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Microbiome and metabolome dysbiosis analysis in impaired glucose tolerance for the prediction of progression to diabetes mellitus

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Journal of Genetics and Genomics 2024年第1期51卷 75-86页

作者： Boxun Zhang Xuan Zhang Zhen Luo jixiang Ren Xiaotong yu Haiyan Zhao yitian Wang Wenhui Zhang Weiwei Tian Xiuxiu Wei Qiyou Ding Haoyu yang Zishan Jin Xiaolin Tong Jun Wang Linhua Zhao Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Faculty of Biological Science and Technology Baotou Teacher's CollegeBaotouInner Mongolia 014030China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Infinitus(China)Company Ltd GuangzhouGuangdong 510405China Affiliated Hospital of Changchun University of Chinese Medicine ChangchunJilin 130021China Department of endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Xinjiekou Community Health Service Center in Xicheng District Beijing 100035China Department of Spleen and Stomach Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong 518033China University of Chinese Academy of Sciences Beijing 100049China Beijing University of Chinese Medicine Beijing 100105China Northeast Asia Institute of Traditional Chinese Medicine Changchun University of Chinese MedicineChangchunJilin 130117China

Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precursor,are ***,we perform metagenomic sequencing and metabolomics on 47 pairs of individuals with IGT and newly diagnosed DM and 46 controls with normal glucose tolerance(NGT);patients with IGT are followed up after 4 years for progression to *** of baseline data reveals significant differences in gut microbiota and serum metabolites among the IGT,DM,and NGT *** addition,13 ty.es of gut microbiota and 17 ty.es of circulating metabolites showed significant differences at baseline before IGT progressed to DM,including higher levels of eggerthella unclassified,Coprobacillus unclassified,Clostridium ramosum,L-valine,L-norleucine,and L-isoleucine,and lower levels of eubacterium eligens,Bacteroides faecis,Lachnospiraceae bacterium 3_1_46FAA,Alistipes senegalensis,Megaspaera elsdenii,Clostridium perfringens,α-linolenic acid,10e,12Z-octadecadienoic acid,and dodecanoic acid.A random forest model based on differential intestinal microbiota and circulating metabolites can predict the progression from IGT to DM(AUC=0.87).These results suggest that microbiome and metabolome dysbiosis occur in individuals with IGT and have important predictive values and potential for intervention in preventing IGT from progressing to DM.

关键词： Impaired glucose tolerance Diabetes mellitus Gut microbiota Metabolomics

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钢悬链线立管全尺寸共振弯曲疲劳试验系统与模态分析

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振动与冲击 2024年第20期43卷 119-127页

作者：徐泽鑫安晨谢智张吉祥林方坚中国石油大学(北京)安全与海洋工程学院北京102249 里约热内卢联邦大学阿尔韦托·路易斯·科英布拉工程研究学院海洋工程系里约热内卢21941-972 2H海洋工程有限公司伦敦GU216HJ

钢悬链线立管(steel catenary riser,SCR)作为支撑海上平台和其他关键设备的重要组成部分,在极端的海洋环境中长时间服役运行时,其结构完整性和安全性至关重要。为确保SCR立管在恶劣环境下的安全运行,对立管进行共振弯曲疲劳试验研究成... 详细信息

钢悬链线立管(steel catenary riser,SCR)作为支撑海上平台和其他关键设备的重要组成部分,在极端的海洋环境中长时间服役运行时,其结构完整性和安全性至关重要。为确保SCR立管在恶劣环境下的安全运行,对立管进行共振弯曲疲劳试验研究成为必要的评估标准,同时也为后续立管疲劳寿命预测和失效分析提供基础。针对两种特定型号的SCR立管,推导并求解不同约束条件下的共振系统的固有频率与振型函数,分析管道长度、管道壁厚、偏心块和配重块质量对共振系统固有频率的影响;在此基础上开展不同特定工况下的全尺寸共振弯曲疲劳试验,同时对SCR立管在全尺寸共振弯曲疲劳试验系统中不同跨距及内压的振动响应特性进行了模拟。结合理论分析、有限元计算和共振弯曲疲劳试验结果,发现管道长度和两端的配重约束是影响共振系统1阶固有频率的重要参数,特别是在管道长度较短和壁厚较薄的情况下,影响更为显著。此外,注水加压和跨距增加会降低共振系统的固有频率,支撑跨距越短,系统的固有频率越大。分析所得结果为SCR立管的共振弯曲疲劳试验系统结构设计和试验方案优化提供了重要的参考依据。

关键词：钢悬链线立管(SCR) 共振弯曲疲劳试验固有频率全尺寸模态特性

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基于遗传算法优化VMD-eSSA的HIFU回波信号降噪研究

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传感技术学报 2024年第6期37卷 1049-1055页

作者：蒋智伟赵雨洁李吉祥邹孝钱盛友湖南师范大学物理与电子科学学院湖南长沙410081

由于高强度聚焦超声(HIFU)信号夹杂环境噪声,提出利用遗传算法优化变分模态分解(VMD)并结合能量均值法(eAM)及奇异谱分析(SSA)来对其进行降噪。遗传算法使得VMD具有更强的抗干扰性,奇异谱分析能够弥补能量均值去噪不完善。仿真实验表明... 详细信息

由于高强度聚焦超声(HIFU)信号夹杂环境噪声,提出利用遗传算法优化变分模态分解(VMD)并结合能量均值法(eAM)及奇异谱分析(SSA)来对其进行降噪。遗传算法使得VMD具有更强的抗干扰性,奇异谱分析能够弥补能量均值去噪不完善。仿真实验表明,所提方法与GA-VMD-e、GA-VMD-SSA、VMD-eSSA降噪方法相比,重构后的信号的信噪比更高,均方根误差和最大误差更小。在实测信号中从频谱和降噪率两个角度证明了该方法的优越性,为通过HIFU回波信号分析生物组织损伤提供了一种更有效的预处理方法。

关键词：高强度聚焦超声去噪变分模态分解遗传算法奇异谱分析

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Some Upper Bounds Related with Domination Number

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Journal of the Operations Research Society of China 2013年第2期1卷 217-225页

作者： Zhao Gu jixiang Meng Zhao Zhang Jin e.Wan College of Mathematics and System Sciences Xin Jiang UniversityUrumqi 830046China College of Information Science and engineering Xin Jiang UniversityUrumqi 830046China

For a simple and connected graph G,denote the domination number,the diameter,and the radius of G asβ(G),D(G),and r(G),*** this paper,we solve two conjectures on the upper bounds ofβ(G)·D(G)andβ(G)+r(G),which are p... 详细信息

关键词： AutoGraphiX Upper bounds extremal tree Domination number

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Fiber Optic Hydrogen Sensors： a Review

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Photonic Sensors 2014年第4期4卷 300-324页

作者： Minghong yANG jixiang DAI National engineering Laboratory for Optical Fiber Sensing Technologies Wuhan University of Technology Wuhan430070 China

Hydrogen is one of the next generation energies in the future, which shows promising applications in aerospace and chemical industries. Hydrogen leakage monitoring is very dangerous and important because of its low ignition energy, high combustion efficiency, and smallest molecule. This paper reviews the state-of-art development of the fiber optic hydrogen sensing technology. The main developing trends of fiber optic hydrogen sensors are based on two kinds of hydrogen sensitive materials, i.e. palladium-alloy thin films and Pt-doped WO3 coatings. In this review work, the advantages and disadvantages of these two kinds of sensing technologies will be evaluated.

关键词： Optical fiber sensors hydrogen sensing thin films coatings

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Connectivities　of　Minimal　Cay.ey　Coset　Digraphs

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Applied Mathematics(A Journal of Chinese Universities) 1996年第4期11卷 497-500页

作者： MeNG jixiang Department of Mathematics Xinjiang University Urumqi

we prove that the Connectivities of Minimal Cay.ey Coset Digraphs are their regular degrees. Connectivity of transitive digraphs and a combinatorial propertyof finite groups Ann., Discrete Math., 8 1980 61--64 Meng jixiang and Huang Qiongxiang On the connectivity of Cay.ey digraphs, to appear Sabidussi, G. Vertex transitive graphs Monatsh. Math., 68 1969 426--438 Watkins, M. e. Connectivity of transitive graphs J. Combin. Theory, 8 1970 23--29 Zemor, G. On positive and negative atoms of Cay.ey digraphs Discrete Applied Math., 23 1989 193--195 Department of Mathematics,Xinjiang University,Urumpi *** MATHeMATICS 3. Statement of Inexact Method Here we assume F to be continuousely differentiable. Inexact Newton method was first studied in the solution of smooth equations (see ). Now, such a technique has been widely used in optimizations, nonlinear complementarity problems and nonsmooth equations (see, and , etc.) In order to establish the related inexact methods,we introduce a nonlinear operator T(x): R n  R n . Its components are defined as follows: (T(x)p) i=[HL(2:1,Z;2,Z] (x k+p k) i, if i∈(x k), H i(x k)+ min {(p k) i,F i(x k) Tp k}, if i∈(x k), F i(x k)+F i(x k) Tp k, i∈(x k).(3.1) Then, it is clear that the subproblem (2.5) turns to T(x k)p k=0.(3.2) In inexact algorithm, we determine p k in the followinginexact way ( see ). ‖T(x k)p k‖ υ k‖H(x k)‖,(3.3) where υ k is a given positive sequence. It is then obviously that (3.2),or equivalently (2.5), is a special case of (3.3) corresponding to υ k=0 . In particular, (3.3) can be used as a termination rule of the iterative process for solving (2.5). The following proposition shows the existence of λ k satisfying (2.4). Proposition 3.1. Let F be continuously differe ntiable. υ k is chosen so that υ k  for some constant ∈(0,1). Then p k generated by (3.3) is a de

关键词： Connectivity Cay.ey coset digraph

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Treatment of drilling wastewater from a sulfonated mud system

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Petroleum Science 2013年第1期10卷 106-111页

作者： Guo jixiang Cui yongjie Cao Jingjing enhanced Oil Recovery Institute China University of Petroleum Shenghua Group Zhungeer energy Co. Ltd

Treatment of drilling wastewater from a sulfonated drilling mud system in the Shengli Oilfield, east China, was studied. The wastewater was deeply treated by a chemical coagulationcentrifugal separation-ozone catalytic oxidation combined process. The factors （i.e. pH value, chemical dosage, reaction time, etc.） influencing the treatment effect were investigated, and pH = 7 was determined as optimal for the coagulation; poly.eric aluminum chloride （PAC） was selected as the optimal coagulant with a dosage of 18 g/L; cationic polyacrylamide （CPAM） with molecular weight of 8 million was selected as the optimal coagulant aid with an optimum dosage of 8 mg/L; and the optimal condition of catalytic ozonation was found to be a pH of 12 and an oxidation time of 40 min. The results showed that the combined treatment process was effective. The oil content and suspended solids content of the effluent reached the first class discharge standard according to China＇s standard GB 8978-1996 （Integrated Wastewater Discharge Standard） and the chemical oxy.en demand （COD） decreased to 195 mg/L from 2.34×10^4 mg/L after coagulation process and ozone oxidation at pH = 12 for 40 min.

关键词： Drilling wastewater sulfonated mud system coagulation and flocculation centrifugalseparation ozone catalytic oxidation

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地震叠后和叠前混合驱动下的页岩油储层多尺度裂缝预测方法

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地球物理学报 2024年第7期67卷 2830-2849页

作者：陈刚李世昌宋斯宇李映艳何吉祥唐廷明朱福玉赵杨卢明辉非常规油气科学技术研究院中国石油大学(北京)北京102249 中国石油新疆油田公司勘探开发研究院新疆克拉玛依834000 中国石油勘探开发研究院北京100083

不同尺度、不同类型的天然裂缝的系统性表征有利于识别优质储层、改进开发效果.建立可靠的多尺度裂缝模型是提高页岩油储层钻遇率的重要依据,其关键在于精细预测小尺度裂缝的空间分布,指导钻井钻进和压裂过程.然而,基于地震属性的传统... 详细信息

不同尺度、不同类型的天然裂缝的系统性表征有利于识别优质储层、改进开发效果.建立可靠的多尺度裂缝模型是提高页岩油储层钻遇率的重要依据,其关键在于精细预测小尺度裂缝的空间分布,指导钻井钻进和压裂过程.然而,基于地震属性的传统裂缝预测方法只能各自突出单一尺度的断裂,不同裂缝属性的数学独立性给综合裂缝系统的识别带来严峻挑战.我们提出一套改进的全尺度裂缝系统评估方案,其关键在于通过优化的各向异性蚁群裂缝识别算法确定小尺度裂缝的发育概率,将小尺度裂缝的发育概率与传统蚂蚁追踪产生的大尺度断层的概率进行融合,得到的综合裂缝系统可以实现全尺度裂缝的感知.详细的属性分析过程表明,方位各向异性能够精确描述微观裂缝特征.基于此,我们将各向异性分析得到的裂缝密度和裂缝走向融入蚁群追踪裂缝的各个阶段,在提高裂缝密集区搜索强度的同时,还对小断距裂缝的发育方向实现了精准刻画.针对页岩油藏的应用案例证明,根据改进方案得到的全尺度裂缝系统能够同时表征大尺度断层、小裂缝和裂缝破碎带的分布情况.研究区的成像测井结果进一步验证了小尺度裂缝预测发育方向的准确性及可靠性,能够为页岩油水平井开发部署提供理论指导.

关键词：天然裂缝页岩油储层方位各向异性多尺度裂缝蚂蚁追踪

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elaborating Spatiotemporal Associations Between the Built environment and Urban Vibrancy:A Case of Guangzhou City,China

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Chinese Geographical Science 2022年第3期32卷 480-492页

作者： WANG Bo LeI yaqin XUe Desheng LIU jixiang WeI Chunzhu School of Geography and Planning Sun Yat-sen UniversityGuangzhou 510275China Southern Marine Science and engineering Guangdong Laboratory(Zhuhai) Zhuhai 519000China Guangdong Provincial Key Laboratory of Urbanization and Geo-simulation Guangzhou 510275China Department of Urban Planning and Design the University of Hong KongHong Kong 999077China

This study applies multi-source datasets(i.e.,Baidu Heat Map data,points of interest(POIs)data,and floor area and land use data)and geographically and temporally weighted regression(GTWR)models to elaborate the spatiotemporal relationships between the built environment and urban vibrancy on both weekdays and weekends,using Guangzhou City as a ***,we verified the spatially and temporally nonstationary nature of the built environment correlates,which have been largely ignored in previous studies based on local regression *** spatially and temporally heterogeneous effects of the built environment on urban vibrancy are then presented and visualized,based on the GTWR *** found that the elasticity of location(i.e.,distance),land use mix(i.e.,diversity),building intensity and numbers of POIs with various functions(i.e.,density)are different across time(2-h intervals within a day)and space(grids),due to people’s everyday lifesty.e,time-space constraints,and geographical context(e.g.,spatial structure).The findings highlight the importance of a better understanding of the local geography on the spatiotemporal relationships for urban planners and local governments so as to put forward decision-making support for fostering and maintaining urban vibrancy.

关键词： urban vibrancy Baidu Heat Map(BHM) built environment heterogeneity geographically and temporally weighted regression

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Recent active thermal management technologies for the development of energy-optimized aerospace vehicles in China

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Chinese Journal of Aeronautics 2021年第2期34卷 1-27页

作者： jixiang WANG yunze LI Xiangdong LIU Chaoqun SHeN Hongsheng ZHANG Kai XIONG College of electrical Energyand Power EngineeringYangzhou UniversityYangzhou 225009China School of Aeronautic Science and engineering Beihang UniversityBeijing 100083China Institute of engineering Thermophysics North China University of Water Conservancy and Electrical PowerZhengzhou 450045China HiWING General Aviation equipment Corporation Limited Beijing 100074China School of Mechanical engineering and Automation Harbin Institute of TechnologyShenzhen Graduate SchoolShenzhen 518117China

Recently, the development of modern vehicles has brought about aggressive integration and miniaturization of on-board electrical and electronic devices. It will lead to exponential growth in both the overall waste heat and heat flux to be dissipated to maintain the devices within a safe temperature range. However, both the total heat sinks aboard and the cooling capacity of currently utilized thermal control strategy are severely limited, which threatens the lifetime of the on-board equipment and even the entire flight system and shrink the vehicle’s flight time and range. Facing these thermal challenges, the USA proposed the program of "INVeNT" to maximize utilities of the available heat sinks and enhance the cooling ability of thermal control strategies. Following the efforts done by the USA researchers, scientists in China fought their ways to develop thermal management technologies for Chinese advanced energy-optimized airplanes and spacecraft. This paper elaborates the available on-board heat sinks and aerospace thermal management systems using both active and passive technologies not confined to the technology in China. Subsequently, active thermal management technologies in China including fuel thermal management system, environment control system, non-fuel liquid cooling strategy are reviewed. At last, space thermal control technologies used in Chinese Space Station and Chang’e-3 and to be used in Chang’e-5 are *** issues to be solved are also identified, which could facilitate the development of aerospace thermal control techniques across the world.

关键词： Aerospace engineering efficiency promotion Fluid dynamics Heat and mass transfer Thermal management

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