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Genotype analysis of rotaviruses isolated from children during a phase III clinical trial with the hexavalent rotavirus vaccine in China

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Virologica Sinica 2023年第6期38卷 889-899页

作者： Wenqi Zou Qingchuan Yu Yan Liu Qingliang Li Hong Chen Jiamei Gao Chen Shi Ying Wang Wei Chen Xuan Bai Biao Yang jiuwei zhang Ben Dong Bo Ruan Liuyifan Zhou Gelin Xu Zhongyu Hu Xiaoming Yang National Engineering Technology Research Center for Combined Vaccines Wuhan Institute of Biological Products Co.LtdWuhan430207China National Institutes for Food and Drug Control Beijing100050China China National Biotec Group Beijing100024China

The oral hexavalent live human-bovine reassortant rotavirus vaccine(RV6)developed by Wuhan Institute of Biological Products Co.,Ltd(WIBP)has finished a randomized,placebo-controlled phase III clinical trial in four provinces of China in *** trail demonstrated that RV6 has a high vaccine efficacy against the prevalent strains and is safe for use in *** the phase III clinical trial(2019–2021),200 rotavirus-positive fecal samples from children with RV gastroenteritis(RVGE)were further *** reverse transcription-polymerase chain reaction and high-throughput sequencing,VP7 and VP4 sequences were obtained and their genetic characteristics,as well as the differences in antigenic epitopes of VP7,were analyzed in *** rotavirus genotypes were *** predominant rotavirus genotype was G9P[8](77.0%),followed by prevalent strains G8P[8](8.0%),G3P[8](3.5%),G3P[9](1.5%),G1P[8](1.0%),G2P[4](1.0%),and G4P[6](1.0%).The amino acid sequence identities of G1,G2,G3,G4,G8,and G9 genotypes of isolates compared to the vaccine strains were 98.8%,98.2%–99.7%,88.4%–99.4%,98.2%,94.2%–100%,and 93.9%–100%,***,the vaccine strains exhibited high similarity in amino acid sequence,with only minor differences in antigenic epitopes compared to the Chinese endemic *** supports the potential application of the vaccine in preventing diseases caused by rotaviruses.

关键词： Rotavirus(RV) Hexavalent rotavirus vaccine Epidemiology Sequence analysis

Home-Nebulized Inhaled Glucocorticoid Therapy in Pediatric Respiratory Diseases

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Journal of Clinical and Nursing Research 2024年第5期8卷 188-193页

作者： jiuwei Dong Lili zhang Xiaohua Jiang Department of Pediatrics Yantai Zhifu District Maternal and Child Health HospitalYantai 264000Shandong ProvinceChina Department of Pediatrics 970 Hospital of the People’s Liberation Army Joint Logistics ForceYantai 264000Shandong ProvinceChina

Objective:To evaluate the therapeutic effect of home-nebulized inhaled glucocorticoid therapy in pediatric respiratory ***:60 cases of children with respiratory diseases admitted between October 2022 and October 2023 were selected as study subjects and randomly divided into the control group and the observation group,30 cases *** control group was provided with conventional treatment only,while the observation group was provided with home-nebulized inhalation glucocorticosteroid treatment,and the treatment effects,clinical symptom relief time,disease recurrence rate,and treatment satisfaction of the children’s families were recorded and compared between the two ***:A comparison of the two groups in terms of gender and age showed that the differences were not statistically significant(P>0.05).In terms of clinical efficacy,the total effective rate of the observation group was 90.00%,which was significantly higher than that of the control group of 66.67%(P<0.05).Compared with the control group,the disappearance time of the clinical symptoms of the observed group was significantly shortened(P<0.05).In addition,the satisfaction scores of the families of the children in the observation group were significantly higher than those of the control group(P<0.05).Conclusion:Home-nebulized inhalation glucocorticoid therapy shows significant clinical efficacy in pediatric respiratory diseases,significantly reduces the time of disappearance of clinical symptoms,and improves the satisfaction of patients’families,which provides an effective treatment option for children.

关键词： Home-nebulized inhalation Glucocorticoids Pediatric respiratory diseases

Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants

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Virologica Sinica 2022年第5期37卷 724-730页

作者： Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen jiuwei zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang Hebei Center for Disease Control and Prevention Shijiazhuang050021China National Engineering Technology Research Center for Combined Vaccines Wuhan Institute of Biological Product Co.Ltd.Wuhan430207China National Institutes for Food and Drug Control Beijing100050China Zhejiang Center for Disease Control and Prevention Hangzhou310051China Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning530028China Hunan Center for Disease Control and Prevention Changsha410005China Zhengding County Center for Disease Control and Prevention Shijiazhuang050800China Daming County Center for Disease Control and Prevention Handan056900China Liucheng County Center for Disease Control and Prevention Liuzhou545200China Xiangtan County Center for Disease Control and Prevention Xiangtan411228China Yuhuan County Center for Disease Control and Prevention Taizhou317600China Yongnian County Center for Disease Control and Prevention Handan056000China Rongshui Miao Autonomous County Center for Disease Control and Prevention Liuzhou545300China You County Center for Disease Control and Prevention Zhuzhou412315China Longyou County Center for Disease Control and Prevention Quzhou324400China Laishui County Center for Disease Control and Prevention Baoding 074100China Jiangshan County Center for Disease Control and Prevention Quzhou324100China China National Biotec Group Company Limited National Engineering Technology Research Center for Combined VaccinesWuhan430207China

A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)*** the subjects received three oral doses of vaccine four weeks *** vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus *** against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also *** adverse events(AEs)were collected for 30 days after each *** AEs(SAEs)and intussusception cases were collected during the entire *** data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)*** against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were *** was no significant difference in incidences of SAEs in HRV and placebo *** study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants.

关键词： Rotavirus gastroenteritis(RVGE) Infants Vaccine Efficacy Safety

神经内镜治疗分隔型慢性硬膜下血肿(附16例分析)

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中国微侵袭神经外科杂志 2009年第2期14卷 61-62页

作者：张久伟郭强抚顺矿业集团总医院神经外科辽宁抚顺113008 广东三九脑科医院神经外科广东广州510510

目的探讨神经内镜在治疗分隔型慢性硬膜下血肿中的应用价值。方法回顾性分析16例分隔型慢性硬膜下血肿病人的手术治疗方法。采用神经内镜在直视下先冲洗硬膜下血肿腔并对腔壁上的小出血点给予电凝止血,术野清晰后找到血肿腔分隔并将其造... 详细信息

目的探讨神经内镜在治疗分隔型慢性硬膜下血肿中的应用价值。方法回顾性分析16例分隔型慢性硬膜下血肿病人的手术治疗方法。采用神经内镜在直视下先冲洗硬膜下血肿腔并对腔壁上的小出血点给予电凝止血,术野清晰后找到血肿腔分隔并将其造瘘,确保充分开放每个分隔,最后待冲洗液完全清亮后将血肿腔与正常硬膜下腔之间的隔膜充分打通,术后不放置引流。结果本组术后头痛症状均明显改善。术后2个月复查CT显示硬膜下腔完全恢复正常,随访3个月～8年,无复发。结论神经内镜治疗分隔型慢性硬膜下血肿是一种直观、便捷、安全、有效的微侵袭技术。

关键词：颅脑损伤血肿硬膜下慢性神经内镜神经外科手术

儿童眼球阵挛-肌阵挛-共济失调综合征临床及预后分析

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中华儿科杂志 2024年第3期62卷 256-261页

作者：周季卓秀伟金眉段超张炜华任长红巩帅田小娟丁昌红任晓暾李久伟国家儿童医学中心、首都医科大学附属北京儿童医院神经内科北京100045 国家儿童医学中心首都医科大学附属北京儿童医院肿瘤内科北京100045

目的总结儿童眼球阵挛-肌阵挛-共济失调综合征(OMAS)患儿的临床及预后特征。方法对2015年6月至2023年6月于北京儿童医院神经内科住院的46例OMAS患儿进行回顾性病例分析。并在2023年6至8月对患儿进行集中的互联网诊疗或电话访视。收集患... 详细信息

目的总结儿童眼球阵挛-肌阵挛-共济失调综合征(OMAS)患儿的临床及预后特征。方法对2015年6月至2023年6月于北京儿童医院神经内科住院的46例OMAS患儿进行回顾性病例分析。并在2023年6至8月对患儿进行集中的互联网诊疗或电话访视。收集患儿住院和门诊随访期间的病例资料,包括临床表现、辅助检查、治疗及预后情况等。根据患儿是否合并肿瘤分为两组,组间比较采用χ^(2)检验或Mann-Whitney U检验。使用单因素Logistic回归分析OMAS复发和预后相关因素。结果46例患儿中男25例,起病年龄1.5(1.2,2.4)岁。26例(57%)患儿病程中确诊神经母细胞瘤,无患儿高危。36例(78%)患儿随访≥6个月,这36例患儿均使用糖皮质激素、丙种球蛋白和(或)促肾上腺皮质激素作为一线治疗,其中9例(25%)使用二线治疗≥3个月(包括利妥昔单抗和环磷酰胺),17例(47%)使用神经母细胞瘤相关的化疗;随访4.2(2.2,5.5)年,10例(28%)患儿出现OMAS复发。36例患儿末次随访时Mitchell and Pike OMS评分量表评分为0.5(0,2.0)分,7例(19%)认知轻度落后于同龄儿,6例(17%)重度落后。仅1例患儿在随访中出现肿瘤复发。未合并肿瘤组起病前疫苗接种或感染病史较合并肿瘤组更多见[55%(11/20)比23%(6/26),χ^(2)=4.95,P=0.026],首发症状肌阵挛出现更频繁[40%(8/20)比4%(1/26),χ^(2)=7.23,P=0.007]。Logistic单因素回归分析发现,合并肿瘤组比未合并肿瘤组更少出现复发[OR=0.19(0.04~0.93),P=0.041],病程6个月内使用二线治疗或化疗预后更好[OR=11.64(1.27~106.72),P=0.030]。结论儿童OMAS多于幼儿期起病,约半数合并神经母细胞瘤。合并OMAS的神经母细胞瘤通常危险分级低,预后好。对比合并和未合并肿瘤的OMAS患儿,后者起病前感染或接种疫苗诱因更常见,首发症状肌阵挛更多见。早期加用二线治疗与OMAS更好的预后相关。

关键词：神经母细胞瘤预后眼球阵挛-肌阵挛综合征

超声造影联合超声弹性成像积分法对乳腺影像报告和数据系统3～4类乳腺肿物的诊断价值

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中华医学超声杂志（电子版） 2017年第10期14卷 766-770页

作者：徐玉桐安婷婷张久维杨秀华哈尔滨医科大学第一临床医学院腹部超声科 150001

目的探讨超声造影积分法、超声弹性成像及二者联合积分法对乳腺影像报告和数据系统(BI-RADS)3~4类乳腺肿物的诊断价值。方法选取2015年10月至2016年3月在哈尔滨医科大学附属第一医院行常规超声检查,并依据BI-RADS分类,将定为3~4类的58... 详细信息

目的探讨超声造影积分法、超声弹性成像及二者联合积分法对乳腺影像报告和数据系统(BI-RADS)3~4类乳腺肿物的诊断价值。方法选取2015年10月至2016年3月在哈尔滨医科大学附属第一医院行常规超声检查,并依据BI-RADS分类,将定为3~4类的58例乳腺肿物患者(共60个病灶)行超声造影及超声弹性成像检查,依据相关观察指标给予评分,最终以手术病理结果为"金标准",采用受试者工作特征(ROC)曲线分别评估超声造影积分法、超声弹性成像及二者联合成像积分法对BI-RADS 3~4类乳腺肿物良、恶性鉴别诊断的价值。结果 60个乳腺病灶,病理结果显示良性29个,恶性31个。联合诊断积分法ROC曲线下面积为0.971,大于超声造影积分法及超声弹性成像单独诊断的ROC曲线下面积(分别为0.916及0.908)。联合诊断积分法的敏感度、特异度及准确性为87.1%、96.6%及92.0%;超声造影积分法诊断的敏感度、特异度及准确性为77.4%、93.1%及85.0%;超声弹性成像诊断的敏感度、特异度及准确性为74.2%、93.1%及83.3%。结论超声造影联合弹性成像积分法能进一步提高BI-RADS 3~4类乳腺肿物的良、恶性鉴别诊断效能。

关键词：乳腺肿物超声弹性成像超声造影

实时组织弹性成像联合超声造影技术在慢性乙型肝炎患者肝纤维化诊断中的应用

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中华医学超声杂志（电子版） 2018年第10期15卷 767-772页

作者：杜昕苓张久维岳民璐王继华杨秀华哈尔滨医科大学附属第一医院腹部超声科 150001

目的探讨实时组织弹性成像(RTE)联合超声造影技术评估乙型肝炎肝纤维化的临床应用价值,为评价慢性乙型肝炎肝纤维化提供新的无创诊断方法。方法选取2016年10月至2017年5月在哈尔滨医科大学附属第一医院就诊的慢性乙型肝炎患者61例,并行... 详细信息

目的探讨实时组织弹性成像(RTE)联合超声造影技术评估乙型肝炎肝纤维化的临床应用价值,为评价慢性乙型肝炎肝纤维化提供新的无创诊断方法。方法选取2016年10月至2017年5月在哈尔滨医科大学附属第一医院就诊的慢性乙型肝炎患者61例,并行肝活检,根据Scheuer标准分为5期(S0～S4),所有患者均行RTE及超声造影检查,计算肝纤维化指数(LFI)与肝肾达峰时间差(Lt-Kt)。采用方差分析比较肝纤维化各组的LFI值与Lt-Kt值,并与病理结果做相关分析。进一步两两比较采用LSD-t检验,以肝活检为"金标准"得到各组诊断受试者工作特征(ROC)曲线。结果 LFI值S1期与S2期间比较,差异无统计学意义(P> 0.05),Lt-Kt值S0期与S1期间比较,差异无统计学意义(P> 0.05),LFI值S0与S1、S2、S3、S4期多重比较(t=-2.32、-3.92、-6.35、-11.58),LFI值S1与S0、S2、S3、S4期多重比较(t=2.32、-1.59、-4.15、-9.44),LFI值S2与S0、S1、S3、S4期多重比较(t=3.92、1.59、-3.31、-9.86),LFI值S3与S0、S1、S2、S4期多重比较(t=6.35、4.15、3.31、6.28),LFI值S4与S0、S1、S2、S3期多重比较(t=11.58、9.44、9.86、6.28)。Lt-Kt值S0与S1、S2、S3、S4期多重比较(t=-1.81、-4.51、-5.98、-9.58),Lt-Kt值S1与S0、S2、S3、S4期多重比较(t=1.81、-2.37、-3.94、-7.60),Lt-Kt值S2与S0、S1、S3、S4期多重比较(t=4.51、2.37、-2.12、-6.69),Lt-Kt值S3与S0、S1、S2、S4期多重比较(t=5.98、3.94、2.12、-4.37),Lt-Kt值S4与S0、S1、S3、S4期多重比较(t=9.58、7.60、6.69、4.37),差异均有统计学意义(P均<0.05)。LFI对应ROC曲线下面积分别为0.953、0.924、0.916、0.983;Lt-Kt对应ROC曲线下面积分别为0.979、0.967、0.902、0.949。二者联合后对应ROC曲线下面积分别为0.988、0.974、0.918、0.966。结论 RTE及超声造影在乙型肝炎肝纤维化诊断中均有重要价值,超声造影在纤维化早期(S1～S2)较RTE更有优势,而RTE在纤维化中晚期(S3～S4)较超声造影更有优势,二者联合可在(S1～S3期)提高纤维化诊断的准确性。

关键词：肝炎,乙型,慢性肝硬化弹性成像技术

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煤矿瓦斯监测及多传感器信息融合的研究

矿山机械 2015年第11期43卷 134-137页

作者：陈强张九卫姚宇乐江西理工大学电气工程与自动化学院江西赣州341000

针对单纯的瓦斯含量监控不能全面反应矿井下的安全状况这一问题,首先对采集的数据信息进行模糊预处理,以得到更全面的矿井下状况信息,然后经过处理转化为满足D-S归一化条件的基本概率分配,最后改进D-S合成算法融合瓦斯监测传感器采集的... 详细信息

针对单纯的瓦斯含量监控不能全面反应矿井下的安全状况这一问题,首先对采集的数据信息进行模糊预处理,以得到更全面的矿井下状况信息,然后经过处理转化为满足D-S归一化条件的基本概率分配,最后改进D-S合成算法融合瓦斯监测传感器采集的高度冲突信息,得出矿井下安全状况的预判结果。通过分析可知,该方法简便有效,提高了瓦斯监测技术水平,从而保障矿井下的安全作业。

关键词：瓦斯监测模糊处理信息融合 D-S理论

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三相逆变电源新型解耦控制策略研究

计算机测量与控制 2016年第4期24卷 80-82页

作者：葛泽龙陈强张九卫江西理工大学电气工程与自动化学院江西赣州341000

随着电网环境日益恶劣,逆变电源改善电能质量作用逐渐突显;作为逆变电源的核心,三相逆变器常采用电压电流双闭环控制策略,该方法在设计电流前馈解耦环时需要计算交流侧电感参数值,而在实际应用设计时往往忽略电感参数对系统性能的影响;... 详细信息

随着电网环境日益恶劣,逆变电源改善电能质量作用逐渐突显;作为逆变电源的核心,三相逆变器常采用电压电流双闭环控制策略,该方法在设计电流前馈解耦环时需要计算交流侧电感参数值,而在实际应用设计时往往忽略电感参数对系统性能的影响;另外电压环非线性处理也直接影响了控制性能的提升;文中提出一种直接电流无电感参数解耦控制策略,在合成矢量的基础上建立同步旋转d-q坐标系下无电感参数模型,给出单位功率控制电流环控制器PI参数设计;Matlab/simulink仿真结果验证了该方法的正确性及可行性。

关键词：逆变电源直接电流控制解耦控制无电感参数