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Effects of marine compound xyloketal B on neuroprotection and potential drug development

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Journal of Coastal Life Medicine 2015年第6期 429-432页

作者： Sammen Huang Wenliang Chen jiyan pang Zhong Pei Guan-Lei Wang Hong-Shuo Sun Department of Surgery Faculty of MedicineUniversity of TorontoTorontoOntarioCanada M5S 1A8 Department of Physiology Faculty of MedicineUniversity of TorontoTorontoOntarioCanada M5S 1A8 Department of Pharmacology and Toxicology Faculty of MedicineUniversity of TorontoTorontoOntarioCanada M5S 1A8 Department of Applied Chemistry School of Chemistry and Chemical EngineeringSun Yat-Sen UniversityGuangzhou 510275China Key Laboratory of Functional Moleculesfrom Oceanic Microorganisms(Sun Yat-Sen University) Department of Education of Guangdong Province510080China Department of Neurology The First Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510080China Department of Pharmacology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China Institute of Medical Science Faculty of MedicineUniversity of TorontoTorontoOntarioCanada M5S 1A8

Coastal medicine is a promising field for research and drug development,because several natural products isolated from marine organisms have been found to be therapeutically useful in a clinical *** comparison to terrestrial products,the merit of marine compounds arises from the diversity in their chemical structure and unique bioactivity.A recently discovered marine compound,xyloketal B,displays neuroprotective and antioxidative effects in in-vitro and in-vivo experimental *** elicits these beneficial effects through mitochondrial protection,free radical scavenging,reducing reactive oxygen species production and suppressing apoptotic *** addition,unpublished data from our lab revealed that transient receptor potential melastatin 7 channel activity,implicated in a myriad of neurodegenerative diseases,was inhibited following xyloketal B *** this review,the therapeutic effect of xyloketal B will be evaluated based on existing evidence and its potential for drug development will be also discussed.

关键词： Marine compound Xyloketal B Neuroprotection Antioxidative Drug development

小儿危重病例评分联合格拉斯哥昏迷量表评分及视频脑电图对小儿重症病毒性脑炎预后的评估价值研究

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中国全科医学 2020年第27期23卷 3402-3407,3415页

作者：蒋绍清潘宣任庞宗钦庞继彦广西玉林市妇幼保健院儿科 537000 广西壮族自治区妇幼保健院儿科广西南宁市530000 广西玉林市第二人民医院神经外科 537000

背景小儿危重病例评分(PCIS)广泛应用于临床小儿重症病例病情的评估中,格拉斯哥昏迷量表(GCS)被推荐用于评估重症患者的脑功能,而脑电图被认为是预测脑损伤的重要指标,目前国内外关于三者联合用于小儿重症病毒性脑炎(SVE)预后评估的研... 详细信息

背景小儿危重病例评分(PCIS)广泛应用于临床小儿重症病例病情的评估中,格拉斯哥昏迷量表(GCS)被推荐用于评估重症患者的脑功能,而脑电图被认为是预测脑损伤的重要指标,目前国内外关于三者联合用于小儿重症病毒性脑炎(SVE)预后评估的研究较少。目的探讨PCIS联合GCS评分及视频脑电图(VEEG)对小儿SVE预后的评估价值。方法采用回顾性分析方法,选取玉林市妇幼保健院重症病房2013年1月-2018年10月诊治的小儿SVE 113例为研究对象。根据预后将患儿分为预后良好组〔37例,儿童格拉斯哥预后量表(CGOS)评级4~5级〕和预后不良组(76例,CGOS评级1~3级)。比较两组患儿临床资料、脑脊液检查及PCIS、GCS评分、VEEG,分析影响小儿SVE预后的危险因素,比较3项独立指标与联合指标(3项指标联合)对小儿SVE预后的评估价值。结果预后良好组痊愈18例,19例有轻度后遗症;预后不良组5例死亡,25例留有严重后遗症,46例有中度后遗症。多因素Logistic回归分析结果显示,PCIS≤80分及VEEG中度异常、重度异常是小儿SVE预后的危险因素(OR=12.626、512.020、160.712),GCS评分>8分是其保护因素(OR=0.042)(P8分为小儿SVE预后的保护性因素。联合评估法对疾病预后预测的准确度相对PCIS、GCS评分、VEEG的独立评估更加优良。

关键词：脑炎,病毒性儿童小儿危重病例评分格拉斯哥昏迷量表脑电相位同步

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红树林真菌Aspergillus sp.次级代谢产物及其生物活性（英文）

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中山大学学报（自然科学版） 2020年第1期59卷 133-143页

作者：郑颖琳佟奕辰孙英英庞冀燕中山大学化学学院广东广州510275 广东省药物新剂型重点实验室/广东药科大学广东广州510006

从曲霉属海洋真菌(Aspergillus sp.)中分离出17种化合物(1-17),其结构由核磁共振波谱(NMR)、质谱(MS)等谱学方法得以确证。其中,化合物1系首次于自然界中被发现,化合物2-17则为已知化合物。对其中部分化合物进行了初步的生物活性测试。... 详细信息

从曲霉属海洋真菌(Aspergillus sp.)中分离出17种化合物(1-17),其结构由核磁共振波谱(NMR)、质谱(MS)等谱学方法得以确证。其中,化合物1系首次于自然界中被发现,化合物2-17则为已知化合物。对其中部分化合物进行了初步的生物活性测试。其中,化合物2对RPMI8226,OCI-MY5及MCF-7细胞表现出了中等的抑制活性,化合物10对热应激下的线虫表现出了显著的保护作用。此外,化合物9及16对化脓性链球菌(Streptococcus pyogenes)表现出轻度的抑制作用,而化合物17则对肺炎链球菌(Streptococcus pneumoniae)表现出轻度的抑制作用。

关键词：海洋真菌天然产物细胞毒活性神经保护活性抗菌活性

C-9不同位阻取代小檗碱衍生物的合成及对DNA键合作用的影响

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中山大学学报（自然科学版） 2009年第2期48卷 58-62页

作者：黄绍智黎姗庞冀燕陈文华中山大学化学与化学工程学院广东广州510275

以小檗碱为原料,合成了小檗碱C-9位不同空间位阻取代的9-乙氧基小檗碱、9-异丙氧基小檗碱,通过MS、1H NMR确认其结构。运用紫外可见吸收光谱法和荧光光谱法研究了化合物与CT DNA的结合作用。结果发现,小檗碱C-9位上的不同空间位阻会影... 详细信息

以小檗碱为原料,合成了小檗碱C-9位不同空间位阻取代的9-乙氧基小檗碱、9-异丙氧基小檗碱,通过MS、1H NMR确认其结构。运用紫外可见吸收光谱法和荧光光谱法研究了化合物与CT DNA的结合作用。结果发现,小檗碱C-9位上的不同空间位阻会影响小檗碱衍生物与CT DNA的相互作用,随空间位阻增大结合强度减小,结合模式也发生了变化,初步证明了小檗碱类化合物可能是从环的C-8,9,10这一侧与DNA相互作用,用实验验证了Mazzini计算机模拟的结合模型。

关键词：小檗碱衍生物 C-9取代 CT DNA 相互作用

加味人参汤联合常规西药治疗脾胃虚寒型胃溃疡临床疗效观察

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辽宁中医杂志 2017年第12期44卷 2593-2595页

作者：庞嘉言何跃杨郦郦雅安职业技术学院四川雅安625000 雅安职业技术学院附属医院四川雅安625000

目的:探讨加味人参汤联合常规西药治疗脾胃虚寒型胃溃疡临床疗效观察。方法:将2014年12月-2015年12月在本院消化内科治疗的120例脾胃虚寒型胃溃疡患者随机分为两组,对照组采用西医常规治疗,观察组采用加味人参汤联合常规西药治疗,比较... 详细信息

目的:探讨加味人参汤联合常规西药治疗脾胃虚寒型胃溃疡临床疗效观察。方法:将2014年12月-2015年12月在本院消化内科治疗的120例脾胃虚寒型胃溃疡患者随机分为两组,对照组采用西医常规治疗,观察组采用加味人参汤联合常规西药治疗,比较两组患者的治疗效果、中医证候改善情况、溃疡面积、Hp清除率及复发情况。结果:观察组治疗有效率为96.67%,显著高于对照组的83.33%,差异有统计学意义(P<0.05);观察组治疗后胃痛胃胀、反酸嗳气、倦怠乏力、畏寒肢冷、神疲懒言等中医证候积分明显低于对照组,差异有统计学意义(P<0.05);观察组治疗后溃疡面积明显小于对照组,差异有统计学意义(P<0.05);观察组Hp根除率为93.33%,明显高于对照组的75%,观察组1年复发率为3.33%,明显低于对照组的21.67%,差异有统计学意义(P<0.05)。结论:加味人参汤联合常规西药治疗脾胃虚寒型胃溃疡效果显著,能够提高Hp根除率,促进溃疡面愈合,减少复发,具有积极的临床意义。

关键词：脾胃虚寒型胃溃疡加味人参汤常规西药疗效观察

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han Yan Su Yiming Zhou Minhui Xu jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

原小檗碱衍生物诱导急性淋巴白血病细胞凋亡活性及PAMPA研究（英文）

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中山大学学报（自然科学版） 2016年第5期55卷 66-72,76页

作者：周杰彬邓春梅施晓柯项琪吴启丽潘景轩庞冀燕中山大学化学与化学工程学院广东广州510275 广东海洋大学实验中心广东湛江524088 中山大学医学院病理生理学研究中心广东广州510089 暨南大学生物制药研发中心广东广州510632

测定了15个原小檗碱衍生物(3-17)及小檗碱(1)和药根碱(2)抑制急性淋巴白血病细胞(包括Reh和Nalm-6细胞)增殖的活性。其中化合物4(9-溴乙基小檗碱),5(9-氯乙基小檗碱)和6(9-溴丙基小檗碱)表现出最为突出的抑制活性:在Reh细胞中,IC50值分... 详细信息

测定了15个原小檗碱衍生物(3-17)及小檗碱(1)和药根碱(2)抑制急性淋巴白血病细胞(包括Reh和Nalm-6细胞)增殖的活性。其中化合物4(9-溴乙基小檗碱),5(9-氯乙基小檗碱)和6(9-溴丙基小檗碱)表现出最为突出的抑制活性:在Reh细胞中,IC50值分别为0.45、0.39和0.57μmol/L;在Nalm-6细胞中,IC50值分别为3.6,4.3和1.17μmol/L。活性均强于先导化合物小檗碱和药根碱(后两者的IC50值均大于20μmol/L)。此外,化合物4和5能够剂量依赖的通过裂解PARP诱导急性淋巴白血病细胞凋亡,降低procaspase-3的浓度,增加活性caspase-3水平,同时提高细胞质中的细胞色素C水平。进一步,Reh细胞用0.5μmol/L的4和5处理36 h,能够显著下调β-catenin蛋白的表达,以上实验结果证明了这类化合物抑制肿瘤细胞增殖的作用机制可能与Wnt/β-catenin通路相关。化合物1、4、5、7和11的PAMPA膜渗透实验说明,C-9位取代的小檗碱衍生物可以提高化合物的细胞膜渗透性。

关键词：原小檗碱衍生物抗肿瘤活性 PAMPA 细胞凋亡

Overestimate of remediation efficiency due to residual sodium persulfate in PAHs contaminated soil and a solution

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Journal of Environmental Sciences 2022年第3期34卷 242-250页

作者： Liping He Jianhao Tong Yuanqiang Yang Jianxun Wu Linqian Li Zhonghua Wei Wei Long Jingli pang jiyan Shi Yunnan Research Academy of Eco-environmental Sciences Kunming 650034China Department of Environmental Engineering College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China Beijing Construction Engineering Group Environmental Remediation Co.Ltd. Beijing 100015China

Oxidation remediation is a commonly used technology for PAHs contaminated soil presently,but the overestimate of efficiency due to ongoing remediation by residual oxidants during extraction and testing has not been paid enough *** this study,persulfate was activated by Fe(Ⅱ)to investigate the effects of residual oxidants on PAHs removal during detection process and the elimination effects of adding Na_(2)SO_(3) and extending sampling time on residual *** verified that the residual oxidants removed PAHs in extraction process,making the results lower than the actual values:the detection recovery rate η of ΣPAHs and 3-6 ring PAHs ranged from 24.3%(25%Na_(2)S_(2)O_(8)treatment)to 87.4%(5%Na_(2)S_(2)O_(8)+4/4Fe^(2+) treatment),20.1%-99.0%,28.9%-87.9%,20.8%-89.4%,and 1.8.6%-76.9%,*** adding Na_(2)SO_(3),the accuracy of detection results increased significantly:the η of ΣPAHs and 3-6 ring PAHs increased to 64.1%-96.5%,58.8%-95.5%,73.8%-114.4%,60.6%-95.6%,and 45.4%-77.1%,*** 49 days of adding oxidants,residual oxidants had no considerable effect on the detection of PAHs,indicating it was appropriate to start soil remediation verification sampling49 days after the remediation was *** observed results will help scientific evaluation of the remediation effects of chemical oxidation on or-ganic contaminated soil.

关键词： Persulfate activation Soil remediation Polycyclic aromatic hydrocarbons Residual oxidant removal

A new technique focusing on retrograde wire externalization in recanalization of coronary chronic total occlusion

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Science Bulletin 2019年第4期64卷 222-223页

作者： jiyan Chen Department of Cardiology Provincial Key Laboratory of Coronary Heart Disease Guangdong Cardiovascular Institute Guangdong General Hospital Guangdong Academy of Medical Sciences

Active greeting technique (AGT) is a new technique that facilitates retrograde wire externalization in recanalization of coronary chronic total occlusion (CTO) lesions published by Prof. Ge [1]. This technique provide... 详细信息

关键词： AGT CTO recanalization