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A simplified method for the determination of vertically loaded pile-soil interface parameters in layered soil based on FLAC3D

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Frontiers of Structural and Civil Engineering 2016年第1期10卷 103-111页

作者： jiu-jiang wu Yan LI Qian-gong CHENG Hua WEN Xin LIAN School of Civil Engineering and Architecture Southwest University of Science and Technology Mianyang 621010 China Department of Geological Engineering Southwest Jiaotong University Chengdu 610031 China Faculty of Civil Engineering Guangxi University of Science and Technology Liuzhou 545006 China

The numerical analysis of pile-soil interaction commonly requires a lot of trial works to determine the interface parameters and the accuracy cannot be ensured normally. Considering this, this paper first conducts a sensitivity analysis to figure out the influence of interface parameters on the bearing behavior of a single pile in sand. Then, a simplified method for the determination of pile-soil interface parameters in layered soil is proposed based on the parameter studies. Finally, a filed loading test is used for the validation of the simplified method, and the calculated results agree well with the monitoring data. In general, the simplified method proposed in this paper works with higher accuracy and consumes less time compared with the traditional trial works, especially on the determinations ofinterfacial cohesive and interracial friction angle.

关键词： determination of interface parameters pile-soil interaction FLAC3D sensitivity analysis layered soil

Stability analysis of a high combination system of soil loess slope reinforced by the nails and stabilization piles

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Frontiers of Structural and Civil Engineering 2014年第3期8卷 252-259页

作者： jiu-jiang wu Qian-gong CHENG Xin LIANG Jian-Lei CAO Department of Geological Engineering Southwest Jiaotong University Chengdu 610031 China

While the soil nails and the corresponding compound technology are widely used as the support techniques for deep foundation pit and normal slopes, few related engineering cases are found for high loess slopes. By utilizing the finite element software of PLAXIS 8.5, the behavior of a high loess slope reinforced by the combination of soil nails and stabilization piles （hereinafter for CSNSP） is studied in this paper. It can be found that the potential slide surface of the slope moves to deeper locations during the process of the multi-staged excavations. The measure of reducing the weight of the top of the slope is a positive factor to the stability of the loess slope, while the rainfhll is a negative factor. The slope can＇t be stable if it＇s reinforced only by stabilization piles or soil nails during the process of the multi-staged excavations. The soil nail contributes greater to the overall system stability when the excavation depth is relatively shallow, while the stabilization pile takes it over when the excavation depth reaches a large value. Compared to the results from the Sweden circular slip surface, the data derived from the method of phi/c reduction is relatively large when the slope is unreinforced or reinforced only by stabilization pile, and the data turns to be small when the slope is strengthened by soil nails or the combination system of soil nails and stabilization piles.

关键词： high loess slope CSNSP PLAXIS philic strength reduction method Sweden circular slip surface

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亚稳态球霰石相碳酸钙的调控制备进展

无机材料学报 2017年第7期32卷 681-690页

作者：蒋久信吴月何瑶高松张晨沈彤刘嘉宁绿色轻质材料与加工湖北工业大学协同创新中心武汉430068 湖北工业大学材料与化学工程学院武汉430068 南京信息工程大学物理与光电工程学院南京210044 TU.Braunschweig Institut für Pharmazeutische Technologie Mendelssohnstr.

球霰石以其独特的机械、物理和化学性能,在日用品与生物医学等领域表现出广阔的应用前景。然而在三种无水碳酸钙晶体中,球霰石的热力学性能最不稳定,在后续的反应和处理过程中常常转变为更稳定的文石或方解石,因此如何抑制球霰石向稳定... 详细信息

球霰石以其独特的机械、物理和化学性能,在日用品与生物医学等领域表现出广阔的应用前景。然而在三种无水碳酸钙晶体中,球霰石的热力学性能最不稳定,在后续的反应和处理过程中常常转变为更稳定的文石或方解石,因此如何抑制球霰石向稳定晶型转变一直都是碳酸钙领域研究的热点。本文在概述了球霰石晶体结构、性质、应用及其转化途径的基础上,以碳酸钙的三种基本制备体系为线索,综述了碳化法、复分解法、微乳液法和溶剂热法等传统方法以及自组装单分子膜法、仿生合成法和热分解法等一些新型调控制备球霰石相方法的研究进展,还就利用添加剂促进球霰石形成与稳定的相关机制加以剖析。文章旨在为球霰石相碳酸钙的有效制备提供理论和实践的参考。

关键词：球霰石碳酸钙亚稳相调控综述

Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： You wu Lijie Yang Wanrong jiang Xinyuan Zhang Zhaohui Yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

含丁辛基二硫代磷酸锌润滑油在磁场中的摩擦学性能

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润滑与密封 2017年第1期42卷 75-79页

作者：江泽琦方建华陈波水郑哲王九吴江中国人民解放军后勤工程学院军事油料应用与管理工程系重庆401311

为研究磁场对含丁辛基二硫代磷酸锌(T202)润滑油摩擦学性能的影响,用改进后的四球摩擦磨损试验机考察有无磁场条件下T202在150SN基础油中的摩擦磨损性能,用扫描电子显微镜(SEM)和X射线光电子能谱仪(XPS)对比分析试件磨斑表面形貌及其典... 详细信息

为研究磁场对含丁辛基二硫代磷酸锌(T202)润滑油摩擦学性能的影响,用改进后的四球摩擦磨损试验机考察有无磁场条件下T202在150SN基础油中的摩擦磨损性能,用扫描电子显微镜(SEM)和X射线光电子能谱仪(XPS)对比分析试件磨斑表面形貌及其典型元素的化学状态,并初步探讨摩擦机制。摩擦学性能测试结果表明,磁场条件下测得的摩擦因数和磨斑直径均比无磁场时小;XPS分析表明,含T202润滑油润滑时磨痕表面发生了复杂的摩擦化学反应,磁场有利于T202中S、O、P、Zn元素与金属表面的结合,促进了金属表面化学反应膜的生成和对金属表面的改性而起到润滑增效的作用。

关键词：磁场丁辛基二硫代磷酸锌摩擦学性能

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang jiang wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

Preparation of Co/S co-doped carbon catalysts for excellent methylene blue degradation

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 169-181页

作者： Haixu Li Haobo He Tiannan jiang Yunfei Du Zhichen wu Liang Xu Xinjie Wang Xiaoguang Liu Wanhua Yu Wendong Xue School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Jinyu Tongda Refractory Technologies Co. Ltd.Beijing 100085China

S and Co co-doped carbon catalysts were prepared via pyrolysis of MOF-71 and thiourea mixtures at 800℃at a mass ratio of MOF-71 to thiourea of 1:0.1 to effectively activate peroxymonosulfate(PMS)for methylene blue(MB)*** effects of two different mixing routes were identified on the MB degradation ***,the catalyst obtained by the alcohol solvent evaporation(MOF-AEP)mixing route could degrade 95.60%MB(50 mg/L)within 4 min(degradation rate:K=0.78 min^(-1)),which was faster than that derived from the direct grinding method(MOF-DGP,80.97%,K=0.39 min^(-1)).X-ray photoelectron spectroscopy revealed that the Co-S content of MOF-AEP(43.39at%)was less than that of MOF-DGP(54.73at%),and the proportion of C-S-C in MOF-AEP(13.56at%)was higher than that of MOF-DGP(10.67at%).Density functional theory calculations revealed that the adsorption energy of Co for PMS was -2.94 eV when sulfur was doped as C-S-C on the carbon skeleton,which was higher than that when sulfur was doped next to cobalt in the form of Co-S bond(-2.86 eV).Thus,the C-S-C sites might provide more contributions to activate PMS compared with ***,the degradation parameters,including pH and MOF-AEP dosage,were ***,radical quenching experiments and electron paramagnetic resonance(EPR)measurements revealed that ^(1)O_(2)might be the primary catalytic species,whereas·O~(2-)might be the secondary one in degrading MB.

关键词： advanced oxidation process alcohol solvent evaporation hydrogen bond S and Co co-doped carbon catalysts wastewater remediation

Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien wu Jiwen jiang Fei Long Liyuan Han Qifeng Han Yi‑Bing Cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi wu Qian-Qian jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS