wu Yongfu XU jiyao Laboratory for Space Weather Center for Space Science and Applied Research Chinese Academy of Sciences Beijing 100080 China Laboratory for Space Weather Center for Space Science and Applied Research Chinese Academy of Sciences Beijing 100080 China

This paper utilizes horizontal velocity measurements observed from 19 chaff rockets and nearly simultaneous temperature measurements collected from 19 falling sphere rockets to study the cause of winter gravity wave spectrum saturation. Results suggest that strong hori-zontal velocity shears larger than 0.04 s?1 are observed to be present at various heights near the winter mesopause. On one single chaff rocket flight, an extremely strong horizontal velocity shear as high as 0.33 s?1 is observed at 87.4 km and is believed to be the strongest value ever meas-ured in the mesosphere. These strong horizontal velocity shears, together with Brunt-V?is?l? frequency squared obtained from the temperature profile, act collectively to yield two dynamical instability regions of Richardson number smaller than 1/4, suggesting that the saturated gravity wave spectrum observed by the chaff rockets in winter is a result of dynamical instability.

关键词： winter spectrum, strong shear, dynamical instability, spectrum saturation.

Occurrence characteristics of branching structures in equatorial plasma bubbles:a statistical study based on all-sky imagers in China

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Earth and Planetary Physics 2021年第5期5卷 407-415页

作者： Kun wu jiyao Xu YaJun Zhu Wei Yuan State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

Branching structure(BS)is a very important phenomenon in the evolution of equatorial plasma bubbles(EPBs),the mechanism of which is widely studied from observation and from simulation.However,occurrence characteristics of branching structure of equatorial plasma bubbles(BSEPBs)have not been well addressed.In this work,we used seven-years(2012-2018)of observations from two all-sky imagers to study occurrence of BSEPBs in detail.These data reveal a high incidence of BS in EPB cases;in particular,most EPBs occurring on days with geomagnetic disturbances exhibited BS.Periods when all EPBs exhibited BS increased significantly in the 2014 solar maximum.Occurrence times of BSEPBs varied with local time;most of the BSEPBs began to appear between 21:00 and 22:00 LT.During the solar maximum,some BSEPBs were observed after midnight.The data also reveal that BSEPBs are characterized primarily by two branches or three branches.Multi-branching appeared only in the solar maximum.EPB events with different coexisting branching structures increased from 2012 to 2014 and decreased from 2014 to 2018.These results strongly suggest that BSEPB occurrence is related to solar activity and geomagnetic activity,and thus provide a new perspective for future studies of EPBs as well as enriching our understanding of ionospheric irregularity.

关键词： branching structure of equatorial plasma bubble equatorial plasma bubble ionospheric irregularity all-sky imager

Amplitude-Integrated Electroencephalography Predicts Outcome in Patients with Coma After Acute Brain Injury

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Neuroscience Bulletin 2018年第4期34卷 639-646页

作者： Wendong You Qilin Tang Xiang wu Junfeng Feng Qing Mao Guoyi Gao jiyao Jiang Department of Neurosurgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Shanghai Institute of Head Trauma Shanghai 200127China

Prognostication of coma patients after brain injury is important, yet challenging. In this study, we evaluated the predictive value of amplitude-integrated electroencephalography （aEEG） for neurological outcomes in coma patients. From January 2013 to January 2016, 128 coma patients after acute brain injury were prospectively enrolled and monitored with aEEG. The 6-month neurological outcome was evaluated using the Cerebral Performance Category Scale. aEEG monitoring commenced at a median of 7.5 days after coma onset. Continuous normal voltage predicted a good 6-month neurological outcome with a sensitivity of 93.6% and specificity of 85.2%. In contrast, continuous extremely low voltage, burst-suppression, or a flat tracing was correlated with poor 6-month neurological outcome with a sensitivity of 76.5% and specificity of 100%. In conclusion, aEEG is a promising predictor of 6-month neurological outcome for coma patients after acute brain injury.

关键词： Amplitude-integrated electroencephalography -Coma Acute brain injury Outcome

中国上空夜间电离层等离子体泡群演化过程的多设备观测

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空间科学学报 2023年第3期43卷 446-455页

作者：吴坤徐寄遥袁韦中国科学院国家空间科学中心北京100190 中国科学院大学北京100049

利用子午工程富克站(19.5°N,109.1°E)全天空气辉成像仪、VHF雷达、三亚站(18.4°N,109.6°E)数字测高仪及C/NOFS卫星观测数据,对2014年3月30日中国上空的等离子体泡进行了研究。结果表明,当天夜间观测到一个等离子体泡群,约由9个等离... 详细信息

利用子午工程富克站(19.5°N,109.1°E)全天空气辉成像仪、VHF雷达、三亚站(18.4°N,109.6°E)数字测高仪及C/NOFS卫星观测数据,对2014年3月30日中国上空的等离子体泡进行了研究。结果表明,当天夜间观测到一个等离子体泡群,约由9个等离子体泡组成,发生在日落后,一直持续到午夜后。其自西向东运动,南北向最大尺度超过1200 km,东西向绵延超过1400 km,在演化中部分结构融合在一起。等离子体泡被气辉成像仪观测到的同时,数字测高仪及VHF雷达观测到了相应扩展F及羽毛状不规则结构。同时,C/NOFS卫星检测到相应电子密度耗散。这表明,该等离子体泡同时被地基光学观测、无线电探测及C/NOFS卫星观测到。研究结果给出了多仪器同时观测到的等离子体泡群演化过程,丰富了多仪器融合研究电离层不规则体的内容。

关键词：电离层等离子体泡全天空气辉成像仪数字测高仪 VHF雷达 C/NOFS卫星

Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage

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International Journal of Oral Science 2021年第4期13卷 408-421页

作者： Lizhong Sun Libang He Wei wu Li Luo Mingyue Han Yifang Liu Shijie Shi Kaijing Zhong Jiaojiao Yang jiyao Li State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqingChina

Unrestrained inflammation is harmful to tissue repair and regeneration.Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflammation.Prevention and early intervention of inflammation can reduce the risk of irreversible tissue damage and loss of function,but no cell membrane-camouflaged nanotechnology has been reported to achieve stage-specific treatment in these conditions.In this study,we investigated the prophylactic and therapeutic efficacy of fibroblast membrane-camouflaged nanoparticles for topical treatment of early inflammation(early pulpitis as the model)with the help of in-depth bioinformatics and molecular biology investigations in vitro and in vivo.Nanoparticles have been proven to act as sentinels to detect and competitively neutralize invasive Escherichia coli lipopolysaccharide(E.coli LPS)with resident fibroblasts to effectively inhibit the activation of intricate signaling pathways.Moreover,nanoparticles can alleviate the secretion of multiple inflammatory cytokines to achieve multitargeted anti-inflammatory effects,attenuating inflammatory conditions in the early stage.Our work verified the feasibility of fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage,which widens the potential cell types for inflammation regulation.

关键词： inflammation treatment nanoparticles

Comprehensive Proteomic Profiling of Patients'Tears Identifies Potential Biomarkers for the Traumatic Vegetative State

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Neuroscience Bulletin 2018年第4期34卷 626-638页

作者： Qilin Tang Chao Zhang Xiang wu Wenbin Duan Weiji Weng Junfeng Feng Qing Mao Shubin Chen jiyao Jiang Guoyi Gao Department of Neurosurgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Shanghai Head Trauma Institute Shanghai 200127China Department of Neurosurgery Baoshan People's HospitalBaoshan 678000China Department of Neurology Anda HospitalShanghai 201204China

The vegetative state is a complex condition with unclear mechanisms and limited diagnostic, prognostic, and therapeutic methods. In this study, we aimed to explore the proteomic profile of tears from patients in a traumatic vegetative state and identify potential diagnostic markers using tears-a body fluid that can be collected noninvasively. Using iTRAQ quantitative proteomic technology, in the discovery phase, tear samples collected from 16 patients in a traumatic vegetative state and 16 normal individuals were analyzed. Among 1080 identified tear proteins, 57 were upregulated and 15 were downregulated in the patients compared to the controls. Bioinformatics analysis revealed that the differentially-expressed proteins were mainly involved in the wound response and immune response signaling pathways. Furthermore, we verified the levels of 7 differentially-expressed proteins in tears from 50 traumatic vegetative state patients and 50 normal controls （including the samples used in the discovery phase） using ELISA. The results showed that this 7-protein panel had a high discrimination ability for traumatic vegetative state （area under the curve = 0.999）. In sum- mary, the altered tear proteomic profile identified in this study provides a basis for potential tear protein markers for diagnosis and prognosis of the traumatic vegetative state and also provides novel insights into the mechanisms of traumatic vegetative state.

关键词： Trauma Vegetative state - Tears - Proteomics iTRAQ