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Synthesis of Quinolone Analogues: 7-[2-Aminomethylaziridin-l-yl]-quinolones

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Chinese Chemical Letters 2006年第11期17卷 1431-1434页

作者： Jin jiang jiu Yu LIU Hui Yuan GUO Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050

New quinolone derivatives of 7-[2-aminomethylaziridin-l-yl]quinolone-3-carboxylic acids were synthesized. The structures of these compounds were characterized by IH NMR and HRESI-MS.

关键词： Aziridine quinolone synthesis.

The synthesis and activity in vitro of a series of 8-difluoromethoxy quinolones: Analogues of gemifloxacin

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Chinese Chemical Letters 2007年第10期18卷 1169-1172页

作者： Jin jiang jiu Yu Liu Hui Yuan Guo Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

7-[4-（Aminomethyl）-3-（methoxyimino）pyrrolidin- 1-yl]- 1-cyclopropyl-6-fluoro-8-difluoromethoxy- 1,4-dihydro-4-oxoquino- line-3-carboxylic acid and its analogues have been prepared and evaluated for antibacterial a... 详细信息

关键词： Quinolone Synthesis Antibacterial activity

Generalization of the Hilbert-Palatini Action in Four-Dimensional Gravity

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Chinese Physics Letters 2001年第3期18卷 328-330页

作者： wu Ya-Bo LI jiu-Li Department of Physics Liaoning Normal UniversityDalian 116029

The generalized two-parametric Hilbert-Palatini action is constructed,which not only includes the well-known Hilbert-Palatini and Ashtekar gravitational theory as special cases,but also gives new *** Hamiltonian formulation,the phase space variables and the corresponding Hamiltonian constraints can be obtained,including the Ashtekar and Barbero type ***,the results of this action are the same as those given by the parametric canonical transformations,although these two methods are completely different.

关键词： Hamiltonian parametric action

基于多维邻近性的药学领域科技创新主导力扩散仿真研究

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现代情报 2025年第1期45卷 60-80页

作者：贺超城黄茜徐雨舒吴江武汉大学信息管理学院湖北武汉430072

[目的/意义]科技创新主导力与创新团队的产出绩效息息相关,在日益庞杂的科技创新合作中至关重要。然而现有科技创新主导力的研究大多集中在定性讨论方面,本文从定量角度深入探讨科技创新主导力网络的演化机制,有助于进一步促进科技创新... 详细信息

[目的/意义]科技创新主导力与创新团队的产出绩效息息相关,在日益庞杂的科技创新合作中至关重要。然而现有科技创新主导力的研究大多集中在定性讨论方面,本文从定量角度深入探讨科技创新主导力网络的演化机制,有助于进一步促进科技创新合作。[方法/过程]本文以药学领域的数据驱动,设定创新主体的搜索规则、主导规则、创新规则,以平均科技创新增益及其扩散速率为评价指标来衡量科技创新主导力的扩散效果,模拟科技创新主导力的扩散过程,并进一步探究多维邻近性与科技创新主导力扩散的动态关系。[结果/结论]结果显示,多维邻近性对科技创新主导力扩散具有重要影响,且不同邻近性在网络演化的不同阶段发挥着不同的作用。本文全面细致地刻画了多维邻近性在科技创新主导力网络演化的不同阶段所发挥的具体作用,进而为机构/企业和创新个体的发展提供参考。

关键词：科技创新主导力扩散机制多维邻近性仿真模拟科研合作网络

Misfit St rain-induced Buckling for Transition-Me tai Dichalcogenide Lateral Heterostructures:A Molecular Dynamics Study

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Acta Mechanica Solida Sinica 2019年第1期32卷 17-28页

作者： Jin-wu jiang Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and MechanicsShanghai UniversityShanghai 200072China

Molecular dynamics simulations are performed to investigate the misfit straininduced buckling of the transition-metai dichalcogenide(TMD)lateral heterostructures,denoted by the seamless epitaxial growth of different TMDs along the in-plane *** Stillinger-Weber potential is utilized to describe both the interaction for each TMD and the coupling between different TMDs,i.e.,MX2(with M=Mo,W and X=S,Se,Te).It is found that the misfit strain can induce strong buckling of the freestanding TMD lateral heterostructures of large area,resulting from the TMDs'atomic-thick *** buckling phenomenon occurs in a variety of TMD lateral heterostructures of different compositions and in various *** findings raise a fundamental mechanical challenge for the structural stability of the freestanding TMD lateral heterostructures.

关键词： Transition-metal dichalcogenide Lateral heterostructure Stillinger-Weber potential Molecular dynamics simulation

Value of T-tube in biliary tract reconstruction during orthotopic liver transplantation:a meta-analysis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第5期12卷 357-364页

作者： Wei-dong HUANG jiu-kun jiang Yuan-qiang LU Department of Emergency the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective:To compare biliary complications after biliary tract reconstruction with or without T-tube in orthotopic liver ***:Randomized control trials(RCTs) and comparative studies were identified by a computerized literature search of the Cochrane Library,MEDLINE(1966/1-2010/4),Scopus(1980/1-2010/4),***(2010/4),the Cochrane Hepato-Biliary Group Controlled Trials Register,and the Cochrane Central Register of Controlled *** and data were extracted and assessed *** outcomes were reported as odds ratios(ORs) and weighted mean difference with 95% confidence intervals(CI).Results:Five RCTs and eight comparative studies with a total of 1 608 subjects were *** data showed that the operation with T-tube had better outcomes for duct stenosis(P=0.01,OR=0.45,95% CI 0.24-0.85).The operations with or without T-tube had equivalent outcomes as follows:overall biliary complications(P=0.85,OR=1.15,95% CI 0.28-4.72),bile leaks(P=0.38,OR=0.75,95% CI 0.39-1.42),and cholangitis(P=0.24,OR=4.64,95% CI 0.36-60.62).These results were strengthened by the analysis of all thirteen non-randomized and randomized ***:Our systematic review and meta-analysis suggest that the insertion of a T-tube reduces the incidence of biliary stenosis without increasing the incidence of other biliary complications.

关键词： Liver transplantation Drainage Biliary tract Meta-analysis T-tube

Some Problems of Recycling Industrial Materials

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Journal of Iron and Steel Research International 2008年第5期15卷 37-41,55页

作者： CAI jiu-ju LU Zhong-wu YUE Qiang SEPA Key Laboratory on Eco-Industry Northeastern University Shenyang 110004 Liaoning China

The industrial system should learn from the natural ecosystem. The resource utilization efficiency should be increased and the environmental load should be decreased, depending on the materials recycled in the system. The classification of industrial materials from the viewpoint of large-scale recycling was stated. Recycling of materials, on three different levels, was introduced in the industrial system. The metal flow diagram in the life cycle of products, in the case of no materials recycled, materials partially recycled, and materials completely recycled, was given. The natural resource conservation and the waste emission reduction were analyzed under the condition of materials completely recycled. The expressions for the relation between resource efficiency and material recycling rate, and the relation between eco-efficiency and material recycling rate were derived, and the curves describing the relationship between them were protracted. The diagram of iron flow in the life cycle of iron and steel products in China, in 2001, was given, and the iron resource efficiency, material recycling rate, and iron eco-efficiency were analyzed. The variation of iron resource efficiency with the material recycling rate was analyzed for two different production ratios.

关键词： recycling industrial material product life cycle resource efficiency eco-efficiency material recycling rate

An empirical description for the hinge-like mechanism in single-layer black phosphorus:The angle–angle cross interaction

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Acta Mechanica Solida Sinica 2017年第3期30卷 227-233页

作者： Jin-wu jiang Shanghai Institute of Applied Mathematics and Mechanics Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai University Shanghai 200072 China

The single-layer black phosphorus is characterized by its puckered configuration that pos- sesses the hinge-like behavior, which leads to the highly anisotropic in-plane Poisson＇s ratios and the negative out-of-plane Poisson＇s ratio. We demonstrate that the hinge-like mechanism can be described by the angle-angle cross interaction, which, combined with the bond stretching and angle bending interactions, is able to provide a good description for the mechanical properties of single-layer black phosphorus. We also propose a nonlinear angle-angle cross interaction, which follows the form of Stillinger-Weber potential and can be advantageous for molecular dynamics simulations of single-layer black phosphorus under large deformation.

关键词： Black phosphorus Stillinger-Weber potential Hinge-like mechanism Molecular dynamics simulation Mechanical properties

Metal hydride work pair development and its application on automobile air conditioning systems

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第2期8卷 197-204页

作者： QIN Feng CHEN jiang-ping ZHANG Wen-feng CHEN Zhi-jiu Institute of Refrigeration and Cryogenic Engineering Shanghai Jiao Tong University Shanghai 200030 China Research Center Zhejiang Yinlun Machinery Co. Ltd. Tiantai 317200 China

Aiming at developing exhaust gas driving automobile air conditioning systems, a hydride pair LaNi4.61Mn0.26A10.13/ La0.6Y0.4Ni4.8Mn0.2 was developed working at 393-473 K/293-323 K/263-273 K. Property tests showed that both alloys have flat plateau slopes and small hystereses; system theoretical coefficient of performance （COP） is 0.711. Based on this work pair, a function proving automobile metal hydride refrigeration system was constructed. The equivalent thermal conductivities of the activated reaction beds were merely 1.1-1.6 W/（m-K）, which had not met practical requirement. Intermittent refrigeration cycles were achieved and the average cooling power was 84.6 W at 423 K/303 K/273 K with COP being 0.26. By altering cycling parameters, experiment data showed that cooling power and system COP increase with the growth of heat source temperature as well as pre-heating and regeneration time while decrease with heat sink temperature increment. This study confirms the feasibility of automobile metal hydride refrigeration systems, while heat transfer properties of reaction beds still need to be improved for better performance.

关键词： Metal hydride Air conditioning Reaction bed Automobile Coefficient of performance (COP)