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Tetraphenylethylene-derived organic cages with persistent photogenic radicaloids and efficient photothermal conversion

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Science China Chemistry 2025年第2期68卷 661-669页

作者： Suqiong Yan Bo Yang Fanda Feng yuan Zhang Shirong Ban Hui Ma Wei Huang State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China Shenzhen Research Institute of Nanjing University Shenzhen 518057China

Transformation of the electronic spin states has received significant interest in recent years because of its applications in the magnetic information storage materials and optical response ***,it can be formidably challenging to use ultraviolet(UV)light as a contactless stimulus to alter the electronic spin states of the supramolecular *** by the approach on the radical cation mechanism of the Scholl reaction and the photocyclization reactivity of tetraphenylethylene(TPE)derivatives,we report two photochromic cages(cage-TPE-1 and cage-TPE-2)that can be photochemically transformed from electron paramagnetic resonance(EPR)-silent to EPR-active form via UV irradiation due to the photo-induced electron transfer process at the TPE *** provided a strong single-electron signal with a g value of 2.003 in cage-TPE-1 and cage-TPE-2 but no signal was detected for the pristine samples without the *** transformation can be monitored by ultraviolet–visible–near-infrared(UV–vis–NIR)and photoluminescence(PL)*** photogenic radical cage intermediate was unstable in solution resulting in the degradation and intramolecular cyclization of the reactive species,while the radicals were found to be stable and persistent in the solid state due to the spin delocalization,the steric protection of confined cavities,and the oxygen *** theoretical calculations and spectral measurements suggest that the photogenic radical cage-TPE-2(•+)experiences photocyclization on the TPE *** with the close-shell cage,the radical cage-TPE-1(•+)and cage-TPE-2(•+)exhibit better photothermal conversion performance due to the incubated infrared absorption from open-shell electron feature and reduced band gap.

关键词： supramolecular cage photogenic radical photocyclization photothermal conversion

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Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma

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World Journal of Clinical Oncology 2025年第2期16卷 29-35页

作者： Shi-Qiong Zhou Peng Wan Seng Zhang yuan Ren hong-Tao Li Qing-Hua Ke Department of Chemoradiotherapy The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor *** it metastasizes to the liver,treatment options become particularly limited and *** treatment options for liver metastatic PDAC are limited,and chemotherapy alone often proves ***,particularly programmed cell death 1(PD-1)inhibitors like sintilimab,shows potential efficacy for various cancers but has limited reports on *** study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic *** To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine(combination group)vs S-1 and gemcitabine used alone(chemotherapy group)for treating liver metastatic pancreatic *** Eligible patients were those with only liver metastatic PDAC,an Eastern Cooperative Oncology Group performance status of 0-1,adequate organ and marrow functions,and no prior anticancer *** in the combination group received intravenous sintilimab 200 mg every 3 weeks,oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle,and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles or until disease progression,death,or unacceptable *** in the chemotherapy group received oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight *** June 2020 and December 2021,66 participants were enrolled,with 32 receiving the combination treatment and 34 receiving chemotherapy *** The group receiving the combined therapy exhibited a markedly prolonged median overall survival(18.8 months compared to 10.3 months,P<0.05)and progression-free survival(9.6 months vs 5.4 months,P<0.05).compared to the chemotherapy *** incidence of severe adverse events did not differ sign

关键词： Immunotherapy Programmed cell death 1 inhibitor Sintilimab Chemotherapy Metastatic Pancreatic ductal adenocarcinoma

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Dual atom-bridge effect promoting interfacial charge transfer in 2D/2D Cs3Bi2Br9/BiOBr epitaxial heterojunction for efficient photocatalysis

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Chinese Chemical Letters 2025年第2期36卷 218-223页

作者： yuan Teng Zichun Zhou Jinghua Chen Siying Huang hongyan Chen Daibin Kuang MOE Key Laboratory of Bioinorganic and Synthetic Chemistry LIFM GBRCE for Functional Molecular Engineering School of Chemistry IGCME Sun Yat-sen University National Experimental Teaching Demonstration Center for Chemistry College of Chemistry and Chemical Engineering Jishou University

Optimizing the interfacial quality of halide perovskites heterojunction to promote the photogenerated charge separation is of great significance in photocatalytic ***,the delicately regulation of interfacial structure and properties of halide perovskites hybrid is still a big challenge owing to the growth uncontrollability and incompatibility between different *** we use Bi OBr nanosheets as the start-template to in situ epitaxially grow Cs3Bi2Br9nanosheets by“cosharing”Bi and Br atoms strategy for designing a 2D/2D Cs3Bi2Br9/BiOBr *** studies show that the epitaxial heterojunction can optimize the synergistic effect of Bi OBr and Cs3Bi2Br9via the formation of tight-contact interfaces,strong interfacial electronic coupling and charge redistribution,which can not only drive the Z-scheme charge transfer mechanism to greatly promote the spatial separation of electronhole pairs,but also modulate the interfacial electronic structure to facilitate the adsorption and activation of toluene *** heterojunction exhibited 62.3 and 2.4-fold photoactivity improvement for toluene oxidation to benzaldehyde than parental Bi OBr and Cs3Bi2Br9,*** study not only proposed a novel dual atom-bridge protocol to engineer high-quality perovskite heterojunctions,but also uncovered the potential of heterojunction in promoting electron-hole separation as well as the application in photocatalytic organic synthesis.

关键词： Bismuth oxyhalide Bismuth-based perovskite Direct Z-scheme heterojunction Dual atom-bridge effect Photocatalytic C(sp3)-H bond activation

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数字弱势群体数字排斥的关键影响因素与政策优化研究——基于理论—政策协同度视角

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情报理论与实践 2025年第1期48卷 104-113页

作者：袁红黄庆庆南通大学管理学院江苏南通226019

[目的/意义]数字化浪潮中,因主客观原因无法有效接入数字技术的数字弱势群体往往表现出数字排斥与抵触行为,探寻该群体数字排斥的关键影响因素,分析当前数字包容政策工具运用现状与优化路径具有重要意义。[方法/过程]基于理论—政策协... 详细信息

[目的/意义]数字化浪潮中,因主客观原因无法有效接入数字技术的数字弱势群体往往表现出数字排斥与抵触行为,探寻该群体数字排斥的关键影响因素,分析当前数字包容政策工具运用现状与优化路径具有重要意义。[方法/过程]基于理论—政策协同视角,依据个人信息世界理论,采用元人种志和DEMATEL方法,明确数字弱势群体数字排斥的关键影响因素,开展当前数字包容政策侧重点的内容分析,并提出政策优化路径。[结果/结论]确定了数字素养、功能—需求匹配度、信息基础设施、志愿服务资源等9个关键影响因素,部分影响因素的理论—政策协同度不高,据此提出相应的政策优化路径。

关键词：数字弱势群体数字排斥个人信息世界理论数字包容理论—政策协同度

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The gut microbiome modulate response to immunotherapy in cancer

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Science China(Life Sciences) 2025年第2期68卷 381-396页

作者： Shan-Shan Jiang Zi-Ran Kang Ying-Xuan Chen Jing-yuan Fang Division of Gastroenterologyand Hepatology Shanghai Instituteof Digestive DiseaseNHC KeyLaboratoryof Digestive DiseasesState KeyLaboratoryfor Oncogenesand Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China

Gut microbiota have been reported to play an important role in the occurrence and development of malignant ***,clinical studies have identified specific gut microbiota and its metabolites associated with efficacy of immunotherapy in multiple types of *** investigations have elucidated that gut microbiota modulate the antitumor immunity and affect the efficacy of cancer *** microbiota and its metabolites may favorably remodel the tumor microenvironment by engaging innate and/or adaptive immune *** how the gut microbiome interacts with cancer immunotherapy opens new avenues for improving treatment *** microbial transplants,probiotics,dietary interventions,and other strategies targeting the microbiota have shown promise in preclinical studies to enhance the *** clinical trials are evaluating these *** review presents the recent advancements in understanding the dynamic interplay among the host immunity,the microbiome,and cancer immunotherapy,as well as strategies for modulating the microbiome,with a view to translating into clinical applications.

关键词： cancer immunotherapy gut microbiota intratumoral microbiota microbiota-derived metabolites innate and adaptive immunity

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Metamorphic P-T-t Evolution of Granulite in the Yishui Area:New Insights into the Tectonic Evolution of the Eastern Block,North China Craton

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Acta Geologica Sinica(English Edition) 2025年第1期99卷 69-82页

作者： CHEN Ziyuan yuan Mingkao Zhong Zhenyu LI Tianqi WANG Guodong XIAO Lingling School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Shandong Provincial Key Laboratory of Water and Soil Conservation and Environmental Protection/School of Resources and Environment Linyi UniversityLinyiShandong 276000China Shandong Institute of Geophysical and Geochemical Exploration Jinan 250013China Institute of Digital Geology and Energy Linyi UniversityLinyiShandong 276000China

The Yishui complex,located in the western Shandong area of the North China Craton,is representative of the Archean crystalline basement of the North China Craton to explore the early tectonic-thermal evolution history of the *** petrography,mineral chemistry,metamorphic evolution and zircon U-Pb dating are presented for felsic granulite and two-pyroxene granulite from the Yishui complex to contribute to new insights into the Neoarchean tectonic evolution of the North China *** mineral assemblages are recognized for these granulite samples,including the prograde(M1),peak(M2)and retrograde(M3)mineral *** geothermobarometry and phase equilibrium modeling yield P-T conditions of 6.5-10.9 kbar/718-839℃ for the peak metamorphism,which define a medium-pressure granulite-facies metamorphism occurred at middle to lower *** P-T paths with near-isobaric cooling(IBC)retrograde segments were *** LA-ICP-MS U-Pb dating suggests that the protolith of the felsic granulite was emplaced at 2541±7 Ma and the subsequent medium-pressure granulite-facies metamorphism occurred at 2518-2494 Ma.A two-stage mantle plume related crustal-scale sagduction geodynamic regime is proposed in the western Shandong terrane in the Neoarchean.

关键词： metamorphic evolution geochronology granulite Yishui complex North China Craton

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Mapping the landscape of gastric cancer immunotherapy:Bibliometric insights into advances and hotspots

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 349-370页

作者： Zhen yuan Jing-Hang Wang Hao Cui Shu-yuan Wang Bo Wei Jian-Xin Cui School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND Immunotherapy has surfaced as a promising therapeutic modality for gastric cancer(GC).A comprehensive review of advancements,current status,and research trends in GC immunotherapy is essential to inform future investigative *** To delineate the trends,advancements,and focal points in immunotherapy for *** We performed a bibliometric analysis of 2906 articles in English concerning GC immunotherapy published from 2000 to December 20,2023,indexed in the Web of Science Core *** analysis and visualization were facilitated by CiteSpace(6.1.6R),VOSviewer v.1.6.17,and GraphPad Prism *** There has been an increase in the annual publication rate of GC immunotherapy *** leads in publication volume,while the United States demonstrates the highest citation *** University is notable for its citation frequency and publication ***-citation analysis and keyword frequency revealed and highlighted a focus on GC prognosis,the tumor microenvironment(TME),and integrative immunotherapy with targeted *** research areas include gastroesophageal junction cancer,adoptive immunotherapy,and the role of Treg cell in *** GC immunotherapy research is an expanding field attracting considerable scientific *** the clinical adoption of immunotherapy in GC,the primary goals are to enhance treatment efficacy and patient *** hematological malignancies,GC's solid TME presents distinct immunological challenges that may attenuate the cytotoxic effects of immune cells on cancer *** instance,although CAR-T therapy is effective in hematological malignancies,it has underperformed in GC *** research is centered on overcoming immunosuppression within the TME,with a focus on combinations of targeted therapy,adoptive immunotherapy,Treg cell dynamics,and precise prognosis prediction in ***,immunotherapy's role in treating gastroesophageal junctio

关键词： Bibliometrics Gastric cancer Immunotherapy Immune checkpoint inhibitor Tumor microenvironment

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang hong-Yu Tang Chun-Mao yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines(Chinese Academy of Sciences) Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Shenzhen Bay Laboratory Shenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Microbial Metabolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201China Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesBeijing 100730China

In the intricate process of natural product biosynthesis,a metabolon can enhance metabolic flux by associating sequential enzymes.A fungal metabolon,comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G,is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide *** notoamide E as a substance,Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation,followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium ***,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol *** provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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Facilitated water dissociation by coupling bimetallic phosphide with manganese oxide to enhance alkaline hydrogen evolution

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Nano Research 2025年第2期18卷 184-192页

作者： Xiaolan Tang Na Yang Zixiao Li Xun He Qiuying Dai Hefeng Wang Yongchao Yao Yujie yuan hong Tang Dongdong Zheng Shengjun Sun Asmaa Farouk Mohamed S.Hamdy Xiaobin Niu Tingshuai Li Xuping Sun Bo Tang School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Center for High Altitude Medicine West China HospitalSichuan UniversityChengdu 610041China Department of Chemistry College of ScienceKing Khalid UniversityP.O.Box 900461413 AbhaSaudi Arabia Laoshan Laboratory Qingdao 266237China

Fabricating catalysts with efficient water dissociation and robust stability is key to advancing the industrialization of the alkaline hydrogen evolution reaction(HER).Establishing an effective phosphide/oxide interface is a feasible way to improve the HER performance of the catalyst in an alkaline medium,but it remains ***,we adopt that manganese oxide nanoparticles decorated on nickel-cobalt phosphide nanowire array on nickel foam(MnO_(x)@NiCoP/NF)via a surface modification strategy that shifts the d-band center downward,promoting the water dissociation and hydrogen intermediate ***,MnO_(x) makes the surface of NiCoP rougher,facilitating bubble release and improving the array ***,MnO_(x)@NiCoP/NF achieves industrial current densities of 500 and 1000 mA·cm^(-2) with overpotentials of 171 and 193 mV,respectively,while maintaining stable operation for over 600 h at 1000 mA·cm^(-2) in 1 M ***,an anion exchange membrane electrolyzer with the catalyst was fabricated and shows potential for practical applications.

关键词： manganese oxide bimetallic phosphides heterojunction hydrogen evolution reaction water electrolysis

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Phase transition thermosensitive photocatalytic hydrogel for enhanced uranium extraction

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Science Bulletin 2025年第1期70卷 4-6页

作者： Jiacheng Zhang Yihui yuan Ning Wang State Key Laboratory of Marine Resource Utilization in South China Sea Collaborative Innovation Center of Marine Science and TechnologyHainan UniversityHaikou 570228China

As a clean energy source,nuclear energy is crucial for realizing carbon neutralization and the construction of many nuclear plants is underway[1].According to an estimate by the International Atomic Energy Agency,the global nuclear energy production is expected to increase by 56%between 2015 and 2030[2].However,with current consumption rate of uranium resources,terrestrial uranium reserves will be depleted within approximately 80 years[3,4].

关键词： approximate transition hydrogel

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