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protection of retinal ganglion cells against optic nerve injury by induction of ischemic preconditioning

International Journal of Ophthalmology(English edition) 2017年第6期10卷 854-861页

作者： Xia Liu jiu-p.ng Liang Ou Sha song-Juan Wang Heng-Guo Li Eric Y.p.Cho Medical Imaging Center the First Affiliated Clinical Hospital of Jinan University Guangzhou 510632 Guangdong Province China School of Biomedical Sciences the Chinese University of Hong Kong Shatin Hong Kong 999077 China Department of preclinical Medicine School of Medicine Shenzhen University Shenzhen 518060 Guangdong Province China Shiyan people＇s Hospital of Baoan District Shenzhen 518108 Guangdong Province China

AIM： To explore if ischemic preconditioning （IpC） can enhance the survival of retinal ganglion cells （RGCs） after optic nerve axotomy. METHODS： Twenty-four hours prior to retinal ischemia 60min or axotomy, IpC was applied for ten minutes in groups of （n=72） animals. The survival of RGCs, the cellular expression of heat shock protein 27 （HSp27） and heat shock protein 70 （HSp70） and the numbers of retinal microglia in the different groups were quantified at 7 and 14d post-injury. The cellular expression of HSp27 and HSp70 and changes in the numbers of retinal microglia were quantified to detect the possible mechanism of the protection of the IpC. RESULTS： Ten minutes of IpC promoted RGC survival in both the optic nerve injury （IpC-ONT） and the retinal ischemia 60min （IpC-IR60） groups, examined at 7d and 14d post-injury. Microglial proliferation showed little correlation with the extent of benefit effects of IpC on the rescue of RGCs. The number of HSp27-positive RGCs was significantly higher in the IpC-ONT group than in the sham IpC-ONT group, although the percentage of HSp27-positive RGCs did not significantly differ between groups. For the IpC-IR60 group, neither the number nor the percentage ofthe HSp27-positive RGCs differed significantly between the IpC and the sham-operated groups. The number of HSp70-positive RGCs was significantly higher for both the IpC-ONT and the IpC-IR60 experimental groups, but the percentages did not differ. CONCLUSION： The induction of IpC enhances the survival of RGCs against both axotomy and retinal ischemia.

关键词： ischemic preconditioning retinal ganglioncells axotomy retinal ischemia/reperfusion heat shockprotein 27 and 70

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Influence of recrystallization on tungsten divertor monoblock under high heat flux

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Tungsten 2022年第3期4卷 194-202页

作者： Yu-Zhong Jin Xiang Liu You-Yun Lian jiu-p.ng song Southwestern Institute of physics Chengdu610225China Xiamen Tungsten Co.Ltd Xiamen361021China

Extremely high heat flux reaching 20 MW·m^(−2) can be foreseen for the future fusion *** high heat flux would induce recrystallization of tungsten(W)material,leading to significant strength loss of tungsten material and increment of ductility at high temperature,in particular when the temperature is much higher than its ductile-to-brittle transition temperature(DBTT).In this paper,an International Thermonuclear Experimental Reactor(ITER)-like tungsten divertor monoblock is modeled,and benchmark has been done first to get consistent results with ***,the monoblock structure has been optimized in order to get a lowest possible temperature and stress during heating and cooling phase separately compared to the baseline *** analysis of two kinds of states:stress-relieved tungsten and recrystallized tungsten using finite element method has been performed,aiming at finding out the recrystallization impact on the mechanical behavior of tungsten in divertor monoblock under cyclic high heat *** due to progressive deformation and time-independent fatigue lifetime of these two states of tungsten have been assessed and compared according to criteria The Structural Design Criteria for ITER In-vessel ***,the impact of different material recrystallization temperature on mechanical behavior has been explored under stationary heat *** result shows that after recrystallization,thermal stress of tungsten material can be released by the larger plastic deformation compared to the stress-relieved ***,it is easier for recrystallized tungsten to get damaged due to progressive deformation as well as fatigue under 20 MW·m^(−2) cyclic heat flux than stress-relieved tungsten because of its relatively lower yield strength and larger plastic strain,which would cause low-cycle strain ***,tungsten with lower recrystallization temperature distorts more seriously,and therefore,it can be predicted the cracks would

关键词： Tungsten Finite element method Divertor High heat flux Thermal stress

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Effect of Ag and Ni on the melting point and solderability of SnSbCu solder alloys

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International Journal of Minerals,Metallurgy and Materials 2009年第6期16卷 691-695页

作者： Yan-fu Yan Yan-sheng Wang Li-fang Feng Ke-xing song jiu-ba Wen Henan Key Laboratory of Advanced Non-ferrous Metals Luoyang 471003 China Architecture and Civil Engineering Institute Henan University of Science and Technology Luoyang 471003 China

To improve the properties of Sn10Sb8Cu solder alloy, two new solders （SnSbCuAg and SnSbCuNi） were formed by adding small amounts of Ag or Ni into the solder alloy. The results show that the melting point of the SnSbCuAg solder alloy decreases by 14.1℃ and the spreading area increases by 16.5% compared to the matrix solder. The melting point of the SnSbCuNi solder alloy decreases by 5.4℃ and the spreading area is slightly less than that of the matrix solder. Microstructure analysis shows that adding trace Ag makes the melting point decline due to the dispersed distribution of SnAg phase with low melting point. Adding trace Ni, Cu6Sn5 and （Cu, Ni）6Sn5 with polyhedron shape on the copper substrate can be easily seen in the SnSbCuNi solder alloy, which makes the viscosity of the melting solder increase and the spreading property of the solder decline.

关键词： solder alloy Ag Ni melting point solderability

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A Rank-Sum Testing Method for Multi-Trait Comprehensive Ranking and Its Application

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Agricultural Sciences in China 2010年第8期9卷 1117-1126页

作者： LUO Ru-jiu HU Zhi-qiu KOng Wen-qian song Wen XU Chen-wu Jiangsu provincial Key Laboratory of Crop Genetics and physiology/Key Laboratory of plant Functional Genomics Ministry of Education/ Yangzhou University Yangzhou 225009 P.R. China Lianyungang Technical College Lianyungang 222006 P.R.China

The rank-sum test is a nonparametric method used in variety evaluation. However, the hypothesis testing of the method hasn＇t been established for multi-trait comprehensive ranking. In this paper, under null hypothesis H0： the variety＇s ranking on each trait is random, the theoretical distribution of sum of ranks （SR） was firstly derived and further used to obtain the critical values for multi-trait comprehensive evaluation in rank-sum testing. A new C＋＋ class and its basic arithmetic were defined to deal with the miscount caused by the precision limitation of built-in data type in common statistical software under large number of varieties and traits. Finally, an application of the theoretical results was demonstrated using five starch viscosity traits of 12 glutinous maize varieties. The proposed method is so simple and convenient that it can be easily used to rank different varieties by multiple traits.

关键词： comprehensive evaluation sum of ranks theoretical distribution critical value

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营口双偏振雷达定标数据质控方法研究

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智能城市 2024年第6期10卷 35-37页

作者：崔福涛姚文原久淞高智营口市气象局辽宁营口115001 大石桥市人工影响天气服务站辽宁营口115100

文章探究营口双偏振天气雷达接收双通道一致性指标下降的原因,总结雷达双偏振升级改造至2021年末出现的所有故障报警信息,分析影响雷达稳定运行与雷达产品质量的主要因素。结合雷达保障工作解决发射机风道内温度过高、冬季雷达设备机房... 详细信息

文章探究营口双偏振天气雷达接收双通道一致性指标下降的原因,总结雷达双偏振升级改造至2021年末出现的所有故障报警信息,分析影响雷达稳定运行与雷达产品质量的主要因素。结合雷达保障工作解决发射机风道内温度过高、冬季雷达设备机房温度过低问题,通过采取各项机房温度提升措施,提高雷达运行指标,进而提升双偏振天气雷达的产品质量。

关键词：双偏振雷达 ZDR标定值数据质控

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Effect and mechanism of reactive oxygen species-mediated NOD-like receptor family pyrin domain-containing 3 inflammasome activation in hepatic alveolar echinococcosis

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World Journal of Gastroenterology 2023年第14期29卷 2153-2171页

作者： Cai-song Chen Yao-Gang Zhang Hai-jiu Wang Hai-Ning Fan Research Center for High Altitude Medicine of Qinghai University Affiliated Hospital of Qinghai UniversityXining 810001Qinghai ProvinceChina Qinghai province Research Key Laboratory for Echinococcosis Affiliated Hospital of Qinghai UniversityXining 810001Qinghai ProvinceChina Department of Hepatobiliary and pancreatic Surgery Qinghai Province Research Key Laboratory for EchinococcosisAffiliated Hospital of Qinghai UniversityXining 810001Qinghai ProvinceChina

BACKGROUND The NOD-like receptor family pyrin domain-containing 3(NLRp3)inflammasome is a significant component of the innate immune system that plays a vital role in the development of various parasitic ***,its role in hepatic alveolar echinococcosis(HAE)remains *** To investigate the NLRp3 inflammasome and its mechanism of activation in *** We assessed the expression of NLRp3,caspase-1,interleukin(IL)-1β,and IL-18 in the marginal zone and corresponding normal liver of 60 patients with HAE.A rat model of HAE was employed to investigate the role of the NLRp3 inflammasome in the marginal zone of *** experiments were conducted to investigate the effect of Echinococcus multilocularis(***)in stimulating Kupffer cells and ***,immunohistochemistry,Western blotting,and enzyme-linked immunosorbent assay were used to evaluate NLRp3,caspase-1,IL-1β,and IL-18 expression;flow cytometry was used to detect apoptosis and reactive oxygen species(ROS).RESULTS NLRp3 inflammasome activation was significantly associated with *** of ROS production decreased NLRp3-caspase-1-IL-1βpathway activation and mitigated hepatocyte damage and *** *** induces hepatocyte damage and inflammation by activating the ROS-mediated NLRp3-caspase-1-IL-1βpathway in Kupffer cells,indicating that ROS may serve as a potential target for the treatment of HAE.

关键词： Hepatic alveolar echinococcosis Inflammasome Inflammation Kupffer cell NLR family pyrin domain-containing 3 protein Reactive oxygen species

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Three New Lanthanide Coordination polymers Constructed from 2,6-Bis(pyrazin-2-yl)pyridine-4-carboxylate: Syntheses, Structures and Luminescence

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Chinese Journal of Structural Chemistry 2020年第4期39卷 793-800页

作者： song Juan DUAN Bo-Feng LU jiu-Fu GE Hong-Guang Shaanxi Key Laboratory of Catalysis College of Chemical&Environment ScienceShaanxi University of TechnologyHanzhong 723001China Mechanical Engineering Training Center Shaanxi University of TechnologyHanzhong 723001China

Three new lanthanide coordination polymers[Ln(bppc)2(suc)0.5(H2O)]n·nH2O(Ln=Eu(1),Ln=Dy(2),Ln=Tb(3),Hbppc=2,6-bis(pyrazin-2-yl)pyridine-4-carboxylate,H2suc=succinic acid)have been hydrothermally synthesized and structurally *** compounds are isostructural and crystallize in triclinic p1 space *** Ln(Ⅲ)ions are eightcoordinated with dodecahedral coordination ***(Ⅲ)cations are linked by carboxylate groups from(bppc)-ligands to form one-dimensional ring chains,which are further connected by the carboxylate groups of(bppc)-and(suc)2-ligands to extend a 2D layer *** coordination polymers display the characteristic emission bands of Ln(Ⅲ)ions in the solid state.

关键词： lanthanide coordination polymers crystal structure luminescence properties

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基于盾构掘进影响的基坑支护玻璃纤维筋锚杆应用研究

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工程建设与设计 2024年第17期 29-31页

作者：李兆国宋海争陈久强中建八局轨道交通建设有限公司南京210046

结合工程实例,分析与盾构隧道连接的基坑在采用锚杆支护的情况下,当盾构掘进通过支护锚杆范围时锚杆与盾构的作用关系,研究锚杆材料、配置参数对盾构的影响因素及影响效果,指出采用玻璃纤维筋作为基坑支护锚杆时对盾构掘进的有益效果,... 详细信息

结合工程实例,分析与盾构隧道连接的基坑在采用锚杆支护的情况下,当盾构掘进通过支护锚杆范围时锚杆与盾构的作用关系,研究锚杆材料、配置参数对盾构的影响因素及影响效果,指出采用玻璃纤维筋作为基坑支护锚杆时对盾构掘进的有益效果,并提供一种基于对盾构影响作用下的玻璃纤维筋锚杆优化的选配设计方法,同时给出实用的计算公式。

关键词：盾构基坑支护锚杆玻璃纤维筋

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二硅化钼的添加对石墨熔融渗硅的影响

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炭素技术 2024年第3期43卷 57-60页

作者：杨金华丁宁刘虎艾莹珺周怡然宋九鹏焦健中国航发北京航空材料研究院先进复合材料科技重点实验室北京100095 空装驻北京地区第六军事代表室北京100013

分别采用硅粉与硅粉+二硅化钼混合粉体对石墨进行熔渗致密化处理,采用扫描电镜及其附带的能谱仪、X射线衍射仪等表征分析了二硅化钼的添加对材料结构及组成的影响。结果表明,钼能够进入石墨基体中并且消除基体中的自由硅含量,且钼元素... 详细信息

分别采用硅粉与硅粉+二硅化钼混合粉体对石墨进行熔渗致密化处理,采用扫描电镜及其附带的能谱仪、X射线衍射仪等表征分析了二硅化钼的添加对材料结构及组成的影响。结果表明,钼能够进入石墨基体中并且消除基体中的自由硅含量,且钼元素以二硅化钼的形式分布在碳化硅扩散反应层所包围的区域内。采用硅粉对石墨进行熔渗处理的试样弯曲强度为(115±10)Mpa,弯曲模量为(24±0.3)Gpa;采用硅粉+二硅化钼混合粉体进行熔渗处理的试样弯曲强度为(119±6)Mpa,弯曲模量为(24±1.3)Gpa,表明二硅化钼的添加对熔渗后材料的性能无明显影响。

关键词：石墨熔渗反应二硅化钼碳化硅自由硅

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考虑承包商环保意识的建筑废弃物资源化补贴模式研究

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数学的实践与认识 2024年第1期54卷 28-40页

作者：申紫薇刘桂宏杨荆松张静谭茹文余民久成都锦城学院建筑学院四川成都611731 四川大学建筑与环境学院四川成都610065

在考虑承包商环保意识的情况下,构建了一个由政府、制造商和承包商组成的建筑材料供应链,对比分析了无补贴、对承包商补贴和对制造商补贴下各利益相关方的决策及其影响因素,从政府角度研究了建筑废弃物资源化补贴政策的制定问题.研究结... 详细信息

在考虑承包商环保意识的情况下,构建了一个由政府、制造商和承包商组成的建筑材料供应链,对比分析了无补贴、对承包商补贴和对制造商补贴下各利益相关方的决策及其影响因素,从政府角度研究了建筑废弃物资源化补贴政策的制定问题.研究结果表明:当政府对承包商补贴时资源化率更低,制造商利润、消费者剩余和社会福利均更高.此时制造商会通过价格机制攫取政府补贴,使得政府补贴支出增加.研究还发现,资源化成本和承包商的环保意识以不同方式影响政府和制造商的决策,因此政府在制定补贴政策促进建筑废弃物资源化之前应了解承包商的环保意识,并评估制造商的资源化成本.

关键词：建筑废弃物资源化环保意识补贴模式

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