检索结果-南通市图书馆

搜寻第二个地球——系外地球(ET)巡天计划

在线全文

学校读者我要写书评

暂无评论

空间科学学报 2024年第3期44卷 400-424页

作者：葛健陈雯陈永和宋宗玺王坚张辉李岩臧伟呈周丹张永帅陈琨阳应权毛淑德黄煦药新雨李兴隆姜海娇于涌唐正宏董峰高伟张鸿飞申超王峰涛魏传新杨宝玉李豫东文林张朋军张聪聪谢基伟马波邓洪平刘慧根段旭亮王昊宇黄江江高扬王伊菲王磊秦根健刘欣宇高婕中国科学院上海天文台上海200030 中国科学院微小卫星创新研究院上海201304 中国科学院上海技术物理研究所上海200083 中国科学院西安光学精密机械研究所西安710119 中国科学技术大学合肥230026 清华大学天文系北京100190 南昆士兰大学天体物理中心图文巴QLD4350 中国航天科技集团公司第八研究院803研究所上海201109 中国科学院新疆理化技术研究所乌鲁木齐830011 南京大学天文系南京210023 中山大学物理与天文学院珠海519082

系外地球科学卫星(ET)将通过采用空间大视场超高精度测光这一关键技术在国际上率先突破生命起源中的系外地球存在及其演化这一重大前沿科学问题. ET卫星将在日地拉格朗日L2点晕(Halo)轨道部署由6台广角凌星望远镜和1台微引力透镜望远镜... 详细信息

系外地球科学卫星(ET)将通过采用空间大视场超高精度测光这一关键技术在国际上率先突破生命起源中的系外地球存在及其演化这一重大前沿科学问题. ET卫星将在日地拉格朗日L2点晕(Halo)轨道部署由6台广角凌星望远镜和1台微引力透镜望远镜构成的空间天文台,结合凌星法和微引力透镜法,利用空间超大视场和超高精度的光学测光观测,首次发现富有重要意义、被广泛关注的系外地球,并确定其发生率,对目前了解甚少的类地行星和流浪行星进行国际上第一次大规模的种群普查,首次发现流浪地球,并确定其发生率,揭示类地行星和流浪行星起源,为地外生命探寻提供候选者和新方向. ET卫星的观测结果、统计研究以及和对理论的检验将回答系外地球在宇宙中有多普遍,类地行星是如何形成和演化的,流浪行星又是如何起源的这些亟待解决的前沿科学问题.对ET卫星发现的系外地球样本的后随观测,将精确测量其质量、密度和大气成分,有助于深入分析宜居性特征.此外,对ET新发现的大量各种系外行星样本的研究,以及对理论的检验将推动这些种类的行星形成和演化规律的更深入认识, ET的大量高精度、高频次和长基线测光数据将推动星震学、银河系考古学、时域天文学、双星和双星黑洞等领域的研究.

关键词：系外行星类地行星宜居带凌星微引力透镜测光

嵌入式制约:唐代给事中封驳的机理及回溯——以合格权力为视角

在线全文

学校读者我要写书评

暂无评论

广州大学学报（社会科学版） 2022年第2期21卷 60-68页

作者：杜纪伟临沂大学马克思主义学院山东临沂276005

以丹尼斯·朗的权力类型理论为观测工具,可以发现,唐代给事中的封驳权是以合法权力为载体的合格权力。其封驳机理是合格权力对诏敕的嵌入式制约:将合格权力嵌入合法权力,把体制外监督因子融入体制内监督形式,以低位权能嵌入高位决策,在... 详细信息

以丹尼斯·朗的权力类型理论为观测工具,可以发现,唐代给事中的封驳权是以合法权力为载体的合格权力。其封驳机理是合格权力对诏敕的嵌入式制约:将合格权力嵌入合法权力,把体制外监督因子融入体制内监督形式,以低位权能嵌入高位决策,在决策与执行之间嵌入等决策制约的四种嵌入面相。从法家、道家的参政实践,儒学政治化正、反、合的演进过程,以及合格权力对皇权监督方式的演化取向等方面回溯唐代给事中的封驳制度,以动态呈现儒法兼备的合格权力制约政治权力的嵌入禀性与特质。

关键词：唐代给事中封驳合格权力嵌入式制约权力监督

在线全文

学校读者我要写书评

暂无评论

二醋酸莫代尔混纺小提花织物的开发

棉纺织技术 2022年第3期50卷 72-74页

作者：曾社平张五九唐建东赵纪卫彭琴新型环保复合面料湖北省重点实验室湖北襄阳441002

总结一款二醋酸纤维与莫代尔纤维混纺织物的生产要点。经纱和纬纱均采用二醋酸纤维/莫代尔纤维50/509.8 tex集聚纱,开发一款轻薄、柔软的小提花服装面料。介绍了产品开发思路、原料选择、织物规格等,分析了生产中遇到的困难。通过整经... 详细信息

总结一款二醋酸纤维与莫代尔纤维混纺织物的生产要点。经纱和纬纱均采用二醋酸纤维/莫代尔纤维50/509.8 tex集聚纱,开发一款轻薄、柔软的小提花服装面料。介绍了产品开发思路、原料选择、织物规格等,分析了生产中遇到的困难。通过整经、浆纱、织造的工艺革新,特别是采用低温上浆技术,确保了产品的顺利生产。总结了织造过程中稀密路、开车印等解决方法。最终平均织机效率达84.2%,平均车速552 r/min,下机一等品率98.42%。认为:开发的产品手感轻薄柔软,兼顾了硬挺与柔软,满足了人们的需要。

关键词：二醋酸纤维莫代尔纤维混纺低温上浆提花织造技术

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

带埋置弹簧界面单元模型研究

河海大学学报（自然科学版） 2019年第2期47卷 125-130页

作者：汪基伟唐亮范家怡赵胤儒河海大学土木与交通学院江苏南京210098 长江勘测规划设计研究有限责任公司湖北武汉430010

为克服采用弹簧单元模拟钢-混凝土组合结构的连接件时网格划分要顾及连接件位置的缺陷,提出了一种新型的带埋置弹簧界面单元模型。在该模型中,界面单元用于模拟钢板和混凝土之间的接触,弹簧用于模拟连接件的作用,可位于界面单元内任何... 详细信息

为克服采用弹簧单元模拟钢-混凝土组合结构的连接件时网格划分要顾及连接件位置的缺陷,提出了一种新型的带埋置弹簧界面单元模型。在该模型中,界面单元用于模拟钢板和混凝土之间的接触,弹簧用于模拟连接件的作用,可位于界面单元内任何位置。该模型既能合理考虑钢板与混凝土界面上的各种连接作用,又能使单元划分不受连接件位置的影响。推出试验模型和钢管混凝土拱桥拱脚等算例表明,该模型网格划分方便,计算精度较高,适用于实际工程的计算分析。

关键词：钢-混凝土组合结构连接件钢板-混凝土界面有限元法单元模型弹簧单元

Detecting novel gene mutations in Usher syndrome families by next generation sequencing technology

在线全文

学校读者我要写书评

暂无评论

Detecting novel gene mutations in Usher syndrome families by...

中华医学会第十五次全国医学遗传学学术会议暨中国医师协会...

作者： Yan Tizhen Li Wugao tang Xiangrong Li Zhetao Wang Lin Mo Lian Huang jiwei Yang Yan Cai Ren tang Ning Key Laboratory of birth defects prevention and control Department of Medical Genetics Liuzhou Municipal Maternity and Child Healthcare Hospital Center of Hearing Liuzhou Municipal Maternity and Child Healthcare Hospital

Objective Usher syndrome(USH) is an autosomal recessive disorder characterized by hearing impairment and vision dysfunction due to retinitis pigmentosa. Phenotypic and genetic heterogeneities of this disease make it impractical to obtain a genetic diagnosis by conventional Sanger sequencing. Method This study explored an approach for detecting disease-causing genetic mutations in candidate genes in 25 cases from unrelated USH families based on targeted next-generation sequencing(NGS) technology. Through systematic data analysis using an established bioinformatics pipeline, all variants that passed filter criteria were validated by Sanger sequencing and co-segregation analysis. Result 44 pathogenic mutations in the USH disease genes were identified in the 25 USH families. We identified 7 novel mutations in CDH23 gene, 9 novel mutations in GPR98 gene, 2 novel mutations in MYO7 A gene, one mutations in PCDH15 gene, one mutations in USH1 C gene, and 12 novel mutations in USH2 A gene. All novel variations segregated with the disease phenotypes in their respective families and were absent from ethnically matched control individuals. Conclusion Targeted exome sequencing precisely and rapidly identified the genetic defects in 25 Chinese USH families and this technique can be applied as a routine examination for these disorders with significant clinical and genetic heterogeneity.

关键词：

A novel insertion mutation in the ATP7A gene associated with delayed infantile onset of Menkes disease

在线全文

cnki会议

学校读者我要写书评

暂无评论

A novel insertion mutation in the ATP7A gene associated with...

中华医学会第十五次全国医学遗传学学术会议暨中国医师协会...

作者： Li Wugao Yan Tizhen tang Ning Li Zhetao Huang jiwei Tan Jianqiang Pan Lizhen Cai Ren Key Laboratory of birth defects prevention and control Department of Medical Genetics Liuzhou Municipal Maternity and Child Healthcare Hospital

Objective Determining the relationship between clinical phenotype and genotype in genetic disea ses is important in clinical practice. In general, frameshift mutations are expected to produce pre mature termination codons, leading to production of mutant transcripts destined for degradation b y nonsense-mediated decay. In X-linked recessive diseases, male patients with frameshift mutati ons typically have a severe or even lethal phenotype. Method We report a case of a 22-month-old boy patient with Menkes disease, an X-linked recess ive copper metabolism disorder, caused by mutations in the ATP7 A copper transporter gene. His clinical presentation involved unexpecte dly late onset and milder symptoms. Result His genomic DNA showed a de novo insertion mutation(c.1036 ins T) in ATP7 A gene, pred icting a translational frameshift and premature stop codon, and a classic severe phenotype. Char acterization of his ATP7 A m RNA showed no abnormal splicing. Conclusion We speculated that translation re-initiation could occur downstream of the premature termination codon, and produce a partially functional ATP7 A protein. Study of the patient‘s fibrobl asts found no evidence of translation reinitiation, however the possibility remains that this pheno menon occurred in neural tissues and influenced the clinical phenotype.

关键词：

Identification and Clinical Implications of Novel MYO15A Mutations in a Non-consanguineous Chinese Family by Targeted Exome Sequencing

在线全文

cnki会议

学校读者我要写书评

暂无评论

Identification and Clinical Implications of Novel MYO15A Mut...

中华医学会第十五次全国医学遗传学学术会议暨中国医师协会...

作者： Yan Tizhen tang Ning Li Zhetao Li Wugao tang Xiangrong Wang Lin Yang Yan Huang jiwei Zheng Pei Cai Ren Zeng Dingyuan Key Laboratory of birth defects prevention and control Department of Medical Genetics Liuzhou Municipal Maternity and Child Healthcare Hospital Center of Hearing Liuzhou Municipal Maternity and Child Healthcare Hospital

Objective Autosomal recessive nonsyndromic hearing loss(ARNSHL) is a genetically heterogen eous sensorineural disorder, generally manifested with prelingual hearing loss and absence of ot her clinical manifestations. The aim of this study is to identify the pathogenic gene in a four-gener ation consanguineous Chinese family with ARNSHL. Method Two novel frame-shift mutations, c.5964+3 G>A and c.7395+1 G>A, in the myoxin XVa ge ne(MYO15 A) was identified by exome sequencing and Sanger sequencing. The compound heterozygous MYO15 A c.5964+3 G>A and c.7395+1 G>A variants co-segregated with the phenotypes in the ARNSHL family and was absent in one hund red normal controls. Result The variant was predicted to interfere with the formation of the Myosin XVa-whirlin-Eps8 c omplex at the tip of stereocilia, which is indispensable for stereocilia elongation. Our data suggest that the compound heterozygous MYO15 A c.5964+3 G>A and c.7395+1 G>A variants might be th e pathogenic mutation, and exome sequencing is a powerful molecular diagnostic strategy for AR NSHL, an extremely heterogeneous disorder. Conclusion Our findings extend the mutation spectrum of the MYO15 A gene and have important implications for genetic counseling for the family.

关键词：

MnSOD基因T>C单核苷酸多态与力竭运动后机体氧化应激的关联性研究

在线全文

cnki会议

学校读者我要写书评

暂无评论

武汉体育学院学报 2014年第10期48卷 46-52,100页

作者：许文鑫姚绩伟唐良华福建师范大学体育科学学院福建福州350117 湖南科技大学体育学院湘潭湖南411201 福建师范大学生命科学学院福建福州350117

目的:探讨MnSOD基因T>C单核苷酸多态性(single nucleotide polymorphism,SNP)与力竭运动氧化应激的关联。方法:选择228名大学生进行本次研究,测定研究对象最大耗氧量(VO2max),在力竭运动过程中测定研究对象VO2max、呼吸商(respiratory q... 详细信息

目的:探讨MnSOD基因T>C单核苷酸多态性(single nucleotide polymorphism,SNP)与力竭运动氧化应激的关联。方法:选择228名大学生进行本次研究,测定研究对象最大耗氧量(VO2max),在力竭运动过程中测定研究对象VO2max、呼吸商(respiratory quotient,RQ)和心率;在力竭运动前后抽取研究对象静脉血,使用酶联免疫吸附法(ELISA)检测研究对象血浆中丙二醛(malondialdehyde,MDA)、8-异前列腺素(8-iso-prostaglandin,8-iso-PG)和总谷胱甘肽(total glutathione,tGSH)等氧化应激指标,采用实时定量PCR检测MnSOD miRNA的表达量,使用WST法检测研血浆MnSOD酶的活性;采用PCR-RFLP基因分型技术检测MnSOD基因T>C位点多态性。结果:MnSOD基因T>C单核苷酸多态性与研究对象VO2max以及力竭运动过程中VO2max、RQ和心率没有关联,同时与研究对象MDA、8-iso-PG和tGSH指标基础值无关联,但是与力竭运动后MDA和8-iso-PG等氧化应激指标有关联。力竭运动后CC基因型个体MDA和8-iso-PG水平显著低于TC和TT基因型个体,且随着T基因型的增加,MDA和8-iso-PG水平也逐渐增加,趋势检验发现具有剂量效应关系(PtrendC位点C基因型相比,T基因型显著降低MnSOD基因mRNA的表达量以及蛋白酶的活性。结论:MnSOD基因T>C单核苷酸多态性与力竭运动氧化应激存在着关联,C基因型个体通过增加MnSOD基因mRNA的表达量以及蛋白酶的活性,从而降低研究对象力竭运动后机体产生的氧化损伤。

关键词： MnSOD 多态性单核苷酸力竭运动氧化应激运动生化

Detection and genetic counseling in carriers of spinal muscular atrophy with two copies of the SMN1 gene

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Detection and genetic counseling in carriers of spinal muscu...

中华医学会第十五次全国医学遗传学学术会议暨中国医师协会...

作者： Yan Tizhen tang Ning Luo Shiqiang Huang jiwei Tan Jianqiang Li Zhetao Li Wugao Wang Yuanliu Cai Ren Key Laboratory of birth defects prevention and control Department of Medical Genetics Liuzhou Municipal Maternity and Child Healthcare Hospital

Objective Spinal muscular atrophy(SMA) is an autosomal recessive disease caused by mutation s in the survival motor neuron1 gene(SMN1). Global carrier frequency is around 1 in 50 and carri er detection is crucial to define couples at risk to have SMA offspring. Most SMA carriers have on e SMN1 copy and are currently detected using quantitative methods. A few, however, have two SMN1 gen es in cis(2/0 carriers), complicating carrier diagnosis in SMA. Method We detected 2/0 carriers from a cohort of 1328 individuals, including SMA parents, SMA relatives, and unrelated individuals of the general population, by multiplex ligationdependent prob e amplification(MLPA) methodology and haplotype analysis. Result In two couples who had an SMA child, both the parents had two SMN1 copies. Conclusion Our results emphasize the importance of performing a detailed carrier study in SMA parents with two SMN1 copies. Expanding the analysis to other key family members might confir m potential 2/0 carriers. When a partner of a known carrier presents two SMN1 copies, the study of both parents will provide a more accurate diagnosis, thus optimizing genetic counseling.

关键词：