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Exploring the Pathogenesis of Autoimmune Liver Diseases from the Heterogeneity of Target Cells

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 659-666页

作者： Zi-Xuan Qiu Lin-Xiang Huang xiao-xiao Wang Zi-Long Wang xiao-He Li Bo Feng Peking university People’s Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijingChina

The incidence of autoimmune liver diseases(ALDs)and research on their pathogenesis are increasing ***,except for autoimmune hepatitis,which responds well to immunosuppression,primary biliary cholangitis and primary sclerosing cholangitis are insensitive to immunosuppressive *** the known effects of the environment,genetics,and immunity on ALDs,the heterogeneity of target cells provides new insights into their *** review started by exploring the heterogeneity in the development,structures,and functions of hepatocytes and epithelial cells of the small and large bile *** example,cytokeratin(CK)8 and CK18 are primarily expressed in hepatocytes,while CK7 and CK19 are primarily expressed in intrahepatic ***,emerging technologies of single-cell RNA sequencing and spatial transcriptomic are being applied to study *** review offered a new perspective on understanding the pathogenic mechanisms and potential treatment strategies for ALDs.

关键词： Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis Disease heterogeneity Single-cell RNA sequencing Pathogenesis

COMPATIBILITY OF PVC WITH POLYURETHANES OF DIFFERENT SOFT SEGMENTS

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Chinese Journal of Polymer science 1988年第1期6卷 84-96页

作者：肖凤飞张贤胡世如马德柱罗筱烈徐懋 Institute of Chemistry Academia Sinica beijing Department of applied Chemistry university of science and {2. of china. Department of Applide Chernistry university of science and {2. of china university of science and {2. of china.

Blends of PVC and polyurethanes with four different soft segments of molecular weight 1000 were prepared and studied by dynamic mechanical and DSC techniques. It was found that the compatibility of PVC with segmented polyurethanes was related to the mixing of PVC molecules and the soft segments of the polyurethanes. Polyester based polyurethanes are more compatible with PVC than polyether based polyurethanes. Solution cast blends of PVC with PCL-polyurethane （1/2.1） exhibit single and narrow glass transition, while the blends with PPO-polyurethane （1/2.1） are completely incompatible. The compatibility was found to decrease with increasing hard segment content for all the polyurethanes used. The methods of blend preparation may change the compatibility of PVC/PU blends through their influence on the mixing or demixing of the hard and soft segments.

关键词： PVC blends PU segmented copolymers PVC/PU blends Compatibility DSC Dynamic mechanical measurement.

Uniqueness on Difference Operators of Meromorphic Functions of Infinite Order

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Acta Mathematica Sinica,English Series 2024年第2期40卷 511-527页

作者： Hui LI Ming Liang FANG xiao YAO School of science China University of Mining and TechnologyBeijing 100083P.R.China Institute of Mathematics Academy of Mathematics and System SciencesChinese Academy of SciencesBeijing 100190P.R.China School of sciences Hangzhou Dianzi UniversityHangzhou 310012P.R.China School of Mathematical sciences and LPMC Nankai UniversityTianjin 300071P.R.China

We investigate the uniqueness problems of meromorphic functions and their difference operators by using a new *** is proved that if a non-constant meromorphic function f shares a non-zero constant and ∞ counting multiplicities with its difference operators Δcf(z) and Δ_(c)^(2.f(z), thenΔcf(z)≡Δ_(c)^(2.f(z).In particular,we give a difference analogue of a result of *** method has two distinct features:(ⅰ) It converts the relations between functions into the corresponding *** makes it possible to deal with the uniqueness problem by linear algebra and combinatorics.(ⅱ) It circumvents the obstacle of the difference logarithmic derivative lemma for meromorphic functions of infinite order,since this method does not depend on the growth of the ***,the idea in this paper can also be applied to the case for several variables.

关键词： Uniqueness meromorphic functions difference operators infinite order

Cyclic Pulsating Pressure Enhanced Segregating Structuration of Ultra-High Molecular Weight Polyethylene/Graphene Composites as High-performance Light-Weight EMI Shields

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Chinese Journal of Polymer science 2024年第7期42卷 958-967,I0008页

作者： Yun-Zhi Huang xiao-xiao Liu Lan-Wei Li Guang-Ming Huang Zhao-Xia Huang Jin-Ping Qu National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing EngineeringMinistry of EducationGuangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced ManufacturingSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641China School of Advanced Manufacturing technology Guangdong Mechanical&Electrical PolytechnicGuangzhou 510550China

Currently,the enhancement in electromagnetic interference(EMI)performance of polymeric composite generally relies on either improving electrical conductivity(σ)for stronger electromagnetic(EM)reflections or tailoring structure for higher EM ***,we proposed a novel technique called cyclic pulsating pressure enhanced segregating structuration(CPP-SS),which can reinforce these two factors *** structural information was supplied by optical microscopy(OM)and scanning electron microscopy(SEM),both of which confirmed the formation and evolution of segregate structured ultra-high molecular weight polyethylene(UHMWPE)/graphene ***,the result showed that CPP-SS can significantly improve theσof ***,advanced specific EMI shielding efficiency of 31.1 d B/mm was achieved for UHMWPE/graphene composite at 1-mm thickness and a low graphene loading of 5 wt%.Meanwhile,it also confirmed that the intrinsic disadvantage of poor mechanical properties of conventional segregated structure composites can be *** work is believed to provide a fundamental understanding of the structural and performance evolutions of segregated structured composites prepared under CPPSS,and to bring us a simple and efficient approach for fabricating high-performance,strong and light-weight polymeric EMI shields.

关键词： Cyclic pulsating pressure Segregated structure Ultra-high molecular weight polyethylene Graphene Electromagnetic interface

Identification and functional analysis of CG352. in spermatogenesis of Drosophila melanogaster

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Insect science 2024年第1期31卷 79-90页

作者： Qihao Hu Yanhong xiao Runnan Wei Ting Tang Liang Wen Yuzhen Lu xiao-Qiang Yu Guangdong Provincial Key Laboratory of Insect Developmental Biology and applied technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhou510631 China

Spermatogenesis is a critical part of reproduction in insects;however,its molecular mechanism is still largely *** this study,we identified a testis-specific gene CG352. in Drosophila *** analysis showed that CG352. contains a zinc binding domain and 2.C2.2.type zinc fingers,and it is clustered to the vertebrate really interesting new gene(RING)family E3 ubiquitin-protein *** CG352. was knocked down by RNA interference(RNAi),the testis became much smaller in size,and the apical tip exhibited a sharp and thin end instead of the blunt and round shape in the control *** importantly,compared to the control flies,only a few mature sperm were present in the seminal vesicle of C587-Gal4>CG352. RNAi *** staining of the testis from CG352. RNAi flies showed that the homeostasis of testis stem cell niche was disrupted,cell distribution in the apical tip was scattered,and the process of spermatogenesis was not ***,we found that the phenotype of CG352. RNAi flies’testis was similar to that of testis of Stat92. RNAi flies,the expression level of CG352. was significantly downregulated in the Stat92.F06346 mutant flies,and the promoter activity of CG352. was upregulated by *** together,our results indicated that CG352. is a downstream effector gene in the JAK-STAT signaling pathway that plays a key role in the spermatogenesis of Drosophila.

关键词： CG352. JAK-STAT spermatogenesis STAT92. testis

The Direct Adaptive Fuzzy Control for Satellite Attitude Control

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The Direct Adaptive Fuzzy Control for Satellite Attitude Con...

THE CHARACTERISTICS OF GREAT COSMIC RAY STORM EVENTS IN MARCH 1989

2.11 Chinese Control and Decision Conference（CCDC）

作者： Ping Guan is with Department of Automatic Control,beijing Information science and {2. university Wei Zhang is with Department of Automatic Control,beijing Information science and {2. university xiao-he Liu is with department of Automatic Control,beijing Information science and {2. university Ming-hui Li is with Department of Automatic Control,beijing Information science and {2. university

In this paper,the direct adaptive fuzzy control is applied to the attitude stabilization control of the *** detailed design procedure of the system is *** controller directly acts on the controlled *** direct adaptive fuzzy controller is designed for the satellite and the parameter adaptive law is *** results show the proposed control law can resist the perturbation effectively and have better dynamic and static performances.

关键词： Adaptive control Fuzzy control Attitude control Satellite

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天文研究与技术 1990年第4期 115-119页

作者： Ye Zonghai, xiao Shaoyu and Xue ShunshengCenter for Space science and {2. Research, Chinese Academy of sciences, beijing 100080, china

The characters of cosmic ray ray Forbush decrease caused by solar flares in March 1989 are analyzed in this paper. The relationship between the cosmic ray intensity variations and the characters of solar flares and ge... 详细信息

关键词： meson cosmic anisotropy characters storm latitude neutron burst proton ionization

Recent advances in vacancy engineering for reliable lithiumsulfur batteries

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Rare Metals 2024年第2期43卷 455-477页

作者： Wen-Dong Liu xiao Tang Jun-An Feng Chao-Yue Zhang Hao Liu Chuan Shi xiao-Xian Zhao Jian-Jun Song College of Physics School of Chemistry and Chemical EngineeringQingdao UniversityQingdao266071China Faculty of science Centre for Clean Energy TechnologySchool of Mathematical and Physical SciencesUniversity of Technology SydneySydneyNSW2007Australia Department of Chemistry College of ScienceHebei Agricultural UniversityBaoding071001China

The high-energy-density and low-cost features endow lithium-sulfur batteries with broad application ***,many drawbacks,especially the detrimental shuttle effect,have hindered the further development of *** response,a lot of new structures have been applied to suppress the shuttle effect and promote the development of ***,vacancy engineering has gained the attention of researchers due to its unique electronic *** review aims to analyze the application of vacancy engineering in ***,the electrochemistry of LSBs has been systematically discussed and the existing challenges as well as improvement tactics of LSBs have also been ***,the preparation methods and characterization technologies of various vacancies are summarized,including oxygen vacancies,sulfur vacancies,selenium vacancies,other anion vacancies,cation vacancies,*** latest applications of vacancy engineering in LSBs are also summarized in this ***,some prospects and insights for further investigation and practical application of vacancy engineering in LSBs are put forward.

关键词： Lithium-sulfur batteries(LSBs) Defects Vacancy engineering Electronic structure Shuttle effect

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利用核磁共振测井评价储层的捕集能力

石油学报 2004年第4期25卷 38-41页

作者：肖立志刘堂宴傅容珊石油大学资源与信息学院北京102249 同济大学海洋和地球科学学院上海200092 中国科学技术大学地球和空间科学学院安徽合肥230026

在常规油藏评价中常常忽略对盖层和储层组合的评价。特定储盖层组合下的综合储集能力主要取决于盖层孔隙半径和储层孔隙半径之间的相对数值关系 ,这个数值关系可以用临界油柱高度表征。盖层一般为泥岩或其他类型的致密岩石 ,对其取心... 详细信息

在常规油藏评价中常常忽略对盖层和储层组合的评价。特定储盖层组合下的综合储集能力主要取决于盖层孔隙半径和储层孔隙半径之间的相对数值关系 ,这个数值关系可以用临界油柱高度表征。盖层一般为泥岩或其他类型的致密岩石 ,对其取心和岩心分析都很困难 ,导致盖层孔隙半径的计算精度不高或根本不能计算。根据核磁共振测井对岩石孔隙结构的敏感性 ,提出了利用核磁测井计算盖层和储层孔隙半径的方法 ,经过压汞资料的刻度后 ,核磁共振测井可以计算连续的孔隙半径。在渤海湾井区的实际应用表明 ,利用核磁共振测井计算的岩石孔隙半径对于确定储盖层的临界油柱高度、评价特定储盖层组合下的油气捕集能力。

关键词：储层盖层储集能力油柱高度孔隙结构油藏评价核磁共振测井