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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu xue Han Yan Su Yiming Zhou Minhui xu jiyan xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

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尿石素A对小鼠异氟醚麻醉所致术后认知功能障碍的改善作用及其机制

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吉林大学学报（医学版） 2024年第3期50卷 596-601页

作者：许敏慧程晓雷许继岩江林昊夏天娇南京大学医学院江苏南京210008 南京大学医学院附属鼓楼医院麻醉科江苏南京210008

目的:探讨尿石素A(UA)对长时程异氟醚麻醉所致小鼠术后认知功能障碍(POCD)的改善作用,并阐明其可能的作用机制。方法:24只健康雄性C57BL/6小鼠随机分为空白对照组、麻醉组和UA组,每组8只。UA组小鼠于麻醉前2 d每天腹腔注射200μL UA溶液... 详细信息

目的:探讨尿石素A(UA)对长时程异氟醚麻醉所致小鼠术后认知功能障碍(POCD)的改善作用,并阐明其可能的作用机制。方法:24只健康雄性C57BL/6小鼠随机分为空白对照组、麻醉组和UA组,每组8只。UA组小鼠于麻醉前2 d每天腹腔注射200μL UA溶液,空白对照组和麻醉组小鼠给予等体积生理盐水,麻醉组和UA组小鼠制备长时程异氟醚麻醉模型,空白对照组小鼠不作处理。采用Y迷宫实验检测各组小鼠轮替正确率、移动距离和移动速度,条件恐惧实验检测各组小鼠僵直时间百分率,Western blotting法检测各组小鼠海马组织中白细胞介素(IL)-1β、IL-10和成熟脑源性神经营养因子(mBDNF)蛋白表达水平。结果:Y迷宫实验,与空白对照组比较,麻醉组小鼠轮替正确率明显降低(P0.05)。Western blotting法,与空白对照组比较,麻醉组小鼠海马组织中IL-1β蛋白表达水平明显升高(P<0.01),IL-10和mBDNF蛋白表达水平明显降低(P<0.01);与麻醉组比较,UA组小鼠海马组织中IL-1β蛋白表达水平明显降低(P<0.05),IL-10和mBDNF蛋白表达水平明显升高(P<0.05或P<0.01)。结论:UA可以改善小鼠的POCD,其作用机制可能与UA的抗炎活性可抑制POCD小鼠的中枢炎症且上调mBDNF蛋白表达有关。

关键词：尿石素A 异氟醚术后认知功能障碍白细胞介素脑源性神经营养因子

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The sedimentary structure characteristics and spatial distribution pattern of the Zhaoji Salt Mine derived from dense array ambient noise tomography

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Journal of Earth Science 2024年

作者： Hongwei Wang Xiaofeng Tian Qiaoxia Liu Jia Cheng Ming Zhou Zhiping xu jiyan Lin Shuaipeng Zhu Geophysics Exploration Center China Earthquake Administration School of Earth Sciences and Resources， China University of Geosciences (Beijing)

Due to the lack of the three-dimensional structure of the Zhaoji salt basin， the salt mining enterprises have obvious clustering when choosing sites. Production capacity declines rapidly as mining deepens， the enterprises are entering a stage of stagnation in production. In this study， a dense seismic array of 125 short-period stations was deployed around the core mining area and its vicinity of the salt mine industry， we use the ambient noise tomography (ANT) method to image the three-dimensional shear wave velocity structure at the depth shallower than 3 km. The results indicate: (1) The overall shear wave velocity in the study area is relatively lower， ranging from 0.8 and 1.8 km/s， which could be related to the loose and thick deposition of the Zhaoji Sub-Depression. (2) The three-dimensional shear wave velocity structure reveals that the sedimentary thickness of the Zhaoji Sub-Depression is deeper in the southeast and shallower in the northwest， with the sedimentary center located around Heping Town and Dahuangzhuang Town. (3) The Zhaoji salt mine is a low-velocity anomalous zone in the shear wave velocity structure with an inverse 'C' character spreading along Nanchenji Town and Zhaoji Town， with a depth ranging from approximately 1.2 to 2.8 km， it may be caused by the development of rock fissures due to water extraction and injection. The surrounding rock exhibits relatively high velocity， which reflects the morphological characteristics of the Zhaoji salt basin. The three-dimensional shear wave velocity model obtained in this study provides scientific guidance for the industrial exploitation of the Zhaoji salt mine and reference for salt exploration of the Hongze Salt Basin. It also provides an important basis for the seismic risk assessment of the salt basins. Simultaneously， it holds significant implications for exploring the application of ambient noise tomography method in spatial detection of salt mine belt.

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RESEARCH ON THE INTEGRETED TECHNOLOGY OF CAD/CAM/DNC OF MANUFACTURING-ORIENTED

RESEARCH ON THE INTEGRETED TECHNOLOGY OF CAD/CAM/DNC OF MANU...

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2006年中国机械工程学会年会暨中国工程院机械与运载工程学部首届年会

作者： HE Yu-an, SHEN Bin, ZHANG Qiling, xu jiyan School of Mechanical and Automation Engineering, Shanghai Institute of Technology, Shanghai 200233, China

Recently, with the development of the computer and network communication technology, Distributed Numerical Control (DNC) network communication technology, which is the most important part of Manufactu

关键词： CAD/CAM DNC Integration technology Network communication CIM.

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Riverine sulfate sources and behaviors in arid environment,Northwest China:Constraints from sulfur and oxygen isotopes

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Journal of Environmental Sciences 2024年第3期137卷 716-731页

作者： Yifu xu Wenjing Liu Bing xu Zhifang xu Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

The fate of riverine sulfate ion (SO_(4)^(2-)) and its environmental effects in arid environment are difficult to evaluate due to its complicated sources and strongly coupled behaviors with water cycle which is significantly modified by *** understand the sulfur cycle in aquatic systems in arid environment,the chemical and sulfur and oxygen isotopic compositions (δ^(34)S_(SO4)and δ^(18)O_(SO4)) of major rivers around the Badain Jaran Desert,northwestern China,were *** rivers had averaged SO_(4)^(2-)content at 1336μmol/L,over 10times higher than the global *** δ^(34)S_(SO4)and δ^(18)O_(SO4)values ranged from-5.3‰to+11.8‰and+1.6‰to+12.8‰,*** end-member analysis and the inverse model showed that riverine sulfate was mainly derived from evaporites dissolution (0-87%),sulfide oxidation (13%-100%) and precipitation (0-33%),indicating heterogeneity in sulfur sources and behaviors along the river drainage with the lithology variations and climate *** isotopic tools combining with hydro-chemistry compositions could be applied to reveal sulfur cycle in arid *** on the calculation,sulfide oxidation plays the primary role in the headwater and upstream in the Qilian-Mountains area,where sulfide is widely *** the proportion of evaporites dissolution contributing to riverine sulfate is much higher in downstream in a drier ***,less precipitation and higher temperature can lead to more intensive evaporation,affecting the process of sulfide oxidation and enhancing the rates of evaporites dissolution and sulfate precipitation in the basin.

关键词： Sulfur and oxygen isotopes Source apportionment Inverse model Arid environment Inland rivers Northwestern China

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温阳通经药对海洛因依赖大鼠戒断症状及免疫功能影响的实验研究

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中医研究 2008年第2期21卷 14-16页

作者：许继艳包头市卫生学校内蒙古包头014030

目的:观察温阳通经药(附子、干姜、细辛等)对海洛因依赖大鼠的戒断症状的影响及免疫低下的改善作用。方法:采用w istar大鼠腹腔注射海洛因的方法造成海洛因依赖模型,造模后用美沙酮、温阳通经药进行治疗,观察戒断症状、体重变化,检测血... 详细信息

目的:观察温阳通经药(附子、干姜、细辛等)对海洛因依赖大鼠的戒断症状的影响及免疫低下的改善作用。方法:采用w istar大鼠腹腔注射海洛因的方法造成海洛因依赖模型,造模后用美沙酮、温阳通经药进行治疗,观察戒断症状、体重变化,检测血清溶血素、腹腔巨噬细胞的吞噬百分率和吞噬指数,并与空白对照组、模型组进行比较。结果:温阳通经药能减轻大鼠的戒断症状、恢复体重,使血清溶血素、吞噬百分率、吞噬指数明显上升。结论:温阳通经药对海洛因依赖大鼠具有一定治疗作用,能够提高海洛因依赖大鼠的免疫力。

关键词：温阳通经海洛因依赖大鼠戒断症状免疫功能

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提升高职辅导员职业幸福感的有效路径研究

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重庆电子工程职业学院学报 2017年第1期26卷 10-12页

作者：徐继燕重庆电子工程职业学院重庆401331

职业幸福感是衡量高职辅导员工作生活质量的重要指标,也是关系高职学生思想政治教育效果的重要决定因素。文章通过分析高职辅导员职业幸福感的研究意义和研究内涵,探讨影响高职辅导员职业幸福感的因素及原因,从而进一步提出提升高职辅... 详细信息

职业幸福感是衡量高职辅导员工作生活质量的重要指标,也是关系高职学生思想政治教育效果的重要决定因素。文章通过分析高职辅导员职业幸福感的研究意义和研究内涵,探讨影响高职辅导员职业幸福感的因素及原因,从而进一步提出提升高职辅导员职业幸福感的实践路径。

关键词：高职辅导员职业幸福感实践路径

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Laboratory evaluation of high-friction thin overlays for pavement preservation

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 936-948页

作者： Ouming xu Rentao xu Lintong JIN School of Highway Chang’an UniversityXi’an 710064China School of Materials Science and Engineering Chang’an UniversityXi’an 710061China

Traditional asphalt concrete(AC)and stone matrix asphalt(SMA),which are used as thin asphalt overlays,are common maintenance strategies to enhancing ride quality,skid resistance,and ***,several studies have used a novel asphalt mixture known as a high-friction thin overlay(HFTO)to improve surface ***,it remains uncertain whether the laboratory properties of HFTO differ significantly from those of conventional *** study aims to evaluate the laboratory properties of HFTO mixtures and compare them with those of AC and *** mixtures with nominal maximum size of 9.5 mm were produced in the laboratory,and performance tests were conducted,including wheel tracking test,low temperature flexural creep test,moisture susceptibility test,Cantabro Abrasion Test,Marshall Test,sand patch test,British pendulum test,and indoor tire-rollingdown *** results showed that the HFTO exhibited a lower tire/pavement noise than the AC and ***,HFTO had superior high-temperature stability,larger macro texture,and higher skid resistance in comparison to those of AC,but lower than those of ***,HFTO mixtures may be considered a suitable replacement for traditional AC mixtures in regions where skid resistance and noise reduction are concerns.

关键词： road engineering pavement maintenance high friction thin overlay performance skid resistance tire/pavement noise

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内蒙古土豆滞销原因分析与对策

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北京农业 2011年第30期 177-178页

作者：徐继燕西华师范大学数学与信息学院

内蒙古是土豆生产大省,2010年当地农民种植的土豆销售情况很好,2011年土豆却遇到了滞销的情况,主要原因在于种植面积大幅度的增加。我们应及时采取有效的措施来应对这种滞销问题,协调各地农产品经销商赴主产区购销土豆,寻找大型食品加... 详细信息

内蒙古是土豆生产大省,2010年当地农民种植的土豆销售情况很好,2011年土豆却遇到了滞销的情况,主要原因在于种植面积大幅度的增加。我们应及时采取有效的措施来应对这种滞销问题,协调各地农产品经销商赴主产区购销土豆,寻找大型食品加工企业对土豆进行深加工,开拓国外市场,做好农产品市场监测工作。

关键词：内蒙古土豆滞销对策

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Granting strength to aerogel fibers through encapsulation

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Science China Materials 2024年第4期67卷 1365-1366页

作者： Wenhui xu Department of Basic Chemistry School of PharmacyJiangxi University of Chinese MedicineNanchang 330004China

Aerogel fibers, distinguished by their lightweight nature, pronounced porosity, large surface area, and superior thermal insulation properties, have diversified applications in thermal management, energy devices, and environmental remediation[1]. However, compared with monolithic ones, these fibershaped aerogels exhibit limited mechanical strength and resilience due to their one-dimensional small size.

关键词： strength fibers thermal

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